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Protein

Glucose-6-phosphate isomerase, cytosolic

Gene

PHI1

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (ZEAMMB73_Zm00001d014644), Glucose-6-phosphate isomerase (ZEAMMB73_Zm00001d034256), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (542313), Glucose-6-phosphate isomerase (542313), Glucose-6-phosphate isomerase, cytosolic (PHI1)
  3. ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (100281464), ATP-dependent 6-phosphofructokinase (100281464), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), ATP-dependent 6-phosphofructokinase (100192478), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100282190), ATP-dependent 6-phosphofructokinase (100280694), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100382182), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (103629493), ATP-dependent 6-phosphofructokinase (103629493), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFPalpha retrogene), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), ATP-dependent 6-phosphofructokinase (100279231), ATP-dependent 6-phosphofructokinase (100857010), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100282190), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (100281464), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (103630144), ATP-dependent 6-phosphofructokinase (103630633), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (100191982)
  4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (542261), Fructose-bisphosphate aldolase (100273196), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, cytoplasmic isozyme, Fructose-bisphosphate aldolase (100272845), Fructose-bisphosphate aldolase (100502020), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (100272913), Fructose-bisphosphate aldolase (ZEAMMB73_Zm00001d028270), Fructose-bisphosphate aldolase (ZEAMMB73_Zm00001d028270), Fructose-bisphosphate aldolase (ZEAMMB73_Zm00001d040084), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (100502020), Fructose-bisphosphate aldolase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei360Proton donorBy similarity1
Active sitei391By similarity1
Active sitei516By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase, cytosolic (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PHI1
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 1

Organism-specific databases

MaizeGDBi13859

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805641 – 567Glucose-6-phosphate isomerase, cytosolicAdd BLAST567

Proteomic databases

PaxDbiP49105
PRIDEiP49105

Expressioni

Gene expression databases

ExpressionAtlasiP49105 differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi4577.GRMZM2G065083_P01

Structurei

3D structure databases

ProteinModelPortaliP49105
SMRiP49105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiKOG2446 Eukaryota
COG0166 LUCA
HOGENOMiHOG000125964
KOiK01810

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

P49105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAALICGT EQWKALQAHV GAIQKTHLRD LMADADRCKA MTAEYEGIFL
60 70 80 90 100
DYSRQQATGE TMEKLLKLAD AAKLKEKIEK MFKGEKINST ENRSVLHVAL
110 120 130 140 150
RAPRDAVINS DGVNVVPEVW SVKDKIKQFS ETFRSGSWVG ATGKPLTNVV
160 170 180 190 200
SVGIGGSFLG PLFVHTALQT DPEAAECAKG RQLRFLANVD PVDVARSIKD
210 220 230 240 250
LDPETTLVVV VSKTFTTAET MLNARTLKEW IVSSLGPQAV AKHMIAVSTN
260 270 280 290 300
LKLVKEFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFPIVQKFLE
310 320 330 340 350
GASSIDNHFY SSSFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL
360 370 380 390 400
APHIQQLSME SNGKGVSIDG AQLSFETGEI DFGEPGTNGQ HSFYQLIHQG
410 420 430 440 450
RVIPCDFIGV VKSQQPVYLK GETVSNHDEL MSNFFAQPDA LAYGKTPEQL
460 470 480 490 500
HSEKVPENLI PHKTFKGNRP SLSLLLPTLS AYEVGQLLSI YEHRIAVQGF
510 520 530 540 550
IWGINSFDQW GVELGKSLAS QVRKQLHGTR MEGKPVEGFN HSTSSLLARY
560
LAVKPSTPYD TTVLPKV
Length:567
Mass (Da):62,237
Last modified:February 1, 1996 - v1
Checksum:iEC135C89DAADACF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17225 mRNA Translation: AAA82734.1
PIRiT02094
RefSeqiNP_001105368.1, NM_001111898.2
UniGeneiZm.3318

Genome annotation databases

EnsemblPlantsiZm00001d034256_T001; Zm00001d034256_P001; Zm00001d034256
Zm00001d034256_T003; Zm00001d034256_P003; Zm00001d034256
Zm00001d034256_T005; Zm00001d034256_P005; Zm00001d034256
GeneIDi542313
GrameneiZm00001d034256_T001; Zm00001d034256_P001; Zm00001d034256
Zm00001d034256_T003; Zm00001d034256_P003; Zm00001d034256
Zm00001d034256_T005; Zm00001d034256_P005; Zm00001d034256
KEGGizma:542313

Similar proteinsi

Entry informationi

Entry nameiG6PI_MAIZE
AccessioniPrimary (citable) accession number: P49105
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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