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P49138

- MAPK2_MOUSE

UniProt

P49138 - MAPK2_MOUSE

Protein

MAP kinase-activated protein kinase 2

Gene

Mapkapk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.8 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Activated following phosphorylation by p38-alpha/MAPK14 following various stresses. Inhibited following sumoylation. Specifically inhibited by pyrrolopyridine inhibitors By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 791ATPPROSITE-ProRule annotation
    Active sitei172 – 1721Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi56 – 649ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. 3'-UTR-mediated mRNA stabilization Source: UniProtKB
    2. cellular response to DNA damage stimulus Source: UniProtKB
    3. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
    4. G2 DNA damage checkpoint Source: UniProtKB
    5. inflammatory response Source: UniProtKB
    6. inner ear development Source: MGI
    7. macropinocytosis Source: UniProtKB
    8. mRNA stabilization Source: MGI
    9. peptidyl-serine phosphorylation Source: Ensembl
    10. protein phosphorylation Source: UniProtKB
    11. regulation of interleukin-6 production Source: UniProtKB
    12. regulation of tumor necrosis factor production Source: UniProtKB
    13. response to cytokine Source: UniProtKB
    14. response to lipopolysaccharide Source: UniProtKB
    15. toll-like receptor signaling pathway Source: UniProtKB
    16. vascular endothelial growth factor receptor signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    DNA damage

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188970. Oxidative Stress Induced Senescence.
    REACT_198689. Tristetraprolin (TTP) destabilizes mRNA.
    REACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.
    REACT_207601. p38MAPK events.
    REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    REACT_222185. Regulation of HSF1-mediated heat shock response.
    REACT_224314. CREB phosphorylation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAP kinase-activated protein kinase 2 (EC:2.7.11.1)
    Short name:
    MAPK-activated protein kinase 2
    Short name:
    MAPKAP kinase 2
    Short name:
    MAPKAP-K2
    Short name:
    MAPKAPK-2
    Short name:
    MK-2
    Short name:
    MK2
    Gene namesi
    Name:Mapkapk2
    Synonyms:Rps6kc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:109298. Mapkapk2.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype. Mice are fertile and do not exhibit behavioral phenotype. Mice show decreased production of inflammatory cytokines such as TNF and IL6 upon LPS-stimulation. Impaired cytokine production make mice less sensitive to LPS-induced endotoxic shock, but more susceptible to bacterial infection. Moreover, the amount of MAP kinase p38 is significantly reduced in cells and tissues. Mice lacking both Mapkapk2 and Mapkapk3 show further reduction of TNF production.3 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi208 – 2081T → A: Strong decrease in kinase activity; when associated with A-320. 1 Publication
    Mutagenesisi208 – 2081T → E: Mimicks phosphorylation state and constitutive protein kinase activity; when associated with E-320. 1 Publication
    Mutagenesisi320 – 3201T → A: Strong decrease in kinase activity; when associated with A-208. 1 Publication
    Mutagenesisi320 – 3201T → E: Mimicks phosphorylation state and constitutive protein kinase activity; when associated with E-208. 1 Publication
    Mutagenesisi329 – 3291K → R: Leads to constitutive protein kinase activity. 1 Publication
    Mutagenesisi335 – 3351W → A: Leads to constitutive protein kinase activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386MAP kinase-activated protein kinase 2PRO_0000086289Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei208 – 2081Phosphothreonine; by MAPK142 Publications
    Modified residuei258 – 2581Phosphoserine; by MAPK14By similarity
    Modified residuei314 – 3141Phosphoserine; by autocatalysisBy similarity
    Modified residuei320 – 3201Phosphothreonine; by MAPK142 Publications
    Cross-linki339 – 339Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

    Post-translational modificationi

    Sumoylation inhibits the protein kinase activity.By similarity
    Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-208; Ser-258 and Thr-320.2 Publications

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP49138.
    PaxDbiP49138.
    PRIDEiP49138.

    PTM databases

    PhosphoSiteiP49138.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP49138.
    BgeeiP49138.
    CleanExiMM_MAPKAPK2.
    MM_RPS6KC1.
    GenevestigatoriP49138.

    Interactioni

    Subunit structurei

    Heterodimer with p38-alpha/MAPK14. The heterodimer with p38-alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts with PHC2 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Mapk14P478112EBI-298776,EBI-298727
    Phc1Q640282EBI-298776,EBI-927346
    Phc2Q9QWH15EBI-298776,EBI-642357

    Protein-protein interaction databases

    BioGridi201308. 8 interactions.
    IntActiP49138. 7 interactions.
    MINTiMINT-4101209.

    Structurei

    3D structure databases

    ProteinModelPortaliP49138.
    SMRiP49138. Positions 37-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 311262Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1273Staurosporine bindingBy similarity
    Regioni314 – 35037Autoinhibitory helixAdd
    BLAST
    Regioni331 – 35424Nuclear export signal (NES)Add
    BLAST
    Regioni352 – 37625p38 MAPK-binding siteBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi342 – 35110Nuclear export signal (NES)By similarity
    Motifi357 – 3604Bipartite nuclear localization signal 1
    Motifi371 – 3755Bipartite nuclear localization signal 2

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi6 – 3025Pro-richAdd
    BLAST
    Compositional biasi13 – 2210Poly-Pro
    Compositional biasi25 – 306Poly-Pro

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233031.
    HOVERGENiHBG106948.
    InParanoidiP49138.
    KOiK04443.
    OMAiLQMLQDC.
    OrthoDBiEOG786H3M.
    PhylomeDBiP49138.
    TreeFamiTF312891.

    Family and domain databases

    Gene3Di4.10.1170.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR027442. MAPKAPK_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P49138-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSGSPGQTP PAPFPSPPPP APAQPPPPFP QFHVKSGLQI RKNAITDDYK    50
    VTSQVLGLGI NGKVLRIFDK RTQQKFALKM LQDCPKARRE VELHWRASQC 100
    PHIVHIVDVY ENLYAGRKCL LIVMECLDGG ELFSRIQDRG DQAFTEREAS 150
    EIMKSIGEAI QYLHSINIAH RDVKPENLLY TSKRPNAILK LTDFGFAKET 200
    TSHNSLTTPC YTPYYVAPEV LGPEKYDKSC DMWSLGVIMY ILLCGYPPFY 250
    SNHGLAISPG MKTRIRMGQY EFPNPEWSEV SEEVKMLIRN LLKTEPTQRM 300
    TITEFMNHPW IMQSTKVPQT PLHTSRVLKE DKERWEDVKE EMTSALATMR 350
    VDYEQIKIKK IEDASNPLLL KRRKKARAVE DAALAH 386
    Length:386
    Mass (Da):44,050
    Last modified:January 4, 2005 - v2
    Checksum:iED7827641A826BF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32LS → IR in CAA54183. (PubMed:8262198)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76850 mRNA. Translation: CAA54183.1.
    BC063064 mRNA. Translation: AAH63064.1.
    CCDSiCCDS15266.1.
    PIRiS78100.
    RefSeqiNP_032577.1. NM_008551.1.
    UniGeneiMm.221235.
    Mm.490983.

    Genome annotation databases

    EnsembliENSMUST00000016672; ENSMUSP00000016672; ENSMUSG00000016528.
    GeneIDi17164.
    KEGGimmu:17164.
    UCSCiuc007cmv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76850 mRNA. Translation: CAA54183.1 .
    BC063064 mRNA. Translation: AAH63064.1 .
    CCDSi CCDS15266.1.
    PIRi S78100.
    RefSeqi NP_032577.1. NM_008551.1.
    UniGenei Mm.221235.
    Mm.490983.

    3D structure databases

    ProteinModelPortali P49138.
    SMRi P49138. Positions 37-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201308. 8 interactions.
    IntActi P49138. 7 interactions.
    MINTi MINT-4101209.

    Chemistry

    ChEMBLi CHEMBL4990.

    PTM databases

    PhosphoSitei P49138.

    Proteomic databases

    MaxQBi P49138.
    PaxDbi P49138.
    PRIDEi P49138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016672 ; ENSMUSP00000016672 ; ENSMUSG00000016528 .
    GeneIDi 17164.
    KEGGi mmu:17164.
    UCSCi uc007cmv.1. mouse.

    Organism-specific databases

    CTDi 9261.
    MGIi MGI:109298. Mapkapk2.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233031.
    HOVERGENi HBG106948.
    InParanoidi P49138.
    KOi K04443.
    OMAi LQMLQDC.
    OrthoDBi EOG786H3M.
    PhylomeDBi P49138.
    TreeFami TF312891.

    Enzyme and pathway databases

    Reactomei REACT_188970. Oxidative Stress Induced Senescence.
    REACT_198689. Tristetraprolin (TTP) destabilizes mRNA.
    REACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.
    REACT_207601. p38MAPK events.
    REACT_215561. Synthesis of Leukotrienes (LT) and Eoxins (EX).
    REACT_222185. Regulation of HSF1-mediated heat shock response.
    REACT_224314. CREB phosphorylation.

    Miscellaneous databases

    ChiTaRSi MAPKAPK2. mouse.
    NextBioi 291442.
    PROi P49138.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P49138.
    Bgeei P49138.
    CleanExi MM_MAPKAPK2.
    MM_RPS6KC1.
    Genevestigatori P49138.

    Family and domain databases

    Gene3Di 4.10.1170.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR027442. MAPKAPK_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The MAP kinase-activated protein kinase 2 contains a proline-rich SH3-binding domain."
      Engel K., Plath K., Gaestel M.
      FEBS Lett. 336:143-147(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-386.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Small heat shock proteins are molecular chaperones."
      Jakob U., Gaestel M., Engel K., Buchner J.
      J. Biol. Chem. 268:1517-1520(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF HSPB1.
    4. "Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif."
      Engel K., Schultz H., Martin F., Kotlyarov A., Plath K., Hahn M., Heinemann U., Gaestel M.
      J. Biol. Chem. 270:27213-27221(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-208 AND THR-320, MUTAGENESIS OF THR-208; THR-320; LYS-329 AND TRP-335.
    5. "MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis."
      Kotlyarov A., Neininger A., Schubert C., Eckert R., Birchmeier C., Volk H.D., Gaestel M.
      Nat. Cell Biol. 1:94-97(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation."
      Engel K., Kotlyarov A., Gaestel M.
      EMBO J. 17:3363-3371(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-208 AND THR-320, NUCLEAR EXPORT SIGNAL (NES).
    7. "Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs."
      Rousseau S., Morrice N., Peggie M., Campbell D.G., Gaestel M., Cohen P.
      EMBO J. 21:6505-6514(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF HNRNPA0.
    8. Cited for: DISRUPTION PHENOTYPE.
    9. "MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding."
      Chrestensen C.A., Schroeder M.J., Shabanowitz J., Hunt D.F., Pelo J.W., Worthington M.T., Sturgill T.W.
      J. Biol. Chem. 279:10176-10184(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF ZFP36.
    10. "The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ."
      Eyers C.E., McNeill H., Knebel A., Morrice N., Arthur S.J.C., Cuenda A., Cohen P.
      Biochem. J. 389:127-135(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF RCSD1.
    11. "The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK."
      Ronkina N., Kotlyarov A., Dittrich-Breiholz O., Kracht M., Hitti E., Milarski K., Askew R., Marusic S., Lin L.L., Gaestel M., Telliez J.B.
      Mol. Cell. Biol. 27:170-181(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    12. "The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways."
      Zaru R., Ronkina N., Gaestel M., Arthur J.S., Watts C.
      Nat. Immunol. 8:1227-1235(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF RPS6KA3.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    14. "p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins."
      Menon M.B., Schwermann J., Singh A.K., Franz-Wachtel M., Pabst O., Seidler U., Omary M.B., Kotlyarov A., Gaestel M.
      J. Biol. Chem. 285:33242-33251(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF KRT18 AND KRT20.
    15. "Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation."
      MacKenzie K.F., Wallace D.A., Hill E.V., Anthony D.F., Henderson D.J., Houslay D.M., Arthur J.S., Baillie G.S., Houslay M.D.
      Biochem. J. 435:755-769(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF PDE4A.

    Entry informationi

    Entry nameiMAPK2_MOUSE
    AccessioniPrimary (citable) accession number: P49138
    Secondary accession number(s): Q6P561
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3