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P49166

- RL37A_YEAST

UniProt

P49166 - RL37A_YEAST

Protein

60S ribosomal protein L37-A

Gene

RPL37A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to the 23S rRNA.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi19 – 191ZincBy similarity
    Metal bindingi22 – 221ZincBy similarity
    Metal bindingi34 – 341ZincBy similarity
    Metal bindingi37 – 371ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri19 – 3719C4-typeSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. rRNA binding Source: UniProtKB-KW
    3. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    Metal-binding, RNA-binding, rRNA-binding, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32308-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L37-A
    Alternative name(s):
    L43
    YL35
    YP55
    Gene namesi
    Name:RPL37A
    Synonyms:RPL35A
    Ordered Locus Names:YLR185W
    ORF Names:L9470.6
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    SGDiS000004175. RPL37A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 888760S ribosomal protein L37-APRO_0000139722Add
    BLAST

    Proteomic databases

    MaxQBiP49166.
    PeptideAtlasiP49166.

    Expressioni

    Gene expression databases

    GenevestigatoriP49166.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31455. 68 interactions.
    DIPiDIP-2135N.
    IntActiP49166. 1 interaction.
    MINTiMINT-8285347.
    STRINGi4932.YLR185W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-Z2-53[»]
    1S1Ielectron microscopy11.70Y2-88[»]
    1VW8electron microscopy6.10k1-88[»]
    1VWUelectron microscopy6.10k1-88[»]
    3IZSelectron microscopy-l1-88[»]
    3J65electron microscopy8.70h1-88[»]
    3O58X-ray4.00d1-88[»]
    3O5HX-ray4.00d1-88[»]
    3U5EX-ray3.00j1-88[»]
    3U5IX-ray3.00j1-88[»]
    4B6Aelectron microscopy8.10j1-88[»]
    4BYNelectron microscopy4.30j2-88[»]
    4BYUelectron microscopy6.60j2-88[»]
    4CUWelectron microscopy3.70j1-88[»]
    ProteinModelPortaliP49166.
    SMRiP49166. Positions 2-88.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP49166.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L37e family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri19 – 3719C4-typeSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00390000005254.
    HOGENOMiHOG000111076.
    KOiK02922.
    OMAiYPAAKMR.
    OrthoDBiEOG79GTKQ.

    Family and domain databases

    Gene3Di2.20.25.30. 1 hit.
    HAMAPiMF_00547. Ribosomal_L37e.
    InterProiIPR011331. Ribosomal_L37ae/L37e.
    IPR001569. Ribosomal_L37e.
    IPR018267. Ribosomal_L37e_CS.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view]
    PANTHERiPTHR10768. PTHR10768. 1 hit.
    PfamiPF01907. Ribosomal_L37e. 1 hit.
    [Graphical view]
    ProDomiPD005132. Ribosomal_L37e. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF57829. SSF57829. 1 hit.
    PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49166-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKGTPSFGK RHNKSHTLCN RCGRRSFHVQ KKTCSSCGYP AAKTRSYNWG   50
    AKAKRRHTTG TGRMRYLKHV SRRFKNGFQT GSASKASA 88
    Length:88
    Mass (Da):9,850
    Last modified:January 23, 2007 - v2
    Checksum:i274D249361EBE5E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731R → RR AA sequence 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17246 Genomic DNA. Translation: AAB67458.1.
    BK006945 Genomic DNA. Translation: DAA09504.1.
    PIRiS51430.
    RefSeqiNP_013286.1. NM_001182072.1.

    Genome annotation databases

    EnsemblFungiiYLR185W; YLR185W; YLR185W.
    GeneIDi850882.
    KEGGisce:YLR185W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17246 Genomic DNA. Translation: AAB67458.1 .
    BK006945 Genomic DNA. Translation: DAA09504.1 .
    PIRi S51430.
    RefSeqi NP_013286.1. NM_001182072.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - Z 2-53 [» ]
    1S1I electron microscopy 11.70 Y 2-88 [» ]
    1VW8 electron microscopy 6.10 k 1-88 [» ]
    1VWU electron microscopy 6.10 k 1-88 [» ]
    3IZS electron microscopy - l 1-88 [» ]
    3J65 electron microscopy 8.70 h 1-88 [» ]
    3O58 X-ray 4.00 d 1-88 [» ]
    3O5H X-ray 4.00 d 1-88 [» ]
    3U5E X-ray 3.00 j 1-88 [» ]
    3U5I X-ray 3.00 j 1-88 [» ]
    4B6A electron microscopy 8.10 j 1-88 [» ]
    4BYN electron microscopy 4.30 j 2-88 [» ]
    4BYU electron microscopy 6.60 j 2-88 [» ]
    4CUW electron microscopy 3.70 j 1-88 [» ]
    ProteinModelPortali P49166.
    SMRi P49166. Positions 2-88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31455. 68 interactions.
    DIPi DIP-2135N.
    IntActi P49166. 1 interaction.
    MINTi MINT-8285347.
    STRINGi 4932.YLR185W.

    Proteomic databases

    MaxQBi P49166.
    PeptideAtlasi P49166.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR185W ; YLR185W ; YLR185W .
    GeneIDi 850882.
    KEGGi sce:YLR185W.

    Organism-specific databases

    SGDi S000004175. RPL37A.

    Phylogenomic databases

    GeneTreei ENSGT00390000005254.
    HOGENOMi HOG000111076.
    KOi K02922.
    OMAi YPAAKMR.
    OrthoDBi EOG79GTKQ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32308-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P49166.
    NextBioi 967236.

    Gene expression databases

    Genevestigatori P49166.

    Family and domain databases

    Gene3Di 2.20.25.30. 1 hit.
    HAMAPi MF_00547. Ribosomal_L37e.
    InterProi IPR011331. Ribosomal_L37ae/L37e.
    IPR001569. Ribosomal_L37e.
    IPR018267. Ribosomal_L37e_CS.
    IPR011332. Ribosomal_zn-bd.
    [Graphical view ]
    PANTHERi PTHR10768. PTHR10768. 1 hit.
    Pfami PF01907. Ribosomal_L37e. 1 hit.
    [Graphical view ]
    ProDomi PD005132. Ribosomal_L37e. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF57829. SSF57829. 1 hit.
    PROSITEi PS01077. RIBOSOMAL_L37E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Studies on the primary structures of yeast ribosomal proteins."
      Itoh T., Higo K., Otaka E., Osawa S.
      (In) Osawa S., Ozeki H., Uchida H., Yura T. (eds.); Genetics and evolution of RNA polymerase, tRNA and ribosomes, pp.609-624, University of Tokyo Press, Tokyo (1980)
      Cited for: PROTEIN SEQUENCE OF 2-88.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 2-53, ELECTRON MICROSCOPY.
    8. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    9. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    10. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL37A_YEAST
    AccessioniPrimary (citable) accession number: P49166
    Secondary accession number(s): D6VYI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 21800 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L37 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3