P49069 (CAMLG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name=CAML

Gene names

Name:	CAMLG
Synonyms:	CAML

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.
Subunit structure	The N-terminal domain binds to TNFRSF13B/TACI.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous. Highest levels in brain, testis and ovary.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	defense response Traceable author statement. Source: ProtInc
Cellular component	endoplasmic reticulum Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IER3	P46695	2	EBI-1748958,EBI-1748945

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Calcium signal-modulating cyclophilin ligand		PRO_0000089291
Regions
	Topological domain	1 – 189	189	Cytoplasmic Potential
	Transmembrane	190 – 210	21	Helical; Potential
	Topological domain	211 – 240	30	Extracellular Potential
	Transmembrane	241 – 257	17	Helical; Potential
	Topological domain	258 – 296	39	Cytoplasmic Potential
Natural variations
	Natural variant	78	1	V → I. Corresponds to variant rs12657663 [ dbSNP | Ensembl ].		VAR_024297
	Natural variant	100	1	G → S. Corresponds to variant rs11552197 [ dbSNP | Ensembl ].		VAR_050710

Sequences

	Sequence		Length	Mass (Da)
	P49069 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 22DCD8CF022FEF09	FASTA	296	32,953
	10 20 30 40 50 60 MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE 70 80 90 100 110 120 SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP 130 140 150 160 170 180 PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN 190 200 210 220 230 240 TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT 250 260 270 280 290 TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Calcium signalling in T cells stimulated by a cyclophilin B-binding protein." Bram R.J., Crabtree G.R. Nature 371:355-358(1994) [PubMed: 7522304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"An immature transcript of the CAMLG gene." Morales V.M., Blumberg R.S. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-296. Tissue: Colon adenocarcinoma.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18242 mRNA. Translation: AAA59420.1. AF068179 mRNA. Translation: AAC23596.1.
IPI	IPI00025729.
PIR	S47594.
RefSeq	NP_001736.1. NM_001745.3.
UniGene	Hs.529846.
3D structure databases
ProteinModelPortal	P49069.
ModBase	Search...
Protein-protein interaction databases
IntAct	P49069. 6 interactions.
STRING	P49069.
PTM databases
PhosphoSite	P49069.
Polymorphism databases
DMDM	1345662.
Proteomic databases
PRIDE	P49069.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000297156; ENSP00000297156; ENSG00000164615.
GeneID	819.
KEGG	hsa:819.
UCSC	uc003kzt.1. human.
Organism-specific databases
CTD	819.
GeneCards	GC05P134074.
H-InvDB	HIX0200779.
HGNC	HGNC:1471. CAMLG.
MIM	601118. gene.
neXtProt	NX_P49069.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000015996.
HOGENOM	HBG445350.
HOVERGEN	HBG050786.
InParanoid	P49069.
OMA	KPSQEDG.
OrthoDB	EOG4CNQS0.
PhylomeDB	P49069.
Gene expression databases
ArrayExpress	P49069.
Bgee	P49069.
CleanEx	HS_CAMLG.
Genevestigator	P49069.
GermOnline	ENSG00000164615. Homo sapiens.
Family and domain databases
InterPro	IPR016719. Ca_signal-mod_cyclophilin_lig. [Graphical view]
PIRSF	PIRSF018259. CAML. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00091. Cyclosporine.
NextBio	3352.
PMAP-CutDB	P49069.
SOURCE	Search...

Entry information

Entry name

CAMLG_HUMAN

Accession

Primary (citable) accession number: P49069

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.