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Protein

Erythropoietin

Gene

EPO

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Erythrocyte maturation

Names & Taxonomyi

Protein namesi
Recommended name:
Erythropoietin
Gene namesi
Name:EPO
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 3

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 194168ErythropoietinPRO_0000008406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 189By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Disulfide bondi55 ↔ 59By similarity
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49157.

Expressioni

Tissue specificityi

Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.

Gene expression databases

GenevisibleiP49157. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008194.

Structurei

3D structure databases

ProteinModelPortaliP49157.
SMRiP49157. Positions 27-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EPO/TPO family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP49157.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG091G0PMA.
TreeFamiTF333413.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49157-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGARECPARL LLLSLLLLPL GLPVLGAPPR LICDSRVLER YILEAKEGEN
60 70 80 90 100
ATMGCAESCS FSENITVPDT KVNFYAWKRM EVQQQAMEVW QGLALLSEAI
110 120 130 140 150
LQGQALLANS SQPSEALQLH VDKAVSGLRS LTSLLRALGA QKEAIPLPDA
160 170 180 190
SPSSATPLRT FAVDTLCKLF RNYSNFLRGK LTLYTGEACR RRDR
Length:194
Mass (Da):21,304
Last modified:May 10, 2005 - v2
Checksum:i77881A6F6F20EA1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249745 mRNA. Translation: CAB96416.1.
AJ249746 Genomic DNA. Translation: CAB96417.1.
L10607 mRNA. Translation: AAA31029.1.
PIRiI46578.
RefSeqiNP_999299.1. NM_214134.1.
UniGeneiSsc.15896.

Genome annotation databases

EnsembliENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
GeneIDi397249.
KEGGissc:397249.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249745 mRNA. Translation: CAB96416.1.
AJ249746 Genomic DNA. Translation: CAB96417.1.
L10607 mRNA. Translation: AAA31029.1.
PIRiI46578.
RefSeqiNP_999299.1. NM_214134.1.
UniGeneiSsc.15896.

3D structure databases

ProteinModelPortaliP49157.
SMRiP49157. Positions 27-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000008194.

Proteomic databases

PaxDbiP49157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000008413; ENSSSCP00000008194; ENSSSCG00000007673.
GeneIDi397249.
KEGGissc:397249.

Organism-specific databases

CTDi2056.

Phylogenomic databases

eggNOGiENOG410IHW5. Eukaryota.
ENOG410XTRF. LUCA.
GeneTreeiENSGT00390000017226.
HOGENOMiHOG000052505.
HOVERGENiHBG003978.
InParanoidiP49157.
KOiK05437.
OMAiNVTMGCA.
OrthoDBiEOG091G0PMA.
TreeFamiTF333413.

Gene expression databases

GenevisibleiP49157. SS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR019767. EPO/TPO_CS.
IPR001323. EPO_TPO.
IPR003013. Erythroptn.
[Graphical view]
PANTHERiPTHR10370. PTHR10370. 1 hit.
PfamiPF00758. EPO_TPO. 1 hit.
[Graphical view]
PIRSFiPIRSF001951. EPO. 1 hit.
PRINTSiPR00272. ERYTHROPTN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00817. EPO_TPO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEPO_PIG
AccessioniPrimary (citable) accession number: P49157
Secondary accession number(s): Q9MYM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.