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P49190

- PTH2R_HUMAN

UniProt

P49190 - PTH2R_HUMAN

Protein

Parathyroid hormone 2 receptor

Gene

PTH2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor By similarity.By similarity

    GO - Molecular functioni

    1. parathyroid hormone receptor activity Source: ProtInc

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18372. Class B/2 (Secretin family receptors).
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Parathyroid hormone 2 receptor
    Short name:
    PTH2 receptor
    Gene namesi
    Name:PTH2R
    Synonyms:PTHR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:9609. PTH2R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400333.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 550526Parathyroid hormone 2 receptorPRO_0000012849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP49190.
    PRIDEiP49190.

    PTM databases

    PhosphoSiteiP49190.

    Expressioni

    Tissue specificityi

    Expressed abundantly in brain and pancreas. Also expressed in the testis.1 Publication

    Gene expression databases

    ArrayExpressiP49190.
    BgeeiP49190.
    CleanExiHS_PTH2R.
    GenevestigatoriP49190.

    Organism-specific databases

    HPAiHPA010655.

    Interactioni

    Subunit structurei

    Binds to TIPF39/TIP39.

    Protein-protein interaction databases

    BioGridi111718. 2 interactions.
    IntActiP49190. 1 interaction.
    MINTiMINT-1217607.
    STRINGi9606.ENSP00000272847.

    Structurei

    3D structure databases

    ProteinModelPortaliP49190.
    SMRiP49190. Positions 24-129, 132-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 145119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini170 – 1767CytoplasmicSequence Analysis
    Topological domaini197 – 23741ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27515CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 31619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini338 – 36427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini384 – 39411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini418 – 550133CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei146 – 16924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei177 – 19620Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 26023Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29722Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei365 – 38319Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei395 – 41723Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293423.
    HOGENOMiHOG000008248.
    HOVERGENiHBG008318.
    InParanoidiP49190.
    KOiK04586.
    OMAiVGCKIAV.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP49190.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49190-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGLGASLHV WGWLMLGSCL LARAQLDSDG TITIEEQIVL VLKAKVQCEL    50
    NITAQLQEGE GNCFPEWDGL ICWPRGTVGK ISAVPCPPYI YDFNHKGVAF 100
    RHCNPNGTWD FMHSLNKTWA NYSDCLRFLQ PDISIGKQEF FERLYVMYTV 150
    GYSISFGSLA VAILIIGYFR RLHCTRNYIH MHLFVSFMLR ATSIFVKDRV 200
    VHAHIGVKEL ESLIMQDDPQ NSIEATSVDK SQYIGCKIAV VMFIYFLATN 250
    YYWILVEGLY LHNLIFVAFF SDTKYLWGFI LIGWGFPAAF VAAWAVARAT 300
    LADARCWELS AGDIKWIYQA PILAAIGLNF ILFLNTVRVL ATKIWETNAV 350
    GHDTRKQYRK LAKSTLVLVL VFGVHYIVFV CLPHSFTGLG WEIRMHCELF 400
    FNSFQGFFVS IIYCYCNGEV QAEVKKMWSR WNLSVDWKRT PPCGSRRCGS 450
    VLTTVTHSTS SQSQVAASTR MVLISGKAAK IASRQPDSHI TLPGYVWSNS 500
    EQDCLPHSFH EETKEDSGRQ GDDILMEKPS RPMESNPDTE GCQGETEDVL 550
    Length:550
    Mass (Da):62,236
    Last modified:February 1, 1996 - v1
    Checksum:i2ADD14DBA68A9BF8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25128 mRNA. Translation: AAC50157.1.
    AY497546 mRNA. Translation: AAR90849.1.
    BC036811 mRNA. Translation: AAH36811.2.
    U47124 Genomic DNA. Translation: AAA96796.1.
    AH006647 Genomic DNA. Translation: AAC50767.1.
    CCDSiCCDS2383.1.
    PIRiA57519.
    RefSeqiNP_005039.1. NM_005048.3.
    UniGeneiHs.570296.

    Genome annotation databases

    EnsembliENST00000272847; ENSP00000272847; ENSG00000144407.
    GeneIDi5746.
    KEGGihsa:5746.
    UCSCiuc002vdb.4. human.

    Polymorphism databases

    DMDMi1346906.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U25128 mRNA. Translation: AAC50157.1 .
    AY497546 mRNA. Translation: AAR90849.1 .
    BC036811 mRNA. Translation: AAH36811.2 .
    U47124 Genomic DNA. Translation: AAA96796.1 .
    AH006647 Genomic DNA. Translation: AAC50767.1 .
    CCDSi CCDS2383.1.
    PIRi A57519.
    RefSeqi NP_005039.1. NM_005048.3.
    UniGenei Hs.570296.

    3D structure databases

    ProteinModelPortali P49190.
    SMRi P49190. Positions 24-129, 132-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111718. 2 interactions.
    IntActi P49190. 1 interaction.
    MINTi MINT-1217607.
    STRINGi 9606.ENSP00000272847.

    Chemistry

    GuidetoPHARMACOLOGYi 332.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P49190.

    Polymorphism databases

    DMDMi 1346906.

    Proteomic databases

    PaxDbi P49190.
    PRIDEi P49190.

    Protocols and materials databases

    DNASUi 5746.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272847 ; ENSP00000272847 ; ENSG00000144407 .
    GeneIDi 5746.
    KEGGi hsa:5746.
    UCSCi uc002vdb.4. human.

    Organism-specific databases

    CTDi 5746.
    GeneCardsi GC02P209224.
    HGNCi HGNC:9609. PTH2R.
    HPAi HPA010655.
    MIMi 601469. gene.
    neXtProti NX_P49190.
    PharmGKBi PA162400333.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293423.
    HOGENOMi HOG000008248.
    HOVERGENi HBG008318.
    InParanoidi P49190.
    KOi K04586.
    OMAi VGCKIAV.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P49190.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_18372. Class B/2 (Secretin family receptors).
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Parathyroid_hormone_2_receptor.
    GenomeRNAii 5746.
    NextBioi 22376.
    PROi P49190.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49190.
    Bgeei P49190.
    CleanExi HS_PTH2R.
    Genevestigatori P49190.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor."
      Usdin T.B., Gruber C., Bonner T.I.
      J. Biol. Chem. 270:15455-15458(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      King M.M., Aronstam R.S., Sharma S.V.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Retina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization."
      Usdin T.B., Modi W., Bonner T.I.
      Genomics 37:140-141(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-40 AND 306-550.
    5. "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues."
      John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.
      Endocrinology 143:1047-1057(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIPF39/TI39.

    Entry informationi

    Entry nameiPTH2R_HUMAN
    AccessioniPrimary (citable) accession number: P49190
    Secondary accession number(s): Q8N429
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3