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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

guaA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.By similarity

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] (guaA)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei105 – 1051NucleophileBy similarity
Active sitei192 – 1921By similarity
Active sitei194 – 1941By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2527ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSSP1148:GJOT-2285-MONOMER.
UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.957.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:guaA
Ordered Locus Names:slr0213
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542GMP synthase [glutamine-hydrolyzing]PRO_0000140196Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiP49057. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP49057.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 218191Glutamine amidotransferase type-1Add
BLAST
Domaini219 – 417199GMPS ATP-PPaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000223965.
InParanoidiP49057.
KOiK01951.
OMAiMILVLDF.
PhylomeDBiP49057.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQIPVPPV VSDQALPDRI SDRLKGQIIV ILDFGSQYSE LIARRIRETE
60 70 80 90 100
VYSEVLSYRT TAQQLREIKP KGIILSGGPN SVYDQGAPEC DPEIFQLGVP
110 120 130 140 150
VLGVCYGMQL MVKQLGGRVE RAKRGEYGKA SLHIDDPTDL LTNVENDSTM
160 170 180 190 200
WMSHGDSCVD LPTGFEILAH TDNTPCAAIA DHQKALFGVQ FHPEVVHSVG
210 220 230 240 250
GIALIRNFVY HICHCEPTWT TAAFIEESIR EVRSQVGDRR VLLALSGGVD
260 270 280 290 300
SSTLAFLLHR AIGDNLTCMF IDQGFMRKGE PERLVELFDH QFHIPVQYVN
310 320 330 340 350
ARDRFLKQLE GVTDPEEKRR LIGHEFIQVF EEESNRLGPF DYLAQGTLYP
360 370 380 390 400
DVIESADSNV DPKTGERVAV KIKSHHNVGG LPKNLRFKLV EPLRKLFKDE
410 420 430 440 450
VRKLGRSIGL PEEIVRRHPF PGPGLAIRII GEVTSERLNI LRDADFIVRD
460 470 480 490 500
EISKRGIYHD YWQAFAVLLP IRSVGVMGDK RTYAHPVVLR FITSEDGMTA
510 520 530 540
DWARVPYDIL EAISNRIVNE VKGVNRVVYD ITSKPPGTIE WE
Length:542
Mass (Da):61,009
Last modified:February 1, 1996 - v1
Checksum:iA0C6F05EFA4C4863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10210.1.
PIRiS76358.

Genome annotation databases

EnsemblBacteriaiBAA10210; BAA10210; BAA10210.
KEGGisyn:slr0213.
PATRICi23841892. VBISynSp132158_2488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10210.1.
PIRiS76358.

3D structure databases

ProteinModelPortaliP49057.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49057. 3 interactions.

Protein family/group databases

MEROPSiC26.957.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10210; BAA10210; BAA10210.
KEGGisyn:slr0213.
PATRICi23841892. VBISynSp132158_2488.

Phylogenomic databases

HOGENOMiHOG000223965.
InParanoidiP49057.
KOiK01951.
OMAiMILVLDF.
PhylomeDBiP49057.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.
BioCyciSSP1148:GJOT-2285-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAA_SYNY3
AccessioniPrimary (citable) accession number: P49057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.