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P49146 (NPY2R_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropeptide Y receptor type 2

Short name=NPY2-R
Alternative name(s):
NPY-Y2 receptor
Short name=Y2 receptor
Gene names
Name:NPY2R
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Traceable author statement Ref.3. Source: ProtInc

behavioral fear response

Inferred from electronic annotation. Source: Ensembl

cardiac left ventricle morphogenesis

Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL

locomotory behavior

Traceable author statement PubMed 9692752. Source: ProtInc

negative regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of excitatory postsynaptic membrane potential

Inferred from electronic annotation. Source: Ensembl

negative regulation of feeding behavior

Inferred from electronic annotation. Source: Ensembl

negative regulation of neurological system process

Inferred from electronic annotation. Source: Ensembl

negative regulation of secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of synaptic transmission, glutamatergic

Inferred from electronic annotation. Source: Ensembl

neuropeptide signaling pathway

Traceable author statement Ref.3. Source: GOC

nitric oxide mediated signal transduction

Inferred from electronic annotation. Source: Ensembl

outflow tract morphogenesis

Inferred from mutant phenotype PubMed 19593212. Source: BHF-UCL

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of circadian sleep/wake cycle, non-REM sleep

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of dopamine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptide secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of smooth muscle contraction

Inferred from electronic annotation. Source: Ensembl

regulation of sensory perception of pain

Inferred from electronic annotation. Source: Ensembl

secretion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of plasma membrane

Traceable author statement Ref.1. Source: ProtInc

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functioncalcium channel regulator activity

Traceable author statement PubMed 8132547. Source: ProtInc

neuropeptide Y receptor activity

Traceable author statement Ref.3. Source: ProtInc

peptide YY receptor activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 23597562. Source: IntAct

receptor activity

Traceable author statement PubMed 1321422. Source: ProtInc

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PYYP100822EBI-6655721,EBI-6655667

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381Neuropeptide Y receptor type 2
PRO_0000069928

Regions

Topological domain1 – 5151Extracellular Potential
Transmembrane52 – 7221Helical; Name=1; Potential
Topological domain73 – 8614Cytoplasmic Potential
Transmembrane87 – 10721Helical; Name=2; Potential
Topological domain108 – 12417Extracellular Potential
Transmembrane125 – 14521Helical; Name=3; Potential
Topological domain146 – 16520Cytoplasmic Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Topological domain187 – 21630Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 26831Cytoplasmic Potential
Transmembrane269 – 28921Helical; Name=6; Potential
Topological domain290 – 30415Extracellular Potential
Transmembrane305 – 32521Helical; Name=7; Potential
Topological domain326 – 38156Cytoplasmic Potential

Amino acid modifications

Lipidation3421S-palmitoyl cysteine Potential
Glycosylation111N-linked (GlcNAc...) Potential
Disulfide bond123 ↔ 203 By similarity

Experimental info

Sequence conflict1341V → A in AAA93170. Ref.3
Sequence conflict1721A → G Ref.4
Sequence conflict1741G → R Ref.4
Sequence conflict2021A → P in AAB07760. Ref.4
Sequence conflict2091G → A in AAB07760. Ref.4
Sequence conflict2481N → S in AAD00248. Ref.6
Sequence conflict3111H → Y in AAD00248. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P49146 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 7D018C0169597BC7

FASTA38142,731
        10         20         30         40         50         60 
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ VVLILAYCSI 

        70         80         90        100        110        120 
ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN TLCLPFTLTY TLMGEWKMGP 

       130        140        150        160        170        180 
VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR CIVYHLESKI SKRISFLIIG LAWGISALLA 

       190        200        210        220        230        240 
SPLAIFREYS LIEIIPDFEI VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT 

       250        260        270        280        290        300 
RIWSKLKNHV SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL 

       310        320        330        340        350        360 
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH SEVSVTFKAK 

       370        380 
KNLEVRKNSG PNDSFTEATN V 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype."
Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A., Weinshank R.L.
J. Biol. Chem. 270:26758-26761(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hippocampus.
[2]"Expression cloning of a human brain neuropeptide Y Y2 receptor."
Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A., Gadski R.A.
Mol. Pharmacol. 49:224-228(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor."
Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R.
J. Biol. Chem. 270:22661-22664(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene."
Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr., Yang-Feng T.L., Thompson D.A.
Genomics 38:392-398(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Human neuropeptide Y Y2 receptor gene."
Zastawny R.L.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Kopatz S.A., Aronstam R.S., Sharma S.V.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U36269 mRNA. Translation: AAC50281.1.
U42766 mRNA. Translation: AAB04120.1.
U32500 mRNA. Translation: AAA93170.1.
U42389 mRNA. Translation: AAB07760.1.
U50146 Genomic DNA. Translation: AAC51115.1.
U76254 Genomic DNA. Translation: AAD00248.1.
AY236540 Genomic DNA. Translation: AAO92062.1.
AC104407 Genomic DNA. Translation: AAY40940.1.
CH471056 Genomic DNA. Translation: EAX04901.1.
BC075053 mRNA. Translation: AAH75053.2.
BC075052 mRNA. Translation: AAH75052.2.
CCDSCCDS3791.1.
PIRI39187.
RefSeqNP_000901.1. NM_000910.2.
XP_005263090.1. XM_005263033.2.
XP_005263091.1. XM_005263034.2.
UniGeneHs.37125.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2IK3model-@1-381[»]
ProteinModelPortalP49146.
SMRP49146. Positions 55-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP49146. 2 interactions.
STRING9606.ENSP00000332591.

Chemistry

BindingDBP49146.
ChEMBLCHEMBL4018.
GuidetoPHARMACOLOGY306.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP49146.

Polymorphism databases

DMDM1352610.

Proteomic databases

PaxDbP49146.
PRIDEP49146.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329476; ENSP00000332591; ENSG00000185149.
ENST00000506608; ENSP00000426366; ENSG00000185149.
GeneID4887.
KEGGhsa:4887.
UCSCuc003ioq.3. human.

Organism-specific databases

CTD4887.
GeneCardsGC04P156129.
HGNCHGNC:7957. NPY2R.
HPAHPA013965.
MIM162642. gene.
neXtProtNX_P49146.
PharmGKBPA31741.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267229.
HOGENOMHOG000050229.
HOVERGENHBG105675.
InParanoidP49146.
KOK04205.
OMACEQRLDS.
OrthoDBEOG7P02JG.
PhylomeDBP49146.
TreeFamTF315303.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP49146.
CleanExHS_NPY2R.
GenevestigatorP49146.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuropeptide_Y_receptor_Y2.
GenomeRNAi4887.
NextBio18814.
PROP49146.
SOURCESearch...

Entry information

Entry nameNPY2R_HUMAN
AccessionPrimary (citable) accession number: P49146
Secondary accession number(s): Q13281 expand/collapse secondary AC list , Q13457, Q4W5G7, Q6AZZ6, Q9UE67
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries