P49118 (BIP_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Luminal-binding protein Short name=BiP Alternative name(s): 78 kDa glucose-regulated protein homolog Short name=GRP-78
Organism	Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [Reference proteome]
Taxonomic identifier	4081 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	666 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.
Subcellular location	Endoplasmic reticulum lumen.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 666	638	Luminal-binding protein		PRO_0000013590
Regions
	Motif	663 – 666	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	617	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P49118 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: A2EB7C9459BD9FCC	FASTA	666	73,235
	10 20 30 40 50 60 MAACSRRGNS LVVLAIVLLG CLSALSNAKE EATKLGTVIG IDLGTTYSCV GVYKNGHVEI 70 80 90 100 110 120 IANDQGNRIT PSWVAFTDNE RLIGEAAKNL AAVNPERTIF DVKRLIGRKF EDKEVQRDMK 130 140 150 160 170 180 LVPYKIVSKD GKPYIQVKIK DGEVKVFSPE EISAMILTKM KETAEAFLGK TIKDAVVTVP 190 200 210 220 230 240 AYFNDAQRQA TKDAGVIAGL NVARIINEPT AAAIAYGLDK KGGEKNILVF DLGGGTFDVS 250 260 270 280 290 300 ILTIDNGVFE VLATNGDTHL GGEDFDQRIM EYFIKLIKKK HGKDISKDNR ALGKLRREAE 310 320 330 340 350 360 RAKRSLSSQH QVRVEIESLF DGTDFSEPLT RARFEELNND LFRKTMGPVK KAMDDAGLQK 370 380 390 400 410 420 NQIDEIVLVG GSTRIPKVQQ LLKDYFDGKE PSKGVNPDEA VAYGAAVQGG ILSGEGGDET 430 440 450 460 470 480 KDILLLDVAP LTLGIETVGG VMTKFIPRNT VIPTKKSQVF TTYQDQQTTV SIQVFEGERS 490 500 510 520 530 540 LTKDCRNLGK FDLTGIPPAP RGTPQIEVTF EVDANGILNV KAEDKGTGKA EKITITNDKG 550 560 570 580 590 600 RLSQEEIERM VREAEEFAEE DKKVKEKIDA RNALETYVYN MKNQINDKDK LADKLESDEK 610 620 630 640 650 660 EKIETATKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGA PGGGASEEED DSHDEL

References

[1]	"Characterization of the tomato endoplasmic reticulum-localized BiP/GRP78 homolog." Meyer D.J., Ewing N.N., Rosichan J.L., Bennett A.B. Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: cv. VFNT Cherry.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L08830 mRNA. Translation: AAA34139.1. L08829 Genomic DNA. Translation: AAA99920.1.
RefSeq	NP_001234636.1. NM_001247707.1.
UniGene	Les.140.
3D structure databases
ProteinModelPortal	P49118.
ModBase	Search...
Proteomic databases
PRIDE	P49118.
ProMEX	P49118.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	543957.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BIP_SOLLC

Accession

Primary (citable) accession number: P49118

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program