P49129LAMP1_CRIGRLysosome-associated membrane glycoprotein 1LAMP-1Lysosome-associated membrane protein 1CD107 antigen-like family member ALysosomal membrane glycoprotein ALGP-ACD107aLAMP1LGPACricetulus griseusChinese hamsterCricetulus barabensis griseusEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulusCell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins.NUCLEOTIDE SEQUENCE [MRNA]Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins.Interacts with ABCB9; this interaction strongly stabilizes ABCB9 and protects ABCB9 against lysosomal degradation. Interacts with FURIN. Interacts with TMEM175; inhibiting the proton channel activity of TMEM175.Lysosome membraneSingle-pass type I membrane proteinEndosome membraneSingle-pass type I membrane proteinLate endosome membraneSingle-pass type I membrane proteinCell membraneSingle-pass type I membrane proteinCytolytic granule membraneSingle-pass type I membrane proteinThis protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (By similarity).O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.Belongs to the LAMP family.Cell membraneDisulfide bondEndosomeGlycoproteinLysosomeMembraneSignalTransmembraneTransmembrane helixMAAPGAPRSLLLLLLAGLAHGASALFVVKDSNGTACIMANFSASFFTIYETGHGSKNSTFELPSSAEVLNSNSSCGRENVSEPILTIAFGSGYLLTLNFTRNATRYSVQDMYFAYNLSDTQHFLNASNKGIHSVDSSTDIKADINKTYRCLSAIQVHMGNVTVTLSDATIQAYLLNSNFSKEETRCTQDGPSPTTVPPSPSPPLVPTNPTVIKYNVTGENGTCLLASMALQMNITYMKKDNMTVTRALNISPNDTASGSCSPHVVTLTVESKNSILDLKFGMNGSSSLFFLQEVRLNMTLPDANVSSLMASNQSLRALQATVGNSYKCNTEEHIFVTKEFSLNVFSVQVQAFKVESDRFGSVEECMQDGNNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI
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