Reviewed, UniProtKB/Swiss-Prot P49148 (RLA1_ALTAL)

Names and origin

Protein names

Recommended name:
    60S acidic ribosomal protein P1
Alternative name(s):
    Allergen Alt a XII
    Allergen=Alt a 12

Gene names

Name:

ALTA12

Organism

Alternaria alternata (Alternaria rot fungus)

Taxonomic identifier

5599 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	110 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Plays an important role in the elongation step of protein synthesis.
Subunit structure	P1 and P2 exist as dimers at the large ribosomal subunit.
Post-translational modification	Phosphorylated By similarity.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Disease	Allergen
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 110	110	60S acidic ribosomal protein P1		PRO_0000157700

Sequences

	Sequence		Length	Mass (Da)
	P49148-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: F06A232B67C3259F	FASTA	110	11,736
	10 20 30 40 50 60 MSTSELATSY AALILADDGV DITADKLQSL IKAAKIEEVE PIWTTLFAKA LEGKDVKDLL 70 80 90 100 110 LNVGSGGGAA PLPEALLLRW RAADAAPAAE EKKEEEKEES DEDMGFGLFD

References

[1]

"Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum." Achatz G., Oberkofler H., Lechenauer E., Simon-Nobbe B., Unger A., Kandler D., Ebner C., Prillinger H., Kraft D., Breitenbach M. Mol. Immunol. 32:213-227(1995) [PubMed: 7898496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGENICITY. Strain: 08-0203-Berlin.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X84216 mRNA. Translation: CAA58998.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR001813. Ribosomal_60S. [Graphical view]
Pfam	PF00428. Ribosomal_60s. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RLA1_ALTAL

Accession

Primary (citable) accession number: P49148

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)