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Protein

Citron Rho-interacting kinase

Gene

Cit

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2 (By similarity).By similarity4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei126 – 1261ATPPROSITE-ProRule annotation
Active sitei221 – 2211Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi103 – 1119ATPPROSITE-ProRule annotation
Zinc fingeri1388 – 143750Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • dendrite development Source: MGI
  • generation of neurons Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • metaphase/anaphase transition of mitotic cell cycle Source: MGI
  • mitotic nuclear division Source: UniProtKB
  • mitotic sister chromatid segregation Source: MGI
  • negative regulation of dendrite morphogenesis Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • positive regulation of cytokinesis Source: MGI
  • spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5625900. RHO GTPases activate CIT.

Names & Taxonomyi

Protein namesi
Recommended name:
Citron Rho-interacting kinase (EC:2.7.11.1)
Short name:
CRIK
Alternative name(s):
Rho-interacting, serine/threonine-protein kinase 21
Gene namesi
Name:Cit
Synonyms:Crik
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105313. Cit.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: MGI
  • cytosol Source: Reactome
  • membrane Source: MGI
  • ruffle Source: MGI
  • vacuole Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Death before reaching adulthood, probably due to lethal epilepsy. Mice display severe defects in the olfactory bulbs, the hippocampus, and the cerebellum. These defects appear to result from impaired cytokinesis followed by the induction of apoptosis in specific neuroblast populations.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi126 – 1261K → A: Loss of phosphorylation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20552055Citron Rho-interacting kinasePRO_0000085909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity
Modified residuei439 – 4391PhosphoserineCombined sources
Modified residuei479 – 4791PhosphoserineCombined sources
Modified residuei581 – 5811PhosphoserineBy similarity
Modified residuei1237 – 12371PhosphotyrosineCombined sources
Modified residuei1747 – 17471N6-acetyllysineBy similarity
Modified residuei1966 – 19661PhosphoserineBy similarity
Modified residuei2021 – 20211PhosphoserineBy similarity
Modified residuei2041 – 20411PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP49025.
PaxDbiP49025.
PeptideAtlasiP49025.
PRIDEiP49025.

PTM databases

iPTMnetiP49025.
PhosphoSiteiP49025.

Expressioni

Tissue specificityi

A major signal was observed in testis and brain, but it was also detected in thymus, spleen, kidney, heart and lung.2 Publications

Developmental stagei

Detected at E10.5 with highest expression in the developing central nervous system. After E16.5 expression decreases and at two weeks after birth is restricted to the proliferating neuronal precursor cells in the external germinal layer of the cerebellum and subventricular migratory stream.1 Publication

Gene expression databases

CleanExiMM_CIT.

Interactioni

Subunit structurei

Interacts with TTC3 (By similarity). Homodimer (Probable). Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form).By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198720. 14 interactions.
IntActiP49025. 5 interactions.
MINTiMINT-1700238.
STRINGi10090.ENSMUSP00000062049.

Structurei

3D structure databases

ProteinModelPortaliP49025.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 359263Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini360 – 43071AGC-kinase C-terminalAdd
BLAST
Domaini1469 – 1589121PHPROSITE-ProRule annotationAdd
BLAST
Domaini1617 – 1907291CNHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1132 – 1328197Interaction with Rho/RacAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili441 – 1086646Sequence analysisAdd
BLAST
Coiled coili1091 – 1247157Sequence analysisAdd
BLAST
Coiled coili1275 – 132551Sequence analysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1979 – 19846SH3-bindingSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi550 – 962413Glu-richAdd
BLAST
Compositional biasi1276 – 12794Poly-Lys

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 CNH domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1388 – 143750Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, SH3-binding, Zinc-finger

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
HOGENOMiHOG000015347.
HOVERGENiHBG071093.
InParanoidiP49025.
PhylomeDBiP49025.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: P49025-1) [UniParc]FASTAAdd to basket
Also known as: CRIK

