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P49130 (LAMP2_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 2

Short name=LAMP-2
Short name=Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
Lysosomal membrane glycoprotein B
Short name=LGP-B
CD_antigen=CD107b
Gene names
Name:LAMP2
Synonyms:LGPB
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane By similarity.

Post-translational modification

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 410382Lysosome-associated membrane glycoprotein 2
PRO_0000017113

Regions

Topological domain29 – 375347Lumenal Potential
Transmembrane376 – 39924Helical; Potential
Topological domain400 – 41011Cytoplasmic Potential
Region29 – 192164First lumenal domain
Region193 – 22836Hinge
Region229 – 375147Second lumenal domain

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation991N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2221N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential
Glycosylation2421N-linked (GlcNAc...) Potential
Glycosylation2601N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3071N-linked (GlcNAc...) Potential
Glycosylation3171N-linked (GlcNAc...) Potential
Glycosylation3561N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 79 By similarity
Disulfide bond153 ↔ 189 By similarity
Disulfide bond232 ↔ 265 By similarity
Disulfide bond331 ↔ 368 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49130 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: ADA8EBF04285C406

FASTA41045,028
        10         20         30         40         50         60 
MMCFRLSPVS GSGLVLSCLL LGAVQSYAFE LNLPDSKATC LFAKWKMNFT ISYETTTNKT 

        70         80         90        100        110        120 
LKTVTISEPH NVTYNGSSCG DDQGVAKIAV QFGSTVSWNV TFTKEESHYV IGSIWLVYNT 

       130        140        150        160        170        180 
SDNTTFPGAI PKGSATVISS QSIEIPLDDI FRCNSLLTFK TGNVVQNYWD IHLQAFVQNG 

       190        200        210        220        230        240 
TVSKEEFVCE EDKSVTTVRP IIHTTVPPPT TTPTPLPPKV GNYSVSNGNA TCLLATMGLQ 

       250        260        270        280        290        300 
LNVTEEKVPF IFNINPSTTN FTGSCHPQTA QLRLNNSQIK YLDFIFAVKS ESHFYLKEVN 

       310        320        330        340        350        360 
VSMYMANGSV FSVANNNLSF WDAPLGSSYM CNKEQVVSVS RTFQINTFNL KVQPFNVTKG 

       370        380        390        400        410 
KYATAQDCSA DEDNFLVPIA VGAALAGVLA LVLLAYFIGL KRHHTGYEQF 

« Hide

References

[1]"Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
Uthayakumar S., Granger B.L.
Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L19357 mRNA. Translation: AAC37683.1.
RefSeqNP_001233678.1. NM_001246749.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100689316.
KEGGcge:100689316.

Organism-specific databases

CTD100689316.

Phylogenomic databases

HOVERGENHBG052303.
KOK06528.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAMP2_CRIGR
AccessionPrimary (citable) accession number: P49130
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families