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P49166 (RL37A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60S ribosomal protein L37-A
Alternative name(s):
L43
YL35
YP55
Gene names
Name:RPL37A
Synonyms:RPL35A
Ordered Locus Names:YLR185W
ORF Names:L9470.6
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length88 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the 23S rRNA By similarity. HAMAP-Rule MF_00547

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00547

Subunit structure

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.4

Subcellular location

Cytoplasm Ref.5.

Miscellaneous

Present with 21800 molecules/cell in log phase SD medium.

There are 2 genes for L37 in yeast.

Sequence similarities

Belongs to the ribosomal protein L37e family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 888760S ribosomal protein L37-A HAMAP-Rule MF_00547
PRO_0000139722

Regions

Zinc finger19 – 3719C4-type Potential

Sites

Metal binding191Zinc By similarity
Metal binding221Zinc By similarity
Metal binding341Zinc By similarity
Metal binding371Zinc By similarity

Experimental info

Sequence conflict731R → RR AA sequence Ref.3

Sequences

Sequence LengthMass (Da)Tools
P49166 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 274D249361EBE5E5

FASTA889,850
        10         20         30         40         50         60 
MGKGTPSFGK RHNKSHTLCN RCGRRSFHVQ KKTCSSCGYP AAKTRSYNWG AKAKRRHTTG 

        70         80 
TGRMRYLKHV SRRFKNGFQT GSASKASA 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Studies on the primary structures of yeast ribosomal proteins."
Itoh T., Higo K., Otaka E., Osawa S.
(In) Osawa S., Ozeki H., Uchida H., Yura T. (eds.); Genetics and evolution of RNA polymerase, tRNA and ribosomes, pp.609-624, University of Tokyo Press, Tokyo (1980)
Cited for: PROTEIN SEQUENCE OF 2-88.
[4]"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
Planta R.J., Mager W.H.
Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NOMENCLATURE, SUBUNIT.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING OF 2-53, ELECTRON MICROSCOPY.
[8]"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
[9]"Crystal structure of the eukaryotic ribosome."
Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
[10]"The structure of the eukaryotic ribosome at 3.0 A resolution."
Ben-Shem A., Garreau de Loubresse N., Melnikov S., Jenner L., Yusupova G., Yusupov M.
Science 334:1524-1529(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U17246 Genomic DNA. Translation: AAB67458.1.
BK006945 Genomic DNA. Translation: DAA09504.1.
PIRS51430.
RefSeqNP_013286.1. NM_001182072.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Z2-53[»]
1S1Ielectron microscopy11.70Y2-88[»]
3IZSelectron microscopy-l1-88[»]
3O58X-ray4.00d1-88[»]
3O5HX-ray4.00d1-88[»]
3U5EX-ray3.00j1-88[»]
3U5IX-ray3.00j1-88[»]
4B6Aelectron microscopy8.10j1-88[»]
4BYNelectron microscopy4.30j2-88[»]
4BYUelectron microscopy6.60j2-88[»]
ProteinModelPortalP49166.
SMRP49166. Positions 2-88.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31455. 68 interactions.
DIPDIP-2135N.
IntActP49166. 1 interaction.
MINTMINT-8285347.
STRING4932.YLR185W.

Proteomic databases

PeptideAtlasP49166.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR185W; YLR185W; YLR185W.
GeneID850882.
KEGGsce:YLR185W.

Organism-specific databases

SGDS000004175. RPL37A.

Phylogenomic databases

GeneTreeENSGT00390000005254.
HOGENOMHOG000111076.
KOK02922.
OMAYPAAKMR.
OrthoDBEOG79GTKQ.

Enzyme and pathway databases

BioCycYEAST:G3O-32308-MONOMER.

Gene expression databases

GenevestigatorP49166.

Family and domain databases

Gene3D2.20.25.30. 1 hit.
HAMAPMF_00547. Ribosomal_L37e.
InterProIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERPTHR10768. PTHR10768. 1 hit.
PfamPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF57829. SSF57829. 1 hit.
PROSITEPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP49166.
NextBio967236.

Entry information

Entry nameRL37A_YEAST
AccessionPrimary (citable) accession number: P49166
Secondary accession number(s): D6VYI8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references