Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serum albumin

Gene

ALB

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Copper
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi271 – 2711ZincBy similarity
Metal bindingi273 – 2731ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Fel d 2
Gene namesi
Name:ALB
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3279. Fel d 2.0101.
346. Fel d 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 246By similarityPRO_0000001063
Chaini25 – 608584Serum albuminPRO_0000001064Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei89 – 891PhosphoserineBy similarity
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Modified residuei229 – 2291N6-succinyllysineBy similarity
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443 – 4431PhosphoserineBy similarity
Modified residuei444 – 4441PhosphothreonineBy similarity
Modified residuei446 – 4461PhosphothreonineBy similarity
Modified residuei460 – 4601N6-succinyllysineBy similarity
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Modified residuei513 – 5131PhosphoserineBy similarity
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei570 – 5701PhosphothreonineBy similarity
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588 – 5881N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP49064.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011000.

Structurei

3D structure databases

ProteinModelPortaliP49064.
SMRiP49064. Positions 26-608.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 210192Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 403193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 601198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOVERGENiHBG004207.
InParanoidiP49064.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VTRREAHQSE IAHRFNDLGE EHFRGLVLVA
60 70 80 90 100
FSQYLQQCPF EDHVKLVNEV TEFAKGCVAD QSAANCEKSL HELLGDKLCT
110 120 130 140 150
VASLRDKYGE MADCCEKKEP ERNECFLQHK DDNPGFGQLV TPEADAMCTA
160 170 180 190 200
FHENEQRFLG KYLYEIARRH PYFYAPELLY YAEEYKGVFT ECCEAADKAA
210 220 230 240 250
CLTPKVDALR EKVLASSAKE RLKCASLQKF GERAFKAWSV ARLSQKFPKA
260 270 280 290 300
EFAEISKLVT DLAKIHKECC HGDLLECADD RADLAKYICE NQDSISTKLK
310 320 330 340 350
ECCGKPVLEK SHCISEVERD ELPADLPPLA VDFVEDKEVC KNYQEAKDVF
360 370 380 390 400
LGTFLYEYSR RHPEYSVSLL LRLAKEYEAT LEKCCATDDP PACYAHVFDE
410 420 430 440 450
FKPLVEEPHN LVKTNCELFE KLGEYGFQNA LLVRYTKKVP QVSTPTLVEV
460 470 480 490 500
SRSLGKVGSK CCTHPEAERL SCAEDYLSVV LNRLCVLHEK TPVSERVTKC
510 520 530 540 550
CTESLVNRRP CFSALQVDET YVPKEFSAET FTFHADLCTL PEAEKQIKKQ
560 570 580 590 600
SALVELLKHK PKATEEQLKT VMGDFGSFVD KCCAAEDKEA CFAEEGPKLV

AAAQAALA
Length:608
Mass (Da):68,659
Last modified:February 1, 1996 - v1
Checksum:i07E629CAC5F60E5F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751K → N in CAD32275 (Ref. 2) Curated
Sequence conflicti94 – 941L → F in CAD32275 (Ref. 2) Curated
Sequence conflicti186 – 1861K → R in CAD32275 (Ref. 2) Curated
Sequence conflicti251 – 2511E → D in CAD32275 (Ref. 2) Curated
Sequence conflicti282 – 2821A → E in CAD32275 (Ref. 2) Curated
Sequence conflicti331 – 3311V → A in CAD32275 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84842 mRNA. Translation: CAA59279.1.
AJ487677 mRNA. Translation: CAD32275.1.
PIRiJC4660. S57632.
RefSeqiNP_001009961.1. NM_001009961.1.

Genome annotation databases

GeneIDi448843.
KEGGifca:448843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84842 mRNA. Translation: CAA59279.1.
AJ487677 mRNA. Translation: CAD32275.1.
PIRiJC4660. S57632.
RefSeqiNP_001009961.1. NM_001009961.1.

3D structure databases

ProteinModelPortaliP49064.
SMRiP49064. Positions 26-608.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011000.

Protein family/group databases

Allergomei3279. Fel d 2.0101.
346. Fel d 2.

Proteomic databases

PRIDEiP49064.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448843.
KEGGifca:448843.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOVERGENiHBG004207.
InParanoidiP49064.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequence of the gene encoding cat (Felis domesticus) serum albumin."
    Hilger C., Grigioni F., Kohnen M., Hentges F.
    Gene 169:295-296(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Escherichia coli expression and purification of recombinant cat albumin:IgE recognition, induction of basophil activation and lymphoproliferative responses in atopic patients."
    Reininger R., Swoboda I., Bohle B., Hauswirth A.W., Valent P., Rumpold H., Valenta R., Spitzauer S.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-608.
    Tissue: Liver.

Entry informationi

Entry nameiALBU_FELCA
AccessioniPrimary (citable) accession number: P49064
Secondary accession number(s): Q7YSG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 11, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.