60S ribosomal protein L37-A - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P49166 (RL37A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 102. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
60S ribosomal protein L37-A

Alternative name(s):
L43
YL35
YP55

Gene names

Name:	RPL37A
Synonyms:	RPL35A
Ordered Locus Names:	YLR185W
ORF Names:	L9470.6

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	88 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the 23S rRNA By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.4
Subcellular location	Cytoplasm Ref.5.
Miscellaneous	Present with 21800 molecules/cell in log phase SD medium. There are 2 genes for L37 in yeast.
Sequence similarities	Belongs to the ribosomal protein L37e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Zinc-finger
Ligand	Metal-binding RNA-binding Zinc rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cytoplasmic translation Traceable author statement Ref.4. Source: SGD
Cellular_component	cytosolic large ribosomal subunit Traceable author statement Ref.4. Source: SGD
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Traceable author statement Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.3

Chain

2 – 88

60S ribosomal protein L37-A

PRO_0000139722

Regions

Zinc finger

19 – 37

C4-type Potential

Sites

Metal binding

Zinc By similarity

Metal binding

Zinc By similarity

Metal binding

Zinc By similarity

Metal binding

Zinc By similarity

Experimental info

Sequence conflict

R → RR AA sequence Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P49166 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 274D249361EBE5E5
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FASTA

9,850

        10         20         30         40         50         60 
MGKGTPSFGK RHNKSHTLCN RCGRRSFHVQ KKTCSSCGYP AAKTRSYNWG AKAKRRHTTG 

        70         80 
TGRMRYLKHV SRRFKNGFQT GSASKASA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Studies on the primary structures of yeast ribosomal proteins." Itoh T., Higo K., Otaka E., Osawa S. (In) Osawa S., Ozeki H., Uchida H., Yura T. (eds.); Genetics and evolution of RNA polymerase, tRNA and ribosomes, pp.609-624, University of Tokyo Press, Tokyo (1980) Cited for: PROTEIN SEQUENCE OF 2-88.
[4]	"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, SUBUNIT.
[5]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]	"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions." Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J. Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 2-53, ELECTRON MICROSCOPY.
[8]	"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation." Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J. EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U17246 Genomic DNA. Translation: AAB67458.1.
BK006945 Genomic DNA. Translation: DAA09504.1.

PIR

S51430.

RefSeq

NP_013286.1. NM_001182072.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K5Y	model	-	Z	2-53	[»]
1S1I	electron microscopy	11.70	Y	2-88	[»]
3IZS	electron microscopy	-	l	1-88	[»]
3O58	X-ray	4.00	d	1-88	[»]
3O5H	X-ray	4.00	d	1-88	[»]
3U5E	X-ray	3.00	j	1-88	[»]
3U5I	X-ray	3.00	j	1-88	[»]
4B6A	electron microscopy	8.10	j	1-88	[»]

ProteinModelPortal

P49166.

SMR

P49166. Positions 2-88.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-2135N.

MINT

MINT-519394.

STRING

4932.YLR185W.

Proteomic databases

PeptideAtlas

P49166.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YLR185W; YLR185W; YLR185W.

GeneID

850882.

KEGG

sce:YLR185W.

Organism-specific databases

SGD

S000004175. RPL37A.

Phylogenomic databases

GeneTree

ENSGT00390000005254.

HOGENOM

HOG000111076.

K02922.

OMA

NGFREGQ.

OrthoDB

EOG4K3Q5Z.

Gene expression databases

Genevestigator

P49166.

GermOnline

YLR185W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

2.20.25.30. 1 hit.

InterPro

IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd_dom.
[Graphical view]

PANTHER

PTHR10768. PTHR10768. 1 hit.

Pfam

PF01907. Ribosomal_L37e. 1 hit.
[Graphical view]

ProDom

PD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF57829. Ribosomal_zn-bd. 1 hit.

PROSITE

PS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P49166.

NextBio

967236.

Entry information

Entry name

RL37A_YEAST

Accession

Primary (citable) accession number: P49166
Secondary accession number(s): D6VYI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 102 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents