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P49069 (CAMLG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium signal-modulating cyclophilin ligand

Short name=CAML
Gene names
Name:CAMLG
Synonyms:CAML
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.

Subunit structure

The N-terminal domain binds to TNFRSF13B/TACI.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous. Highest levels in brain, testis and ovary.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdefense response

Traceable author statement. Source: ProtInc

   Cellular componentendoplasmic reticulum

Inferred from direct assay. Source: MGI

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionprotein binding

Inferred from physical interaction. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

IER3P466952EBI-1748958,EBI-1748945

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Calcium signal-modulating cyclophilin ligand
PRO_0000089291

Regions

Topological domain1 – 189189Cytoplasmic Potential
Transmembrane190 – 21021Helical; Potential
Topological domain211 – 24030Extracellular Potential
Transmembrane241 – 25717Helical; Potential
Topological domain258 – 29639Cytoplasmic Potential

Natural variations

Natural variant781V → I.
Corresponds to variant rs12657663 [ dbSNP | Ensembl ].
VAR_024297
Natural variant1001G → S.
Corresponds to variant rs11552197 [ dbSNP | Ensembl ].
VAR_050710

Sequences

Sequence LengthMass (Da)Tools
P49069 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 22DCD8CF022FEF09

FASTA29632,953
        10         20         30         40         50         60 
MESMAVATDG GERPGVPAGS GLSASQRRAE LRRRKLLMNS EQRINRIMGF HRPGSGAEEE 

        70         80         90        100        110        120 
SQTKSKQQDS DKLNSLSVPS VSKRVVLGDS VSTGTTDQQG GVAEVKGTQL GDKLDSFIKP 

       130        140        150        160        170        180 
PECSSDVNLE LRQRNRGDLT ADSVQRGSRH GLEQYLSRFE EAMKLRKQLI SEKPSQEDGN 

       190        200        210        220        230        240 
TTEEFDSFRI FRLVGCALLA LGVRAFVCKY LSIFAPFLTL QLAYMGLYKY FPKSEKKIKT 

       250        260        270        280        290 
TVLTAALLLS GIPAEVINRS MDTYSKMGEV FTDLCVYFFT FIFCHELLDY WGSEVP 

« Hide

References

« Hide 'large scale' references
[1]"Calcium signalling in T cells stimulated by a cyclophilin B-binding protein."
Bram R.J., Crabtree G.R.
Nature 371:355-358(1994) [PubMed: 7522304] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"An immature transcript of the CAMLG gene."
Morales V.M., Blumberg R.S.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-296.
Tissue: Colon adenocarcinoma.
[3]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18242 mRNA. Translation: AAA59420.1.
AF068179 mRNA. Translation: AAC23596.1.
IPIIPI00025729.
PIRS47594.
RefSeqNP_001736.1. NM_001745.3.
UniGeneHs.529846.

3D structure databases

ProteinModelPortalP49069.
ModBaseSearch...

Protein-protein interaction databases

IntActP49069. 6 interactions.
STRINGP49069.

PTM databases

PhosphoSiteP49069.

Polymorphism databases

DMDM1345662.

Proteomic databases

PRIDEP49069.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297156; ENSP00000297156; ENSG00000164615.
GeneID819.
KEGGhsa:819.
UCSCuc003kzt.1. human.

Organism-specific databases

CTD819.
GeneCardsGC05P134074.
H-InvDBHIX0200779.
HGNCHGNC:1471. CAMLG.
MIM601118. gene.
neXtProtNX_P49069.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00390000015996.
HOGENOMHBG445350.
HOVERGENHBG050786.
InParanoidP49069.
OMAKPSQEDG.
OrthoDBEOG4CNQS0.
PhylomeDBP49069.

Gene expression databases

ArrayExpressP49069.
BgeeP49069.
CleanExHS_CAMLG.
GenevestigatorP49069.
GermOnlineENSG00000164615. Homo sapiens.

Family and domain databases

InterProIPR016719. Ca_signal-mod_cyclophilin_lig.
[Graphical view]
PIRSFPIRSF018259. CAML. 1 hit.
ProtoNetSearch...

Other

DrugBankDB00091. Cyclosporine.
NextBio3352.
PMAP-CutDBP49069.
SOURCESearch...

Entry information

Entry nameCAMLG_HUMAN
AccessionPrimary (citable) accession number: P49069
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 25, 2012
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot