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Protein

Vascular endothelial growth factor A

Gene

VEGFA

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Angiogenesis, Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-SSC-114608. Platelet degranulation.
R-SSC-194313. VEGF ligand-receptor interactions.
R-SSC-195399. VEGF binds to VEGFR leading to receptor dimerization.
R-SSC-3928663. EPHA-mediated growth cone collapse.
R-SSC-4420097. VEGFA-VEGFR2 Pathway.
R-SSC-5218921. VEGFR2 mediated cell proliferation.

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial growth factor A
Short name:
VEGF-A
Alternative name(s):
Vascular permeability factor
Short name:
VPF
Gene namesi
Name:VEGFA
Synonyms:VEGF
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

  • Secreted By similarity

  • Note: Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002338927 – 190Vascular endothelial growth factor AAdd BLAST164

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 93By similarity
Disulfide bondi76InterchainBy similarity
Disulfide bondi82 ↔ 127By similarity
Disulfide bondi85InterchainBy similarity
Disulfide bondi86 ↔ 129By similarity
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49151.

Expressioni

Gene expression databases

BgeeiENSSSCG00000001695.
ExpressionAtlasiP49151. baseline.
GenevisibleiP49151. SS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Also found as heterodimer with PGF (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001845.

Structurei

3D structure databases

ProteinModelPortaliP49151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDGF/VEGF growth factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOVERGENiHBG000105.
InParanoidiP49151.
KOiK05448.
OMAiERSFCRT.
OrthoDBiEOG091G0G6M.
TreeFamiTF319554.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49151-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLLSWVHW SLALLLYLHH AKWSQAAPMA EGDQKPHEVV KFMDVYQRSY
60 70 80 90 100
CRPIETLVDI FQEYPDEIEY IFKPSCVPLM RCGGCCNDEG LECVPTEEFN
110 120 130 140 150
ITMQIMRIKP HQGQHIGEMS FLQHNKCECR PKKDRARQEN PCGPCSERRK
160 170 180 190
HLFVQDPQTC KCSCKNTDSR CKARQLELNE RTCRCDKPRR
Length:190
Mass (Da):22,368
Last modified:February 1, 1996 - v1
Checksum:i04D40B8D7913047F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102T → A in AAG33064 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81380 mRNA. Translation: CAA57143.1.
AF318502 mRNA. Translation: AAG33064.1.
PIRiS52130.
RefSeqiNP_999249.1. NM_214084.1.
UniGeneiSsc.57541.

Genome annotation databases

EnsembliENSSSCT00000001892; ENSSSCP00000001845; ENSSSCG00000001695.
GeneIDi397157.
KEGGissc:397157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81380 mRNA. Translation: CAA57143.1.
AF318502 mRNA. Translation: AAG33064.1.
PIRiS52130.
RefSeqiNP_999249.1. NM_214084.1.
UniGeneiSsc.57541.

3D structure databases

ProteinModelPortaliP49151.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001845.

Proteomic databases

PaxDbiP49151.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000001892; ENSSSCP00000001845; ENSSSCG00000001695.
GeneIDi397157.
KEGGissc:397157.

Organism-specific databases

CTDi7422.

Phylogenomic databases

eggNOGiENOG410IGCM. Eukaryota.
ENOG410ZWYU. LUCA.
GeneTreeiENSGT00730000110791.
HOVERGENiHBG000105.
InParanoidiP49151.
KOiK05448.
OMAiERSFCRT.
OrthoDBiEOG091G0G6M.
TreeFamiTF319554.

Enzyme and pathway databases

ReactomeiR-SSC-114608. Platelet degranulation.
R-SSC-194313. VEGF ligand-receptor interactions.
R-SSC-195399. VEGF binds to VEGFR leading to receptor dimerization.
R-SSC-3928663. EPHA-mediated growth cone collapse.
R-SSC-4420097. VEGFA-VEGFR2 Pathway.
R-SSC-5218921. VEGFR2 mediated cell proliferation.

Gene expression databases

BgeeiENSSSCG00000001695.
ExpressionAtlasiP49151. baseline.
GenevisibleiP49151. SS.

Family and domain databases

CDDicd00135. PDGF. 1 hit.
Gene3Di2.10.160.10. 1 hit.
2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR023581. PD_growth_factor_CS.
IPR000072. PDGF/VEGF_dom.
IPR027928. VEGF_C.
[Graphical view]
PfamiPF00341. PDGF. 1 hit.
PF14554. VEGF_C. 1 hit.
[Graphical view]
SMARTiSM00141. PDGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
SSF57593. SSF57593. 1 hit.
PROSITEiPS00249. PDGF_1. 1 hit.
PS50278. PDGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVEGFA_PIG
AccessioniPrimary (citable) accession number: P49151
Secondary accession number(s): Q9GL52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.