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Protein

Calcium signal-modulating cyclophilin ligand

Gene

CAMLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

GO - Biological processi

  • defense response Source: ProtInc
  • epidermal growth factor receptor signaling pathway Source: Ensembl
  • receptor recycling Source: Ensembl
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Protein family/group databases

TCDBi3.A.19.1.1. the tms recognition/insertion complex (trc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name:
CAML
Gene namesi
Name:CAMLG
Synonyms:CAML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1471. CAMLG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189CytoplasmicSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Topological domaini211 – 24030ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 25717HelicalSequence analysisAdd
BLAST
Topological domaini258 – 29639CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26053.

Chemistry

DrugBankiDB00091. Cyclosporine.

Polymorphism and mutation databases

BioMutaiCAMLG.
DMDMi1345662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Calcium signal-modulating cyclophilin ligandPRO_0000089291Add
BLAST

Proteomic databases

EPDiP49069.
MaxQBiP49069.
PaxDbiP49069.
PRIDEiP49069.

PTM databases

iPTMnetiP49069.
PhosphoSiteiP49069.

Miscellaneous databases

PMAP-CutDBP49069.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in brain, testis and ovary.

Gene expression databases

BgeeiP49069.
CleanExiHS_CAMLG.
ExpressionAtlasiP49069. baseline and differential.
GenevisibleiP49069. HS.

Organism-specific databases

HPAiHPA052636.
HPA056472.

Interactioni

Subunit structurei

The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-1748958,EBI-297353
IER3P466952EBI-1748958,EBI-1748945
KCNA2P163893EBI-1748958,EBI-10210559

Protein-protein interaction databases

BioGridi107269. 16 interactions.
IntActiP49069. 14 interactions.
STRINGi9606.ENSP00000297156.

Structurei

3D structure databases

ProteinModelPortaliP49069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49069.
OMAiHHGLEQY.
PhylomeDBiP49069.
TreeFamiTF331902.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.

Sequencei

Sequence statusi: Complete.

P49069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF
60 70 80 90 100
HRPGSGAEEE SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG
110 120 130 140 150
GVAEVKGTQL GDKLDSFIKP PECSSDVNLE LRQRNRGDLT ADSVQRGSRH
160 170 180 190 200
GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN TTEEFDSFRI FRLVGCALLA
210 220 230 240 250
LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT TVLTAALLLS
260 270 280 290
GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP
Length:296
Mass (Da):32,953
Last modified:February 1, 1996 - v1
Checksum:i22DCD8CF022FEF09
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781V → I.
Corresponds to variant rs12657663 [ dbSNP | Ensembl ].
VAR_024297
Natural varianti100 – 1001G → S.
Corresponds to variant rs11552197 [ dbSNP | Ensembl ].
VAR_050710

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA. Translation: AAA59420.1.
AK313156 mRNA. Translation: BAG35974.1.
CH471062 Genomic DNA. Translation: EAW62243.1.
CH471062 Genomic DNA. Translation: EAW62244.1.
BC130325 mRNA. Translation: AAI30326.1.
AF068179 mRNA. Translation: AAC23596.1.
CCDSiCCDS4178.1.
PIRiS47594.
RefSeqiNP_001736.1. NM_001745.3.
UniGeneiHs.529846.

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615.
GeneIDi819.
KEGGihsa:819.
UCSCiuc003kzt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA. Translation: AAA59420.1.
AK313156 mRNA. Translation: BAG35974.1.
CH471062 Genomic DNA. Translation: EAW62243.1.
CH471062 Genomic DNA. Translation: EAW62244.1.
BC130325 mRNA. Translation: AAI30326.1.
AF068179 mRNA. Translation: AAC23596.1.
CCDSiCCDS4178.1.
PIRiS47594.
RefSeqiNP_001736.1. NM_001745.3.
UniGeneiHs.529846.

3D structure databases

ProteinModelPortaliP49069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107269. 16 interactions.
IntActiP49069. 14 interactions.
STRINGi9606.ENSP00000297156.

Chemistry

DrugBankiDB00091. Cyclosporine.

Protein family/group databases

TCDBi3.A.19.1.1. the tms recognition/insertion complex (trc) family.

PTM databases

iPTMnetiP49069.
PhosphoSiteiP49069.

Polymorphism and mutation databases

BioMutaiCAMLG.
DMDMi1345662.

Proteomic databases

EPDiP49069.
MaxQBiP49069.
PaxDbiP49069.
PRIDEiP49069.

Protocols and materials databases

DNASUi819.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615.
GeneIDi819.
KEGGihsa:819.
UCSCiuc003kzt.4. human.

Organism-specific databases

CTDi819.
GeneCardsiCAMLG.
H-InvDBHIX0164331.
HGNCiHGNC:1471. CAMLG.
HPAiHPA052636.
HPA056472.
MIMi601118. gene.
neXtProtiNX_P49069.
PharmGKBiPA26053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49069.
OMAiHHGLEQY.
PhylomeDBiP49069.
TreeFamiTF331902.

Miscellaneous databases

ChiTaRSiCAMLG. human.
GeneWikiiCAMLG.
GenomeRNAii819.
NextBioi3352.
PMAP-CutDBP49069.
PROiP49069.
SOURCEiSearch...

Gene expression databases

BgeeiP49069.
CleanExiHS_CAMLG.
ExpressionAtlasiP49069. baseline and differential.
GenevisibleiP49069. HS.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein."
    Bram R.J., Crabtree G.R.
    Nature 371:355-358(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "An immature transcript of the CAMLG gene."
    Morales V.M., Blumberg R.S.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-296.
    Tissue: Colon adenocarcinoma.
  6. "Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis."
    Feng P., Park J., Lee B.S., Lee S.H., Bram R.J., Jung J.U.
    J. Virol. 76:11491-11504(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-8 PROTEIN K7.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCAMLG_HUMAN
AccessioniPrimary (citable) accession number: P49069
Secondary accession number(s): A1L3Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 16, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.