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLKFKYGVRN PPEASASEPI ASRASRLNLF FQGKPPLMTQ QQMSALSREG
60 70 80 90 100
MLDALFALFE ECSQPALMKM KHVSSFVQKY SDTIAELREL QPSARDFEVR
110 120 130 140 150
SLVGCGHFAE VQVVREKATG DVYAMKIMKK KALLAQEQVS FFEEERNILS
160 170 180 190 200
RSTSPWIPQL QYAFQDKNNL YLVMEYQPGG DFLSLLNRYE DQLDESMIQF
210 220 230 240 250
YLAELILAVH SVHQMGYVHR DIKPENILID RTGEIKLVDF GSAAKMNSNK
260 270 280 290 300
VDAKLPIGTP DYMAPEVLTV MNEDRRGTYG LDCDWWSVGV VAYEMVYGKT
310 320 330 340 350
PFTEGTSART FNNIMNFQRF LKFPDDPKVS SELLDLLQSL LCVQKERLKF
360 370 380 390 400
EGLCCHPFFA RTDWNNIRNS PPPFVPTLKS DDDTSNFDEP EKNSWVSSSV
410 420 430 440 450
CQLSPSGFSG EELPFVGFSY SKALGYLGRS ESVVSSLDSP AKVSSMEKKL
460 470 480 490 500
LIKSKELQDS QDKCHKMEQE MTRLHRRVSE VEAVLSQKEV ELKASETQRS
510 520 530 540 550
LLEQDLATYI TECSSLKRSL EQARMEVSQE DDKALQLLHD IREQSRKLQE
560 570 580 590 600
IKEQEYQAQV EEMRLMMNQL EEDLVSARRR SDLYESELRE SRLAAEEFKR
610 620 630 640 650
KANECQHKLM KAKDQGKPEV GEYSKLEKIN AEQQLKIQEL QEKLEKAVKA
660 670 680 690 700
STEATELLQN IRQAKERAER ELEKLHNRED SSEGIKKKLV EAEERRHSLE
710 720 730 740 750
NKVKRLETME RRENRLKDDI QTKSEQIQQM ADKILELEEK HREAQVSAQH
760 770 780 790 800
LEVHLKQKEQ HYEEKIKVLD NQIKKDLADK ESLENMMQRH EEEAHEKGKI
810 820 830 840 850
LSEQKAMINA MDSKIRSLEQ RIVELSEANK LAANSSLFTQ RNMKAQEEMI
860 870 880 890 900
SELRQQKFYL ETQAGKLEAQ NRKLEEQLEK ISHQDHSDKS RLLELETRLR
910 920 930 940 950
EVSLEHEEQK LELKRQLTEL QLSLQERESQ LTALQAARAA LESQLRQAKT
960 970 980 990 1000
ELEETTAEAE EEIQALTAHR DEIQRKFDAL RNSCTVITDL EEQLNQLTED
1010 1020 1030 1040 1050
NAELNNQNFY LSKQLDEASG ANDEIVQLRS EVDHLRREIT EREMQLTSQK
1060 1070 1080 1090 1100
QTMEALKTTC TMLEEQVLDL EALNDELLEK ERQWEAWRSV LGDEKSQFEC
1110 1120 1130 1140 1150
RVRELQRMLD TEKQSRARAD QRITESRQVV ELAVKEHKAE ILALQQALKE
1160 1170 1180 1190 1200
QKLKAESLSD KLNDLEKKHA MLEMNARSLQ QKLETERELK QRLLEEQAKL
1210 1220 1230 1240 1250
QQQMDLQKNH IFRLTQGLQE ALDRADLLKT ERSDLEYQLE NIQVLYSHEK
1260 1270 1280 1290 1300
VKMEGTISQQ TKLIDFLQAK MDQPAKKKKV PLQYNELKLA LEKEKARCAE
1310 1320 1330 1340 1350
LEEALQKTRI ELRSAREEAA HRKATDHPHP STPATARQQI AMSAIVRSPE
1360 1370 1380 1390 1400
HQPSAMSLLA PPSSRRKESS TPEEFSRRLK ERMHHNIPHR FNVGLNMRAT
1410 1420 1430 1440 1450
KCAVCLDTVH FGRQASKCLE CQVMCHPKCS TCLPATCGLP AEYATHFTEA
1460 1470 1480 1490 1500
FCRDKMNSPG LQSKEPGSSL HLEGWMKVPR NNKRGQQGWD RKYIVLEGSK
1510 1520 1530 1540 1550
VLIYDNEARE AGQRPVEEFE LCLPDGDVSI HGAVGASELA NTAKADVPYI
1560 1570 1580 1590 1600
LKMESHPHTT CWPGRTLYLL APSFPDKQRW VTALESVVAG GRVSREKAEA
1610 1620 1630 1640 1650
DAKLLGNSLL KLEGDDRLDM NCTLPFSDQV VLVGTEEGLY ALNVLKNSLT
1660 1670 1680 1690 1700
HIPGIGAVFQ IYIIKDLEKL LMIAGEERAL CLVDVKKVKQ SLAQSHLPAQ
1710 1720 1730 1740 1750
PDVSPNIFEA VKGCHLFAAG KIENSLCICA AMPSKVVILR YNDNLSKYCI
1760 1770 1780 1790 1800
RKEIETSEPC SCIHFTNYSI LIGTNKFYEI DMKQYTLDEF LDKNDHSLAP
1810 1820 1830 1840 1850
AVFASSSNSF PVSIVQANSA GQREEYLLCF HEFGVFVDSY GRRSRTDDLK
1860 1870 1880 1890 1900
WSRLPLAFAY REPYLFVTHF NSLEVIEIQA RSSLGSPARA YLEIPNPRYL
1910 1920 1930 1940 1950
GPAISSGAIY LASSYQDKLR VICCKGNLVK ESGTEQHRVP STSRSSPNKR
1960 1970 1980 1990 2000
GPPTYNEHIT KRVASSPAPP EGPSHPREPS TPHRYRDREG RTELRRDKSP
2010 2020 2030 2040 2050
GRPLEREKSP GRMLSTRRER SPGRLFEDSS RGRLPAGAVR TPLSQVNKVW

DQSSV
Length:2,055
Mass (Da):235,389
Last modified:November 8, 2005 - v3
Checksum:iBDA9A12C14E12DF8
GO
Isoform 2 (identifier: P49025-2) [UniParc]FASTAAdd to basket
Also known as: CRIK-SK

The sequence of this isoform differs from the canonical sequence as follows:
     467-494: MEQEMTRLHRRVSEVEAVLSQKEVELKA → VSISTAGLRPCSRILQSIYAEGSAGGHC
     495-2055: Missing.

