Reviewed, UniProtKB/Swiss-Prot P49116 (NR2C2_HUMAN)

Names and origin

Protein names

Recommended name:
    Nuclear receptor subfamily 2 group C member 2
Alternative name(s):
    Orphan nuclear receptor TR4
    Testicular receptor 4
    Orphan nuclear receptor TAK1

Gene names

Name:	NR2C2
Synonyms:	TAK1, TR4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Orphan nuclear receptor. May regulate gene expression during the late phase of spermatogenesis.
Subunit structure	Interacts with NR2C2AP/TRA16 which represses the activity of NR2C2. Ref.3
Subcellular location	Nucleus Probable.
Developmental stage	Transiently repressed during the meiotic phase of spermatogenesis.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	nervous system development Traceable author statement. Source: ProtInc regulation of transcription, DNA-dependent Traceable author statement. Source: ProtInc transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro transcription coactivator activity Traceable author statement. Source: ProtInc transcription factor activity Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Nuclear receptor subfamily 2 group C member 2		PRO_0000053588
Regions
	DNA binding	114 – 189	76	Nuclear receptor
	Zinc finger	117 – 137	21	NR C4-type
	Zinc finger	153 – 177	25	NR C4-type
Amino acid modifications
	Modified residue	68	1	Phosphoserine Ref.4
	Modified residue	219	1	Phosphoserine Ref.5
	Modified residue	224	1	Phosphothreonine Ref.5
Experimental info
	Sequence conflict	24	1	Q → QGSEPASGPLSVFTSLNKEK in AAA21474. Ref.2
	Sequence conflict	156	1	N → S in AAA21474. Ref.2
	Sequence conflict	400	1	W → R in AAA21474. Ref.2
	Sequence conflict	409	1	A → G in AAA21474. Ref.2
	Sequence conflict	484 – 485	2	KL → NW in AAA21474. Ref.2
	Sequence conflict	594	1	A → V in AAA21474. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P49116-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 5180BDC3F3C8BD79	FASTA	596	65,414
	10 20 30 40 50 60 MTSPSPRIQI ISTDSAVASP QRIQIVTDQQ TGQKIQIVTA VDASGSPKQQ FILTSPDGAG 70 80 90 100 110 120 TGKVILASPE TSSAKQLIFT TSDNLVPGRI QIVTDSASVE RLLGKTDVQR PQVVEYCVVC 130 140 150 160 170 180 GDKASGRHYG AVSCEGCKGF FKRSVRKNLT YSCRSNQDCI INKHHRNRCQ FCRLKKCLEM 190 200 210 220 230 240 GMKMESVQSE RKPFDVQREK PSNCAASTEK IYIRKDLRSP LIATPTFVAD KDGARQTGLL 250 260 270 280 290 300 DPGMLVNIQQ PLIREDGTVL LATDSKAETS QGALGTLANV VTSLANLSES LNNGDTSEIQ 310 320 330 340 350 360 PEDQSASEIT RAFDTLAKAL NTTDSSSSPS LADGIDTSGG GSIHVISRDQ STPIIEVEGP 370 380 390 400 410 420 LLSDTHVTFK LTMPSPMPEY LNVHYICESA SRLLFLSMHW ARSIPAFQAL GQDCNTSLVR 430 440 450 460 470 480 ACWNELFTLG LAQCAQVMSL STILAAIVNH LQNSIQEDKL SGDRIKQVME HIWKLQEFCN 490 500 510 520 530 540 SMAKLDIDGY EYAYLKAIVL FSPDHPGLTS TSQIEKFQEK AQMELQDYVQ KTYSEDTYRL 550 560 570 580 590 ARILVRLPAL RLMSSNITEE LFFTGLIGNV SIDSIIPYIL KMETAEYNGQ ITGASL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily." Hirose T., Fujimoto W., Yamaai T., Kim K.H., Matsuura H., Jetten A.M. Mol. Endocrinol. 8:1667-1680(1994) [PubMed: 7708055] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily." Chang C., da Silva S.L., Ideta R., Lee Y., Yeh S., Burbach J.P. Proc. Natl. Acad. Sci. U.S.A. 91:6040-6044(1994) [PubMed: 8016112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Prostate and Testis.
[3]	"Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation." Yang Y., Wang X., Dong T., Kim E., Lin W.-J., Chang C. J. Biol. Chem. 278:7709-7717(2003) [PubMed: 12486131] [Abstract] Cited for: INTERACTION WITH NR2C2AP.
[4]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, MASS SPECTROMETRY.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219 AND THR-224, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U10990 mRNA. Translation: AAC50118.1. L27586 mRNA. Translation: AAA21474.1.
IPI	IPI00749258.
PIR	A57031. I59309.
RefSeq	NP_003289.2.
UniGene	Hs.591667
3D structure databases
HSSP	HSSP built from PDB template 1HCQ based on UniProtKB P03372.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5999N.
PTM databases
PhosphoSite	P49116.
Proteomic databases
PRIDE	P49116.
Genome annotation databases
Ensembl	ENSG00000177463. Homo sapiens. [Contig view]
GeneID	7182.
KEGG	hsa:7182.
Organism-specific databases
GeneCards	GC03P014964.
H-InvDB	HIX0018362. HIX0057298.
HGNC	HGNC:7972. NR2C2.
HPA	HPA006313.
MIM	601426. gene.
PharmGKB	PA31755.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P49116.
Enzyme and pathway databases
Pathway_Interaction_DB	ar_tf_pathway. Regulation of Androgen receptor activity.
Gene expression databases
ArrayExpress	P49116.
Bgee	P49116.
CleanEx	HS_NR2C2.
GermOnline	ENSG00000177463. Homo sapiens.
Family and domain databases
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR000324. VitD_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Gene3D	G3DSA:1.10.565.10. Nucl_hrmn_rcpt_lig_bd. 1 hit. G3DSA:3.30.50.10. Znf_NHR/GATA. 1 hit.
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR00398. STRDHORMONER. PR00047. STROIDFINGER. PR00350. VITAMINDR.
ProDom	PD000035. Znf_C4steroid. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	28158.
SOURCE	Search...

Entry information

Entry name

NR2C2_HUMAN

Accession

Primary (citable) accession number: P49116
Secondary accession number(s): P55092

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)