Reviewed, UniProtKB/Swiss-Prot P49069 (CAMLG_HUMAN)

Names and origin

Protein names

Recommended name:
    Calcium signal-modulating cyclophilin ligand
      Short name=CAML

Gene names

Name:	CAMLG
Synonyms:	CAML

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
Subunit structure	The N-terminal domain binds to TNFRSF13B/TACI.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous. Highest levels in brain, testis and ovary.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	defense response Ref.1 Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IER3	P46695	1	EBI-1748958,EBI-1748945

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Calcium signal-modulating cyclophilin ligand		PRO_0000089291
Regions
	Topological domain	1 – 189	189	Cytoplasmic Potential
	Transmembrane	190 – 210	21	Potential
	Topological domain	211 – 240	30	Extracellular Potential
	Transmembrane	241 – 257	17	Potential
	Topological domain	258 – 296	39	Cytoplasmic Potential
Natural variations
	Natural variant	78	1	V → I: dbSNP rs12657663.		VAR_024297
	Natural variant	100	1	G → S: dbSNP rs11552197.		VAR_050710

Sequences

	Sequence		Length	Mass (Da)
	P49069-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 22DCD8CF022FEF09	FASTA	296	32,953
	10 20 30 40 50 60 MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE 70 80 90 100 110 120 SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP 130 140 150 160 170 180 PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN 190 200 210 220 230 240 TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT 250 260 270 280 290 TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Calcium signalling in T cells stimulated by a cyclophilin B-binding protein." Bram R.J., Crabtree G.R. Nature 371:355-358(1994) [PubMed: 7522304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"An immature transcript of the CAMLG gene." Morales V.M., Blumberg R.S. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-296. Tissue: Colon adenocarcinoma.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U18242 mRNA. Translation: AAA59420.1. AF068179 mRNA. Translation: AAC23596.1.
IPI	IPI00025729.
PIR	S47594.
RefSeq	NP_001736.1.
UniGene	Hs.529846
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P49069. 1 interaction.
STRING	P49069.
Proteomic databases
PRIDE	P49069.
Genome annotation databases
Ensembl	ENST00000297156; ENSP00000297156; ENSG00000164615; Homo sapiens. [Genome view]
GeneID	819.
KEGG	hsa:819.
UCSC	uc003kzt.1. human.
Organism-specific databases
CTD	819.
GeneCards	GC05P134102.
H-InvDB	HIX0005186.
HGNC	HGNC:1471. CAMLG.
MIM	601118. gene.
PharmGKB	PA26053.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P49069.
HOVERGEN	P49069.
OMA	YWGSEVP.
Gene expression databases
ArrayExpress	P49069.
Bgee	P49069.
CleanEx	HS_CAMLG.
Genevestigator	P49069.
GermOnline	ENSG00000164615. Homo sapiens.
Family and domain databases
InterPro	IPR016719. Ca_signal-mod_cyclophilin_lig. [Graphical view]
PIRSF	PIRSF018259. CAML. 1 hit.
ProtoNet	Search...
Other Resources
DrugBank	DB00091. Cyclosporine.
NextBio	3352.
PMAP-CutDB	P49069.
SOURCE	Search...

Entry information

Entry name

CAMLG_HUMAN

Accession

Primary (citable) accession number: P49069

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.