Reviewed, UniProtKB/Swiss-Prot P49033 (MYC_HYLLA)

Names and origin

Protein names

Recommended name:
    Myc proto-oncogene protein
Alternative name(s):
    c-Myc
    Transcription factor p64

Gene names

Name:

MYC

Organism

Hylobates lar (Common gibbon)

Taxonomic identifier

9580 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hylobatidae › Hylobates

Protein attributes

Sequence length	439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes By similarity.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with KDM5A and KDM5B By similarity.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylated by PRKDC By similarity.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Disease	Proto-oncogene
Ligand	DNA-binding
Molecular function	Activator
PTM	Acetylation Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 439	439	Myc proto-oncogene protein		PRO_0000127294
Regions
	Domain	368 – 407	40	Helix-loop-helix motif
	Domain	413 – 434	22	Leucine-zipper Potential
	DNA binding	354 – 367	14	Basic motif
	Compositional bias	33 – 37	5	Poly-Gln
	Compositional bias	88 – 91	4	Poly-Gly
Amino acid modifications
	Modified residue	58	1	Phosphothreonine; alternate By similarity
	Modified residue	62	1	Phosphoserine By similarity
	Modified residue	71	1	Phosphoserine By similarity
	Modified residue	143	1	N6-acetyllysine; by PCAF By similarity
	Modified residue	148	1	N6-acetyllysine By similarity
	Modified residue	157	1	N6-acetyllysine; by PCAF By similarity
	Modified residue	275	1	N6-acetyllysine; by PCAF By similarity
	Modified residue	317	1	N6-acetyllysine; by PCAF By similarity
	Modified residue	323	1	N6-acetyllysine; by PCAF By similarity
	Modified residue	371	1	N6-acetyllysine; by PCAF By similarity
	Glycosylation	58	1	O-linked (GlcNAc); alternate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P49033-1 [UniParc]. Last modified February 1, 1996. Version 1. Checksum: 272EB5D9FA89D64B	FASTA	439	48,820
	10 20 30 40 50 60 MPLNVSFTNR NYDLDYDSVQ PYFYCDEEEN FYQQQQQSEL QPPAPSEDIW KKFELLPTPP 70 80 90 100 110 120 LSPSRRSGLC SPSYVAVTPF SPRGDNDGGG GSFSTADQLE MVTELLGGDM VNQSFICDPD 130 140 150 160 170 180 DETFIKNIII QDCMWSGFSA AAKLVSEKLA SYQAARKDSS SPNPARGHSV CSTSSLYLQD 190 200 210 220 230 240 LSAAASECID PSVVFPYPLN DSSSPKSCAS PDSSAFSPSS DSLLSSTESS PQASPEPLVL 250 260 270 280 290 300 HEETPPTTSS DSEEEQEDEE EIDVVSVEKR QAPSKRSESG SPSAGGHSKP PHSPLVLKRC 310 320 330 340 350 360 HVSTHQHNYA APPSTRKDYP AAKRVKLDSV RVLRQISNNR KCTSPRSSDT EENDKRRTHN 370 380 390 400 410 420 VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQGEE QKLTSEKDLL 430 RKRREQLKHK LEQLRNSCA

References

[1]	"Gibbon and marmoset c-myc nucleotide sequences." Eladari M.E., Mohammad-Ali K., Argaut C., Galibert F. Gene 116:231-243(1992) [PubMed: 1634119] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	M88115 Genomic DNA. Translation: AAA35465.1.
PIR	JC1178.
3D structure databases
HSSP	HSSP built from PDB template 1A93 based on UniProtKB P01106.
SMR	P49033. Positions 353-434.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P49033.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. IPR003327. Myc-LZ. IPR002418. Tscrpt_reg_Myc. IPR012682. Tscrpt_reg_Myc_N. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. PF02344. Myc-LZ. 1 hit. PF01056. Myc_N. 1 hit. [Graphical view]
PRINTS	PR00044. LEUZIPPRMYC.
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYC_HYLLA

Accession

Primary (citable) accession number: P49033

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	October 13, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)