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P49190

- PTH2R_HUMAN

UniProt

P49190 - PTH2R_HUMAN

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Protein

Parathyroid hormone 2 receptor

Gene
PTH2R, PTHR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.

GO - Molecular functioni

  1. parathyroid hormone receptor activity Source: ProtInc

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:PTH2R
Synonyms:PTHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:9609. PTH2R.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 145119Extracellular Reviewed predictionAdd
BLAST
Transmembranei146 – 16924Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini170 – 1767Cytoplasmic Reviewed prediction
Transmembranei177 – 19620Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini197 – 23741Extracellular Reviewed predictionAdd
BLAST
Transmembranei238 – 26023Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini261 – 27515Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei276 – 29722Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini298 – 31619Extracellular Reviewed predictionAdd
BLAST
Transmembranei317 – 33721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini338 – 36427Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei365 – 38319Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini384 – 39411Extracellular Reviewed predictionAdd
BLAST
Transmembranei395 – 41723Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini418 – 550133Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 550526Parathyroid hormone 2 receptorPRO_0000012849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49190.
PRIDEiP49190.

PTM databases

PhosphoSiteiP49190.

Expressioni

Tissue specificityi

Expressed abundantly in brain and pancreas. Also expressed in the testis.1 Publication

Gene expression databases

ArrayExpressiP49190.
BgeeiP49190.
CleanExiHS_PTH2R.
GenevestigatoriP49190.

Organism-specific databases

HPAiHPA010655.

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.1 Publication

Protein-protein interaction databases

BioGridi111718. 2 interactions.
IntActiP49190. 1 interaction.
MINTiMINT-1217607.
STRINGi9606.ENSP00000272847.

Structurei

3D structure databases

ProteinModelPortaliP49190.
SMRiP49190. Positions 24-129, 132-423.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293423.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiP49190.
KOiK04586.
OMAiVGCKIAV.
OrthoDBiEOG7TF78W.
PhylomeDBiP49190.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49190-1 [UniParc]FASTAAdd to Basket

« Hide

MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL    50
NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF 100
RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV 150
GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV 200
VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN 250
YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 300
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV 350
GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF 400
FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS 450
VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS 500
EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL 550
Length:550
Mass (Da):62,236
Last modified:February 1, 1996 - v1
Checksum:i2ADD14DBA68A9BF8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25128 mRNA. Translation: AAC50157.1.
AY497546 mRNA. Translation: AAR90849.1.
BC036811 mRNA. Translation: AAH36811.2.
U47124 Genomic DNA. Translation: AAA96796.1.
AH006647 Genomic DNA. Translation: AAC50767.1.
CCDSiCCDS2383.1.
PIRiA57519.
RefSeqiNP_005039.1. NM_005048.3.
UniGeneiHs.570296.

Genome annotation databases

EnsembliENST00000272847; ENSP00000272847; ENSG00000144407.
GeneIDi5746.
KEGGihsa:5746.
UCSCiuc002vdb.4. human.

Polymorphism databases

DMDMi1346906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U25128 mRNA. Translation: AAC50157.1 .
AY497546 mRNA. Translation: AAR90849.1 .
BC036811 mRNA. Translation: AAH36811.2 .
U47124 Genomic DNA. Translation: AAA96796.1 .
AH006647 Genomic DNA. Translation: AAC50767.1 .
CCDSi CCDS2383.1.
PIRi A57519.
RefSeqi NP_005039.1. NM_005048.3.
UniGenei Hs.570296.

3D structure databases

ProteinModelPortali P49190.
SMRi P49190. Positions 24-129, 132-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111718. 2 interactions.
IntActi P49190. 1 interaction.
MINTi MINT-1217607.
STRINGi 9606.ENSP00000272847.

Chemistry

GuidetoPHARMACOLOGYi 332.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P49190.

Polymorphism databases

DMDMi 1346906.

Proteomic databases

PaxDbi P49190.
PRIDEi P49190.

Protocols and materials databases

DNASUi 5746.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272847 ; ENSP00000272847 ; ENSG00000144407 .
GeneIDi 5746.
KEGGi hsa:5746.
UCSCi uc002vdb.4. human.

Organism-specific databases

CTDi 5746.
GeneCardsi GC02P209224.
HGNCi HGNC:9609. PTH2R.
HPAi HPA010655.
MIMi 601469. gene.
neXtProti NX_P49190.
PharmGKBi PA162400333.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293423.
HOGENOMi HOG000008248.
HOVERGENi HBG008318.
InParanoidi P49190.
KOi K04586.
OMAi VGCKIAV.
OrthoDBi EOG7TF78W.
PhylomeDBi P49190.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_18372. Class B/2 (Secretin family receptors).
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Parathyroid_hormone_2_receptor.
GenomeRNAii 5746.
NextBioi 22376.
PROi P49190.
SOURCEi Search...

Gene expression databases

ArrayExpressi P49190.
Bgeei P49190.
CleanExi HS_PTH2R.
Genevestigatori P49190.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor."
    Usdin T.B., Gruber C., Bonner T.I.
    J. Biol. Chem. 270:15455-15458(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    King M.M., Aronstam R.S., Sharma S.V.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization."
    Usdin T.B., Modi W., Bonner T.I.
    Genomics 37:140-141(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-40 AND 306-550.
  5. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
    John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
    Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIPF39/TI39.

Entry informationi

Entry nameiPTH2R_HUMAN
AccessioniPrimary (citable) accession number: P49190
Secondary accession number(s): Q8N429
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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