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Protein

Calcium signal-modulating cyclophilin ligand

Gene

Camlg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

GO - Biological processi

  • epidermal growth factor receptor signaling pathway Source: MGI
  • receptor recycling Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name:
CAML
Gene namesi
Name:Camlg
Synonyms:Caml
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:104728. Caml.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 187187CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Topological domaini209 – 23830ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25517HelicalSequence analysisAdd
BLAST
Topological domaini256 – 29439CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Calcium signal-modulating cyclophilin ligandPRO_0000089292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49070.
MaxQBiP49070.
PaxDbiP49070.
PeptideAtlasiP49070.
PRIDEiP49070.

PTM databases

iPTMnetiP49070.
PhosphoSiteiP49070.

Expressioni

Gene expression databases

BgeeiP49070.
CleanExiMM_CAML.
GenevisibleiP49070. MM.

Interactioni

Subunit structurei

The N-terminal domain binds to TNFRSF13B/TACI.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Ryr1E9PZQ03EBI-309114,EBI-642079

Protein-protein interaction databases

IntActiP49070. 5 interactions.
MINTiMINT-1563183.
STRINGi10090.ENSMUSP00000021963.

Structurei

3D structure databases

ProteinModelPortaliP49070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49070.
OMAiHHGLEQY.
OrthoDBiEOG7H4DVG.
PhylomeDBiP49070.
TreeFamiTF331902.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.

Sequencei

Sequence statusi: Complete.

P49070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPVPAATDG GERPATPSGL SASQRRAELR RRKLLMNSEQ RINRIMGFHR
60 70 80 90 100
PGSGSEEENQ TKSKPQDSDK LNSLSIPSVS KRVVLGDSVD GGGADQLGGV
110 120 130 140 150
AEVRGTQLGD KLDSFIKAPE CSSKDGAELR QRTRGDLTAD PAQRASHHGL
160 170 180 190 200
EQYLSRFEEA MKLRKQLISE KPSQEDGSTA EEFDSFRIFR LVGCALLALG
210 220 230 240 250
VRAFVCKYLS IFAPFLTLQL AYMGLYKYFP KGEKKVKTTV LTAALLLSGI
260 270 280 290
PAEVINRSMD TYSKMGEVFT DLCVYFFTFI FCHELLDYWG PEVP
Length:294
Mass (Da):32,542
Last modified:May 30, 2003 - v2
Checksum:iD21AC54BC9F609E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti254 – 2541V → A in AAA87004 (PubMed:7590290).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21960 mRNA. Translation: AAA87004.1.
BC005688 mRNA. Translation: AAH05688.1.
AF078112 Genomic DNA. Translation: AAC33940.1.
CCDSiCCDS26551.1.
RefSeqiNP_031622.2. NM_007596.2.
UniGeneiMm.2313.

Genome annotation databases

EnsembliENSMUST00000021963; ENSMUSP00000021963; ENSMUSG00000021501.
GeneIDi12328.
KEGGimmu:12328.
UCSCiuc007qrv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21960 mRNA. Translation: AAA87004.1.
BC005688 mRNA. Translation: AAH05688.1.
AF078112 Genomic DNA. Translation: AAC33940.1.
CCDSiCCDS26551.1.
RefSeqiNP_031622.2. NM_007596.2.
UniGeneiMm.2313.

3D structure databases

ProteinModelPortaliP49070.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49070. 5 interactions.
MINTiMINT-1563183.
STRINGi10090.ENSMUSP00000021963.

PTM databases

iPTMnetiP49070.
PhosphoSiteiP49070.

Proteomic databases

EPDiP49070.
MaxQBiP49070.
PaxDbiP49070.
PeptideAtlasiP49070.
PRIDEiP49070.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021963; ENSMUSP00000021963; ENSMUSG00000021501.
GeneIDi12328.
KEGGimmu:12328.
UCSCiuc007qrv.1. mouse.

Organism-specific databases

CTDi12328.
MGIiMGI:104728. Caml.

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49070.
OMAiHHGLEQY.
OrthoDBiEOG7H4DVG.
PhylomeDBiP49070.
TreeFamiTF331902.

Miscellaneous databases

PROiP49070.
SOURCEiSearch...

Gene expression databases

BgeeiP49070.
CleanExiMM_CAML.
GenevisibleiP49070. MM.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the gene encoding the mouse homologue of the human calcium signal-modulating ligand."
    Kim H.S., Morales V.M., Dass C., Encinas J., Teitell M., Blumberg R.S.
    Gene 163:323-324(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Sequence of the promoter region of the mouse CAMLG gene."
    Morales V.M., Snapper S.B., Blumberg R.S.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-55.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiCAMLG_MOUSE
AccessioniPrimary (citable) accession number: P49070
Secondary accession number(s): Q99JU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 30, 2003
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.