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P49146

- NPY2R_HUMAN

UniProt

P49146 - NPY2R_HUMAN

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Protein

Neuropeptide Y receptor type 2

Gene

NPY2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

GO - Molecular functioni

  1. calcium channel regulator activity Source: ProtInc
  2. neuropeptide Y receptor activity Source: ProtInc
  3. peptide YY receptor activity Source: Ensembl
  4. receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
  2. behavioral fear response Source: Ensembl
  3. cardiac left ventricle morphogenesis Source: BHF-UCL
  4. locomotory behavior Source: ProtInc
  5. negative regulation of cAMP biosynthetic process Source: Ensembl
  6. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
  7. negative regulation of feeding behavior Source: Ensembl
  8. negative regulation of neurological system process Source: Ensembl
  9. negative regulation of secretion Source: Ensembl
  10. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
  11. neuropeptide signaling pathway Source: GOC
  12. nitric oxide mediated signal transduction Source: Ensembl
  13. outflow tract morphogenesis Source: BHF-UCL
  14. positive regulation of cell adhesion Source: Ensembl
  15. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  16. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  17. positive regulation of dopamine secretion Source: Ensembl
  18. positive regulation of peptide secretion Source: Ensembl
  19. positive regulation of smooth muscle contraction Source: Ensembl
  20. regulation of sensory perception of pain Source: Ensembl
  21. secretion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide Y receptor type 2
Short name:
NPY2-R
Alternative name(s):
NPY-Y2 receptor
Short name:
Y2 receptor
Gene namesi
Name:NPY2R
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:7957. NPY2R.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31741.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 381381Neuropeptide Y receptor type 2PRO_0000069928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 203PROSITE-ProRule annotation
Lipidationi342 – 3421S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP49146.
PRIDEiP49146.

PTM databases

PhosphoSiteiP49146.

Expressioni

Tissue specificityi

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Gene expression databases

BgeeiP49146.
CleanExiHS_NPY2R.
GenevestigatoriP49146.

Organism-specific databases

HPAiHPA013965.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PYYP100822EBI-6655721,EBI-6655667

Protein-protein interaction databases

IntActiP49146. 2 interactions.
STRINGi9606.ENSP00000332591.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2IK3model-@1-381[»]
ProteinModelPortaliP49146.
SMRiP49146. Positions 55-336.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151ExtracellularSequence AnalysisAdd
BLAST
Topological domaini73 – 8614CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini108 – 12417ExtracellularSequence AnalysisAdd
BLAST
Topological domaini146 – 16520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini187 – 21630ExtracellularSequence AnalysisAdd
BLAST
Topological domaini238 – 26831CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini290 – 30415ExtracellularSequence AnalysisAdd
BLAST
Topological domaini326 – 38156CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei305 – 32521Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG267229.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000050229.
HOVERGENiHBG105675.
InParanoidiP49146.
KOiK04205.
OMAiCEQRLDS.
OrthoDBiEOG7P02JG.
PhylomeDBiP49146.
TreeFamiTF315303.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49146-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ
60 70 80 90 100
VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN
110 120 130 140 150
TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR
160 170 180 190 200
CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI
210 220 230 240 250
VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV
260 270 280 290 300
SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL
310 320 330 340 350
KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH
360 370 380
SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V
Length:381
Mass (Da):42,731
Last modified:February 1, 1996 - v1
Checksum:i7D018C0169597BC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341V → A in AAA93170. (PubMed:7559383)Curated
Sequence conflicti172 – 1721A → G(PubMed:8643460)Curated
Sequence conflicti174 – 1741G → R(PubMed:8643460)Curated
Sequence conflicti202 – 2021A → P in AAB07760. (PubMed:8643460)Curated
Sequence conflicti209 – 2091G → A in AAB07760. (PubMed:8643460)Curated
Sequence conflicti248 – 2481N → S in AAD00248. 1 PublicationCurated
Sequence conflicti311 – 3111H → Y in AAD00248. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36269 mRNA. Translation: AAC50281.1.
U42766 mRNA. Translation: AAB04120.1.
U32500 mRNA. Translation: AAA93170.1.
U42389 mRNA. Translation: AAB07760.1.
U50146 Genomic DNA. Translation: AAC51115.1.
U76254 Genomic DNA. Translation: AAD00248.1.
AY236540 Genomic DNA. Translation: AAO92062.1.
AC104407 Genomic DNA. Translation: AAY40940.1.
CH471056 Genomic DNA. Translation: EAX04901.1.
BC075053 mRNA. Translation: AAH75053.2.
BC075052 mRNA. Translation: AAH75052.2.
CCDSiCCDS3791.1.
PIRiI39187.
RefSeqiNP_000901.1. NM_000910.2.
XP_005263090.1. XM_005263033.2.
XP_005263091.1. XM_005263034.2.
UniGeneiHs.37125.

