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P49053

- PRXC_CURIN

UniProt

P49053 - PRXC_CURIN

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Protein

Vanadium chloroperoxidase

Gene

CPO

Organism
Curvularia inaequalis
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

RH + Cl- + H2O2 = RCl + 2 H2O.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei404 – 4041
Metal bindingi496 – 4961Vanadium

GO - Molecular functioni

  1. chloride peroxidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Ligandi

Chloride, Metal-binding, Vanadium

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15997.
SABIO-RKP49053.

Protein family/group databases

PeroxiBasei5892. CinaVCPo.

Names & Taxonomyi

Protein namesi
Recommended name:
Vanadium chloroperoxidase (EC:1.11.1.10)
Alternative name(s):
Vanadium chloride peroxidase
Short name:
VCPO
Gene namesi
Name:CPO
OrganismiCurvularia inaequalis
Taxonomic identifieri38902 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeCurvularia

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Vanadium chloroperoxidasePRO_0000097055Add
BLAST

Post-translational modificationi

The N-terminus is blocked.

Structurei

Secondary structure

1
609
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 205Combined sources
Helixi22 – 4019Combined sources
Helixi47 – 6822Combined sources
Beta strandi72 – 743Combined sources
Beta strandi77 – 793Combined sources
Helixi85 – 873Combined sources
Helixi98 – 11417Combined sources
Turni118 – 1258Combined sources
Helixi131 – 14717Combined sources
Helixi157 – 17317Combined sources
Turni176 – 1794Combined sources
Beta strandi202 – 2076Combined sources
Beta strandi215 – 2184Combined sources
Helixi226 – 2294Combined sources
Helixi248 – 2503Combined sources
Helixi254 – 26815Combined sources
Helixi280 – 2889Combined sources
Turni295 – 2973Combined sources
Helixi300 – 31415Combined sources
Beta strandi317 – 3193Combined sources
Beta strandi321 – 3233Combined sources
Helixi325 – 35632Combined sources
Helixi361 – 3666Combined sources
Turni371 – 3733Combined sources
Beta strandi388 – 3903Combined sources
Helixi403 – 41917Combined sources
Turni420 – 4223Combined sources
Beta strandi436 – 4405Combined sources
Beta strandi444 – 4474Combined sources
Beta strandi449 – 4535Combined sources
Helixi461 – 4633Combined sources
Beta strandi466 – 4683Combined sources
Beta strandi473 – 4775Combined sources
Helixi479 – 49214Combined sources
Helixi498 – 5014Combined sources
Helixi504 – 5074Combined sources
Helixi530 – 5323Combined sources
Beta strandi538 – 5414Combined sources
Beta strandi542 – 5443Combined sources
Helixi552 – 56514Combined sources
Helixi573 – 5753Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IDQX-ray2.03A1-609[»]
1IDUX-ray2.24A1-609[»]
1VNCX-ray2.10A1-609[»]
1VNEX-ray2.15A1-609[»]
1VNFX-ray2.35A1-609[»]
1VNGX-ray2.20A1-609[»]
1VNHX-ray2.11A1-609[»]
1VNIX-ray2.15A1-609[»]
1VNSX-ray1.66A1-609[»]
3BB0X-ray1.50A1-609[»]
ProteinModelPortaliP49053.
SMRiP49053. Positions 3-578.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP49053.

Family & Domainsi

Family and domain databases

Gene3Di1.10.606.10. 1 hit.
1.20.144.10. 1 hit.
InterProiIPR016119. Br/Cl_peroxidase_C.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

P49053-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSVTPIPLP KIDEPEEYNT NYILFWNHVG LELNRVTHTV GGPLTGPPLS
60 70 80 90 100
ARALGMLHLA IHDAYFSICP PTDFTTFLSP DTENAAYRLP SPNGANDARQ
110 120 130 140 150
AVAGAALKML SSLYMKPVEQ PNPNPGANIS DNAYAQLGLV LDRSVLEAPG
160 170 180 190 200
GVDRESASFM FGEDVADVFF ALLNDPRGAS QEGYHPTPGR YKFDDEPTHP
210 220 230 240 250
VVLIPVDPNN PNGPKMPFRQ YHAPFYGKTT KRFATQSEHF LADPPGLRSN
260 270 280 290 300
ADETAEYDDA VRVAIAMGGA QALNSTKRSP WQTAQGLYWA YDGSNLIGTP
310 320 330 340 350
PRFYNQIVRR IAVTYKKEED LANSEVNNAD FARLFALVDV ACTDAGIFSW
360 370 380 390 400
KEKWEFEFWR PLSGVRDDGR PDHGDPFWLT LGAPATNTND IPFKPPFPAY
410 420 430 440 450
PSGHATFGGA VFQMVRRYYN GRVGTWKDDE PDNIAIDMMI SEELNGVNRD
460 470 480 490 500
LRQPYDPTAP IEDQPGIVRT RIVRHFDSAW ELMFENAISR IFLGVHWRFD
510 520 530 540 550
AAAARDILIP TTTKDVYAVD NNGATVFQNV EDIRYTTRGT REDPEGLFPI
560 570 580 590 600
GGVPLGIEIA DEIFNNGLKP TPPEIQPMPQ ETPVQKPVGQ QPVKGMWEEE

QAPVVKEAP
Length:609
Mass (Da):67,531
Last modified:February 1, 1996 - v1
Checksum:iA7B710DDF937D3E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti454 – 4541P → S AA sequence (PubMed:7744081)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85369 mRNA. Translation: CAA59686.1.
PIRiS69334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85369 mRNA. Translation: CAA59686.1 .
PIRi S69334.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IDQ X-ray 2.03 A 1-609 [» ]
1IDU X-ray 2.24 A 1-609 [» ]
1VNC X-ray 2.10 A 1-609 [» ]
1VNE X-ray 2.15 A 1-609 [» ]
1VNF X-ray 2.35 A 1-609 [» ]
1VNG X-ray 2.20 A 1-609 [» ]
1VNH X-ray 2.11 A 1-609 [» ]
1VNI X-ray 2.15 A 1-609 [» ]
1VNS X-ray 1.66 A 1-609 [» ]
3BB0 X-ray 1.50 A 1-609 [» ]
ProteinModelPortali P49053.
SMRi P49053. Positions 3-578.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

PeroxiBasei 5892. CinaVCPo.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-15997.
SABIO-RK P49053.

Miscellaneous databases

EvolutionaryTracei P49053.

Family and domain databases

Gene3Di 1.10.606.10. 1 hit.
1.20.144.10. 1 hit.
InterProi IPR016119. Br/Cl_peroxidase_C.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view ]
Pfami PF01569. PAP2. 1 hit.
[Graphical view ]
SUPFAMi SSF48317. SSF48317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Primary structure and characterization of the vanadium chloroperoxidase from the fungus Curvularia inaequalis."
    Simons B.H., Barnett P., Vollenbroek E.G.M., Dekker H.L., Muijsers A.O., Messerschmidt A., Wever R.
    Eur. J. Biochem. 229:566-574(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. "X-ray structure of a vanadium-containing enzyme: chloroperoxidase from the fungus Curvularia inaequalis."
    Messerschmidt A., Wever R.
    Proc. Natl. Acad. Sci. U.S.A. 93:392-396(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS).

Entry informationi

Entry nameiPRXC_CURIN
AccessioniPrimary (citable) accession number: P49053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3