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Protein

Parathyroid hormone 2 receptor

Gene

PTH2R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).By similarity

GO - Molecular functioni

  • parathyroid hormone receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: InterPro
  • G-protein coupled receptor signaling pathway Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373080. Class B/2 (Secretin family receptors).
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP49190.

Names & Taxonomyi

Protein namesi
Recommended name:
Parathyroid hormone 2 receptor
Short name:
PTH2 receptor
Gene namesi
Name:PTH2R
Synonyms:PTHR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144407.9.
HGNCiHGNC:9609. PTH2R.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 145ExtracellularSequence analysisAdd BLAST119
Transmembranei146 – 169Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini170 – 176CytoplasmicSequence analysis7
Transmembranei177 – 196Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini197 – 237ExtracellularSequence analysisAdd BLAST41
Transmembranei238 – 260Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini261 – 275CytoplasmicSequence analysisAdd BLAST15
Transmembranei276 – 297Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini298 – 316ExtracellularSequence analysisAdd BLAST19
Transmembranei317 – 337Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini338 – 364CytoplasmicSequence analysisAdd BLAST27
Transmembranei365 – 383Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini384 – 394ExtracellularSequence analysisAdd BLAST11
Transmembranei395 – 417Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini418 – 550CytoplasmicSequence analysisAdd BLAST133

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5746.
OpenTargetsiENSG00000144407.
PharmGKBiPA162400333.

Chemistry databases

DrugBankiDB05829. Parathyroid hormone.
GuidetoPHARMACOLOGYi332.

Polymorphism and mutation databases

DMDMi1346906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001284925 – 550Parathyroid hormone 2 receptorAdd BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP49190.
PeptideAtlasiP49190.
PRIDEiP49190.
TopDownProteomicsiP49190.

PTM databases

iPTMnetiP49190.
PhosphoSitePlusiP49190.

Expressioni

Tissue specificityi

Expressed abundantly in brain and pancreas. Also expressed in the testis.1 Publication

Gene expression databases

BgeeiENSG00000144407.
CleanExiHS_PTH2R.
ExpressionAtlasiP49190. baseline and differential.
GenevisibleiP49190. HS.

Organism-specific databases

HPAiHPA010655.

Interactioni

Subunit structurei

Binds to TIPF39/TIP39.

Binary interactionsi

WithEntry#Exp.IntActNotes
HMG20AQ9NP663EBI-1045772,EBI-740641

Protein-protein interaction databases

BioGridi111718. 3 interactors.
IntActiP49190. 3 interactors.
MINTiMINT-1217607.
STRINGi9606.ENSP00000272847.

Structurei

3D structure databases

ProteinModelPortaliP49190.
SMRiP49190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008248.
HOVERGENiHBG008318.
InParanoidiP49190.
KOiK04586.
OMAiCGGHRYG.
OrthoDBiEOG091G0NF8.
PhylomeDBiP49190.
TreeFamiTF315710.

Family and domain databases

Gene3Di4.10.1240.10. 1 hit.
InterProiView protein in InterPro
IPR017981. GPCR_2-like.
IPR036445. GPCR_2_extracell_dom_sf.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
PfamiView protein in Pfam
PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
PRINTSiPR00249. GPCRSECRETIN.
SMARTiView protein in SMART
SM00008. HormR. 1 hit.
SUPFAMiSSF111418. SSF111418. 1 hit.
PROSITEiView protein in PROSITE
PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL
60 70 80 90 100
NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF
110 120 130 140 150
RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV
160 170 180 190 200
GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV
210 220 230 240 250
VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN
260 270 280 290 300
YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT
310 320 330 340 350
LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV
360 370 380 390 400
GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF
410 420 430 440 450
FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS
460 470 480 490 500
VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS
510 520 530 540 550
EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL
Length:550
Mass (Da):62,236
Last modified:February 1, 1996 - v1
Checksum:i2ADD14DBA68A9BF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U25128 mRNA. Translation: AAC50157.1.
AY497546 mRNA. Translation: AAR90849.1.
BC036811 mRNA. Translation: AAH36811.2.
U47124 Genomic DNA. Translation: AAA96796.1.
AH006647 Genomic DNA. Translation: AAC50767.1.
CCDSiCCDS2383.1.
PIRiA57519.
RefSeqiNP_001296445.1. NM_001309516.1.
NP_005039.1. NM_005048.3.
UniGeneiHs.570296.

Genome annotation databases

EnsembliENST00000272847; ENSP00000272847; ENSG00000144407.
GeneIDi5746.
KEGGihsa:5746.
UCSCiuc002vdb.5. human.

Similar proteinsi

Entry informationi

Entry nameiPTH2R_HUMAN
AccessioniPrimary (citable) accession number: P49190
Secondary accession number(s): Q8N429
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 25, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families