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Protein

Calcium signal-modulating cyclophilin ligand

Gene

CAMLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

GO - Biological processi

  • defense response Source: ProtInc
  • epidermal growth factor receptor signaling pathway Source: Ensembl
  • receptor recycling Source: Ensembl
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164615-MONOMER.

Protein family/group databases

TCDBi3.A.19.1.1. the tms recognition/insertion complex (trc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium signal-modulating cyclophilin ligand
Short name:
CAML
Gene namesi
Name:CAMLG
Synonyms:CAML
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1471. CAMLG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189CytoplasmicSequence analysisAdd BLAST189
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 240ExtracellularSequence analysisAdd BLAST30
Transmembranei241 – 257HelicalSequence analysisAdd BLAST17
Topological domaini258 – 296CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi819.
OpenTargetsiENSG00000164615.
PharmGKBiPA26053.

Chemistry databases

DrugBankiDB00091. Cyclosporine.

Polymorphism and mutation databases

BioMutaiCAMLG.
DMDMi1345662.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892911 – 296Calcium signal-modulating cyclophilin ligandAdd BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP49069.
MaxQBiP49069.
PaxDbiP49069.
PeptideAtlasiP49069.
PRIDEiP49069.

PTM databases

iPTMnetiP49069.
PhosphoSitePlusiP49069.

Miscellaneous databases

PMAP-CutDBP49069.

Expressioni

Tissue specificityi

Ubiquitous. Highest levels in brain, testis and ovary.

Gene expression databases

BgeeiENSG00000164615.
CleanExiHS_CAMLG.
ExpressionAtlasiP49069. baseline and differential.
GenevisibleiP49069. HS.

Organism-specific databases

HPAiHPA052636.
HPA056472.

Interactioni

Subunit structurei

The N-terminal domain binds to TNFRSF13B/TACI. Interacts with human herpes virus 8/HHV-8 protein K7; this interaction modulates intracellular calcium concentration.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-1748958,EBI-297353
IER3P466952EBI-1748958,EBI-1748945
KCNA2P163893EBI-1748958,EBI-10210559

Protein-protein interaction databases

BioGridi107269. 16 interactors.
IntActiP49069. 15 interactors.
STRINGi9606.ENSP00000297156.

Structurei

3D structure databases

ProteinModelPortaliP49069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49069.
OMAiHHGLEQY.
OrthoDBiEOG091G0HL4.
PhylomeDBiP49069.
TreeFamiTF331902.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.

Sequencei

Sequence statusi: Complete.

P49069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF
60 70 80 90 100
HRPGSGAEEE SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG
110 120 130 140 150
GVAEVKGTQL GDKLDSFIKP PECSSDVNLE LRQRNRGDLT ADSVQRGSRH
160 170 180 190 200
GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN TTEEFDSFRI FRLVGCALLA
210 220 230 240 250
LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT TVLTAALLLS
260 270 280 290
GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP
Length:296
Mass (Da):32,953
Last modified:February 1, 1996 - v1
Checksum:i22DCD8CF022FEF09
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02429778V → I.Corresponds to variant rs12657663dbSNPEnsembl.1
Natural variantiVAR_050710100G → S.Corresponds to variant rs11552197dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA. Translation: AAA59420.1.
AK313156 mRNA. Translation: BAG35974.1.
CH471062 Genomic DNA. Translation: EAW62243.1.
CH471062 Genomic DNA. Translation: EAW62244.1.
BC130325 mRNA. Translation: AAI30326.1.
AF068179 mRNA. Translation: AAC23596.1.
CCDSiCCDS4178.1.
PIRiS47594.
RefSeqiNP_001736.1. NM_001745.3.
UniGeneiHs.529846.

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615.
GeneIDi819.
KEGGihsa:819.
UCSCiuc003kzt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18242 mRNA. Translation: AAA59420.1.
AK313156 mRNA. Translation: BAG35974.1.
CH471062 Genomic DNA. Translation: EAW62243.1.
CH471062 Genomic DNA. Translation: EAW62244.1.
BC130325 mRNA. Translation: AAI30326.1.
AF068179 mRNA. Translation: AAC23596.1.
CCDSiCCDS4178.1.
PIRiS47594.
RefSeqiNP_001736.1. NM_001745.3.
UniGeneiHs.529846.

3D structure databases

ProteinModelPortaliP49069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107269. 16 interactors.
IntActiP49069. 15 interactors.
STRINGi9606.ENSP00000297156.

Chemistry databases

DrugBankiDB00091. Cyclosporine.

Protein family/group databases

TCDBi3.A.19.1.1. the tms recognition/insertion complex (trc) family.

PTM databases

iPTMnetiP49069.
PhosphoSitePlusiP49069.

Polymorphism and mutation databases

BioMutaiCAMLG.
DMDMi1345662.

Proteomic databases

EPDiP49069.
MaxQBiP49069.
PaxDbiP49069.
PeptideAtlasiP49069.
PRIDEiP49069.

Protocols and materials databases

DNASUi819.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000297156; ENSP00000297156; ENSG00000164615.
GeneIDi819.
KEGGihsa:819.
UCSCiuc003kzt.4. human.

Organism-specific databases

CTDi819.
DisGeNETi819.
GeneCardsiCAMLG.
H-InvDBHIX0164331.
HGNCiHGNC:1471. CAMLG.
HPAiHPA052636.
HPA056472.
MIMi601118. gene.
neXtProtiNX_P49069.
OpenTargetsiENSG00000164615.
PharmGKBiPA26053.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEK3. Eukaryota.
ENOG4111HUY. LUCA.
GeneTreeiENSGT00390000015996.
HOGENOMiHOG000220891.
HOVERGENiHBG050786.
InParanoidiP49069.
OMAiHHGLEQY.
OrthoDBiEOG091G0HL4.
PhylomeDBiP49069.
TreeFamiTF331902.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164615-MONOMER.

Miscellaneous databases

ChiTaRSiCAMLG. human.
GeneWikiiCAMLG.
GenomeRNAii819.
PMAP-CutDBP49069.
PROiP49069.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164615.
CleanExiHS_CAMLG.
ExpressionAtlasiP49069. baseline and differential.
GenevisibleiP49069. HS.

Family and domain databases

InterProiIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PANTHERiPTHR15026. PTHR15026. 1 hit.
PfamiPF14963. CAML. 1 hit.
[Graphical view]
PIRSFiPIRSF018259. CAML. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAMLG_HUMAN
AccessioniPrimary (citable) accession number: P49069
Secondary accession number(s): A1L3Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.