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P49167

- RL38_YEAST

UniProt

P49167 - RL38_YEAST

Protein

60S ribosomal protein L38

Gene

RPL38

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32408-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L38
    Gene namesi
    Name:RPL38
    Ordered Locus Names:YLR325C
    ORF Names:L8543.2
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR325c.
    SGDiS000004317. RPL38.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 787760S ribosomal protein L38PRO_0000215445Add
    BLAST

    Proteomic databases

    MaxQBiP49167.
    PaxDbiP49167.
    PeptideAtlasiP49167.

    Expressioni

    Gene expression databases

    GenevestigatoriP49167.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31588. 45 interactions.
    DIPiDIP-3950N.
    IntActiP49167. 12 interactions.
    MINTiMINT-8285362.
    STRINGi4932.YLR325C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10l1-78[»]
    1VWUelectron microscopy6.10l1-78[»]
    3IZSelectron microscopy-n1-78[»]
    3J65electron microscopy8.70i1-78[»]
    3U5EX-ray3.00k1-78[»]
    3U5IX-ray3.00k1-78[»]
    4B6Aelectron microscopy8.10k1-78[»]
    4BYNelectron microscopy4.30k2-78[»]
    4BYUelectron microscopy6.60k2-78[»]
    4CUWelectron microscopy3.70k1-78[»]
    ProteinModelPortaliP49167.
    SMRiP49167. Positions 2-78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L38e family.Curated

    Phylogenomic databases

    eggNOGiNOG323549.
    GeneTreeiENSGT00390000003718.
    HOGENOMiHOG000188979.
    KOiK02923.
    OMAiRKDASQA.
    OrthoDBiEOG7FFN53.

    Family and domain databases

    InterProiIPR002675. Ribosomal_L38e.
    [Graphical view]
    PANTHERiPTHR10965. PTHR10965. 1 hit.
    PfamiPF01781. Ribosomal_L38e. 1 hit.
    [Graphical view]
    ProDomiPD010361. Ribosomal_L38e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49167-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAREITDIKQ FLELTRRADV KTATVKINKK LNKAGKPFRQ TKFKVRGSSS   50
    LYTLVINDAG KAKKLIQSLP PTLKVNRL 78
    Length:78
    Mass (Da):8,827
    Last modified:February 1, 1996 - v1
    Checksum:i0ECB20AD9A4A0D42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20618 Genomic DNA. Translation: AAB64512.1.
    BK006945 Genomic DNA. Translation: DAA09633.1.
    PIRiS53402.
    RefSeqiNP_013429.1. NM_001182214.1.

    Genome annotation databases

    EnsemblFungiiYLR325C; YLR325C; YLR325C.
    GeneIDi851035.
    KEGGisce:YLR325C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U20618 Genomic DNA. Translation: AAB64512.1 .
    BK006945 Genomic DNA. Translation: DAA09633.1 .
    PIRi S53402.
    RefSeqi NP_013429.1. NM_001182214.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 l 1-78 [» ]
    1VWU electron microscopy 6.10 l 1-78 [» ]
    3IZS electron microscopy - n 1-78 [» ]
    3J65 electron microscopy 8.70 i 1-78 [» ]
    3U5E X-ray 3.00 k 1-78 [» ]
    3U5I X-ray 3.00 k 1-78 [» ]
    4B6A electron microscopy 8.10 k 1-78 [» ]
    4BYN electron microscopy 4.30 k 2-78 [» ]
    4BYU electron microscopy 6.60 k 2-78 [» ]
    4CUW electron microscopy 3.70 k 1-78 [» ]
    ProteinModelPortali P49167.
    SMRi P49167. Positions 2-78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31588. 45 interactions.
    DIPi DIP-3950N.
    IntActi P49167. 12 interactions.
    MINTi MINT-8285362.
    STRINGi 4932.YLR325C.

    Proteomic databases

    MaxQBi P49167.
    PaxDbi P49167.
    PeptideAtlasi P49167.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR325C ; YLR325C ; YLR325C .
    GeneIDi 851035.
    KEGGi sce:YLR325C.

    Organism-specific databases

    CYGDi YLR325c.
    SGDi S000004317. RPL38.

    Phylogenomic databases

    eggNOGi NOG323549.
    GeneTreei ENSGT00390000003718.
    HOGENOMi HOG000188979.
    KOi K02923.
    OMAi RKDASQA.
    OrthoDBi EOG7FFN53.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32408-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 967628.
    PROi P49167.

    Gene expression databases

    Genevestigatori P49167.

    Family and domain databases

    InterProi IPR002675. Ribosomal_L38e.
    [Graphical view ]
    PANTHERi PTHR10965. PTHR10965. 1 hit.
    Pfami PF01781. Ribosomal_L38e. 1 hit.
    [Graphical view ]
    ProDomi PD010361. Ribosomal_L38e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    4. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
      Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
      Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: YAL6B.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL38_YEAST
    AccessioniPrimary (citable) accession number: P49167
    Secondary accession number(s): D6VYW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 50200 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3