Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P49190 (PTH2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Parathyroid hormone 2 receptor

Short name=PTH2 receptor
Gene names
Name:PTH2R
Synonyms:PTHR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.

Subunit structure

Binds to TIPF39/TIP39. Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed abundantly in brain and pancreas. Also expressed in the testis. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 550526Parathyroid hormone 2 receptor
PRO_0000012849

Regions

Topological domain27 – 145119Extracellular Potential
Transmembrane146 – 16924Helical; Name=1; Potential
Topological domain170 – 1767Cytoplasmic Potential
Transmembrane177 – 19620Helical; Name=2; Potential
Topological domain197 – 23741Extracellular Potential
Transmembrane238 – 26023Helical; Name=3; Potential
Topological domain261 – 27515Cytoplasmic Potential
Transmembrane276 – 29722Helical; Name=4; Potential
Topological domain298 – 31619Extracellular Potential
Transmembrane317 – 33721Helical; Name=5; Potential
Topological domain338 – 36427Cytoplasmic Potential
Transmembrane365 – 38319Helical; Name=6; Potential
Topological domain384 – 39411Extracellular Potential
Transmembrane395 – 41723Helical; Name=7; Potential
Topological domain418 – 550133Cytoplasmic Potential

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1211N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P49190 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2ADD14DBA68A9BF8

FASTA55062,236
        10         20         30         40         50         60 
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE 

        70         80         90        100        110        120 
GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA 

       130        140        150        160        170        180 
NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH 

       190        200        210        220        230        240 
MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV 

       250        260        270        280        290        300 
VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 

       310        320        330        340        350        360 
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK 

       370        380        390        400        410        420 
LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV 

       430        440        450        460        470        480 
QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK 

       490        500        510        520        530        540 
IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE 

       550 
GCQGETEDVL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor."
Usdin T.B., Gruber C., Bonner T.I.
J. Biol. Chem. 270:15455-15458(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain.
[2]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
King M.M., Aronstam R.S., Sharma S.V.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Retina.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization."
Usdin T.B., Modi W., Bonner T.I.
Genomics 37:140-141(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-40 AND 306-550.
[5]"Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TIPF39/TI39.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U25128 mRNA. Translation: AAC50157.1.
AY497546 mRNA. Translation: AAR90849.1.
BC036811 mRNA. Translation: AAH36811.2.
U47124 Genomic DNA. Translation: AAA96796.1.
AH006647 Genomic DNA. Translation: AAC50767.1.
PIRA57519.
RefSeqNP_005039.1. NM_005048.3.
UniGeneHs.570296.

3D structure databases

ProteinModelPortalP49190.
SMRP49190. Positions 24-129, 132-423.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111718. 2 interactions.
IntActP49190. 1 interaction.
MINTMINT-1217607.
STRING9606.ENSP00000272847.

Chemistry

GuidetoPHARMACOLOGY332.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP49190.

Polymorphism databases

DMDM1346906.

Proteomic databases

PaxDbP49190.
PRIDEP49190.

Protocols and materials databases

DNASU5746.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272847; ENSP00000272847; ENSG00000144407.
GeneID5746.
KEGGhsa:5746.
UCSCuc002vdb.4. human.

Organism-specific databases

CTD5746.
GeneCardsGC02P209224.
HGNCHGNC:9609. PTH2R.
HPAHPA010655.
MIM601469. gene.
neXtProtNX_P49190.
PharmGKBPA162400333.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293423.
HOGENOMHOG000008248.
HOVERGENHBG008318.
InParanoidP49190.
KOK04586.
OMAVGCKIAV.
OrthoDBEOG7TF78W.
PhylomeDBP49190.
TreeFamTF315710.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP49190.
BgeeP49190.
CleanExHS_PTH2R.
GenevestigatorP49190.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiParathyroid_hormone_2_receptor.
GenomeRNAi5746.
NextBio22376.
PROP49190.
SOURCESearch...

Entry information

Entry namePTH2R_HUMAN
AccessionPrimary (citable) accession number: P49190
Secondary accession number(s): Q8N429
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries