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P49068 (MT1A_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Metallothionein-1A
Short name=MT-1A
Alternative name(s):
Metallothionein-IA
Short name=MT-IA
Gene names
Name:MT1A
Synonyms:MT1
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.

Subunit structure

Monomer.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6161Metallothionein-1A
PRO_0000197208

Regions

Region1 – 2929Beta
Region30 – 6132Alpha

Sites

Metal binding51Divalent metal cation; cluster B
Metal binding71Divalent metal cation; cluster B
Metal binding131Divalent metal cation; cluster B
Metal binding151Divalent metal cation; cluster B
Metal binding191Divalent metal cation; cluster B
Metal binding211Divalent metal cation; cluster B
Metal binding241Divalent metal cation; cluster B
Metal binding261Divalent metal cation; cluster B
Metal binding291Divalent metal cation; cluster B
Metal binding331Divalent metal cation; cluster A
Metal binding341Divalent metal cation; cluster A
Metal binding361Divalent metal cation; cluster A
Metal binding371Divalent metal cation; cluster A
Metal binding411Divalent metal cation; cluster A
Metal binding441Divalent metal cation; cluster A
Metal binding481Divalent metal cation; cluster A
Metal binding501Divalent metal cation; cluster A
Metal binding571Divalent metal cation; cluster A
Metal binding591Divalent metal cation; cluster A
Metal binding601Divalent metal cation; cluster A

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Experimental info

Sequence conflict131C → R in BAA19177. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P49068 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: BC5643119BDF7122

FASTA615,969
        10         20         30         40         50         60 
MDPNCSCPTG GSCSCAGSCT CKACRCTSCK KSCCSCCPAG CARCAQGCIC KGASDKCSCC 


A

« Hide

References

[1]"Change in hepatic gene expression after shock/resuscitation."
Buchman T.G., Cabin D.E., Porter J.M., Bulkley G.B.
Surgery 106:283-290(1989) [PubMed: 2474864] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Multiple isoforms of metallothionein are expressed in the porcine liver."
Huang M.-C., Pan P.K., Zheng T.F., Chen N.C., Peng J.Y., Huang P.C.
Gene 211:49-55(1998) [PubMed: 9573337] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M29515 mRNA. Translation: AAA02939.1.
AB000786 mRNA. Translation: BAA19176.1.
AB000787 mRNA. Translation: BAA19177.1.
PIRI46602.
RefSeqNP_001001266.1. NM_001001266.1.
UniGeneSsc.15694.
Ssc.9079.

3D structure databases

ProteinModelPortalP49068.
SMRP49068. Positions 1-61.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397417.
KEGGssc:397417.

Organism-specific databases

CTD4489.

Phylogenomic databases

HOVERGENHBG009063.

Family and domain databases

InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
Gene3DG3DSA:4.10.10.10. Metallothionein_vert. 1 hit.
KOK14739.
PANTHERPTHR23299. Metallothionein_vert. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. Metallothionein_sfam. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMT1A_PIG
AccessionPrimary (citable) accession number: P49068
Secondary accession number(s): P79375
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Metallothioneins

Classification of metallothioneins and list of entries

SIMILARITY comments

Index of protein domains and families

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