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P49134

- ITB1_RAT

UniProt

P49134 - ITB1_RAT

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Protein

Integrin beta-1

Gene

Itgb1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi152 – 1521MagnesiumBy similarity
Metal bindingi154 – 1541Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi156 – 1561Calcium 1By similarity
Metal bindingi157 – 1571Calcium 1By similarity
Metal bindingi189 – 1891Calcium 2By similarity
Metal bindingi244 – 2441Calcium 2By similarity
Metal bindingi246 – 2461Calcium 2By similarity
Metal bindingi248 – 2481Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi249 – 2491Calcium 2By similarity
Metal bindingi249 – 2491MagnesiumBy similarity

GO - Molecular functioni

  1. actin binding Source: RGD
  2. alpha-actinin binding Source: RGD
  3. collagen binding Source: RGD
  4. fibronectin binding Source: RGD
  5. glycoprotein binding Source: RGD
  6. integrin binding Source: RGD
  7. kinase binding Source: RGD
  8. laminin binding Source: RGD
  9. metal ion binding Source: UniProtKB-KW
  10. peptide binding Source: RGD
  11. protease binding Source: RGD
  12. protein complex binding Source: RGD
  13. protein domain specific binding Source: RGD
  14. protein heterodimerization activity Source: RGD
  15. protein kinase binding Source: RGD
  16. receptor activity Source: InterPro
  17. receptor binding Source: RGD

GO - Biological processi

  1. axon extension Source: Ensembl
  2. calcium-independent cell-matrix adhesion Source: Ensembl
  3. cardiac muscle cell differentiation Source: Ensembl
  4. cell adhesion Source: RGD
  5. cell-cell adhesion mediated by integrin Source: Ensembl
  6. cell fate specification Source: Ensembl
  7. cell migration involved in sprouting angiogenesis Source: Ensembl
  8. cellular calcium ion homeostasis Source: RGD
  9. cellular response to ionizing radiation Source: RGD
  10. cellular response to mechanical stimulus Source: RGD
  11. cellular response to vitamin D Source: RGD
  12. formation of radial glial scaffolds Source: Ensembl
  13. G1/S transition of mitotic cell cycle Source: Ensembl
  14. germ cell migration Source: Ensembl
  15. integrin-mediated signaling pathway Source: RGD
  16. in utero embryonic development Source: Ensembl
  17. leukocyte cell-cell adhesion Source: Ensembl
  18. maternal process involved in female pregnancy Source: RGD
  19. negative regulation of anoikis Source: Ensembl
  20. negative regulation of cell projection organization Source: RGD
  21. negative regulation of cell proliferation Source: RGD
  22. negative regulation of neuron differentiation Source: RGD
  23. positive regulation of apoptotic process Source: Ensembl
  24. positive regulation of cell migration Source: RGD
  25. positive regulation of cell proliferation Source: Ensembl
  26. positive regulation of cell-substrate adhesion Source: RGD
  27. positive regulation of endocytosis Source: RGD
  28. positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
  29. positive regulation of MAPK cascade Source: RGD
  30. positive regulation of neuron differentiation Source: RGD
  31. positive regulation of neuron projection development Source: RGD
  32. positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
  33. protein transport within lipid bilayer Source: RGD
  34. regulation of cell cycle Source: Ensembl
  35. regulation of collagen catabolic process Source: UniProtKB
  36. regulation of G-protein coupled receptor protein signaling pathway Source: RGD
  37. response to activity Source: RGD
  38. response to drug Source: RGD
  39. response to gonadotropin Source: RGD
  40. response to nutrient levels Source: RGD
  41. response to transforming growth factor beta Source: RGD
  42. sarcomere organization Source: Ensembl
  43. tight junction assembly Source: RGD
  44. tissue homeostasis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_197259. Laminin interactions.
REACT_197512. Fibronectin matrix formation.
REACT_198300. Syndecan interactions.
REACT_198592. Molecules associated with elastic fibres.
REACT_198594. Elastic fibre formation.
REACT_198757. ECM proteoglycans.
REACT_217921. CHL1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-1
Alternative name(s):
Beta oligodendroglia
Short name:
Beta OL
Fibronectin receptor subunit beta
VLA-4 subunit beta
CD_antigen: CD29
Gene namesi
Name:Itgb1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 19

Organism-specific databases

RGDi2927. Itgb1.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Cell projectioninvadopodium membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Cell projectionruffle membrane By similarity; Single-pass type I membrane protein Sequence Analysis. Recycling endosome By similarity. Melanosome By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle By similarity
Note: Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner.By similarity

GO - Cellular componenti

  1. acrosomal vesicle Source: RGD
  2. adherens junction Source: RGD
  3. basement membrane Source: RGD
  4. cell-cell junction Source: RGD
  5. cell surface Source: RGD
  6. endosome Source: UniProtKB-KW
  7. external side of plasma membrane Source: Ensembl
  8. extracellular vesicular exosome Source: Ensembl
  9. filopodium Source: Ensembl
  10. focal adhesion Source: RGD
  11. hemidesmosome Source: RGD
  12. integrin alpha3-beta1 complex Source: RGD
  13. integrin alpha7-beta1 complex Source: Ensembl
  14. integrin alpha9-beta1 complex Source: RGD
  15. integrin complex Source: RGD
  16. intercalated disc Source: Ensembl
  17. invadopodium membrane Source: UniProtKB
  18. membrane Source: RGD
  19. membrane raft Source: RGD
  20. myelin sheath abaxonal region Source: Ensembl
  21. neuromuscular junction Source: Ensembl
  22. plasma membrane Source: Reactome
  23. ruffle membrane Source: Ensembl
  24. sarcolemma Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 798778Integrin beta-1PRO_0000016336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 45By similarity
Disulfide bondi35 ↔ 465By similarity
Disulfide bondi38 ↔ 75By similarity
Disulfide bondi48 ↔ 64By similarity
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi97 – 971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi207 ↔ 213By similarity
Glycosylationi212 – 2121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi261 ↔ 301By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi401 ↔ 415By similarity
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi417 – 4171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi435 ↔ 463By similarity
Disulfide bondi467 ↔ 692By similarity
Disulfide bondi478 ↔ 490By similarity
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi487 ↔ 526By similarity
Disulfide bondi492 ↔ 501By similarity
Disulfide bondi503 ↔ 517By similarity
Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi532 ↔ 537By similarity
Disulfide bondi534 ↔ 569By similarity
Disulfide bondi539 ↔ 554By similarity
Disulfide bondi556 ↔ 561By similarity
Disulfide bondi575 ↔ 580By similarity
Disulfide bondi577 ↔ 608By similarity
Disulfide bondi582 ↔ 591By similarity
Glycosylationi585 – 5851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi593 ↔ 600By similarity
Disulfide bondi614 ↔ 619By similarity
Disulfide bondi616 ↔ 662By similarity
Disulfide bondi621 ↔ 631By similarity
Disulfide bondi634 ↔ 637By similarity
Disulfide bondi641 ↔ 650By similarity
Disulfide bondi647 ↔ 724By similarity
Disulfide bondi666 ↔ 700By similarity
Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
Modified residuei778 – 7781PhosphothreonineBy similarity
Modified residuei784 – 7841PhosphotyrosineBy similarity
Modified residuei795 – 7951N6-acetyllysineBy similarity

Post-translational modificationi

The cysteine residues are involved in intrachain disulfide bonds.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP49134.
PRIDEiP49134.

PTM databases

PhosphoSiteiP49134.

Expressioni

Gene expression databases

GenevestigatoriP49134.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FLNA, FLNB, FLNC and RANBP9. Interacts with KRT1 in the presence of GNB2L1 and SRC. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization. Interacts with RAB21. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with FGR and HCK. Interacts with MYO10. Interacts with DAB2. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.By similarity

Protein-protein interaction databases

BioGridi246668. 6 interactions.
IntActiP49134. 2 interactions.
MINTiMINT-122445.

Structurei

3D structure databases

ProteinModelPortaliP49134.
SMRiP49134. Positions 722-798.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 729709ExtracellularSequence AnalysisAdd
BLAST
Topological domaini753 – 79947CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei730 – 75223HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini140 – 378239VWFAAdd
BLAST
Repeati467 – 51650IAdd
BLAST
Repeati517 – 56044IIAdd
BLAST
Repeati561 – 59939IIIAdd
BLAST
Repeati600 – 63637IVAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni467 – 636170Cysteine-rich tandem repeatsAdd
BLAST
Regioni763 – 7686Signal for sorting from recycling endosomes; interaction with ACAP1By similarity
Regioni786 – 7938Interaction with ITGB1BP1By similarity

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG287997.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
HOVERGENiHBG006190.
InParanoidiP49134.
KOiK05719.
OrthoDBiEOG7T7GSB.
PhylomeDBiP49134.
TreeFamiTF105392.

Family and domain databases

Gene3Di1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLQLVFWIG LISLICSVFG QTDKNRCLKA NAKSCGECIQ AGPNCGWCTN
60 70 80 90 100
TTFLQEGMPT SARCDDLEAL KKKGCHPSDI ENPRGSQTIK KNKNVTNRSK
110 120 130 140 150
GMAEKLRPED ITQIQPQQLL LKLRSGEPQK FTLKFKRAED YPIDLYYLMD
160 170 180 190 200
LSYSMKDDLE NVKSLGTDLM NEMRRITSDF RIGFGSFVEK TVMPYISTTP
210 220 230 240 250
AKLRNPCTSE QNCTSPFSYK NVLSLTDRGE FFNELVGQQR ISGNLDSPEG
260 270 280 290 300
GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ
310 320 330 340 350
CHLENNVYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN
360 370 380 390 400
LIPKSAVGTL SGNSSNVIQL IIDAYNSLSS EVILENSKLP DGVTINYKSY
410 420 430 440 450
CKNGVNGTGE NGRKCSNISI GDEVQFEISI TANKCPNKES ENQLKLNPLG
460 470 480 490 500
FTEEVEVVLQ FICKCNCQSH GIPASPKCHE GNGTFECGAC RCNEGRVGRH
510 520 530 540 550
CECSTDEVNS EDMDAYCRKE NSSEICSNNG ECVCGQCVCR KRENTNEIYS
560 570 580 590 600
GKFCECDNFN CDRSNGLICG GNGVCRCRVC ECYPNYTGSA CDCSLDTVPC
610 620 630 640 650
VATNGQICNG RGICECGACK CTDPKFQGPT CETCQTCLGV CAEHKECVQC
660 670 680 690 700
RAFNKGEKKD TCAQECSHFN LTKVESREKL PQPVQVDPVT HCKEKDIDDC
710 720 730 740 750
WFYFTYSVNS KGEAHVHVVE TPDCPTGPDI IPIVAGVVAG IVLIGLALLL
760 770 780 790
IWKLLMIIHD RREFAKFEKE KMNAKWDTGE NPIYKSAVTT VVNPKYEGK
Length:799
Mass (Da):88,495
Last modified:February 1, 1996 - v1
Checksum:iF4475202EB8A3EA6
GO

Sequence cautioni

The sequence AAI31846.1 differs from that shown. Reason: Frameshift at positions 442, 443 and 447.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti76 – 761H → Q in AAI31846. (PubMed:15489334)Curated
Sequence conflicti711 – 7111K → N in AAI31846. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12309 mRNA. Translation: AAA86669.1.
BC131845 mRNA. Translation: AAI31846.1. Frameshift.
PIRiJC4126.
RefSeqiNP_058718.2. NM_017022.2.
UniGeneiRn.25733.

Genome annotation databases

EnsembliENSRNOT00000014785; ENSRNOP00000014785; ENSRNOG00000010966.
GeneIDi24511.
KEGGirno:24511.
UCSCiRGD:2927. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12309 mRNA. Translation: AAA86669.1 .
BC131845 mRNA. Translation: AAI31846.1 . Frameshift.
PIRi JC4126.
RefSeqi NP_058718.2. NM_017022.2.
UniGenei Rn.25733.

3D structure databases

ProteinModelPortali P49134.
SMRi P49134. Positions 722-798.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 246668. 6 interactions.
IntActi P49134. 2 interactions.
MINTi MINT-122445.

Chemistry

BindingDBi P49134.

PTM databases

PhosphoSitei P49134.

Proteomic databases

PaxDbi P49134.
PRIDEi P49134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000014785 ; ENSRNOP00000014785 ; ENSRNOG00000010966 .
GeneIDi 24511.
KEGGi rno:24511.
UCSCi RGD:2927. rat.

Organism-specific databases

CTDi 3688.
RGDi 2927. Itgb1.

Phylogenomic databases

eggNOGi NOG287997.
GeneTreei ENSGT00760000119064.
HOGENOMi HOG000252936.
HOVERGENi HBG006190.
InParanoidi P49134.
KOi K05719.
OrthoDBi EOG7T7GSB.
PhylomeDBi P49134.
TreeFami TF105392.

Enzyme and pathway databases

Reactomei REACT_197259. Laminin interactions.
REACT_197512. Fibronectin matrix formation.
REACT_198300. Syndecan interactions.
REACT_198592. Molecules associated with elastic fibres.
REACT_198594. Elastic fibre formation.
REACT_198757. ECM proteoglycans.
REACT_217921. CHL1 interactions.

Miscellaneous databases

NextBioi 603533.
PROi P49134.

Gene expression databases

Genevestigatori P49134.

Family and domain databases

Gene3Di 1.20.5.630. 1 hit.
3.40.50.410. 1 hit.
InterProi IPR013111. EGF_extracell.
IPR027071. Integrin_beta-1.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR002369. Integrin_bsu_N.
IPR012896. Integrin_bsu_tail.
IPR016201. Plexin-like_fold.
IPR002035. VWF_A.
[Graphical view ]
PANTHERi PTHR10082. PTHR10082. 1 hit.
PTHR10082:SF28. PTHR10082:SF28. 1 hit.
Pfami PF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
[Graphical view ]
PIRSFi PIRSF002512. Integrin_B. 1 hit.
PRINTSi PR01186. INTEGRINB.
SMARTi SM00187. INB. 1 hit.
SM00423. PSI. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF103575. SSF103575. 1 hit.
SSF53300. SSF53300. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS00243. INTEGRIN_BETA. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit."
    Malek-Hedayat S., Rome L.H.
    Gene 158:287-290(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Oligodendrocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiITB1_RAT
AccessioniPrimary (citable) accession number: P49134
Secondary accession number(s): A2RRT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3