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P49053

- PRXC_CURIN

UniProt

P49053 - PRXC_CURIN

Protein

Vanadium chloroperoxidase

Gene

CPO

Organism
Curvularia inaequalis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + Cl- + H2O2 = RCl + 2 H2O.

    Cofactori

    Vanadium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei404 – 4041
    Metal bindingi496 – 4961Vanadium

    GO - Molecular functioni

    1. chloride peroxidase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase, Peroxidase

    Keywords - Ligandi

    Chloride, Metal-binding, Vanadium

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-15997.
    SABIO-RKP49053.

    Protein family/group databases

    PeroxiBasei5892. CinaVCPo.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vanadium chloroperoxidase (EC:1.11.1.10)
    Alternative name(s):
    Vanadium chloride peroxidase
    Short name:
    VCPO
    Gene namesi
    Name:CPO
    OrganismiCurvularia inaequalis
    Taxonomic identifieri38902 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeCurvularia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 609609Vanadium chloroperoxidasePRO_0000097055Add
    BLAST

    Post-translational modificationi

    The N-terminus is blocked.

    Structurei

    Secondary structure

    1
    609
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 205
    Helixi22 – 4019
    Helixi47 – 6822
    Beta strandi72 – 743
    Beta strandi77 – 793
    Helixi85 – 873
    Helixi98 – 11417
    Turni118 – 1258
    Helixi131 – 14717
    Helixi157 – 17317
    Turni176 – 1794
    Beta strandi202 – 2076
    Beta strandi215 – 2184
    Helixi226 – 2294
    Helixi248 – 2503
    Helixi254 – 26815
    Helixi280 – 2889
    Turni295 – 2973
    Helixi300 – 31415
    Beta strandi317 – 3193
    Beta strandi321 – 3233
    Helixi325 – 35632
    Helixi361 – 3666
    Turni371 – 3733
    Beta strandi388 – 3903
    Helixi403 – 41917
    Turni420 – 4223
    Beta strandi436 – 4405
    Beta strandi444 – 4474
    Beta strandi449 – 4535
    Helixi461 – 4633
    Beta strandi466 – 4683
    Beta strandi473 – 4775
    Helixi479 – 49214
    Helixi498 – 5014
    Helixi504 – 5074
    Helixi530 – 5323
    Beta strandi538 – 5414
    Beta strandi542 – 5443
    Helixi552 – 56514
    Helixi573 – 5753

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IDQX-ray2.03A1-609[»]
    1IDUX-ray2.24A1-609[»]
    1VNCX-ray2.10A1-609[»]
    1VNEX-ray2.15A1-609[»]
    1VNFX-ray2.35A1-609[»]
    1VNGX-ray2.20A1-609[»]
    1VNHX-ray2.11A1-609[»]
    1VNIX-ray2.15A1-609[»]
    1VNSX-ray1.66A1-609[»]
    3BB0X-ray1.50A1-609[»]
    ProteinModelPortaliP49053.
    SMRiP49053. Positions 3-578.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP49053.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.10.606.10. 1 hit.
    1.20.144.10. 1 hit.
    InterProiIPR016119. Br/Cl_peroxidase_C.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view]
    PfamiPF01569. PAP2. 1 hit.
    [Graphical view]
    SUPFAMiSSF48317. SSF48317. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P49053-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSVTPIPLP KIDEPEEYNT NYILFWNHVG LELNRVTHTV GGPLTGPPLS    50
    ARALGMLHLA IHDAYFSICP PTDFTTFLSP DTENAAYRLP SPNGANDARQ 100
    AVAGAALKML SSLYMKPVEQ PNPNPGANIS DNAYAQLGLV LDRSVLEAPG 150
    GVDRESASFM FGEDVADVFF ALLNDPRGAS QEGYHPTPGR YKFDDEPTHP 200
    VVLIPVDPNN PNGPKMPFRQ YHAPFYGKTT KRFATQSEHF LADPPGLRSN 250
    ADETAEYDDA VRVAIAMGGA QALNSTKRSP WQTAQGLYWA YDGSNLIGTP 300
    PRFYNQIVRR IAVTYKKEED LANSEVNNAD FARLFALVDV ACTDAGIFSW 350
    KEKWEFEFWR PLSGVRDDGR PDHGDPFWLT LGAPATNTND IPFKPPFPAY 400
    PSGHATFGGA VFQMVRRYYN GRVGTWKDDE PDNIAIDMMI SEELNGVNRD 450
    LRQPYDPTAP IEDQPGIVRT RIVRHFDSAW ELMFENAISR IFLGVHWRFD 500
    AAAARDILIP TTTKDVYAVD NNGATVFQNV EDIRYTTRGT REDPEGLFPI 550
    GGVPLGIEIA DEIFNNGLKP TPPEIQPMPQ ETPVQKPVGQ QPVKGMWEEE 600
    QAPVVKEAP 609
    Length:609
    Mass (Da):67,531
    Last modified:February 1, 1996 - v1
    Checksum:iA7B710DDF937D3E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti454 – 4541P → S AA sequence (PubMed:7744081)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85369 mRNA. Translation: CAA59686.1.
    PIRiS69334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85369 mRNA. Translation: CAA59686.1 .
    PIRi S69334.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IDQ X-ray 2.03 A 1-609 [» ]
    1IDU X-ray 2.24 A 1-609 [» ]
    1VNC X-ray 2.10 A 1-609 [» ]
    1VNE X-ray 2.15 A 1-609 [» ]
    1VNF X-ray 2.35 A 1-609 [» ]
    1VNG X-ray 2.20 A 1-609 [» ]
    1VNH X-ray 2.11 A 1-609 [» ]
    1VNI X-ray 2.15 A 1-609 [» ]
    1VNS X-ray 1.66 A 1-609 [» ]
    3BB0 X-ray 1.50 A 1-609 [» ]
    ProteinModelPortali P49053.
    SMRi P49053. Positions 3-578.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    PeroxiBasei 5892. CinaVCPo.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BioCyci MetaCyc:MONOMER-15997.
    SABIO-RK P49053.

    Miscellaneous databases

    EvolutionaryTracei P49053.

    Family and domain databases

    Gene3Di 1.10.606.10. 1 hit.
    1.20.144.10. 1 hit.
    InterProi IPR016119. Br/Cl_peroxidase_C.
    IPR000326. P_Acid_Pase_2/haloperoxidase.
    [Graphical view ]
    Pfami PF01569. PAP2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48317. SSF48317. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure and characterization of the vanadium chloroperoxidase from the fungus Curvularia inaequalis."
      Simons B.H., Barnett P., Vollenbroek E.G.M., Dekker H.L., Muijsers A.O., Messerschmidt A., Wever R.
      Eur. J. Biochem. 229:566-574(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    2. "X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis."
      Messerschmidt A., Wever R.
      Proc. Natl. Acad. Sci. U.S.A. 93:392-396(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

    Entry informationi

    Entry nameiPRXC_CURIN
    AccessioniPrimary (citable) accession number: P49053
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3