ID   NPY2R_HUMAN             Reviewed;         381 AA.
AC   P49146; Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   27-MAR-2024, entry version 190.
DE   RecName: Full=Neuropeptide Y receptor type 2;
DE            Short=NPY2-R;
DE   AltName: Full=NPY-Y2 receptor;
DE            Short=Y2 receptor;
GN   Name=NPY2R;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hippocampus;
RX   PubMed=7592910; DOI=10.1074/jbc.270.45.26758;
RA   Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A.,
RA   Weinshank R.L.;
RT   "Expression cloning and pharmacological characterization of a human
RT   hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.";
RL   J. Biol. Chem. 270:26758-26761(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8632753;
RA   Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A.,
RA   Gadski R.A.;
RT   "Expression cloning of a human brain neuropeptide Y Y2 receptor.";
RL   Mol. Pharmacol. 49:224-228(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7559383; DOI=10.1074/jbc.270.39.22661;
RA   Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M.,
RA   Kodukula K., Kienzle B., Seethala R.;
RT   "Cloning and functional expression of a cDNA encoding a human type 2
RT   neuropeptide Y receptor.";
RL   J. Biol. Chem. 270:22661-22664(1995).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8643460; DOI=10.1073/pnas.93.10.4661;
RA   Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F.,
RA   Karbon W.;
RT   "Cloning and functional expression of cDNAs encoding human and rat
RT   pancreatic polypeptide receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8975716; DOI=10.1006/geno.1996.0642;
RA   Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr.,
RA   Yang-Feng T.L., Thompson D.A.;
RT   "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R)
RT   and localization to the chromosome 4q region containing the type 1
RT   neuropeptide Y receptor gene.";
RL   Genomics 38:392-398(1996).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zastawny R.L.;
RT   "Human neuropeptide Y Y2 receptor gene.";
RL   Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT   "cDNA clones of human proteins involved in signal transduction sequenced by
RT   the Guthrie cDNA resource center (www.cdna.org).";
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of
CC       affinity of this receptor for pancreatic polypeptides is PYY > NPY >
CC       PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY >
CC       PP, [Pro-34] PYY and NPY free acid.
CC   -!- INTERACTION:
CC       P49146; P10082: PYY; NbExp=2; IntAct=EBI-6655721, EBI-6655667;
CC       P49146; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-6655721, EBI-11988865;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: High levels in amygdala, corpus callosum,
CC       hippocampus and subthalamic nucleus. Also detectable in caudate
CC       nucleus, hypothalamus and substantia nigra.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; U36269; AAC50281.1; -; mRNA.
DR   EMBL; U42766; AAB04120.1; -; mRNA.
DR   EMBL; U32500; AAA93170.1; -; mRNA.
DR   EMBL; U42389; AAB07760.1; -; mRNA.
DR   EMBL; U50146; AAC51115.1; -; Genomic_DNA.
DR   EMBL; U76254; AAD00248.1; -; Genomic_DNA.
DR   EMBL; AY236540; AAO92062.1; -; Genomic_DNA.
DR   EMBL; AC104407; AAY40940.1; -; Genomic_DNA.
DR   EMBL; CH471056; EAX04901.1; -; Genomic_DNA.
DR   EMBL; BC075053; AAH75053.2; -; mRNA.
DR   EMBL; BC075052; AAH75052.2; -; mRNA.
DR   CCDS; CCDS3791.1; -.
DR   PIR; I39187; I39187.
DR   RefSeq; NP_000901.1; NM_000910.3.
DR   RefSeq; XP_005263090.1; XM_005263033.4.
DR   RefSeq; XP_005263091.1; XM_005263034.4.
DR   PDB; 7X9B; EM; 3.40 A; R=1-353.
DR   PDB; 7YON; EM; 2.95 A; R=2-381.
DR   PDB; 7YOO; EM; 3.11 A; R=2-381.
DR   PDBsum; 7X9B; -.
DR   PDBsum; 7YON; -.
DR   PDBsum; 7YOO; -.
DR   AlphaFoldDB; P49146; -.
DR   BMRB; P49146; -.
DR   EMDB; EMD-33070; -.
DR   SMR; P49146; -.
DR   BioGRID; 110947; 76.
DR   IntAct; P49146; 57.
DR   STRING; 9606.ENSP00000332591; -.
DR   BindingDB; P49146; -.
DR   ChEMBL; CHEMBL4018; -.
DR   DrugBank; DB00847; Cysteamine.
DR   DrugBank; DB05045; Obinepitide.
DR   DrugBank; DB05004; Peptide YY (3-36).
DR   DrugCentral; P49146; -.
DR   GuidetoPHARMACOLOGY; 306; -.
DR   TCDB; 9.A.14.13.33; the g-protein-coupled receptor (gpcr) family.
DR   GlyCosmos; P49146; 1 site, No reported glycans.
