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Protein

60S ribosomal protein L38

Gene

RPL38

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 50200 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribonucleoprotein complex assembly Source: GO_Central
  • translation Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32408-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L381 Publication
Alternative name(s):
Large ribosomal subunit protein eL381 Publication
Gene namesi
Name:RPL381 Publication
Ordered Locus Names:YLR325C
ORF Names:L8543.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR325C.
SGDiS000004317. RPL38.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002154452 – 7860S ribosomal protein L38Add BLAST77

Proteomic databases

MaxQBiP49167.
PRIDEiP49167.
TopDownProteomicsiP49167.

PTM databases

iPTMnetiP49167.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA3P094352EBI-15356,EBI-8611

Protein-protein interaction databases

BioGridi31588. 138 interactors.
DIPiDIP-3950N.
IntActiP49167. 22 interactors.
MINTiMINT-8285362.
STRINGi4932.YLR325C.

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Helixi8 – 14Combined sources7
Beta strandi17 – 19Combined sources3
Beta strandi22 – 31Combined sources10
Beta strandi33 – 35Combined sources3
Beta strandi37 – 46Combined sources10
Beta strandi51 – 56Combined sources6
Helixi59 – 68Combined sources10
Beta strandi73 – 77Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10781-78[»]
3J6Yelectron microscopy6.10781-78[»]
3J77electron microscopy6.20881-78[»]
3J78electron microscopy6.30881-78[»]
3JCTelectron microscopy3.08k1-78[»]
4U3MX-ray3.00O8/o82-78[»]
4U3NX-ray3.20O8/o82-78[»]
4U3UX-ray2.90O8/o82-78[»]
4U4NX-ray3.10O8/o82-78[»]
4U4OX-ray3.60O8/o82-78[»]
4U4QX-ray3.00O8/o82-78[»]
4U4RX-ray2.80O8/o82-78[»]
4U4UX-ray3.00O8/o82-78[»]
4U4YX-ray3.20O8/o82-78[»]
4U4ZX-ray3.10O8/o82-78[»]
4U50X-ray3.20O8/o82-78[»]
4U51X-ray3.20O8/o82-78[»]
4U52X-ray3.00O8/o82-78[»]
4U53X-ray3.30O8/o82-78[»]
4U55X-ray3.20O8/o82-78[»]
4U56X-ray3.45O8/o82-78[»]
4U6FX-ray3.10O8/o82-78[»]
4V6Ielectron microscopy8.80Bn1-78[»]
4V7Felectron microscopy8.70i1-78[»]
4V88X-ray3.00Bk/Dk1-78[»]
4V8Telectron microscopy8.10k1-78[»]
4V8Yelectron microscopy4.30Bk2-78[»]
4V8Zelectron microscopy6.60Bk2-78[»]
4V91electron microscopy3.70k1-78[»]
5APNelectron microscopy3.91k1-78[»]
5APOelectron microscopy3.41k1-78[»]
5DATX-ray3.15O8/o82-78[»]
5DC3X-ray3.25O8/o82-78[»]
5DGEX-ray3.45O8/o82-78[»]
5DGFX-ray3.30O8/o82-78[»]
5DGVX-ray3.10O8/o82-78[»]
5FCIX-ray3.40O8/o82-78[»]
5FCJX-ray3.10O8/o82-78[»]
5FL8electron microscopy9.50k1-78[»]
5GAKelectron microscopy3.88m1-78[»]
5H4Pelectron microscopy3.07k1-78[»]
5I4LX-ray3.10O8/o82-78[»]
5JCSelectron microscopy9.50k1-78[»]
5JUOelectron microscopy4.00PA1-78[»]
5JUPelectron microscopy3.50PA1-78[»]
5JUSelectron microscopy4.20PA1-78[»]
5JUTelectron microscopy4.00PA1-78[»]
5JUUelectron microscopy4.00PA1-78[»]
5LYBX-ray3.25O8/o82-78[»]
5M1Jelectron microscopy3.30k52-78[»]
5MC6electron microscopy3.80AI1-78[»]
5T62electron microscopy3.30x1-78[»]
5T6Relectron microscopy4.50x1-78[»]
5TGAX-ray3.30O8/o82-78[»]
5TGMX-ray3.50O8/o82-78[»]
ProteinModelPortaliP49167.
SMRiP49167.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003718.
HOGENOMiHOG000188979.
InParanoidiP49167.
KOiK02923.
OMAiRDIKQFI.
OrthoDBiEOG092C5V1O.

Family and domain databases

InterProiView protein in InterPro
IPR002675. Ribosomal_L38e.
PANTHERiPTHR10965. PTHR10965. 1 hit.
PfamiView protein in Pfam
PF01781. Ribosomal_L38e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010361. Ribosomal_L38e. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49167-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAREITDIKQ FLELTRRADV KTATVKINKK LNKAGKPFRQ TKFKVRGSSS
60 70
LYTLVINDAG KAKKLIQSLP PTLKVNRL
Length:78
Mass (Da):8,827
Last modified:February 1, 1996 - v1
Checksum:i0ECB20AD9A4A0D42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20618 Genomic DNA. Translation: AAB64512.1.
BK006945 Genomic DNA. Translation: DAA09633.1.
PIRiS53402.
RefSeqiNP_013429.1. NM_001182214.1.

Genome annotation databases

EnsemblFungiiYLR325C; YLR325C; YLR325C.
GeneIDi851035.
KEGGisce:YLR325C.

Similar proteinsi

Entry informationi

Entry nameiRL38_YEAST
AccessioniPrimary (citable) accession number: P49167
Secondary accession number(s): D6VYW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 27, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names