ID   MYC_HYLLA               Reviewed;         439 AA.
AC   P49033;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   24-NOV-2009, entry version 58.
DE   RecName: Full=Myc proto-oncogene protein;
DE   AltName: Full=c-Myc;
DE   AltName: Full=Transcription factor p64;
GN   Name=MYC;
OS   Hylobates lar (Common gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hylobatidae; Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=92339896; PubMed=1634119; DOI=10.1016/0378-1119(92)90520-Y;
RA   Eladari M.E., Mohammad-Ali K., Argaut C., Galibert F.;
RT   "Gibbon and marmoset c-myc nucleotide sequences.";
RL   Gene 116:231-243(1992).
CC   -!- FUNCTION: Participates in the regulation of gene transcription.
CC       Binds DNA in a non-specific manner, yet also specifically
CC       recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate
CC       the transcription of growth-related genes (By similarity).
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another
CC       bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with
CC       TAF1C and SPAG9. Interacts with KDM5A and KDM5B (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Phosphorylated by PRKDC (By similarity).
CC   -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
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DR   EMBL; M88115; AAA35465.1; -; Genomic_DNA.
DR   PIR; JC1178; JC1178.
DR   SMR; P49033; 353-434.
DR   HOVERGEN; P49033; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001092; HLH_basic.
DR   InterPro; IPR011598; HLH_DNA_bd.
DR   InterPro; IPR003327; Myc-LZ.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Gene3D; G3DSA:4.10.280.10; HLH_DNA_bd; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF02344; Myc-LZ; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   PROSITE; PS50888; HLH; 1.
PE   3: Inferred from homology;
KW   Acetylation; Activator; DNA-binding; Glycoprotein; Nucleus;
KW   Phosphoprotein; Proto-oncogene; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    439       Myc proto-oncogene protein.
FT                                /FTId=PRO_0000127294.
FT   DOMAIN      368    407       Helix-loop-helix motif.
FT   DOMAIN      413    434       Leucine-zipper (Potential).
FT   DNA_BIND    354    367       Basic motif.
FT   COMPBIAS     33     37       Poly-Gln.
FT   COMPBIAS     88     91       Poly-Gly.
FT   MOD_RES       6      6       Phosphoserine (By similarity).
FT   MOD_RES      58     58       Phosphothreonine; alternate (By
FT                                similarity).
FT   MOD_RES      62     62       Phosphoserine (By similarity).
FT   MOD_RES      71     71       Phosphoserine (By similarity).
FT   MOD_RES     143    143       N6-acetyllysine; by PCAF (By similarity).
FT   MOD_RES     148    148       N6-acetyllysine (By similarity).
FT   MOD_RES     157    157       N6-acetyllysine; by PCAF (By similarity).
FT   MOD_RES     275    275       N6-acetyllysine; by PCAF (By similarity).
FT   MOD_RES     317    317       N6-acetyllysine; by PCAF (By similarity).
FT   MOD_RES     323    323       N6-acetyllysine; by PCAF (By similarity).
FT   MOD_RES     344    344       Phosphoserine (By similarity).
FT   MOD_RES     348    348       Phosphoserine (By similarity).
FT   MOD_RES     371    371       N6-acetyllysine; by PCAF (By similarity).
FT   CARBOHYD     58     58       O-linked (GlcNAc); alternate (By
FT                                similarity).
SQ   SEQUENCE   439 AA;  48820 MW;  272EB5D9FA89D64B CRC64;
     MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP
     LSPSRRSGLC SPSYVAVTPF SPRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD
     DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSS SPNPARGHSV CSTSSLYLQD
     LSAAASECID PSVVFPYPLN DSSSPKSCAS PDSSAFSPSS DSLLSSTESS PQASPEPLVL
     HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPSKRSESG SPSAGGHSKP PHSPLVLKRC
     HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENDKRRTHN
     VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQGEE QKLTSEKDLL
     RKRREQLKHK LEQLRNSCA
//