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P49129 (LAMP1_CRIGR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 1

Short name=LAMP-1
Short name=Lysosome-associated membrane protein 1
Alternative name(s):
CD107 antigen-like family member A
Lysosomal membrane glycoprotein A
Short name=LGP-A
CD_antigen=CD107a
Gene names
Name:LAMP1
Synonyms:LGPA
OrganismCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Late endosome By similarity. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.

Post-translational modification

O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 407386Lysosome-associated membrane glycoprotein 1
PRO_0000017108

Regions

Topological domain22 – 371350Lumenal Potential
Transmembrane372 – 39524Helical; Potential
Topological domain396 – 40712Cytoplasmic Potential
Region22 – 189168First lumenal domain
Region190 – 21930Hinge
Region220 – 371152Second lumenal domain

Amino acid modifications

Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation401N-linked (GlcNAc...) Potential
Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation721N-linked (GlcNAc...) Potential
Glycosylation791N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1161N-linked (GlcNAc...) Potential
Glycosylation1251N-linked (GlcNAc...) Potential
Glycosylation1451N-linked (GlcNAc...) Potential
Glycosylation1601N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Glycosylation2411N-linked (GlcNAc...) Potential
Glycosylation2531N-linked (GlcNAc...) Potential
Glycosylation2831N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation3041N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 75 By similarity
Disulfide bond150 ↔ 186 By similarity
Disulfide bond223 ↔ 260 By similarity
Disulfide bond328 ↔ 365 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49129 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 651002040F86BB3D

FASTA40743,787
        10         20         30         40         50         60 
MAAPGAPRSL LLLLLAGLAH GASALFVVKD SNGTACIMAN FSASFFTIYE TGHGSKNSTF 

        70         80         90        100        110        120 
ELPSSAEVLN SNSSCGRENV SEPILTIAFG SGYLLTLNFT RNATRYSVQD MYFAYNLSDT 

       130        140        150        160        170        180 
QHFLNASNKG IHSVDSSTDI KADINKTYRC LSAIQVHMGN VTVTLSDATI QAYLLNSNFS 

       190        200        210        220        230        240 
KEETRCTQDG PSPTTVPPSP SPPLVPTNPT VIKYNVTGEN GTCLLASMAL QMNITYMKKD 

       250        260        270        280        290        300 
NMTVTRALNI SPNDTASGSC SPHVVTLTVE SKNSILDLKF GMNGSSSLFF LQEVRLNMTL 

       310        320        330        340        350        360 
PDANVSSLMA SNQSLRALQA TVGNSYKCNT EEHIFVTKEF SLNVFSVQVQ AFKVESDRFG 

       370        380        390        400 
SVEECMQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS HAGYQTI 

« Hide

References

[1]"Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
Uthayakumar S., Granger B.L.
Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L18986 mRNA. Translation: AAC37682.1.
RefSeqNP_001233759.1. NM_001246830.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP49129.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100689406.
KEGGcge:100689406.

Organism-specific databases

CTD100689406.

Phylogenomic databases

HOVERGENHBG052303.
KOK06528.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 2 hits.
PS00311. LAMP_2. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLAMP1_CRIGR
AccessionPrimary (citable) accession number: P49129
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families