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P49129

- LAMP1_CRIGR

UniProt

P49129 - LAMP1_CRIGR

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Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis By similarity.By similarity

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Lysosomal membrane glycoprotein A
Short name:
LGP-A
CD_antigen: CD107a
Gene namesi
Name:LAMP1
Synonyms:LGPA
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation. Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.By similarity

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosome Source: MGI
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 407386Lysosome-associated membrane glycoprotein 1PRO_0000017108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 75PROSITE-ProRule annotation
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi150 ↔ 186PROSITE-ProRule annotation
Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi223 ↔ 260PROSITE-ProRule annotation
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi328 ↔ 365PROSITE-ProRule annotation

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP49129.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 371350LumenalSequence AnalysisAdd
BLAST
Topological domaini396 – 40712CytoplasmicPROSITE-ProRule annotationAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei372 – 39524HelicalPROSITE-ProRule annotationAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 189168First lumenal domainAdd
BLAST
Regioni190 – 21930HingeAdd
BLAST
Regioni220 – 371152Second lumenal domainAdd
BLAST

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49129-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPGAPRSL LLLLLAGLAH GASALFVVKD SNGTACIMAN FSASFFTIYE
60 70 80 90 100
TGHGSKNSTF ELPSSAEVLN SNSSCGRENV SEPILTIAFG SGYLLTLNFT
110 120 130 140 150
RNATRYSVQD MYFAYNLSDT QHFLNASNKG IHSVDSSTDI KADINKTYRC
160 170 180 190 200
LSAIQVHMGN VTVTLSDATI QAYLLNSNFS KEETRCTQDG PSPTTVPPSP
210 220 230 240 250
SPPLVPTNPT VIKYNVTGEN GTCLLASMAL QMNITYMKKD NMTVTRALNI
260 270 280 290 300
SPNDTASGSC SPHVVTLTVE SKNSILDLKF GMNGSSSLFF LQEVRLNMTL
310 320 330 340 350
PDANVSSLMA SNQSLRALQA TVGNSYKCNT EEHIFVTKEF SLNVFSVQVQ
360 370 380 390 400
AFKVESDRFG SVEECMQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS

HAGYQTI
Length:407
Mass (Da):43,787
Last modified:February 1, 1996 - v1
Checksum:i651002040F86BB3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18986 mRNA. Translation: AAC37682.1.
RefSeqiNP_001233759.1. NM_001246830.1.

Genome annotation databases

GeneIDi100689406.
KEGGicge:100689406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18986 mRNA. Translation: AAC37682.1 .
RefSeqi NP_001233759.1. NM_001246830.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689406.
KEGGi cge:100689406.

Organism-specific databases

CTDi 3916.

Phylogenomic databases

HOVERGENi HBG052303.
KOi K06528.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
    Uthayakumar S., Granger B.L.
    Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLAMP1_CRIGR
AccessioniPrimary (citable) accession number: P49129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3