Parathyroid hormone 2 receptor precursor

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P49190 (PTH2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Parathyroid hormone 2 receptor
Short name=PTH2 receptor

Gene names

Name:	PTH2R
Synonyms:	PTHR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.
Subunit structure	Binds to TIPF39/TIP39. Ref.5
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed abundantly in brain and pancreas. Also expressed in the testis. Ref.1
Sequence similarities	Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	parathyroid hormone receptor activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 550

526

Parathyroid hormone 2 receptor

PRO_0000012849

Regions

Topological domain

27 – 145

119

Extracellular Potential

Transmembrane

146 – 169

Helical; Name=1; Potential

Topological domain

170 – 176

Cytoplasmic Potential

Transmembrane

177 – 196

Helical; Name=2; Potential

Topological domain

197 – 237

Extracellular Potential

Transmembrane

238 – 260

Helical; Name=3; Potential

Topological domain

261 – 275

Cytoplasmic Potential

Transmembrane

276 – 297

Helical; Name=4; Potential

Topological domain

298 – 316

Extracellular Potential

Transmembrane

317 – 337

Helical; Name=5; Potential

Topological domain

338 – 364

Cytoplasmic Potential

Transmembrane

365 – 383

Helical; Name=6; Potential

Topological domain

384 – 394

Extracellular Potential

Transmembrane

395 – 417

Helical; Name=7; Potential

Topological domain

418 – 550

133

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

106

N-linked (GlcNAc...) Potential

Glycosylation

116

N-linked (GlcNAc...) Potential

Glycosylation

121

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P49190 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 2ADD14DBA68A9BF8
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FASTA

550

62,236

        10         20         30         40         50         60 
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL NITAQLQEGE 

        70         80         90        100        110        120 
GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF RHCNPNGTWD FMHSLNKTWA 

       130        140        150        160        170        180 
NYSDCLRFLQ PDISIGKQEF FERLYVMYTV GYSISFGSLA VAILIIGYFR RLHCTRNYIH 

       190        200        210        220        230        240 
MHLFVSFMLR ATSIFVKDRV VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV 

       250        260        270        280        290        300 
VMFIYFLATN YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 

       310        320        330        340        350        360 
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV GHDTRKQYRK 

       370        380        390        400        410        420 
LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF FNSFQGFFVS IIYCYCNGEV 

       430        440        450        460        470        480 
QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS VLTTVTHSTS SQSQVAASTR MVLISGKAAK 

       490        500        510        520        530        540 
IASRQPDSHI TLPGYVWSNS EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE 

       550 
GCQGETEDVL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor." Usdin T.B., Gruber C., Bonner T.I. J. Biol. Chem. 270:15455-15458(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain.
[2]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M., Aronstam R.S., Sharma S.V. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Retina.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization." Usdin T.B., Modi W., Bonner T.I. Genomics 37:140-141(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-40 AND 306-550.
[5]	"Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues." John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H. Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TIPF39/TI39.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U25128 mRNA. Translation: AAC50157.1. AY497546 mRNA. Translation: AAR90849.1. BC036811 mRNA. Translation: AAH36811.2. U47124 Genomic DNA. Translation: AAA96796.1. AH006647 Genomic DNA. Translation: AAC50767.1.
IPI	IPI00927172.
PIR	A57519.
RefSeq	NP_005039.1. NM_005048.3.
UniGene	Hs.570296.
3D structure databases
ProteinModelPortal	P49190.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49190. 1 interaction.
MINT	MINT-1217607.
STRING	9606.ENSP00000272847.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P49190.
Polymorphism databases
DMDM	1346906.
Proteomic databases
PaxDb	P49190.
PRIDE	P49190.
Protocols and materials databases
DNASU	5746.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272847; ENSP00000272847; ENSG00000144407.
GeneID	5746.
KEGG	hsa:5746.
UCSC	uc002vdb.3. human.
Organism-specific databases
CTD	5746.
GeneCards	GC02P209224.
HGNC	HGNC:9609. PTH2R.
MIM	601469. gene.
neXtProt	NX_P49190.
PharmGKB	PA162400333.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG293423.
HOGENOM	HOG000008248.
HOVERGEN	HBG008318.
InParanoid	P49190.
KO	K04586.
OMA	VGCKIAV.
PhylomeDB	P49190.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P49190.
Bgee	P49190.
CleanEx	HS_PTH2R.
Genevestigator	P49190.
GermOnline	ENSG00000144407. Homo sapiens.
Family and domain databases
InterPro	IPR017981. GPCR_2-like. IPR001879. GPCR_2_extracellular_dom. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF02793. HRM. 1 hit. [Graphical view]
PRINTS	PR00249. GPCRSECRETIN.
SMART	SM00008. HormR. 1 hit. [Graphical view]
PROSITE	PS00649. G_PROTEIN_RECEP_F2_1. 1 hit. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50227. G_PROTEIN_RECEP_F2_3. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5746.
NextBio	22376.
SOURCE	Search...

Entry information

Entry name

PTH2R_HUMAN

Accession

Primary (citable) accession number: P49190
Secondary accession number(s): Q8N429

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents