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Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
Lysosomal membrane glycoprotein B
Short name:
LGP-B
CD_antigen: CD107b
Gene namesi
Name:LAMP2
Synonyms:LGPB
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation
  • Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation
  • Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation

  • Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 375LumenalSequence analysisAdd BLAST347
Transmembranei376 – 399HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini400 – 410CytoplasmicPROSITE-ProRule annotationAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001711329 – 410Lysosome-associated membrane glycoprotein 2Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 79PROSITE-ProRule annotation
Glycosylationi48N-linked (GlcNAc...)Sequence analysis1
Glycosylationi58N-linked (GlcNAc...)Sequence analysis1
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi99N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi232 ↔ 265PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...)Sequence analysis1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi307N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with MLLT11.By similarity

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 192First lumenal domainAdd BLAST164
Regioni193 – 228HingeAdd BLAST36
Regioni229 – 375Second lumenal domainAdd BLAST147

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCFRLSPVS GSGLVLSCLL LGAVQSYAFE LNLPDSKATC LFAKWKMNFT
60 70 80 90 100
ISYETTTNKT LKTVTISEPH NVTYNGSSCG DDQGVAKIAV QFGSTVSWNV
110 120 130 140 150
TFTKEESHYV IGSIWLVYNT SDNTTFPGAI PKGSATVISS QSIEIPLDDI
160 170 180 190 200
FRCNSLLTFK TGNVVQNYWD IHLQAFVQNG TVSKEEFVCE EDKSVTTVRP
210 220 230 240 250
IIHTTVPPPT TTPTPLPPKV GNYSVSNGNA TCLLATMGLQ LNVTEEKVPF
260 270 280 290 300
IFNINPSTTN FTGSCHPQTA QLRLNNSQIK YLDFIFAVKS ESHFYLKEVN
310 320 330 340 350
VSMYMANGSV FSVANNNLSF WDAPLGSSYM CNKEQVVSVS RTFQINTFNL
360 370 380 390 400
KVQPFNVTKG KYATAQDCSA DEDNFLVPIA VGAALAGVLA LVLLAYFIGL
410
KRHHTGYEQF
Length:410
Mass (Da):45,028
Last modified:February 1, 1996 - v1
Checksum:iADA8EBF04285C406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19357 mRNA. Translation: AAC37683.1.
RefSeqiNP_001233678.1. NM_001246749.1.

Genome annotation databases

GeneIDi100689316.
KEGGicge:100689316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19357 mRNA. Translation: AAC37683.1.
RefSeqiNP_001233678.1. NM_001246749.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100689316.
KEGGicge:100689316.

Organism-specific databases

CTDi3920.

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP2_CRIGR
AccessioniPrimary (citable) accession number: P49130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 9, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.