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P49118

- BIP_SOLLC

UniProt

P49118 - BIP_SOLLC

Protein

Luminal-binding protein

Gene
N/A
Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: EnsemblPlants/Gramene
    2. polar nucleus fusion Source: EnsemblPlants/Gramene
    3. response to cadmium ion Source: EnsemblPlants/Gramene
    4. response to endoplasmic reticulum stress Source: EnsemblPlants/Gramene

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Luminal-binding protein
    Short name:
    BiP
    Alternative name(s):
    78 kDa glucose-regulated protein homolog
    Short name:
    GRP-78
    OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
    Taxonomic identifieri4081 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
    ProteomesiUP000004994: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cell wall Source: EnsemblPlants/Gramene
    2. chloroplast Source: EnsemblPlants/Gramene
    3. cytosol Source: EnsemblPlants/Gramene
    4. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    5. Golgi apparatus Source: EnsemblPlants/Gramene
    6. mediator complex Source: EnsemblPlants/Gramene
    7. nucleolus Source: EnsemblPlants/Gramene
    8. plasma membrane Source: EnsemblPlants/Gramene
    9. plasmodesma Source: EnsemblPlants/Gramene
    10. vacuolar membrane Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 666638Luminal-binding proteinPRO_0000013590Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP49118.
    ProMEXiP49118.

    Structurei

    3D structure databases

    ProteinModelPortaliP49118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi663 – 6664Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    KOiK09490.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49118-1 [UniParc]FASTAAdd to Basket

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    MAACSRRGNS LVVLAIVLLG CLSALSNAKE EATKLGTVIG IDLGTTYSCV    50
    GVYKNGHVEI IANDQGNRIT PSWVAFTDNE RLIGEAAKNL AAVNPERTIF 100
    DVKRLIGRKF EDKEVQRDMK LVPYKIVSKD GKPYIQVKIK DGEVKVFSPE 150
    EISAMILTKM KETAEAFLGK TIKDAVVTVP AYFNDAQRQA TKDAGVIAGL 200
    NVARIINEPT AAAIAYGLDK KGGEKNILVF DLGGGTFDVS ILTIDNGVFE 250
    VLATNGDTHL GGEDFDQRIM EYFIKLIKKK HGKDISKDNR ALGKLRREAE 300
    RAKRSLSSQH QVRVEIESLF DGTDFSEPLT RARFEELNND LFRKTMGPVK 350
    KAMDDAGLQK NQIDEIVLVG GSTRIPKVQQ LLKDYFDGKE PSKGVNPDEA 400
    VAYGAAVQGG ILSGEGGDET KDILLLDVAP LTLGIETVGG VMTKFIPRNT 450
    VIPTKKSQVF TTYQDQQTTV SIQVFEGERS LTKDCRNLGK FDLTGIPPAP 500
    RGTPQIEVTF EVDANGILNV KAEDKGTGKA EKITITNDKG RLSQEEIERM 550
    VREAEEFAEE DKKVKEKIDA RNALETYVYN MKNQINDKDK LADKLESDEK 600
    EKIETATKEA LEWLDDNQSA EKEDYDEKLK EVEAVCNPII TAVYQRSGGA 650
    PGGGASEEED DSHDEL 666
    Length:666
    Mass (Da):73,235
    Last modified:February 1, 1996 - v1
    Checksum:iA2EB7C9459BD9FCC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08830 mRNA. Translation: AAA34139.1.
    L08829 Genomic DNA. Translation: AAA99920.1.
    RefSeqiNP_001234636.1. NM_001247707.1.
    UniGeneiLes.140.

    Genome annotation databases

    GeneIDi543957.
    KEGGisly:543957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08830 mRNA. Translation: AAA34139.1 .
    L08829 Genomic DNA. Translation: AAA99920.1 .
    RefSeqi NP_001234636.1. NM_001247707.1.
    UniGenei Les.140.

    3D structure databases

    ProteinModelPortali P49118.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P49118.
    ProMEXi P49118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 543957.
    KEGGi sly:543957.

    Phylogenomic databases

    KOi K09490.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the tomato endoplasmic reticulum-localized BiP/GRP78 homolog."
      Meyer D.J., Ewing N.N., Rosichan J.L., Bennett A.B.
      Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: cv. VFNT Cherry.

    Entry informationi

    Entry nameiBIP_SOLLC
    AccessioniPrimary (citable) accession number: P49118
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3