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P49118

- BIP_SOLLC

UniProt

P49118 - BIP_SOLLC

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Protein
Luminal-binding protein
Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblPlants/Gramene
  2. polar nucleus fusion Source: EnsemblPlants/Gramene
  3. response to cadmium ion Source: EnsemblPlants/Gramene
  4. response to endoplasmic reticulum stress Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein
Short name:
BiP
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: EnsemblPlants/Gramene
  2. cell wall Source: EnsemblPlants/Gramene
  3. chloroplast Source: EnsemblPlants/Gramene
  4. cytosol Source: EnsemblPlants/Gramene
  5. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  6. mediator complex Source: EnsemblPlants/Gramene
  7. nucleolus Source: EnsemblPlants/Gramene
  8. plasma membrane Source: EnsemblPlants/Gramene
  9. plasmodesma Source: EnsemblPlants/Gramene
  10. vacuolar membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 666638Luminal-binding protein
PRO_0000013590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi617 – 6171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP49118.
ProMEXiP49118.

Structurei

3D structure databases

ProteinModelPortaliP49118.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi663 – 6664Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK09490.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49118-1 [UniParc]FASTAAdd to Basket

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MAACSRRGNS LVVLAIVLLG CLSALSNAKE EATKLGTVIG IDLGTTYSCV    50
GVYKNGHVEI IANDQGNRIT PSWVAFTDNE RLIGEAAKNL AAVNPERTIF 100
DVKRLIGRKF EDKEVQRDMK LVPYKIVSKD GKPYIQVKIK DGEVKVFSPE 150
EISAMILTKM KETAEAFLGK TIKDAVVTVP AYFNDAQRQA TKDAGVIAGL 200
NVARIINEPT AAAIAYGLDK KGGEKNILVF DLGGGTFDVS ILTIDNGVFE 250
VLATNGDTHL GGEDFDQRIM EYFIKLIKKK HGKDISKDNR ALGKLRREAE 300
RAKRSLSSQH QVRVEIESLF DGTDFSEPLT RARFEELNND LFRKTMGPVK 350
KAMDDAGLQK NQIDEIVLVG GSTRIPKVQQ LLKDYFDGKE PSKGVNPDEA 400
VAYGAAVQGG ILSGEGGDET KDILLLDVAP LTLGIETVGG VMTKFIPRNT 450
VIPTKKSQVF TTYQDQQTTV SIQVFEGERS LTKDCRNLGK FDLTGIPPAP 500
RGTPQIEVTF EVDANGILNV KAEDKGTGKA EKITITNDKG RLSQEEIERM 550
VREAEEFAEE DKKVKEKIDA RNALETYVYN MKNQINDKDK LADKLESDEK 600
EKIETATKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGA 650
PGGGASEEED DSHDEL 666
Length:666
Mass (Da):73,235
Last modified:February 1, 1996 - v1
Checksum:iA2EB7C9459BD9FCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08830 mRNA. Translation: AAA34139.1.
L08829 Genomic DNA. Translation: AAA99920.1.
RefSeqiNP_001234636.1. NM_001247707.1.
UniGeneiLes.140.

Genome annotation databases

GeneIDi543957.
KEGGisly:543957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08830 mRNA. Translation: AAA34139.1 .
L08829 Genomic DNA. Translation: AAA99920.1 .
RefSeqi NP_001234636.1. NM_001247707.1.
UniGenei Les.140.

3D structure databases

ProteinModelPortali P49118.
ModBasei Search...

Proteomic databases

PRIDEi P49118.
ProMEXi P49118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 543957.
KEGGi sly:543957.

Phylogenomic databases

KOi K09490.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the tomato endoplasmic reticulum-localized BiP/GRP78 homolog."
    Meyer D.J., Ewing N.N., Rosichan J.L., Bennett A.B.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. VFNT Cherry.

Entry informationi

Entry nameiBIP_SOLLC
AccessioniPrimary (citable) accession number: P49118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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