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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processAngiogenesis, Differentiation

Enzyme and pathway databases

ReactomeiR-SSC-114608 Platelet degranulation
R-SSC-194313 VEGF ligand-receptor interactions
R-SSC-195399 VEGF binds to VEGFR leading to receptor dimerization
R-SSC-3928662 EPHB-mediated forward signaling
R-SSC-4420097 VEGFA-VEGFR2 Pathway
R-SSC-5218921 VEGFR2 mediated cell proliferation

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002338927 – 190Vascular endothelial growth factor AAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi76InterchainBy similarity
Disulfide bondi82 ↔ 127By similarity
Disulfide bondi85InterchainBy similarity
Disulfide bondi86 ↔ 129By similarity
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49151

Expressioni

Gene expression databases

BgeeiENSSSCG00000001695
GenevisibleiP49151 SS

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity). Interacts with NRP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP49151
STRINGi9823.ENSSSCP00000001845

Structurei

3D structure databases

ProteinModelPortaliP49151
SMRiP49151
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGCM Eukaryota
ENOG410ZWYU LUCA
HOVERGENiHBG000105
InParanoidiP49151
KOiK05448
OMAiERSFCRT
OrthoDBiEOG091G0G6M
TreeFamiTF319554

Family and domain databases

CDDicd00135 PDGF, 1 hit
Gene3Di2.10.160.10, 1 hit
2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR023581 PD_growth_factor_CS
IPR000072 PDGF/VEGF_dom
IPR027928 VEGF_C
IPR036841 VEGF_C_sf
PfamiView protein in Pfam
PF00341 PDGF, 1 hit
PF14554 VEGF_C, 1 hit
SMARTiView protein in SMART
SM00141 PDGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
SSF57593 SSF57593, 1 hit
PROSITEiView protein in PROSITE
PS00249 PDGF_1, 1 hit
PS50278 PDGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGDQKPHEVV KFMDVYQRSY
60 70 80 90 100
CRPIETLVDI FQEYPDEIEY IFKPSCVPLM RCGGCCNDEG LECVPTEEFN
110 120 130 140 150
ITMQIMRIKP HQGQHIGEMS FLQHNKCECR PKKDRARQEN PCGPCSERRK
160 170 180 190
HLFVQDPQTC KCSCKNTDSR CKARQLELNE RTCRCDKPRR
Length:190
Mass (Da):22,368
Last modified:February 1, 1996 - v1
Checksum:i04D40B8D7913047F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102T → A in AAG33064 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81380 mRNA Translation: CAA57143.1
AF318502 mRNA Translation: AAG33064.1
PIRiS52130
RefSeqiNP_999249.1, NM_214084.1
UniGeneiSsc.57541

Genome annotation databases

GeneIDi397157
KEGGissc:397157

Similar proteinsi

Entry informationi

Entry nameiVEGFA_PIG
AccessioniPrimary (citable) accession number: P49151
Secondary accession number(s): Q9GL52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health