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P49118 (BIP_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Luminal-binding protein

Short name=BiP
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name=GRP-78
OrganismSolanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier4081 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Subcellular location

Endoplasmic reticulum lumen.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processER-associated ubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

polar nucleus fusion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to cadmium ion

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

response to endoplasmic reticulum stress

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

cell wall

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

chloroplast

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

cytosol

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

mediator complex

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

nucleolus

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

plasma membrane

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

plasmodesma

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

vacuolar membrane

Inferred from electronic annotation. Source: EnsemblPlants/Gramene

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 666638Luminal-binding protein
PRO_0000013590

Regions

Motif663 – 6664Prevents secretion from ER Potential

Amino acid modifications

Glycosylation6171N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P49118 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: A2EB7C9459BD9FCC

FASTA66673,235
        10         20         30         40         50         60 
MAACSRRGNS LVVLAIVLLG CLSALSNAKE EATKLGTVIG IDLGTTYSCV GVYKNGHVEI 

        70         80         90        100        110        120 
IANDQGNRIT PSWVAFTDNE RLIGEAAKNL AAVNPERTIF DVKRLIGRKF EDKEVQRDMK 

       130        140        150        160        170        180 
LVPYKIVSKD GKPYIQVKIK DGEVKVFSPE EISAMILTKM KETAEAFLGK TIKDAVVTVP 

       190        200        210        220        230        240 
AYFNDAQRQA TKDAGVIAGL NVARIINEPT AAAIAYGLDK KGGEKNILVF DLGGGTFDVS 

       250        260        270        280        290        300 
ILTIDNGVFE VLATNGDTHL GGEDFDQRIM EYFIKLIKKK HGKDISKDNR ALGKLRREAE 

       310        320        330        340        350        360 
RAKRSLSSQH QVRVEIESLF DGTDFSEPLT RARFEELNND LFRKTMGPVK KAMDDAGLQK 

       370        380        390        400        410        420 
NQIDEIVLVG GSTRIPKVQQ LLKDYFDGKE PSKGVNPDEA VAYGAAVQGG ILSGEGGDET 

       430        440        450        460        470        480 
KDILLLDVAP LTLGIETVGG VMTKFIPRNT VIPTKKSQVF TTYQDQQTTV SIQVFEGERS 

       490        500        510        520        530        540 
LTKDCRNLGK FDLTGIPPAP RGTPQIEVTF EVDANGILNV KAEDKGTGKA EKITITNDKG 

       550        560        570        580        590        600 
RLSQEEIERM VREAEEFAEE DKKVKEKIDA RNALETYVYN MKNQINDKDK LADKLESDEK 

       610        620        630        640        650        660 
EKIETATKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGA PGGGASEEED 


DSHDEL 

« Hide

References

[1]"Characterization of the tomato endoplasmic reticulum-localized BiP/GRP78 homolog."
Meyer D.J., Ewing N.N., Rosichan J.L., Bennett A.B.
Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: cv. VFNT Cherry.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08830 mRNA. Translation: AAA34139.1.
L08829 Genomic DNA. Translation: AAA99920.1.
RefSeqNP_001234636.1. NM_001247707.1.
UniGeneLes.140.

3D structure databases

ProteinModelPortalP49118.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP49118.
ProMEXP49118.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID543957.
KEGGsly:543957.

Phylogenomic databases

KOK09490.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBIP_SOLLC
AccessionPrimary (citable) accession number: P49118
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families