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Protein

Calcium signal-modulating cyclophilin ligand

Gene

Camlg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

GO - Molecular functioni

GO - Biological processi

  • epidermal growth factor receptor signaling pathway Source: MGI
  • receptor recycling Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name:
CAML
Gene namesi
Name:Camlg
Synonyms:Caml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:104728 Caml

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 187CytoplasmicSequence analysisAdd BLAST187
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 238ExtracellularSequence analysisAdd BLAST30
Transmembranei239 – 255HelicalSequence analysisAdd BLAST17
Topological domaini256 – 294CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892921 – 294Calcium signal-modulating cyclophilin ligandAdd BLAST294

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP49070
PaxDbiP49070
PeptideAtlasiP49070
PRIDEiP49070

PTM databases

iPTMnetiP49070
PhosphoSitePlusiP49070

Expressioni

Gene expression databases

BgeeiENSMUSG00000021501
CleanExiMM_CAML
GenevisibleiP49070 MM

Interactioni

Subunit structurei

The N-terminal domain binds to TNFRSF13B/TACI.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ryr1E9PZQ03EBI-309114,EBI-642079

GO - Molecular functioni

Protein-protein interaction databases

CORUMiP49070
IntActiP49070, 5 interactors
MINTiP49070
STRINGi10090.ENSMUSP00000021963

Structurei

3D structure databases

ProteinModelPortaliP49070
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEK3 Eukaryota
ENOG4111HUY LUCA
GeneTreeiENSGT00390000015996
HOGENOMiHOG000220891
HOVERGENiHBG050786
InParanoidiP49070
KOiK22385
OMAiHHGLEQY
OrthoDBiEOG091G0HL4
PhylomeDBiP49070
TreeFamiTF331902

Family and domain databases

InterProiView protein in InterPro
IPR016719 Ca_signal-mod_cyclophilin_lig
PANTHERiPTHR15026 PTHR15026, 1 hit
PfamiView protein in Pfam
PF14963 CAML, 1 hit
PIRSFiPIRSF018259 CAML, 1 hit

Sequencei

Sequence statusi: Complete.

P49070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVPAATDG GERPATPSGL SASQRRAELR RRKLLMNSEQ RINRIMGFHR
60 70 80 90 100
PGSGSEEENQ TKSKPQDSDK LNSLSIPSVS KRVVLGDSVD GGGADQLGGV
110 120 130 140 150
AEVRGTQLGD KLDSFIKAPE CSSKDGAELR QRTRGDLTAD PAQRASHHGL
160 170 180 190 200
EQYLSRFEEA MKLRKQLISE KPSQEDGSTA EEFDSFRIFR LVGCALLALG
210 220 230 240 250
VRAFVCKYLS IFAPFLTLQL AYMGLYKYFP KGEKKVKTTV LTAALLLSGI
260 270 280 290
PAEVINRSMD TYSKMGEVFT DLCVYFFTFI FCHELLDYWG PEVP
Length:294
Mass (Da):32,542
Last modified:May 30, 2003 - v2
Checksum:iD21AC54BC9F609E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti254V → A in AAA87004 (PubMed:7590290).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21960 mRNA Translation: AAA87004.1
BC005688 mRNA Translation: AAH05688.1
AF078112 Genomic DNA Translation: AAC33940.1
CCDSiCCDS26551.1
RefSeqiNP_031622.2, NM_007596.2
UniGeneiMm.2313

Genome annotation databases

EnsembliENSMUST00000021963; ENSMUSP00000021963; ENSMUSG00000021501
GeneIDi12328
KEGGimmu:12328
UCSCiuc007qrv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCAMLG_MOUSE
AccessioniPrimary (citable) accession number: P49070
Secondary accession number(s): Q99JU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2003
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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