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P49095

- GCSP_YEAST

UniProt

P49095 - GCSP_YEAST

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Protein

Glycine dehydrogenase (decarboxylating), mitochondrial

Gene

GCV2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The glycine cleavage system (glycine decarboxylase complex) catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.

Cofactori

Pyridoxal phosphate.By similarity

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: SGD
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: SGD
  2. one-carbon metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:YMR189W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating), mitochondrial (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P protein
Glycine decarboxylase
Glycine decarboxylase complex subunit P
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:GCV2
Synonyms:GSD2
Ordered Locus Names:YMR189W
ORF Names:YM9646.01
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR189w.
SGDiS000004801. GCV2.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. glycine cleavage complex Source: SGD
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1034Glycine dehydrogenase (decarboxylating), mitochondrialPRO_0000010752
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei773 – 7731N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

MaxQBiP49095.
PaxDbiP49095.
PeptideAtlasiP49095.

Expressioni

Inductioni

By glycine.1 Publication

Gene expression databases

GenevestigatoriP49095.

Interactioni

Subunit structurei

Component of the glycine decarboxylase complex (GDC), which is composed of four proteins: P, T, L and H.

Protein-protein interaction databases

BioGridi35367. 20 interactions.
IntActiP49095. 5 interactions.
MINTiMINT-659294.
STRINGi4932.YMR189W.

Structurei

3D structure databases

ProteinModelPortaliP49095.
SMRiP49095. Positions 63-1022.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1003.
GeneTreeiENSGT00390000017970.
HOGENOMiHOG000239369.
InParanoidiP49095.
KOiK00281.
OMAiQPANEEQ.
OrthoDBiEOG7KWSS4.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49095-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRTRVTALL CRATVRSSTN YVSLARTRSF HSQSILLKTA ATDITSTQYS
60 70 80 90 100
RIFNPDLKNI DRPLDTFARR HLGPSPSDVK KMLKTMGYSD LNAFIEELVP
110 120 130 140 150
PNILKRRPLK LEAPSKGFCE QEMLQHLEKI ANKNHYKVKN FIGKGYYGTI
160 170 180 190 200
LPPVIQRNLL ESPEWYTSYT PYQPEISQGR LEALLNFQTV VSDLTGLPVA
210 220 230 240 250
NASLLDEGTA AGEAMLLSFN ISRKKKLKYV IDKKLHQQTK SVLHTRAKPF
260 270 280 290 300
NIEIIEVDCS DIKKAVDVLK NPDVSGCLVQ YPATDGSILP PDSMKQLSDA
310 320 330 340 350
LHSHKSLLSV ASDLMALTLL KPPAHYGADI VLGSSQRFGV PMGYGGPHAA
360 370 380 390 400
FFAVIDKLNR KIPGRIVGIS KDRLGKTALR LALQTREQHI KRDKATSNIC
410 420 430 440 450
TAQALLANVA SSYCVYHGPK GLQNISRRIF SLTSILANAI ENDSCPHELI
460 470 480 490 500
NKTWFDTLTI KLGNGISSEQ LLDKALKEFN INLFAVDTTT ISLALDETTT
510 520 530 540 550
KADVENLLKV FDIENSSQFL SEDYSNSFPR EFQRTDEILR NEVFHMHHSE
560 570 580 590 600
TAMLRYLHRL QSRDLSLANS MIPLGSCTMK LNSTVEMMPI TWPQFSNIHP
610 620 630 640 650
FQPSNQVQGY KELITSLEKD LCSITGFDGI SLQPNSGAQG EYTGLRVIRS
660 670 680 690 700
YLESKGENHR NVCLIPVSAH GTNPASAAMA GLKVVPVNCL QDGSLDLVDL
710 720 730 740 750
KNKAEQHSKE LAAVMITYPS TYGLFEPGIQ HAIDIVHSFG GQVYLDGANM
760 770 780 790 800
NAQVGLTSPG DLGADVCHLN LHKTFSIPHG GGGPAGAPIC VKSHLIPHLP
810 820 830 840 850
KHDVVDMITG IGGSKSIDSV SSAPYGNALV LPISYAYIKM MGNEGLPFSS
860 870 880 890 900
VIAMLNSNYM MTRLKDHYKI LFVNEMSTLK HCAHEFIVDL REYKAKGVEA
910 920 930 940 950
IDVAKRLQDY GFHAPTLAFP VPGTLMIEPT ESENLEELDR FCDAMISIKE
960 970 980 990 1000
EINALVAGQP KGQILKNAPH SLEDLITSSN WDTRGYTREE AAYPLPFLRY
1010 1020 1030
NKFWPTVARL DDTYGDMNLI CTCPSVEEIA NETE
Length:1,034
Mass (Da):114,451
Last modified:February 1, 1996 - v1
Checksum:iF4D52642B0BDA041
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20641 Genomic DNA. Translation: AAB18933.1.
Z47815 Genomic DNA. Translation: CAA87810.1.
BK006946 Genomic DNA. Translation: DAA10087.1.
PIRiS50917.
RefSeqiNP_013914.1. NM_001182695.1.

Genome annotation databases

EnsemblFungiiYMR189W; YMR189W; YMR189W.
GeneIDi855227.
KEGGisce:YMR189W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U20641 Genomic DNA. Translation: AAB18933.1 .
Z47815 Genomic DNA. Translation: CAA87810.1 .
BK006946 Genomic DNA. Translation: DAA10087.1 .
PIRi S50917.
RefSeqi NP_013914.1. NM_001182695.1.

3D structure databases

ProteinModelPortali P49095.
SMRi P49095. Positions 63-1022.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35367. 20 interactions.
IntActi P49095. 5 interactions.
MINTi MINT-659294.
STRINGi 4932.YMR189W.

Proteomic databases

MaxQBi P49095.
PaxDbi P49095.
PeptideAtlasi P49095.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR189W ; YMR189W ; YMR189W .
GeneIDi 855227.
KEGGi sce:YMR189W.

Organism-specific databases

CYGDi YMR189w.
SGDi S000004801. GCV2.

Phylogenomic databases

eggNOGi COG1003.
GeneTreei ENSGT00390000017970.
HOGENOMi HOG000239369.
InParanoidi P49095.
KOi K00281.
OMAi QPANEEQ.
OrthoDBi EOG7KWSS4.

Enzyme and pathway databases

BioCyci YEAST:YMR189W-MONOMER.

Miscellaneous databases

NextBioi 978759.
PROi P49095.

Gene expression databases

Genevestigatori P49095.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae."
    Sinclair D.A., Hong S.-P., Dawes I.W.
    Mol. Microbiol. 19:611-623(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGCSP_YEAST
AccessioniPrimary (citable) accession number: P49095
Secondary accession number(s): D6W013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 12000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3