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P49129

- LAMP1_CRIGR

UniProt

P49129 - LAMP1_CRIGR

Protein

Lysosome-associated membrane glycoprotein 1

Gene

LAMP1

Organism
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis By similarity.By similarity

    GO - Biological processi

    1. protein stabilization Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 1
    Short name:
    LAMP-1
    Short name:
    Lysosome-associated membrane protein 1
    Alternative name(s):
    CD107 antigen-like family member A
    Lysosomal membrane glycoprotein A
    Short name:
    LGP-A
    CD_antigen: CD107a
    Gene namesi
    Name:LAMP1
    Synonyms:LGPA
    OrganismiCricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
    Taxonomic identifieri10029 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaCricetidaeCricetinaeCricetulus

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation. Late endosome By similarity
    Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane. Colocalizes with OSBPL1A at the late endosome By similarity.By similarity

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. late endosome Source: UniProtKB-SubCell
    4. lysosomal membrane Source: UniProtKB-SubCell
    5. lysosome Source: MGI
    6. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 407386Lysosome-associated membrane glycoprotein 1PRO_0000017108Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi36 ↔ 75PROSITE-ProRule annotation
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi116 – 1161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi145 – 1451N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi150 ↔ 186PROSITE-ProRule annotation
    Glycosylationi160 – 1601N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 260PROSITE-ProRule annotation
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi283 – 2831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi328 ↔ 365PROSITE-ProRule annotation

    Post-translational modificationi

    O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP49129.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 371350LumenalSequence AnalysisAdd
    BLAST
    Topological domaini396 – 40712CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei372 – 39524HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 189168First lumenal domainAdd
    BLAST
    Regioni190 – 21930HingeAdd
    BLAST
    Regioni220 – 371152Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG052303.
    KOiK06528.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49129-1 [UniParc]FASTAAdd to Basket

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    MAAPGAPRSL LLLLLAGLAH GASALFVVKD SNGTACIMAN FSASFFTIYE    50
    TGHGSKNSTF ELPSSAEVLN SNSSCGRENV SEPILTIAFG SGYLLTLNFT 100
    RNATRYSVQD MYFAYNLSDT QHFLNASNKG IHSVDSSTDI KADINKTYRC 150
    LSAIQVHMGN VTVTLSDATI QAYLLNSNFS KEETRCTQDG PSPTTVPPSP 200
    SPPLVPTNPT VIKYNVTGEN GTCLLASMAL QMNITYMKKD NMTVTRALNI 250
    SPNDTASGSC SPHVVTLTVE SKNSILDLKF GMNGSSSLFF LQEVRLNMTL 300
    PDANVSSLMA SNQSLRALQA TVGNSYKCNT EEHIFVTKEF SLNVFSVQVQ 350
    AFKVESDRFG SVEECMQDGN NMLIPIAVGG ALAGLVLIVL IAYLIGRKRS 400
    HAGYQTI 407
    Length:407
    Mass (Da):43,787
    Last modified:February 1, 1996 - v1
    Checksum:i651002040F86BB3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18986 mRNA. Translation: AAC37682.1.
    RefSeqiNP_001233759.1. NM_001246830.1.

    Genome annotation databases

    GeneIDi100689406.
    KEGGicge:100689406.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L18986 mRNA. Translation: AAC37682.1 .
    RefSeqi NP_001233759.1. NM_001246830.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P49129.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100689406.
    KEGGi cge:100689406.

    Organism-specific databases

    CTDi 3916.

    Phylogenomic databases

    HOVERGENi HBG052303.
    KOi K06528.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 2 hits.
    PS00311. LAMP_2. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cell surface accumulation of overexpressed hamster lysosomal membrane glycoproteins."
      Uthayakumar S., Granger B.L.
      Cell. Mol. Biol. Res. 41:405-420(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiLAMP1_CRIGR
    AccessioniPrimary (citable) accession number: P49129
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3