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P49166

- RL37A_YEAST

UniProt

P49166 - RL37A_YEAST

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Protein

60S ribosomal protein L37-A

Gene

RPL37A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191ZincBy similarity
Metal bindingi22 – 221ZincBy similarity
Metal bindingi34 – 341ZincBy similarity
Metal bindingi37 – 371ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3719C4-typeSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. rRNA binding Source: UniProtKB-KW
  3. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32308-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L37-A
Alternative name(s):
L43
YL35
YP55
Gene namesi
Name:RPL37A
Synonyms:RPL35A
Ordered Locus Names:YLR185W
ORF Names:L9470.6
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

SGDiS000004175. RPL37A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 888760S ribosomal protein L37-APRO_0000139722Add
BLAST

Proteomic databases

MaxQBiP49166.
PeptideAtlasiP49166.

Expressioni

Gene expression databases

GenevestigatoriP49166.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31455. 68 interactions.
DIPiDIP-2135N.
IntActiP49166. 1 interaction.
MINTiMINT-8285347.
STRINGi4932.YLR185W.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-Z2-53[»]
1S1Ielectron microscopy11.70Y2-88[»]
1VW8electron microscopy6.10k1-88[»]
1VWUelectron microscopy6.10k1-88[»]
1VXVelectron microscopy6.20k1-88[»]
1VXYelectron microscopy6.30k1-88[»]
3IZSelectron microscopy-l1-88[»]
3J65electron microscopy8.70h1-88[»]
3O58X-ray4.00d1-88[»]
3O5HX-ray4.00d1-88[»]
3U5EX-ray3.00j1-88[»]
3U5IX-ray3.00j1-88[»]
4B6Aelectron microscopy8.10j1-88[»]
4BYNelectron microscopy4.30j2-88[»]
4BYUelectron microscopy6.60j2-88[»]
4CUWelectron microscopy3.70j1-88[»]
ProteinModelPortaliP49166.
SMRiP49166. Positions 2-88.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49166.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L37e family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3719C4-typeSequence AnalysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00390000005254.
HOGENOMiHOG000111076.
InParanoidiP49166.
KOiK02922.
OMAiYPAAKMR.
OrthoDBiEOG79GTKQ.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PANTHERiPTHR10768. PTHR10768. 1 hit.
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49166-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKGTPSFGK RHNKSHTLCN RCGRRSFHVQ KKTCSSCGYP AAKTRSYNWG
60 70 80
AKAKRRHTTG TGRMRYLKHV SRRFKNGFQT GSASKASA
Length:88
Mass (Da):9,850
Last modified:January 23, 2007 - v2
Checksum:i274D249361EBE5E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731R → RR AA sequence 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17246 Genomic DNA. Translation: AAB67458.1.
BK006945 Genomic DNA. Translation: DAA09504.1.
PIRiS51430.
RefSeqiNP_013286.1. NM_001182072.1.

Genome annotation databases

EnsemblFungiiYLR185W; YLR185W; YLR185W.
GeneIDi850882.
KEGGisce:YLR185W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17246 Genomic DNA. Translation: AAB67458.1 .
BK006945 Genomic DNA. Translation: DAA09504.1 .
PIRi S51430.
RefSeqi NP_013286.1. NM_001182072.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - Z 2-53 [» ]
1S1I electron microscopy 11.70 Y 2-88 [» ]
1VW8 electron microscopy 6.10 k 1-88 [» ]
1VWU electron microscopy 6.10 k 1-88 [» ]
1VXV electron microscopy 6.20 k 1-88 [» ]
1VXY electron microscopy 6.30 k 1-88 [» ]
3IZS electron microscopy - l 1-88 [» ]
3J65 electron microscopy 8.70 h 1-88 [» ]
3O58 X-ray 4.00 d 1-88 [» ]
3O5H X-ray 4.00 d 1-88 [» ]
3U5E X-ray 3.00 j 1-88 [» ]
3U5I X-ray 3.00 j 1-88 [» ]
4B6A electron microscopy 8.10 j 1-88 [» ]
4BYN electron microscopy 4.30 j 2-88 [» ]
4BYU electron microscopy 6.60 j 2-88 [» ]
4CUW electron microscopy 3.70 j 1-88 [» ]
ProteinModelPortali P49166.
SMRi P49166. Positions 2-88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31455. 68 interactions.
DIPi DIP-2135N.
IntActi P49166. 1 interaction.
MINTi MINT-8285347.
STRINGi 4932.YLR185W.

Proteomic databases

MaxQBi P49166.
PeptideAtlasi P49166.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR185W ; YLR185W ; YLR185W .
GeneIDi 850882.
KEGGi sce:YLR185W.

Organism-specific databases

SGDi S000004175. RPL37A.

Phylogenomic databases

GeneTreei ENSGT00390000005254.
HOGENOMi HOG000111076.
InParanoidi P49166.
KOi K02922.
OMAi YPAAKMR.
OrthoDBi EOG79GTKQ.

Enzyme and pathway databases

BioCyci YEAST:G3O-32308-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.

Miscellaneous databases

EvolutionaryTracei P49166.
NextBioi 967236.

Gene expression databases

Genevestigatori P49166.

Family and domain databases

Gene3Di 2.20.25.30. 1 hit.
HAMAPi MF_00547. Ribosomal_L37e.
InterProi IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view ]
PANTHERi PTHR10768. PTHR10768. 1 hit.
Pfami PF01907. Ribosomal_L37e. 1 hit.
[Graphical view ]
ProDomi PD005132. Ribosomal_L37e. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF57829. SSF57829. 1 hit.
PROSITEi PS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Studies on the primary structures of yeast ribosomal proteins."
    Itoh T., Higo K., Otaka E., Osawa S.
    (In) Osawa S., Ozeki H., Uchida H., Yura T. (eds.); Genetics and evolution of RNA polymerase, tRNA and ribosomes, pp.609-624, University of Tokyo Press, Tokyo (1980)
    Cited for: PROTEIN SEQUENCE OF 2-88.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 2-53, ELECTRON MICROSCOPY.
  8. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
  9. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  10. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL37A_YEAST
AccessioniPrimary (citable) accession number: P49166
Secondary accession number(s): D6VYI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 21800 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L37 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3