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P49130

- LAMP2_CRIGR

UniProt

P49130 - LAMP2_CRIGR

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Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens (By similarity).By similarity

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
Lysosomal membrane glycoprotein B
Short name:
LGP-B
CD_antigen: CD107b
Gene namesi
Name:LAMP2
Synonyms:LGPB
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.By similarity

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 410382Lysosome-associated membrane glycoprotein 2PRO_0000017113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 79PROSITE-ProRule annotation
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi222 – 2221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi232 ↔ 265PROSITE-ProRule annotation
Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi307 – 3071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi317 – 3171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to Lamp-2 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 375347LumenalSequence AnalysisAdd
BLAST
Topological domaini400 – 41011CytoplasmicPROSITE-ProRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei376 – 39924HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 192164First lumenal domainAdd
BLAST
Regioni193 – 22836HingeAdd
BLAST
Regioni229 – 375147Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49130 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MMCFRLSPVS GSGLVLSCLL LGAVQSYAFE LNLPDSKATC LFAKWKMNFT
60 70 80 90 100
ISYETTTNKT LKTVTISEPH NVTYNGSSCG DDQGVAKIAV QFGSTVSWNV
110 120 130 140 150
TFTKEESHYV IGSIWLVYNT SDNTTFPGAI PKGSATVISS QSIEIPLDDI
160 170 180 190 200
FRCNSLLTFK TGNVVQNYWD IHLQAFVQNG TVSKEEFVCE EDKSVTTVRP
210 220 230 240 250
IIHTTVPPPT TTPTPLPPKV GNYSVSNGNA TCLLATMGLQ LNVTEEKVPF
260 270 280 290 300
IFNINPSTTN FTGSCHPQTA QLRLNNSQIK YLDFIFAVKS ESHFYLKEVN
310 320 330 340 350
VSMYMANGSV FSVANNNLSF WDAPLGSSYM CNKEQVVSVS RTFQINTFNL
360 370 380 390 400
KVQPFNVTKG KYATAQDCSA DEDNFLVPIA VGAALAGVLA LVLLAYFIGL
410
KRHHTGYEQF
Length:410
Mass (Da):45,028
Last modified:February 1, 1996 - v1
Checksum:iADA8EBF04285C406
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19357 mRNA. Translation: AAC37683.1.
RefSeqiNP_001233678.1. NM_001246749.1.

Genome annotation databases

GeneIDi100689316.
KEGGicge:100689316.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L19357 mRNA. Translation: AAC37683.1 .
RefSeqi NP_001233678.1. NM_001246749.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689316.
KEGGi cge:100689316.

Organism-specific databases

CTDi 3920.

Phylogenomic databases

HOVERGENi HBG052303.
KOi K06528.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
    Uthayakumar S., Granger B.L.
    Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLAMP2_CRIGR
AccessioniPrimary (citable) accession number: P49130
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3