Genome annotation databases

EnsembliENST00000329476; ENSP00000332591; ENSG00000185149.
ENST00000506608; ENSP00000426366; ENSG00000185149.
GeneIDi4887.
KEGGihsa:4887.
UCSCiuc003ioq.3. human.

Polymorphism databases

DMDMi1352610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36269 mRNA. Translation: AAC50281.1 .
U42766 mRNA. Translation: AAB04120.1 .
U32500 mRNA. Translation: AAA93170.1 .
U42389 mRNA. Translation: AAB07760.1 .
U50146 Genomic DNA. Translation: AAC51115.1 .
U76254 Genomic DNA. Translation: AAD00248.1 .
AY236540 Genomic DNA. Translation: AAO92062.1 .
AC104407 Genomic DNA. Translation: AAY40940.1 .
CH471056 Genomic DNA. Translation: EAX04901.1 .
BC075053 mRNA. Translation: AAH75053.2 .
BC075052 mRNA. Translation: AAH75052.2 .
CCDSi CCDS3791.1.
PIRi I39187.
RefSeqi NP_000901.1. NM_000910.2.
XP_005263090.1. XM_005263033.2.
XP_005263091.1. XM_005263034.2.
UniGenei Hs.37125.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2IK3 model - @ 1-381 [» ]
ProteinModelPortali P49146.
SMRi P49146. Positions 55-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P49146. 2 interactions.
STRINGi 9606.ENSP00000332591.

Chemistry

BindingDBi P49146.
ChEMBLi CHEMBL4018.
DrugBanki DB00847. Cysteamine.
GuidetoPHARMACOLOGYi 306.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P49146.

Polymorphism databases

DMDMi 1352610.

Proteomic databases

PaxDbi P49146.
PRIDEi P49146.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329476 ; ENSP00000332591 ; ENSG00000185149 .
ENST00000506608 ; ENSP00000426366 ; ENSG00000185149 .
GeneIDi 4887.
KEGGi hsa:4887.
UCSCi uc003ioq.3. human.

Organism-specific databases

CTDi 4887.
GeneCardsi GC04P156129.
HGNCi HGNC:7957. NPY2R.
HPAi HPA013965.
MIMi 162642. gene.
neXtProti NX_P49146.
PharmGKBi PA31741.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267229.
GeneTreei ENSGT00760000118781.
HOGENOMi HOG000050229.
HOVERGENi HBG105675.
InParanoidi P49146.
KOi K04205.
OMAi CEQRLDS.
OrthoDBi EOG7P02JG.
PhylomeDBi P49146.
TreeFami TF315303.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuropeptide_Y_receptor_Y2.
GenomeRNAii 4887.
NextBioi 18814.
PROi P49146.
SOURCEi Search...

Gene expression databases

Bgeei P49146.
CleanExi HS_NPY2R.
Genevestigatori P49146.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001358. NPY2_rcpt.
IPR000611. NPY_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01014. NRPEPTIDEY2R.
PR01012. NRPEPTIDEYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype."
    Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A., Weinshank R.L.
    J. Biol. Chem. 270:26758-26761(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hippocampus.
  2. "Expression cloning of a human brain neuropeptide Y Y2 receptor."
    Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A., Gadski R.A.
    Mol. Pharmacol. 49:224-228(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor."
    Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R.
    J. Biol. Chem. 270:22661-22664(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
    Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
    Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene."
    Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr., Yang-Feng T.L., Thompson D.A.
    Genomics 38:392-398(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Human neuropeptide Y Y2 receptor gene."
    Zastawny R.L.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Kopatz S.A., Aronstam R.S., Sharma S.V.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNPY2R_HUMAN
AccessioniPrimary (citable) accession number: P49146
Secondary accession number(s): Q13281
, Q13457, Q4W5G7, Q6AZZ6, Q9UE67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3