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P49146

- NPY2R_HUMAN

UniProt

P49146 - NPY2R_HUMAN

Protein

Neuropeptide Y receptor type 2

Gene

NPY2R

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu-31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.

    GO - Molecular functioni

    1. calcium channel regulator activity Source: ProtInc
    2. neuropeptide Y receptor activity Source: ProtInc
    3. peptide YY receptor activity Source: Ensembl
    4. protein binding Source: IntAct
    5. receptor activity Source: ProtInc

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: ProtInc
    2. behavioral fear response Source: Ensembl
    3. cardiac left ventricle morphogenesis Source: BHF-UCL
    4. locomotory behavior Source: ProtInc
    5. negative regulation of cAMP biosynthetic process Source: Ensembl
    6. negative regulation of excitatory postsynaptic membrane potential Source: Ensembl
    7. negative regulation of feeding behavior Source: Ensembl
    8. negative regulation of neurological system process Source: Ensembl
    9. negative regulation of secretion Source: Ensembl
    10. negative regulation of synaptic transmission, glutamatergic Source: Ensembl
    11. neuropeptide signaling pathway Source: GOC
    12. nitric oxide mediated signal transduction Source: Ensembl
    13. outflow tract morphogenesis Source: BHF-UCL
    14. positive regulation of cell adhesion Source: Ensembl
    15. positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    16. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    17. positive regulation of dopamine secretion Source: Ensembl
    18. positive regulation of peptide secretion Source: Ensembl
    19. positive regulation of smooth muscle contraction Source: Ensembl
    20. regulation of sensory perception of pain Source: Ensembl
    21. secretion Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropeptide Y receptor type 2
    Short name:
    NPY2-R
    Alternative name(s):
    NPY-Y2 receptor
    Short name:
    Y2 receptor
    Gene namesi
    Name:NPY2R
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:7957. NPY2R.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31741.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Neuropeptide Y receptor type 2PRO_0000069928Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 203PROSITE-ProRule annotation
    Lipidationi342 – 3421S-palmitoyl cysteineSequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP49146.
    PRIDEiP49146.

    PTM databases

    PhosphoSiteiP49146.

    Expressioni

    Tissue specificityi

    High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

    Gene expression databases

    BgeeiP49146.
    CleanExiHS_NPY2R.
    GenevestigatoriP49146.

    Organism-specific databases

    HPAiHPA013965.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PYYP100822EBI-6655721,EBI-6655667

    Protein-protein interaction databases

    IntActiP49146. 2 interactions.
    STRINGi9606.ENSP00000332591.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IK3model-@1-381[»]
    ProteinModelPortaliP49146.
    SMRiP49146. Positions 55-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5151ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini73 – 8614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 12417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini146 – 16520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini187 – 21630ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 26831CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 30415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini326 – 38156CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei52 – 7221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei125 – 14521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei305 – 32521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG267229.
    HOGENOMiHOG000050229.
    HOVERGENiHBG105675.
    InParanoidiP49146.
    KOiK04205.
    OMAiCEQRLDS.
    OrthoDBiEOG7P02JG.
    PhylomeDBiP49146.
    TreeFamiTF315303.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001358. NPY2_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01014. NRPEPTIDEY2R.
    PR01012. NRPEPTIDEYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPIGAEADE NQTVEEMKVE QYGPQTTPRG ELVPDPEPEL IDSTKLIEVQ    50
    VVLILAYCSI ILLGVIGNSL VIHVVIKFKS MRTVTNFFIA NLAVADLLVN 100
    TLCLPFTLTY TLMGEWKMGP VLCHLVPYAQ GLAVQVSTIT LTVIALDRHR 150
    CIVYHLESKI SKRISFLIIG LAWGISALLA SPLAIFREYS LIEIIPDFEI 200
    VACTEKWPGE EKSIYGTVYS LSSLLILYVL PLGIISFSYT RIWSKLKNHV 250
    SPGAANDHYH QRRQKTTKML VCVVVVFAVS WLPLHAFQLA VDIDSQVLDL 300
    KEYKLIFTVF HIIAMCSTFA NPLLYGWMNS NYRKAFLSAF RCEQRLDAIH 350
    SEVSVTFKAK KNLEVRKNSG PNDSFTEATN V 381
    Length:381
    Mass (Da):42,731
    Last modified:February 1, 1996 - v1
    Checksum:i7D018C0169597BC7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341V → A in AAA93170. (PubMed:7559383)Curated
    Sequence conflicti172 – 1721A → G(PubMed:8643460)Curated
    Sequence conflicti174 – 1741G → R(PubMed:8643460)Curated
    Sequence conflicti202 – 2021A → P in AAB07760. (PubMed:8643460)Curated
    Sequence conflicti209 – 2091G → A in AAB07760. (PubMed:8643460)Curated
    Sequence conflicti248 – 2481N → S in AAD00248. 1 PublicationCurated
    Sequence conflicti311 – 3111H → Y in AAD00248. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36269 mRNA. Translation: AAC50281.1.
    U42766 mRNA. Translation: AAB04120.1.
    U32500 mRNA. Translation: AAA93170.1.
    U42389 mRNA. Translation: AAB07760.1.
    U50146 Genomic DNA. Translation: AAC51115.1.
    U76254 Genomic DNA. Translation: AAD00248.1.
    AY236540 Genomic DNA. Translation: AAO92062.1.
    AC104407 Genomic DNA. Translation: AAY40940.1.
    CH471056 Genomic DNA. Translation: EAX04901.1.
    BC075053 mRNA. Translation: AAH75053.2.
    BC075052 mRNA. Translation: AAH75052.2.
    CCDSiCCDS3791.1.
    PIRiI39187.
    RefSeqiNP_000901.1. NM_000910.2.
    XP_005263090.1. XM_005263033.2.
    XP_005263091.1. XM_005263034.2.
    UniGeneiHs.37125.

