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P49065 (ALBU_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serum albumin
Gene names
Name:ALB
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Contains 3 albumin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 224 By similarity
PRO_0000001077
Chain25 – 608584Serum albumin
PRO_0000001078

Regions

Domain19 – 210192Albumin 1
Domain211 – 403193Albumin 2
Domain404 – 601198Albumin 3

Sites

Metal binding271Copper
Metal binding911Zinc By similarity
Metal binding1231Zinc By similarity
Metal binding2711Zinc By similarity
Metal binding2731Zinc By similarity

Amino acid modifications

Modified residue821Phosphoserine By similarity
Modified residue4431Phosphoserine By similarity
Modified residue4441Phosphothreonine By similarity
Modified residue4461Phosphothreonine By similarity
Disulfide bond77 ↔ 86 By similarity
Disulfide bond99 ↔ 115 By similarity
Disulfide bond114 ↔ 125 By similarity
Disulfide bond148 ↔ 193 By similarity
Disulfide bond192 ↔ 201 By similarity
Disulfide bond224 ↔ 270 By similarity
Disulfide bond269 ↔ 277 By similarity
Disulfide bond289 ↔ 303 By similarity
Disulfide bond302 ↔ 313 By similarity
Disulfide bond340 ↔ 385 By similarity
Disulfide bond384 ↔ 393 By similarity
Disulfide bond416 ↔ 462 By similarity
Disulfide bond461 ↔ 472 By similarity
Disulfide bond485 ↔ 501 By similarity
Disulfide bond500 ↔ 511 By similarity
Disulfide bond538 ↔ 583 By similarity
Disulfide bond582 ↔ 591 By similarity

Secondary structure

1 ...................................................................... 608
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P49065 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 9EECAFDA86B1EF09

FASTA60868,910
        10         20         30         40         50         60 
MKWVTFISLL FLFSSAYSRG VFRREAHKSE IAHRFNDVGE EHFIGLVLIT FSQYLQKCPY 

        70         80         90        100        110        120 
EEHAKLVKEV TDLAKACVAD ESAANCDKSL HDIFGDKICA LPSLRDTYGD VADCCEKKEP 

       130        140        150        160        170        180 
ERNECFLHHK DDKPDLPPFA RPEADVLCKA FHDDEKAFFG HYLYEVARRH PYFYAPELLY 

       190        200        210        220        230        240 
YAQKYKAILT ECCEAADKGA CLTPKLDALE GKSLISAAQE RLRCASIQKF GDRAYKAWAL 

       250        260        270        280        290        300 
VRLSQRFPKA DFTDISKIVT DLTKVHKECC HGDLLECADD RADLAKYMCE HQETISSHLK 

       310        320        330        340        350        360 
ECCDKPILEK AHCIYGLHND ETPAGLPAVA EEFVEDKDVC KNYEEAKDLF LGKFLYEYSR 

       370        380        390        400        410        420 
RHPDYSVVLL LRLGKAYEAT LKKCCATDDP HACYAKVLDE FQPLVDEPKN LVKQNCELYE 

       430        440        450        460        470        480 
QLGDYNFQNA LLVRYTKKVP QVSTPTLVEI SRSLGKVGSK CCKHPEAERL PCVEDYLSVV 

       490        500        510        520        530        540 
LNRLCVLHEK TPVSEKVTKC CSESLVDRRP CFSALGPDET YVPKEFNAET FTFHADICTL 

       550        560        570        580        590        600 
PETERKIKKQ TALVELVKHK PHATNDQLKT VVGEFTALLD KCCSAEDKEA CFAVEGPKLV 


ESSKATLG

« Hide

References

[1]"Potent antithrombin activity and delayed clearance from the circulation characterize recombinant hirudin genetically fused to albumin."
Syed S., Schuyler P.D., Kulczycky M., Sheffield W.P.
Blood 89:3243-3252(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: New Zealand white.
Tissue: Liver.
[2]Sheffield W.P.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 322-323 AND 506-507.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U18344 mRNA. Translation: AAB58347.2.
RefSeqNP_001075813.1. NM_001082344.1.
UniGeneOcu.3074.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3V09X-ray2.27A25-608[»]
ProteinModelPortalP49065.
SMRP49065. Positions 26-608.
ModBaseSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000014006.

Protein family/group databases

Allergome759. Ory c 6.

Proteomic databases

PRIDEP49065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009195.

Organism-specific databases

CTD213.

Phylogenomic databases

eggNOGNOG45992.
HOGENOMHOG000293137.
HOVERGENHBG004207.
OrthoDBEOG4Z0B55.

Family and domain databases

InterProIPR000264. ALB/AFP/VDB.
IPR001703. Alpha-fetoprotein.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMSSF48552. Serum_albumin. 3 hits.
PROSITEPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChEMBLCHEMBL6104.

Entry information

Entry nameALBU_RABIT
AccessionPrimary (citable) accession number: P49065
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 1, 2004
Last modified: May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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