Serum albumin precursor - Felis catus (Cat)

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P49064 (ALBU_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 83. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serum albumin

Alternative name(s):
Allergen=Fel d 2

Gene names

Name:

ALB

Organism

Felis catus (Cat) (Felis silvestris catus) [Complete proteome]

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	608 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca²⁺, Na⁺, K⁺, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Subcellular location	Secreted.
Tissue specificity	Plasma.
Post-translational modification	Phosphorylation sites are present in the extracellular medium By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the ALB/AFP/VDB family. Contains 3 albumin domains.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Repeat Signal
Ligand	Copper Lipid-binding Metal-binding Zinc
PTM	Cleavage on pair of basic residues Disulfide bond Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular response to starvation Inferred from sequence or structural similarity. Source: UniProtKB hemolysis by symbiont of host erythrocytes Inferred from sequence or structural similarity. Source: UniProtKB maintenance of mitochondrion location Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of apoptotic process Inferred from sequence or structural similarity. Source: UniProtKB transport Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular space Inferred from electronic annotation. Source: InterPro protein complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB drug binding Inferred from sequence or structural similarity. Source: UniProtKB fatty acid binding Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW pyridoxal phosphate binding Inferred from sequence or structural similarity. Source: UniProtKB toxin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

By similarity

Propeptide

19 – 22

By similarity

PRO_0000001063

Chain

25 – 608

584

Serum albumin

PRO_0000001064

Regions

Domain

19 – 210

192

Albumin 1

Domain

211 – 403

193

Albumin 2

Domain

404 – 601

198

Albumin 3

Sites

Metal binding

Copper

Metal binding

Zinc By similarity

Metal binding

123

Zinc By similarity

Metal binding

271

Zinc By similarity

Metal binding

273

Zinc By similarity

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

443

Phosphoserine By similarity

Modified residue

444

Phosphothreonine By similarity

Modified residue

446

Phosphothreonine By similarity

Disulfide bond

77 ↔ 86

By similarity

Disulfide bond

99 ↔ 115

By similarity

Disulfide bond

114 ↔ 125

By similarity

Disulfide bond

148 ↔ 193

By similarity

Disulfide bond

192 ↔ 201

By similarity

Disulfide bond

224 ↔ 270

By similarity

Disulfide bond

269 ↔ 277

By similarity

Disulfide bond

289 ↔ 303

By similarity

Disulfide bond

302 ↔ 313

By similarity

Disulfide bond

340 ↔ 385

By similarity

Disulfide bond

384 ↔ 393

By similarity

Disulfide bond

416 ↔ 462

By similarity

Disulfide bond

461 ↔ 472

By similarity

Disulfide bond

485 ↔ 501

By similarity

Disulfide bond

500 ↔ 511

By similarity

Disulfide bond

538 ↔ 583

By similarity

Disulfide bond

582 ↔ 591

By similarity

Experimental info

Sequence conflict

K → N in CAD32275. Ref.2

Sequence conflict

L → F in CAD32275. Ref.2

Sequence conflict

186

K → R in CAD32275. Ref.2

Sequence conflict

251

E → D in CAD32275. Ref.2

Sequence conflict

282

A → E in CAD32275. Ref.2

Sequence conflict

331

V → A in CAD32275. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P49064 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 07E629CAC5F60E5F
Show »

FASTA

608

68,659

        10         20         30         40         50         60 
MKWVTFISLL LLFSSAYSRG VTRREAHQSE IAHRFNDLGE EHFRGLVLVA FSQYLQQCPF 

        70         80         90        100        110        120 
EDHVKLVNEV TEFAKGCVAD QSAANCEKSL HELLGDKLCT VASLRDKYGE MADCCEKKEP 

       130        140        150        160        170        180 
ERNECFLQHK DDNPGFGQLV TPEADAMCTA FHENEQRFLG KYLYEIARRH PYFYAPELLY 

       190        200        210        220        230        240 
YAEEYKGVFT ECCEAADKAA CLTPKVDALR EKVLASSAKE RLKCASLQKF GERAFKAWSV 

       250        260        270        280        290        300 
ARLSQKFPKA EFAEISKLVT DLAKIHKECC HGDLLECADD RADLAKYICE NQDSISTKLK 

       310        320        330        340        350        360 
ECCGKPVLEK SHCISEVERD ELPADLPPLA VDFVEDKEVC KNYQEAKDVF LGTFLYEYSR 

       370        380        390        400        410        420 
RHPEYSVSLL LRLAKEYEAT LEKCCATDDP PACYAHVFDE FKPLVEEPHN LVKTNCELFE 

       430        440        450        460        470        480 
KLGEYGFQNA LLVRYTKKVP QVSTPTLVEV SRSLGKVGSK CCTHPEAERL SCAEDYLSVV 

       490        500        510        520        530        540 
LNRLCVLHEK TPVSERVTKC CTESLVNRRP CFSALQVDET YVPKEFSAET FTFHADLCTL 

       550        560        570        580        590        600 
PEAEKQIKKQ SALVELLKHK PKATEEQLKT VMGDFGSFVD KCCAAEDKEA CFAEEGPKLV 


AAAQAALA

« Hide

References

[1]

"Sequence of the gene encoding cat (Felis domesticus) serum albumin."
Hilger C., Grigioni F., Kohnen M., Hentges F.
Gene 169:295-296(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[2]

"Escherichia coli expression and purification of recombinant cat albumin:IgE recognition, induction of basophil activation and lymphoproliferative responses in atopic patients."
Reininger R., Swoboda I., Bohle B., Hauswirth A.W., Valent P., Rumpold H., Valenta R., Spitzauer S.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-608.
Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X84842 mRNA. Translation: CAA59279.1. AJ487677 mRNA. Translation: CAD32275.1.
PIR	S57632. JC4660.
RefSeq	NP_001009961.1. NM_001009961.1.
3D structure databases
ProteinModelPortal	P49064.
SMR	P49064. Positions 26-608.
ModBase	Search...
Protein-protein interaction databases
STRING	9685.ENSFCAP00000011000.
Protein family/group databases
Allergome	3279. Fel d 2.0101. 346. Fel d 2.
Proteomic databases
PRIDE	P49064.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	448843.
KEGG	fca:448843.
Organism-specific databases
CTD	213.
Phylogenomic databases
eggNOG	NOG45992.
HOVERGEN	HBG004207.
KO	K16141.
Family and domain databases
InterPro	IPR000264. ALB/AFP/VDB. IPR020858. Serum_albumin-like. IPR021177. Serum_albumin/AFP. IPR020857. Serum_albumin_CS. IPR014760. Serum_albumin_N. [Graphical view]
Pfam	PF00273. Serum_albumin. 3 hits. [Graphical view]
PIRSF	PIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTS	PR00802. SERUMALBUMIN.
SMART	SM00103. ALBUMIN. 3 hits. [Graphical view]
SUPFAM	SSF48552. Serum_albumin. 3 hits.
PROSITE	PS00212. ALBUMIN_1. 3 hits. PS51438. ALBUMIN_2. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALBU_FELCA

Accession

Primary (citable) accession number: P49064
Secondary accession number(s): Q7YSG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Allergens

Nomenclature of allergens and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents