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P49130

- LAMP2_CRIGR

UniProt

P49130 - LAMP2_CRIGR

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Protein
Lysosome-associated membrane glycoprotein 2
Gene
LAMP2, LGPB
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens By similarity.

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
Lysosomal membrane glycoprotein B
Short name:
LGP-B
CD_antigen: CD107b
Gene namesi
Name:LAMP2
Synonyms:LGPB
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 375347Lumenal Reviewed prediction
Add
BLAST
Transmembranei376 – 39924Helical; Reviewed prediction
Add
BLAST
Topological domaini400 – 41011Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 410382Lysosome-associated membrane glycoprotein 2
PRO_0000017113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 79 By similarity
Glycosylationi48 – 481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi71 – 711N-linked (GlcNAc...) Reviewed prediction
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi99 – 991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi153 ↔ 189 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi222 – 2221N-linked (GlcNAc...) Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi232 ↔ 265 By similarity
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi260 – 2601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi307 – 3071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi317 – 3171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi331 ↔ 368 By similarity
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 192164First lumenal domain
Add
BLAST
Regioni193 – 22836Hinge
Add
BLAST
Regioni229 – 375147Second lumenal domain
Add
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49130-1 [UniParc]FASTAAdd to Basket

« Hide

MMCFRLSPVS GSGLVLSCLL LGAVQSYAFE LNLPDSKATC LFAKWKMNFT    50
ISYETTTNKT LKTVTISEPH NVTYNGSSCG DDQGVAKIAV QFGSTVSWNV 100
TFTKEESHYV IGSIWLVYNT SDNTTFPGAI PKGSATVISS QSIEIPLDDI 150
FRCNSLLTFK TGNVVQNYWD IHLQAFVQNG TVSKEEFVCE EDKSVTTVRP 200
IIHTTVPPPT TTPTPLPPKV GNYSVSNGNA TCLLATMGLQ LNVTEEKVPF 250
IFNINPSTTN FTGSCHPQTA QLRLNNSQIK YLDFIFAVKS ESHFYLKEVN 300
VSMYMANGSV FSVANNNLSF WDAPLGSSYM CNKEQVVSVS RTFQINTFNL 350
KVQPFNVTKG KYATAQDCSA DEDNFLVPIA VGAALAGVLA LVLLAYFIGL 400
KRHHTGYEQF 410
Length:410
Mass (Da):45,028
Last modified:February 1, 1996 - v1
Checksum:iADA8EBF04285C406
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19357 mRNA. Translation: AAC37683.1.
RefSeqiNP_001233678.1. NM_001246749.1.

Genome annotation databases

GeneIDi100689316.
KEGGicge:100689316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19357 mRNA. Translation: AAC37683.1 .
RefSeqi NP_001233678.1. NM_001246749.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689316.
KEGGi cge:100689316.

Organism-specific databases

CTDi 3920.

Phylogenomic databases

HOVERGENi HBG052303.
KOi K06528.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
    Uthayakumar S., Granger B.L.
    Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLAMP2_CRIGR
AccessioniPrimary (citable) accession number: P49130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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