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Protein

Serum albumin

Gene

ALB

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi271 – 2711ZincBy similarity
Metal bindingi273 – 2731ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei759. Ory c 6.

Chemistry

ChEMBLiCHEMBL6104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 246By similarityPRO_0000001077
Chaini25 – 608584Serum albuminPRO_0000001078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei89 – 891PhosphoserineBy similarity
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Modified residuei107 – 1071PhosphothreonineBy similarity
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Modified residuei229 – 2291N6-succinyllysineBy similarity
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Modified residuei297 – 2971PhosphoserineBy similarity
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443 – 4431PhosphoserineBy similarity
Modified residuei444 – 4441PhosphothreonineBy similarity
Modified residuei446 – 4461PhosphothreonineBy similarity
Modified residuei460 – 4601N6-succinyllysineBy similarity
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Modified residuei513 – 5131PhosphoserineBy similarity
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei570 – 5701PhosphothreonineBy similarity
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588 – 5881N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP49065.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014006.

Structurei

Secondary structure

1
608
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 5425Combined sources
Helixi60 – 7920Combined sources
Turni84 – 874Combined sources
Helixi90 – 9910Combined sources
Turni105 – 1073Combined sources
Helixi110 – 1145Combined sources
Helixi121 – 1288Combined sources
Helixi144 – 15310Combined sources
Helixi155 – 16915Combined sources
Helixi175 – 19218Combined sources
Beta strandi195 – 1973Combined sources
Helixi198 – 23033Combined sources
Helixi232 – 24615Combined sources
Helixi252 – 27019Combined sources
Helixi274 – 29017Combined sources
Helixi292 – 2943Combined sources
Helixi297 – 3015Combined sources
Turni302 – 3043Combined sources
Helixi307 – 31610Combined sources
Helixi330 – 3334Combined sources
Helixi339 – 3457Combined sources
Helixi347 – 36014Combined sources
Helixi367 – 38519Combined sources
Beta strandi387 – 3893Combined sources
Helixi390 – 3945Combined sources
Turni395 – 3984Combined sources
Helixi399 – 4013Combined sources
Helixi402 – 43837Combined sources
Helixi444 – 46118Combined sources
Helixi466 – 49025Combined sources
Helixi495 – 5039Combined sources
Helixi508 – 5136Combined sources
Helixi528 – 5303Combined sources
Helixi536 – 5394Combined sources
Helixi542 – 55918Combined sources
Helixi565 – 58218Combined sources
Beta strandi585 – 5873Combined sources
Helixi588 – 60619Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V09X-ray2.27A25-608[»]
ProteinModelPortaliP49065.
SMRiP49065. Positions 26-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 210192Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 403193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP49065.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRREAHKSE IAHRFNDVGE EHFIGLVLIT
60 70 80 90 100
FSQYLQKCPY EEHAKLVKEV TDLAKACVAD ESAANCDKSL HDIFGDKICA
110 120 130 140 150
LPSLRDTYGD VADCCEKKEP ERNECFLHHK DDKPDLPPFA RPEADVLCKA
160 170 180 190 200
FHDDEKAFFG HYLYEVARRH PYFYAPELLY YAQKYKAILT ECCEAADKGA
210 220 230 240 250
CLTPKLDALE GKSLISAAQE RLRCASIQKF GDRAYKAWAL VRLSQRFPKA
260 270 280 290 300
DFTDISKIVT DLTKVHKECC HGDLLECADD RADLAKYMCE HQETISSHLK
310 320 330 340 350
ECCDKPILEK AHCIYGLHND ETPAGLPAVA EEFVEDKDVC KNYEEAKDLF
360 370 380 390 400
LGKFLYEYSR RHPDYSVVLL LRLGKAYEAT LKKCCATDDP HACYAKVLDE
410 420 430 440 450
FQPLVDEPKN LVKQNCELYE QLGDYNFQNA LLVRYTKKVP QVSTPTLVEI
460 470 480 490 500
SRSLGKVGSK CCKHPEAERL PCVEDYLSVV LNRLCVLHEK TPVSEKVTKC
510 520 530 540 550
CSESLVDRRP CFSALGPDET YVPKEFNAET FTFHADICTL PETERKIKKQ
560 570 580 590 600
TALVELVKHK PHATNDQLKT VVGEFTALLD KCCSAEDKEA CFAVEGPKLV

ESSKATLG
Length:608
Mass (Da):68,910
Last modified:March 1, 2004 - v2
Checksum:i9EECAFDA86B1EF09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18344 mRNA. Translation: AAB58347.2.
RefSeqiNP_001075813.1. NM_001082344.1.
UniGeneiOcu.3074.

Genome annotation databases

GeneIDi100009195.
KEGGiocu:100009195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18344 mRNA. Translation: AAB58347.2.
RefSeqiNP_001075813.1. NM_001082344.1.
UniGeneiOcu.3074.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3V09X-ray2.27A25-608[»]
ProteinModelPortaliP49065.
SMRiP49065. Positions 26-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000014006.

Chemistry

ChEMBLiCHEMBL6104.

Protein family/group databases

Allergomei759. Ory c 6.

Proteomic databases

PRIDEiP49065.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009195.
KEGGiocu:100009195.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP49065.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin."
    Syed S., Schuyler P.D., Kulczycky M., Sheffield W.P.
    Blood 89:3243-3252(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: New Zealand white.
    Tissue: Liver.
  2. Sheffield W.P.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 322-323 AND 506-507.

Entry informationi

Entry nameiALBU_RABIT
AccessioniPrimary (citable) accession number: P49065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 1, 2004
Last modified: December 9, 2015
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.