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P49118

- BIP_SOLLC

UniProt

P49118 - BIP_SOLLC

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Protein

Luminal-binding protein

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Luminal-binding protein
Short name:
BiP
Alternative name(s):
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 666638Luminal-binding proteinPRO_0000013590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP49118.
ProMEXiP49118.

Structurei

3D structure databases

ProteinModelPortaliP49118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi663 – 6664Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK09490.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49118-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAACSRRGNS LVVLAIVLLG CLSALSNAKE EATKLGTVIG IDLGTTYSCV
60 70 80 90 100
GVYKNGHVEI IANDQGNRIT PSWVAFTDNE RLIGEAAKNL AAVNPERTIF
110 120 130 140 150
DVKRLIGRKF EDKEVQRDMK LVPYKIVSKD GKPYIQVKIK DGEVKVFSPE
160 170 180 190 200
EISAMILTKM KETAEAFLGK TIKDAVVTVP AYFNDAQRQA TKDAGVIAGL
210 220 230 240 250
NVARIINEPT AAAIAYGLDK KGGEKNILVF DLGGGTFDVS ILTIDNGVFE
260 270 280 290 300
VLATNGDTHL GGEDFDQRIM EYFIKLIKKK HGKDISKDNR ALGKLRREAE
310 320 330 340 350
RAKRSLSSQH QVRVEIESLF DGTDFSEPLT RARFEELNND LFRKTMGPVK
360 370 380 390 400
KAMDDAGLQK NQIDEIVLVG GSTRIPKVQQ LLKDYFDGKE PSKGVNPDEA
410 420 430 440 450
VAYGAAVQGG ILSGEGGDET KDILLLDVAP LTLGIETVGG VMTKFIPRNT
460 470 480 490 500
VIPTKKSQVF TTYQDQQTTV SIQVFEGERS LTKDCRNLGK FDLTGIPPAP
510 520 530 540 550
RGTPQIEVTF EVDANGILNV KAEDKGTGKA EKITITNDKG RLSQEEIERM
560 570 580 590 600
VREAEEFAEE DKKVKEKIDA RNALETYVYN MKNQINDKDK LADKLESDEK
610 620 630 640 650
EKIETATKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGA
660
PGGGASEEED DSHDEL
Length:666
Mass (Da):73,235
Last modified:February 1, 1996 - v1
Checksum:iA2EB7C9459BD9FCC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08830 mRNA. Translation: AAA34139.1.
L08829 Genomic DNA. Translation: AAA99920.1.
RefSeqiNP_001234636.1. NM_001247707.1.
UniGeneiLes.140.

Genome annotation databases

GeneIDi543957.
KEGGisly:543957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08830 mRNA. Translation: AAA34139.1 .
L08829 Genomic DNA. Translation: AAA99920.1 .
RefSeqi NP_001234636.1. NM_001247707.1.
UniGenei Les.140.

3D structure databases

ProteinModelPortali P49118.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P49118.
ProMEXi P49118.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 543957.
KEGGi sly:543957.

Phylogenomic databases

KOi K09490.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of the tomato endoplasmic reticulum-localized BiP/GRP78 homolog."
    Meyer D.J., Ewing N.N., Rosichan J.L., Bennett A.B.
    Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. VFNT Cherry.

Entry informationi

Entry nameiBIP_SOLLC
AccessioniPrimary (citable) accession number: P49118
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3