DR   GlyGen; P49146; 1 site.
DR   iPTMnet; P49146; -.
DR   PhosphoSitePlus; P49146; -.
DR   BioMuta; NPY2R; -.
DR   DMDM; 1352610; -.
DR   EPD; P49146; -.
DR   jPOST; P49146; -.
DR   MassIVE; P49146; -.
DR   PaxDb; 9606-ENSP00000332591; -.
DR   PeptideAtlas; P49146; -.
DR   ProteomicsDB; 55966; -.
DR   Antibodypedia; 2964; 370 antibodies from 39 providers.
DR   DNASU; 4887; -.
DR   Ensembl; ENST00000329476.4; ENSP00000332591.3; ENSG00000185149.6.
DR   Ensembl; ENST00000506608.1; ENSP00000426366.1; ENSG00000185149.6.
DR   GeneID; 4887; -.
DR   KEGG; hsa:4887; -.
DR   MANE-Select; ENST00000329476.4; ENSP00000332591.3; NM_000910.4; NP_000901.1.
DR   UCSC; uc003ioq.3; human.
DR   AGR; HGNC:7957; -.
DR   CTD; 4887; -.
DR   DisGeNET; 4887; -.
DR   GeneCards; NPY2R; -.
DR   HGNC; HGNC:7957; NPY2R.
DR   HPA; ENSG00000185149; Tissue enhanced (brain, breast).
DR   MIM; 162642; gene.
DR   neXtProt; NX_P49146; -.
DR   OpenTargets; ENSG00000185149; -.
DR   PharmGKB; PA31741; -.
DR   VEuPathDB; HostDB:ENSG00000185149; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000155973; -.
DR   HOGENOM; CLU_009579_6_1_1; -.
DR   InParanoid; P49146; -.
DR   OMA; HRCIIYH; -.
DR   OrthoDB; 2995026at2759; -.
DR   PhylomeDB; P49146; -.
DR   TreeFam; TF315303; -.
DR   PathwayCommons; P49146; -.
DR   Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   SignaLink; P49146; -.
DR   SIGNOR; P49146; -.
DR   BioGRID-ORCS; 4887; 8 hits in 1149 CRISPR screens.
DR   ChiTaRS; NPY2R; human.
DR   GeneWiki; Neuropeptide_Y_receptor_Y2; -.
DR   GenomeRNAi; 4887; -.
DR   Pharos; P49146; Tchem.
DR   PRO; PR:P49146; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; P49146; Protein.
DR   Bgee; ENSG00000185149; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 83 other cell types or tissues.
DR   GO; GO:0005929; C:cilium; IDA:MGI.
DR   GO; GO:0097730; C:non-motile cilium; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0005246; F:calcium channel regulator activity; TAS:ProtInc.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; TAS:ProtInc.
DR   GO; GO:0001601; F:peptide YY receptor activity; IEA:Ensembl.
DR   GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; TAS:ProtInc.
DR   GO; GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
DR   GO; GO:0007626; P:locomotory behavior; TAS:ProtInc.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
DR   CDD; cd15399; 7tmA_NPY2R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001358; NPY2_rcpt.
DR   InterPro; IPR000611; NPY_rcpt.
DR   PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR   PANTHER; PTHR24235:SF20; NEUROPEPTIDE Y RECEPTOR TYPE 2; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01014; NRPEPTIDEY2R.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; P49146; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..381
FT                   /note="Neuropeptide Y receptor type 2"
FT                   /id="PRO_0000069928"
FT   TOPO_DOM        1..51
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        73..86
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..124
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..165
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..216
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        217..237
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        238..268
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..304
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        326..381
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           342
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        11
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        123..203
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        134
FT                   /note="V -> A (in Ref. 3; AAA93170)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        172
FT                   /note="A -> G (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="G -> R (in Ref. 4)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="A -> P (in Ref. 4; AAB07760)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209
FT                   /note="G -> A (in Ref. 4; AAB07760)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        248
FT                   /note="N -> S (in Ref. 6; AAD00248)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        311
FT                   /note="H -> Y (in Ref. 6; AAD00248)"
FT                   /evidence="ECO:0000305"
FT   HELIX           47..77
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           84..103
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           105..111
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   STRAND          113..115
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           122..124
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           126..152
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           162..179
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           181..183
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   TURN            184..186
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   STRAND          195..197
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   STRAND          208..211
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           214..248
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   STRAND          252..255
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           260..293
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   STRAND          294..298
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           303..327
FT                   /evidence="ECO:0007829|PDB:7X9B"
FT   HELIX           330..339
FT                   /evidence="ECO:0007829|PDB:7X9B"
SQ   SEQUENCE   381 AA;  42731 MW;  7D018C0169597BC7 CRC64;
     MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI
     ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP
     VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA
     SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT
     RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
     KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK
     KNLEVRKNSG PNDSFTEATN V
//