    Genome annotation databases

    EnsembliENST00000329476; ENSP00000332591; ENSG00000185149.
    ENST00000506608; ENSP00000426366; ENSG00000185149.
    GeneIDi4887.
    KEGGihsa:4887.
    UCSCiuc003ioq.3. human.

    Polymorphism databases

    DMDMi1352610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36269 mRNA. Translation: AAC50281.1 .
    U42766 mRNA. Translation: AAB04120.1 .
    U32500 mRNA. Translation: AAA93170.1 .
    U42389 mRNA. Translation: AAB07760.1 .
    U50146 Genomic DNA. Translation: AAC51115.1 .
    U76254 Genomic DNA. Translation: AAD00248.1 .
    AY236540 Genomic DNA. Translation: AAO92062.1 .
    AC104407 Genomic DNA. Translation: AAY40940.1 .
    CH471056 Genomic DNA. Translation: EAX04901.1 .
    BC075053 mRNA. Translation: AAH75053.2 .
    BC075052 mRNA. Translation: AAH75052.2 .
    CCDSi CCDS3791.1.
    PIRi I39187.
    RefSeqi NP_000901.1. NM_000910.2.
    XP_005263090.1. XM_005263033.2.
    XP_005263091.1. XM_005263034.2.
    UniGenei Hs.37125.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IK3 model - @ 1-381 [» ]
    ProteinModelPortali P49146.
    SMRi P49146. Positions 55-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P49146. 2 interactions.
    STRINGi 9606.ENSP00000332591.

    Chemistry

    BindingDBi P49146.
    ChEMBLi CHEMBL4018.
    GuidetoPHARMACOLOGYi 306.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P49146.

    Polymorphism databases

    DMDMi 1352610.

    Proteomic databases

    PaxDbi P49146.
    PRIDEi P49146.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329476 ; ENSP00000332591 ; ENSG00000185149 .
    ENST00000506608 ; ENSP00000426366 ; ENSG00000185149 .
    GeneIDi 4887.
    KEGGi hsa:4887.
    UCSCi uc003ioq.3. human.

    Organism-specific databases

    CTDi 4887.
    GeneCardsi GC04P156129.
    HGNCi HGNC:7957. NPY2R.
    HPAi HPA013965.
    MIMi 162642. gene.
    neXtProti NX_P49146.
    PharmGKBi PA31741.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267229.
    HOGENOMi HOG000050229.
    HOVERGENi HBG105675.
    InParanoidi P49146.
    KOi K04205.
    OMAi CEQRLDS.
    OrthoDBi EOG7P02JG.
    PhylomeDBi P49146.
    TreeFami TF315303.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuropeptide_Y_receptor_Y2.
    GenomeRNAii 4887.
    NextBioi 18814.
    PROi P49146.
    SOURCEi Search...

    Gene expression databases

    Bgeei P49146.
    CleanExi HS_NPY2R.
    Genevestigatori P49146.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001358. NPY2_rcpt.
    IPR000611. NPY_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01014. NRPEPTIDEY2R.
    PR01012. NRPEPTIDEYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype."
      Gerald C., Walker M.W., Vaysse P.J.-J., He C., Branchek T.A., Weinshank R.L.
      J. Biol. Chem. 270:26758-26761(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hippocampus.
    2. "Expression cloning of a human brain neuropeptide Y Y2 receptor."
      Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A., Gadski R.A.
      Mol. Pharmacol. 49:224-228(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    3. "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor."
      Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., Kienzle B., Seethala R.
      J. Biol. Chem. 270:22661-22664(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors."
      Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., Karbon W.
      Proc. Natl. Acad. Sci. U.S.A. 93:4661-4665(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene."
      Ammar D.A., Eadie D.M., Wong D.J., Ma Y.-Y., Kolakowski L.F. Jr., Yang-Feng T.L., Thompson D.A.
      Genomics 38:392-398(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Human neuropeptide Y Y2 receptor gene."
      Zastawny R.L.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A., Aronstam R.S., Sharma S.V.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiNPY2R_HUMAN
    AccessioniPrimary (citable) accession number: P49146
    Secondary accession number(s): Q13281
    , Q13457, Q4W5G7, Q6AZZ6, Q9UE67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3