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Protein

MAP kinase-activated protein kinase 2

Gene

MAPk-Ak2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei142Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • peptidyl-serine phosphorylation Source: GO_Central
  • positive regulation of cell size Source: FlyBase
  • protein autophosphorylation Source: GO_Central
  • protein phosphorylation Source: FlyBase
  • regulation of JNK cascade Source: FlyBase
  • response to salt stress Source: FlyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 1994
ReactomeiR-DME-171007 p38MAPK events
R-DME-199920 CREB phosphorylation
R-DME-2559580 Oxidative Stress Induced Senescence
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4420097 VEGFA-VEGFR2 Pathway
R-DME-450302 activated TAK1 mediates p38 MAPK activation
R-DME-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
SignaLinkiP49071

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase-activated protein kinase 2 (EC:2.7.11.1)
Short name:
MAPK-activated protein kinase 2
Short name:
MAPKAP kinase 2
Short name:
MAPKAPK-2
Gene namesi
ORF Names:CG3086
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0013987 MAPk-Ak2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862911 – 359MAP kinase-activated protein kinase 2Add BLAST359

Post-translational modificationi

Phosphorylated and activated by MAP kinase.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP49071
PRIDEiP49071

Expressioni

Gene expression databases

BgeeiFBgn0013987
ExpressionAtlasiP49071 differential
GenevisibleiP49071 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi69137, 6 interactors
DIPiDIP-21714N
IntActiP49071, 4 interactors
STRINGi7227.FBpp0070802

Structurei

3D structure databases

ProteinModelPortaliP49071
SMRiP49071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST262

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0604 Eukaryota
ENOG410XP8F LUCA
GeneTreeiENSGT00900000140876
InParanoidiP49071
KOiK04443
OMAiCRHIVNI
OrthoDBiEOG091G14PL
PhylomeDBiP49071

Family and domain databases

Gene3Di4.10.1170.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR027442 MAPKAPK_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P49071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLQNQRQP KTTPLTDDYV TSNTVLGYGI NGKVVQCTHR RTQQNYALKV
60 70 80 90 100
LLDSERARRE VDLHWRVSGC RYIVNIIDVY ENTFKDRKCL LVVMECMEGG
110 120 130 140 150
ELFQRIQDKA DGAFTEREAA QIMHEICAAV DYLHSRDIAH RDLKPENLLY
160 170 180 190 200
TTTQPNATLK LTDFGFAKET FTSYTLQTPC YTPYYVAPEV LGPEKYDKSC
210 220 230 240 250
DIWSLGVVMY IIMCGFPPFY SNHGLAISPG MKNRIRTGQY DFPDPEWTNV
260 270 280 290 300
SQAAKDLIKG MLNVDPSKRL RIQDVISNKW IAQYNAVPQT PLCTGRMLKE
310 320 330 340 350
AEETWPEVQE EMTRSLATMR VDYDQMQIKA LDKSNNPLLT KRRKKIEEME

LYMANATRN
Length:359
Mass (Da):41,401
Last modified:February 1, 1996 - v1
Checksum:i69C5F9A94D1511EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20757 mRNA Translation: AAA86885.1
AE014298 Genomic DNA Translation: AAG22408.1
PIRiJC4297
RefSeqiNP_001188547.1, NM_001201618.1
NP_001245536.1, NM_001258607.2
NP_524769.1, NM_080030.5
NP_788861.1, NM_176688.3
UniGeneiDm.1442

Genome annotation databases

EnsemblMetazoaiFBtr0070837; FBpp0070802; FBgn0013987
FBtr0070839; FBpp0070804; FBgn0013987
FBtr0302940; FBpp0292066; FBgn0013987
FBtr0308577; FBpp0300801; FBgn0013987
GeneIDi44573
KEGGidme:Dmel_CG3086

Similar proteinsi

Entry informationi

Entry nameiMAPK2_DROME
AccessioniPrimary (citable) accession number: P49071
Secondary accession number(s): Q9W480
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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