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P49129

- LAMP1_CRIGR

UniProt

P49129 - LAMP1_CRIGR

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Protein
Lysosome-associated membrane glycoprotein 1
Gene
LAMP1, LGPA
Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis By similarity.

GO - Biological processi

  1. protein stabilization Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 1
Short name:
LAMP-1
Short name:
Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Lysosomal membrane glycoprotein A
Short name:
LGP-A
CD_antigen: CD107a
Gene namesi
Name:LAMP1
Synonyms:LGPA
OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifieri10029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Late endosome By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 371350Lumenal Reviewed prediction
Add
BLAST
Transmembranei372 – 39524Helical; Reviewed prediction
Add
BLAST
Topological domaini396 – 40712Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endosome membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. late endosome Source: UniProtKB-SubCell
  4. lysosomal membrane Source: UniProtKB-SubCell
  5. lysosome Source: MGI
  6. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarity
Add
BLAST
Chaini22 – 407386Lysosome-associated membrane glycoprotein 1
PRO_0000017108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi36 ↔ 75 By similarity
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi79 – 791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi116 – 1161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi145 – 1451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi150 ↔ 186 By similarity
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi223 ↔ 260 By similarity
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi241 – 2411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi253 – 2531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi283 – 2831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi297 – 2971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi304 – 3041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi328 ↔ 365 By similarity

Post-translational modificationi

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP49129.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 189168First lumenal domain
Add
BLAST
Regioni190 – 21930Hinge
Add
BLAST
Regioni220 – 371152Second lumenal domain
Add
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG052303.
KOiK06528.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49129-1 [UniParc]FASTAAdd to Basket

« Hide

MAAPGAPRSL LLLLLAGLAH GASALFVVKD SNGTACIMAN FSASFFTIYE    50
TGHGSKNSTF ELPSSAEVLN SNSSCGRENV SEPILTIAFG SGYLLTLNFT 100
RNATRYSVQD MYFAYNLSDT QHFLNASNKG IHSVDSSTDI KADINKTYRC 150
LSAIQVHMGN VTVTLSDATI QAYLLNSNFS KEETRCTQDG PSPTTVPPSP 200
SPPLVPTNPT VIKYNVTGEN GTCLLASMAL QMNITYMKKD NMTVTRALNI 250
SPNDTASGSC SPHVVTLTVE SKNSILDLKF GMNGSSSLFF LQEVRLNMTL 300
PDANVSSLMA SNQSLRALQA TVGNSYKCNT EEHIFVTKEF SLNVFSVQVQ 350
AFKVESDRFG SVEECMQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS 400
HAGYQTI 407
Length:407
Mass (Da):43,787
Last modified:February 1, 1996 - v1
Checksum:i651002040F86BB3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18986 mRNA. Translation: AAC37682.1.
RefSeqiNP_001233759.1. NM_001246830.1.

Genome annotation databases

GeneIDi100689406.
KEGGicge:100689406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L18986 mRNA. Translation: AAC37682.1 .
RefSeqi NP_001233759.1. NM_001246830.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49129.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100689406.
KEGGi cge:100689406.

Organism-specific databases

CTDi 3916.

Phylogenomic databases

HOVERGENi HBG052303.
KOi K06528.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
    Uthayakumar S., Granger B.L.
    Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiLAMP1_CRIGR
AccessioniPrimary (citable) accession number: P49129
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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