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Protein

Serum albumin

Gene

ALB

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Copper1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi271ZincBy similarity1
Metal bindingi273ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Alternative name(s):
Allergen: Fel d 2
Gene namesi
Name:ALB
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3279 Fel d 2.0101
346 Fel d 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000106319 – 24By similarity6
ChainiPRO_000000106425 – 608Serum albuminAdd BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
Modified residuei229N6-succinyllysineBy similarity1
Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
Modified residuei443PhosphoserineBy similarity1
Modified residuei444PhosphothreonineBy similarity1
Modified residuei446PhosphothreonineBy similarity1
Modified residuei460N6-succinyllysineBy similarity1
Disulfide bondi461 ↔ 472PROSITE-ProRule annotation
Disulfide bondi485 ↔ 501PROSITE-ProRule annotation
Disulfide bondi500 ↔ 511PROSITE-ProRule annotation
Modified residuei513PhosphoserineBy similarity1
Disulfide bondi538 ↔ 583PROSITE-ProRule annotation
Modified residuei558N6-methyllysineBy similarity1
Modified residuei570PhosphothreonineBy similarity1
Disulfide bondi582 ↔ 591PROSITE-ProRule annotation
Modified residuei588N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PRIDEiP49064

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000011000

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YXEX-ray3.40A25-608[»]
ProteinModelPortaliP49064
SMRiP49064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 210Albumin 1PROSITE-ProRule annotationAdd BLAST192
Domaini211 – 403Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini404 – 601Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOVERGENiHBG004207
InParanoidiP49064
KOiK16141

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VTRREAHQSE IAHRFNDLGE EHFRGLVLVA
60 70 80 90 100
FSQYLQQCPF EDHVKLVNEV TEFAKGCVAD QSAANCEKSL HELLGDKLCT
110 120 130 140 150
VASLRDKYGE MADCCEKKEP ERNECFLQHK DDNPGFGQLV TPEADAMCTA
160 170 180 190 200
FHENEQRFLG KYLYEIARRH PYFYAPELLY YAEEYKGVFT ECCEAADKAA
210 220 230 240 250
CLTPKVDALR EKVLASSAKE RLKCASLQKF GERAFKAWSV ARLSQKFPKA
260 270 280 290 300
EFAEISKLVT DLAKIHKECC HGDLLECADD RADLAKYICE NQDSISTKLK
310 320 330 340 350
ECCGKPVLEK SHCISEVERD ELPADLPPLA VDFVEDKEVC KNYQEAKDVF
360 370 380 390 400
LGTFLYEYSR RHPEYSVSLL LRLAKEYEAT LEKCCATDDP PACYAHVFDE
410 420 430 440 450
FKPLVEEPHN LVKTNCELFE KLGEYGFQNA LLVRYTKKVP QVSTPTLVEV
460 470 480 490 500
SRSLGKVGSK CCTHPEAERL SCAEDYLSVV LNRLCVLHEK TPVSERVTKC
510 520 530 540 550
CTESLVNRRP CFSALQVDET YVPKEFSAET FTFHADLCTL PEAEKQIKKQ
560 570 580 590 600
SALVELLKHK PKATEEQLKT VMGDFGSFVD KCCAAEDKEA CFAEEGPKLV

AAAQAALA
Length:608
Mass (Da):68,659
Last modified:February 1, 1996 - v1
Checksum:i07E629CAC5F60E5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75K → N in CAD32275 (Ref. 2) Curated1
Sequence conflicti94L → F in CAD32275 (Ref. 2) Curated1
Sequence conflicti186K → R in CAD32275 (Ref. 2) Curated1
Sequence conflicti251E → D in CAD32275 (Ref. 2) Curated1
Sequence conflicti282A → E in CAD32275 (Ref. 2) Curated1
Sequence conflicti331V → A in CAD32275 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84842 mRNA Translation: CAA59279.1
AJ487677 mRNA Translation: CAD32275.1
PIRiJC4660 S57632
RefSeqiNP_001009961.1, NM_001009961.1

Genome annotation databases

GeneIDi448843
KEGGifca:448843

Similar proteinsi

Entry informationi

Entry nameiALBU_FELCA
AccessioniPrimary (citable) accession number: P49064
Secondary accession number(s): Q7YSG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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