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Protein

Ski oncogene

Gene

SKI

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. May function in TGF-beta signaling (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • protein heterodimerization activity Source: AgBase
  • protein homodimerization activity Source: AgBase
  • repressing transcription factor binding Source: AgBase
  • sequence-specific DNA binding Source: AgBase
  • SMAD binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ski oncogene
Alternative name(s):
Proto-oncogene c-Ski
Gene namesi
Name:SKI
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: AgBase
  • transcription factor complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Ski oncogenePRO_0000129384Add
BLAST

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SNW1Q135734EBI-6392357,EBI-632715From a different organism.

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • protein heterodimerization activity Source: AgBase
  • protein homodimerization activity Source: AgBase
  • repressing transcription factor binding Source: AgBase
  • SMAD binding Source: GO_Central

Protein-protein interaction databases

BioGridi687293. 2 interactions.
IntActiP49140. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP49140.
SMRiP49140. Positions 74-175, 200-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili558 – 732175Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

HOVERGENiHBG006599.
InParanoidiP49140.
PhylomeDBiP49140.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

P49140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVSRSSFQ PHPGLQKTLE QFHLSSMSSL GGPAAFSARW AQEMYKKDNG
60 70 80 90 100
KDPAEPVLHL PPIQPPPVMP GPFFMPSDRS TERCETILEG ETISCFVVGG
110 120 130 140 150
EKRLCLPQIL NSVLRDFSLQ QINSVCDELH IYCSRCTADQ LEILKVMGIL
160 170 180 190 200
PFSAPSCGLI TKTDAERLCN ALLYGGTYPP HCKKEFSSTI ELELTEKSFK
210 220 230 240 250
VYHECFGKCK GLLVPELYSN PSAACIQCLD CRLMYPPHKF VVHSHKSLEN
260 270 280 290 300
RTCHWGFDSA NWRSYILLSQ DYTGKEEKAR LGQLLDEMKE KFDYNNKYKR
310 320 330 340 350
KAPRNRESPR VQLRRTKMFK TMLWDPAGGS AVLQRQPDGN EVPSDPPASK
360 370 380 390 400
KTKIDDSASQ SPASTEKEKQ SSWLRSLSSS SNKSIGCVHP RQRLSAFRPW
410 420 430 440 450
SPAVSANEKE LSTHLPALIR DSSFYSYKSF ENAVAPNVAL APPAQQKVVS
460 470 480 490 500
NPPCATVVSR SSEPPSSAAQ PRKRKHAAET PAVPEPVATV TAPEEDKESE
510 520 530 540 550
AEIEVETREE FTSSLSSLSS PSFTSSSSAK DMSSPGMQAP VPVNSSYEVA
560 570 580 590 600
AHSDSHSSGL EAELEHLRQA LDSGLDTKEA KEKFLHEVVK MRVKQEEKLN
610 620 630 640 650
AALQAKRSLH QELEFLRVAK KEKLREATEA KRNLRKEIER LRAENEKKMK
660 670 680 690 700
EANESRIRLK RELEQARQIR VCDKGCEAGR LRAKYSAQIE DLQVKLQHAE
710 720 730 740 750
ADREQLRADL MHEREAREHL EKVVKELQEQ LWPKSSSQSS SENTTSNMEN
Length:750
Mass (Da):84,282
Last modified:February 1, 1996 - v1
Checksum:i01E322EEBE0C402B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28517 Genomic DNA. Translation: AAA48730.1.
PIRiA32575.
B32575.
RefSeqiNP_001034407.1. NM_001039318.1.
UniGeneiGga.26111.

Genome annotation databases

GeneIDi428181.
KEGGigga:428181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28517 Genomic DNA. Translation: AAA48730.1.
PIRiA32575.
B32575.
RefSeqiNP_001034407.1. NM_001039318.1.
UniGeneiGga.26111.

3D structure databases

ProteinModelPortaliP49140.
SMRiP49140. Positions 74-175, 200-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi687293. 2 interactions.
IntActiP49140. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428181.
KEGGigga:428181.

Organism-specific databases

CTDi6497.

Phylogenomic databases

HOVERGENiHBG006599.
InParanoidiP49140.
PhylomeDBiP49140.

Miscellaneous databases

PROiP49140.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Isolation and characterization of three distinct cDNAs for the chicken c-ski gene."
    Sutrave P., Hughes S.H.
    Mol. Cell. Biol. 9:4046-4051(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiSKI_CHICK
AccessioniPrimary (citable) accession number: P49140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.