P49105 (G6PI_MAIZE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase, cytosolic
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:

PHI1

Organism

Zea mays (Maize)

Taxonomic identifier

4577 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogoneae › Zea

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 567	567	Glucose-6-phosphate isomerase, cytosolic		PRO_0000180564
Sites
	Active site	360	1	Proton donor By similarity
	Active site	391	1	By similarity
	Active site	516	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49105 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: EC135C89DAADACF2	FASTA	567	62,237
	10 20 30 40 50 60 MASAALICGT EQWKALQAHV GAIQKTHLRD LMADADRCKA MTAEYEGIFL DYSRQQATGE 70 80 90 100 110 120 TMEKLLKLAD AAKLKEKIEK MFKGEKINST ENRSVLHVAL RAPRDAVINS DGVNVVPEVW 130 140 150 160 170 180 SVKDKIKQFS ETFRSGSWVG ATGKPLTNVV SVGIGGSFLG PLFVHTALQT DPEAAECAKG 190 200 210 220 230 240 RQLRFLANVD PVDVARSIKD LDPETTLVVV VSKTFTTAET MLNARTLKEW IVSSLGPQAV 250 260 270 280 290 300 AKHMIAVSTN LKLVKEFGID PNNAFAFWDW VGGRYSVCSA VGVLPLSLQY GFPIVQKFLE 310 320 330 340 350 360 GASSIDNHFY SSSFEKNIPV LLGLLSVWNV SFLGYPARAI LPYSQALEKL APHIQQLSME 370 380 390 400 410 420 SNGKGVSIDG AQLSFETGEI DFGEPGTNGQ HSFYQLIHQG RVIPCDFIGV VKSQQPVYLK 430 440 450 460 470 480 GETVSNHDEL MSNFFAQPDA LAYGKTPEQL HSEKVPENLI PHKTFKGNRP SLSLLLPTLS 490 500 510 520 530 540 AYEVGQLLSI YEHRIAVQGF IWGINSFDQW GVELGKSLAS QVRKQLHGTR MEGKPVEGFN 550 560 HSTSSLLARY LAVKPSTPYD TTVLPKV

References

[1]	"Cloning and characterization of an anaerobically induced cDNA encoding glucose-6-phosphate isomerase from maize." Lal S.K., Sachs M.M. Plant Physiol. 108:1295-1296(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. B73. Tissue: Root.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U17225 mRNA. Translation: AAA82734.1.
PIR	T02094.
RefSeq	NP_001105368.1. NM_001111898.1.
UniGene	Zm.3318.
3D structure databases
ProteinModelPortal	P49105.
ModBase	Search...
Proteomic databases
PRIDE	P49105.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	542313.
KEGG	zma:542313.
Organism-specific databases
Gramene	P49105.
MaizeGDB	13859.
Phylogenomic databases
HOGENOM	HOG000125964.
KO	K01810.
Enzyme and pathway databases
UniPathway	UPA00109; UER00181.
Family and domain databases
Gene3D	1.10.1390.10. 1 hit.
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_MAIZE

Accession

Primary (citable) accession number: P49105

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program