Reviewed,
UniProtKB/Swiss-Prot P49079 (AKH1_MAIZE)
Last modified
July 22, 2008.
Version 62.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic Short name=AK-HSDH 1 Short name=AK-HD 1 Including the following 2 domains: 1- Recommended name: Aspartokinase EC=2.7.2.4 2- Recommended name: Homoserine dehydrogenase EC=1.1.1.3 | ||
| Gene names |
| ||
| Organism | Zea mays (Maize) | ||
| Taxonomic identifier | 4577 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › PACCAD clade › Panicoideae › Andropogoneae › Zea |
Protein attributes
| Sequence length | 920 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. ATP + L-aspartate = ADP + 4-phospho-L-aspartate. |
| Pathway | Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5. |
| Subunit structure | Homo- or heterodimer Potential. |
| Subcellular location | |
| Sequence similarities | In the N-terminal section; belongs to the aspartokinase family. In the C-terminal section; belongs to the homoserine dehydrogenase family. Contains 2 ACT domains. |
Ontologies
Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Methionine biosynthesis |
| Cellular component | Chloroplast Plastid |
| Domain | Repeat Transit peptide |
| Ligand | NADP |
| Molecular function | Kinase Oxidoreductase Transferase |
| Technical term | Multifunctional enzyme |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 92 | 92 | Chloroplast Potential | |||||
| Chain | 93 – 920 | 828 | Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic | |||||
Regions | ||||||||
| Domain | 412 – 480 | 69 | ACT 1 | |||||
| Domain | 496 – 563 | 68 | ACT 2 | |||||
| Nucleotide binding | 568 – 573 | 6 | NADP Potential | |||||
| Region | 93 – 341 | 249 | Aspartokinase | |||||
| Region | 342 – 566 | 225 | Interface | |||||
| Region | 567 – 920 | 354 | Homoserine dehydrogenase | |||||
Sequences
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References
| [1] | "Molecular genetics of the maize (Zea mays L.) aspartate kinase-homoserine dehydrogenase gene family." Muehlbauer G.J., Somers D.A., Matthews B.F., Gengenbach B.G. Plant Physiol. 106:1303-1312(1994) [PubMed: 7846152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Seedling leaf. |
Cross-references
Sequence databases | |
|---|---|
| L33912 mRNA. Translation: AAA74360.1. | |
| PIR | T02953. |
| RefSeq | NP_001105325.1. |
| UniGene | Zm.94547 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EBF based on UniProtKB P31116. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 542249. |
Organism-specific databases | |
| Gramene | P49079. |
| MaizeGDB | 66609. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR001048. Asp/Glu/Uridylate_kinase. IPR005106. Asp/hSer_DHase_NAD-bd. IPR001341. Asp_kin_reg. IPR001342. hSer_DHase_cat. IPR016040. NAD(P)-bd. [Graphical view] |
| Gene3D | G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF00696. AA_kinase. 1 hit. PF01842. ACT. 2 hits. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00657. asp_kinases. 1 hit. |
| PROSITE | PS00324. ASPARTOKINASE. 1 hit. PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view] |
| ProDom | P49079. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | AKH1_MAIZE | ||||||||
| Accession | Primary (citable) accession number: P49079 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


