UniProtKB - P49157 (EPO_PIG)
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Protein
Erythropoietin
Gene
EPO
Organism
Sus scrofa (Pig)
Status
Functioni
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.By similarity
GO - Molecular functioni
- cytokine activity Source: Ensembl
- erythropoietin receptor binding Source: UniProtKB
- hormone activity Source: UniProtKB-KW
- protein kinase activator activity Source: Ensembl
GO - Biological processi
- apoptotic process Source: Ensembl
- cell proliferation Source: UniProtKB
- cellular hyperosmotic response Source: Ensembl
- embryo implantation Source: Ensembl
- erythrocyte differentiation Source: UniProtKB
- erythrocyte maturation Source: UniProtKB-KW
- erythropoietin-mediated signaling pathway Source: UniProtKB
- hemoglobin biosynthetic process Source: Ensembl
- negative regulation of calcium ion transport into cytosol Source: Ensembl
- negative regulation of cation channel activity Source: Ensembl
- negative regulation of erythrocyte apoptotic process Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of cell proliferation Source: Ensembl
- positive regulation of DNA replication Source: Ensembl
- positive regulation of Ras protein signal transduction Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
- response to hypoxia Source: Ensembl
Keywordsi
Molecular function | Hormone |
Biological process | Erythrocyte maturation |
Names & Taxonomyi
Protein namesi | Recommended name: Erythropoietin |
Gene namesi | Name:EPO |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000008406 | 27 – 194 | ErythropoietinAdd BLAST | 168 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 ↔ 189 | By similarity | ||
Glycosylationi | 50 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 55 ↔ 59 | By similarity | ||
Glycosylationi | 64 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 172 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P49157. |
PRIDEi | P49157. |
Expressioni
Tissue specificityi
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
Gene expression databases
Bgeei | ENSSSCG00000007673. |
Genevisiblei | P49157. SS. |
Interactioni
GO - Molecular functioni
- cytokine activity Source: Ensembl
- erythropoietin receptor binding Source: UniProtKB
- hormone activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000008194. |
Family & Domainsi
Sequence similaritiesi
Belongs to the EPO/TPO family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IHW5. Eukaryota. ENOG410XTRF. LUCA. |
GeneTreei | ENSGT00390000017226. |
HOGENOMi | HOG000052505. |
HOVERGENi | HBG003978. |
InParanoidi | P49157. |
KOi | K05437. |
OMAi | EAENVTM. |
OrthoDBi | EOG091G0PMA. |
TreeFami | TF333413. |
Family and domain databases
InterProi | View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR019767. EPO/TPO_CS. IPR001323. EPO_TPO. IPR003013. Erythroptn. |
PANTHERi | PTHR10370. PTHR10370. 1 hit. |
Pfami | View protein in Pfam PF00758. EPO_TPO. 1 hit. |
PIRSFi | PIRSF001951. EPO. 1 hit. |
PRINTSi | PR00272. ERYTHROPTN. |
SUPFAMi | SSF47266. SSF47266. 1 hit. |
PROSITEi | View protein in PROSITE PS00817. EPO_TPO. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P49157-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGARECPARL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILEAKEGEN
60 70 80 90 100
ATMGCAESCS FSENITVPDT KVNFYAWKRM EVQQQAMEVW QGLALLSEAI
110 120 130 140 150
LQGQALLANS SQPSEALQLH VDKAVSGLRS LTSLLRALGA QKEAIPLPDA
160 170 180 190
SPSSATPLRT FAVDTLCKLF RNYSNFLRGK LTLYTGEACR RRDR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ249745 mRNA. Translation: CAB96416.1. AJ249746 Genomic DNA. Translation: CAB96417.1. L10607 mRNA. Translation: AAA31029.1. |
PIRi | I46578. |
RefSeqi | NP_999299.1. NM_214134.1. |
UniGenei | Ssc.15896. |
Genome annotation databases
Ensembli | ENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673. |
GeneIDi | 397249. |
KEGGi | ssc:397249. |
Similar proteinsi
Entry informationi
Entry namei | EPO_PIG | |
Accessioni | P49157Primary (citable) accession number: P49157 Secondary accession number(s): Q9MYM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | May 10, 2005 | |
Last modified: | March 28, 2018 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |