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Protein

Parathyroid hormone 2 receptor

Gene

PTH2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).By similarity

GO - Molecular functioni

  • parathyroid hormone receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-418555 G alpha (s) signalling events
SIGNORiP49190

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:PTH2R
Synonyms:PTHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144407.9
HGNCiHGNC:9609 PTH2R
MIMi601469 gene
neXtProtiNX_P49190

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 145ExtracellularSequence analysisAdd BLAST119
Transmembranei146 – 169Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini170 – 176CytoplasmicSequence analysis7
Transmembranei177 – 196Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini197 – 237ExtracellularSequence analysisAdd BLAST41
Transmembranei238 – 260Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini261 – 275CytoplasmicSequence analysisAdd BLAST15
Transmembranei276 – 297Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini298 – 316ExtracellularSequence analysisAdd BLAST19
Transmembranei317 – 337Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini338 – 364CytoplasmicSequence analysisAdd BLAST27
Transmembranei365 – 383Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini384 – 394ExtracellularSequence analysisAdd BLAST11
Transmembranei395 – 417Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini418 – 550CytoplasmicSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5746
OpenTargetsiENSG00000144407
PharmGKBiPA162400333

Chemistry databases

DrugBankiDB05829 Parathyroid hormone
GuidetoPHARMACOLOGYi332

Polymorphism and mutation databases

DMDMi1346906

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001284925 – 550Parathyroid hormone 2 receptorAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49190
PeptideAtlasiP49190
PRIDEiP49190
ProteomicsDBi55969
TopDownProteomicsiP49190

PTM databases

iPTMnetiP49190
PhosphoSitePlusiP49190

Expressioni

Tissue specificityi

Expressed abundantly in brain and pancreas. Also expressed in the testis.1 Publication

Gene expression databases

BgeeiENSG00000144407
CleanExiHS_PTH2R
ExpressionAtlasiP49190 baseline and differential
GenevisibleiP49190 HS

Organism-specific databases

HPAiHPA010655

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.

Binary interactionsi

WithEntry#Exp.IntActNotes
HMG20AQ9NP663EBI-1045772,EBI-740641

Protein-protein interaction databases

BioGridi111718, 3 interactors
IntActiP49190, 3 interactors
MINTiP49190
STRINGi9606.ENSP00000272847

Structurei

3D structure databases

ProteinModelPortaliP49190
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008248
HOVERGENiHBG008318
InParanoidiP49190
KOiK04586
OMAiCGGHRYG
OrthoDBiEOG091G0NF8
PhylomeDBiP49190
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF
110 120 130 140 150
RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV
160 170 180 190 200
GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV
210 220 230 240 250
VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN
260 270 280 290 300
YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT
310 320 330 340 350
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV
360 370 380 390 400
GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF
410 420 430 440 450
FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS
460 470 480 490 500
VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS
510 520 530 540 550
EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL
Length:550
Mass (Da):62,236
Last modified:February 1, 1996 - v1
Checksum:i2ADD14DBA68A9BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25128 mRNA Translation: AAC50157.1
AY497546 mRNA Translation: AAR90849.1
BC036811 mRNA Translation: AAH36811.2
U47124 Genomic DNA Translation: AAA96796.1
AH006647 Genomic DNA Translation: AAC50767.1
CCDSiCCDS2383.1
PIRiA57519
RefSeqiNP_001296445.1, NM_001309516.1
NP_005039.1, NM_005048.3
UniGeneiHs.570296

Genome annotation databases

EnsembliENST00000272847; ENSP00000272847; ENSG00000144407
GeneIDi5746
KEGGihsa:5746
UCSCiuc002vdb.5 human

Similar proteinsi

Entry informationi

Entry nameiPTH2R_HUMAN
AccessioniPrimary (citable) accession number: P49190
Secondary accession number(s): Q8N429
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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