EPO

Functionⁱ

Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.By similarity

GO - Molecular functionⁱ

cytokine activity Source: Ensembl
erythropoietin receptor binding Source: UniProtKB
hormone activity Source: UniProtKB-KW
protein kinase activator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: Ensembl
cell proliferation Source: UniProtKB
cellular hyperosmotic response Source: Ensembl
embryo implantation Source: Ensembl
erythrocyte differentiation Source: UniProtKB
erythrocyte maturation Source: UniProtKB-KW
erythropoietin-mediated signaling pathway Source: UniProtKB
hemoglobin biosynthetic process Source: Ensembl
negative regulation of calcium ion transport into cytosol Source: Ensembl
negative regulation of cation channel activity Source: Ensembl
negative regulation of erythrocyte apoptotic process Source: Ensembl
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
peptidyl-serine phosphorylation Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of DNA replication Source: Ensembl
positive regulation of Ras protein signal transduction Source: Ensembl
positive regulation of transcription, DNA-templated Source: Ensembl
positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
response to hypoxia Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone
Biological process	Erythrocyte maturation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Erythropoietin
Gene namesⁱ	Name:EPO
Organismⁱ	Sus scrofa (Pig)
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000008227 Componentⁱ: Chromosome 3

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000008406	27 – 194	ErythropoietinAdd BLAST		168

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	33 ↔ 189	By similarity
Glycosylationⁱ	50	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	55 ↔ 59	By similarity
Glycosylationⁱ	64	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	109	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	172	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P49157.
PRIDEⁱ	P49157.

Expressionⁱ

Tissue specificityⁱ

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

Bgeeⁱ	ENSSSCG00000007673.
Genevisibleⁱ	P49157. SS.

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity Source: Ensembl
erythropoietin receptor binding Source: UniProtKB
hormone activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000008194.

STRINGⁱ

9823.ENSSSCP00000008194.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P49157.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the EPO/TPO family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IHW5. Eukaryota. ENOG410XTRF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017226.
HOGENOMⁱ	HOG000052505.
HOVERGENⁱ	HBG003978.
InParanoidⁱ	P49157.
KEGG Orthology (KO) More...KOⁱ	K05437.
OMAⁱ	EAENVTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMA.
TreeFamⁱ	TF333413.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR019767. EPO/TPO_CS. IPR001323. EPO_TPO. IPR003013. Erythroptn.
PANTHERⁱ	PTHR10370. PTHR10370. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00758. EPO_TPO. 1 hit.
PIRSFⁱ	PIRSF001951. EPO. 1 hit.
PRINTSⁱ	PR00272. ERYTHROPTN.
SUPFAMⁱ	SSF47266. SSF47266. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00817. EPO_TPO. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P49157-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGARECPARL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILEAKEGEN 
        60         70         80         90        100
ATMGCAESCS FSENITVPDT KVNFYAWKRM EVQQQAMEVW QGLALLSEAI 
       110        120        130        140        150
LQGQALLANS SQPSEALQLH VDKAVSGLRS LTSLLRALGA QKEAIPLPDA 
       160        170        180        190 
SPSSATPLRT FAVDTLCKLF RNYSNFLRGK LTLYTGEACR RRDR

Length:194

Mass (Da):21,304

Last modified:May 10, 2005 - v2

Checksum:ⁱ77881A6F6F20EA1C

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249745 mRNA. Translation: CAB96416.1. AJ249746 Genomic DNA. Translation: CAB96417.1. L10607 mRNA. Translation: AAA31029.1.
PIRⁱ	I46578.
NCBI Reference Sequences More...RefSeqⁱ	NP_999299.1. NM_214134.1.
UniGeneⁱ	Ssc.15896.

Genome annotation databases

Ensemblⁱ	ENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
GeneIDⁱ	397249.
KEGGⁱ	ssc:397249.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P49157	P01588 G9JKG7 U3MHQ9 A0A2K5MX68 A0A2J8XUH6 UPI000B7B6F81 T2DKX4 A0A0D9RZC0 G3RS27 A0A096MVK4 +71	Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Papio anubis (Olive baboon) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Gorilla gorilla gorilla (Western lowland gorilla) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Pan troglodytes (Chimpanzee) Gorilla gorilla (western gorilla) And more	193	UniRef50_P01588	Cluster: Erythropoietin	82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ249745 mRNA. Translation: CAB96416.1. AJ249746 Genomic DNA. Translation: CAB96417.1. L10607 mRNA. Translation: AAA31029.1.
PIRⁱ	I46578.
NCBI Reference Sequences More...RefSeqⁱ	NP_999299.1. NM_214134.1.
UniGeneⁱ	Ssc.15896.

3D structure databases

ProteinModelPortalⁱ	P49157.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9823.ENSSSCP00000008194.

STRINGⁱ

9823.ENSSSCP00000008194.

Proteomic databases

PaxDbⁱ	P49157.
PRIDEⁱ	P49157.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
GeneIDⁱ	397249.
KEGGⁱ	ssc:397249.

Organism-specific databases

CTDⁱ	2056.

CTDⁱ

2056.

Phylogenomic databases

eggNOGⁱ	ENOG410IHW5. Eukaryota. ENOG410XTRF. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017226.
HOGENOMⁱ	HOG000052505.
HOVERGENⁱ	HBG003978.
InParanoidⁱ	P49157.
KEGG Orthology (KO) More...KOⁱ	K05437.
OMAⁱ	EAENVTM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PMA.
TreeFamⁱ	TF333413.

Gene expression databases

Bgeeⁱ	ENSSSCG00000007673.
Genevisibleⁱ	P49157. SS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009079. 4_helix_cytokine-like_core. IPR019767. EPO/TPO_CS. IPR001323. EPO_TPO. IPR003013. Erythroptn.
PANTHERⁱ	PTHR10370. PTHR10370. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00758. EPO_TPO. 1 hit.
PIRSFⁱ	PIRSF001951. EPO. 1 hit.
PRINTSⁱ	PR00272. ERYTHROPTN.
SUPFAMⁱ	SSF47266. SSF47266. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00817. EPO_TPO. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPO_PIG
Accessionⁱ	P49157Primary (citable) accession number: P49157 Secondary accession number(s): Q9MYM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	May 10, 2005
	Last modified:	March 28, 2018
	This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P49157 (EPO_PIG)

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Erythropoietin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