Show »
Length:494
Mass (Da):55,650
Checksum:iE4AEAEA4C22D0051
GO
Isoform 3 (identifier: P49025-3) [UniParc]FASTAAdd to basket
Also known as: Citron

The sequence of this isoform differs from the canonical sequence as follows:
     1-458: Missing.
     459-466: DSQDKCHK → MLLGEEAM

Show »
Length:1,597
Mass (Da):183,449
Checksum:i7B7286C2305676DA
GO
Isoform 4 (identifier: P49025-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     693-735: Missing.

Show »
Length:2,012
Mass (Da):230,083
Checksum:i50944A35251224E9
GO
Isoform 5 (identifier: P49025-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1279-1279: K → KGLFSRRKEDPALPTQ
     1602-1602: A → AARDHTSSEHQPVWVE

Note: No experimental confirmation available.
Show »
Length:2,085
Mass (Da):238,846
Checksum:i996B21DE7CBF45AD
GO

Sequence cautioni

The sequence AAC72822 differs from that shown. Reason: Frameshift at positions 396 and 408. Curated
The sequence AAC72823 differs from that shown. Reason: Frameshift at positions 396 and 408. Curated
The sequence AAH23775 differs from that shown. Reason: Frameshift at position 1011. Curated
The sequence AAH51165 differs from that shown. Reason: Frameshift at position 1011. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781Q → R in BAE26199 (PubMed:16141072).Curated
Sequence conflicti182 – 1821F → L in BAE26199 (PubMed:16141072).Curated
Sequence conflicti234 – 2341E → H in BAE26199 (PubMed:16141072).Curated
Sequence conflicti1945 – 19451Missing in AAH51165 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 458458Missing in isoform 3. 1 PublicationVSP_012436Add
BLAST
Alternative sequencei459 – 4668DSQDKCHK → MLLGEEAM in isoform 3. 1 PublicationVSP_012437
Alternative sequencei467 – 49428MEQEM…VELKA → VSISTAGLRPCSRILQSIYA EGSAGGHC in isoform 2. 2 PublicationsVSP_012438Add
BLAST
Alternative sequencei495 – 20551561Missing in isoform 2. 2 PublicationsVSP_012439Add
BLAST
Alternative sequencei693 – 73543Missing in isoform 4. 1 PublicationVSP_016093Add
BLAST
Alternative sequencei1279 – 12791K → KGLFSRRKEDPALPTQ in isoform 5. 1 PublicationVSP_016094
Alternative sequencei1602 – 16021A → AARDHTSSEHQPVWVE in isoform 5. 1 PublicationVSP_016095

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39904 mRNA. Translation: AAC52341.1.
AF086823 mRNA. Translation: AAC72822.1. Frameshift.
AF086824 mRNA. Translation: AAC72823.1. Frameshift.
AK145037 mRNA. Translation: BAE26199.1.
AF070066 mRNA. Translation: AAC27933.1.
BC023775 mRNA. Translation: AAH23775.1. Frameshift.
BC051165 mRNA. Translation: AAH51165.1. Frameshift.
CCDSiCCDS19597.1. [P49025-1]
PIRiS68420.
RefSeqiXP_006530214.1. XM_006530151.2. [P49025-3]
UniGeneiMm.426282.
Mm.8321.

Genome annotation databases

GeneIDi12704.
UCSCiuc008zep.1. mouse. [P49025-2]
uc008zet.1. mouse. [P49025-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39904 mRNA. Translation: AAC52341.1.
AF086823 mRNA. Translation: AAC72822.1. Frameshift.
AF086824 mRNA. Translation: AAC72823.1. Frameshift.
AK145037 mRNA. Translation: BAE26199.1.
AF070066 mRNA. Translation: AAC27933.1.
BC023775 mRNA. Translation: AAH23775.1. Frameshift.
BC051165 mRNA. Translation: AAH51165.1. Frameshift.
CCDSiCCDS19597.1. [P49025-1]
PIRiS68420.
RefSeqiXP_006530214.1. XM_006530151.2. [P49025-3]
UniGeneiMm.426282.
Mm.8321.

3D structure databases

ProteinModelPortaliP49025.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198720. 14 interactions.
IntActiP49025. 5 interactions.
MINTiMINT-1700238.
STRINGi10090.ENSMUSP00000062049.

PTM databases

iPTMnetiP49025.
PhosphoSiteiP49025.

Proteomic databases

MaxQBiP49025.
PaxDbiP49025.
PeptideAtlasiP49025.
PRIDEiP49025.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi12704.
UCSCiuc008zep.1. mouse. [P49025-2]
uc008zet.1. mouse. [P49025-3]

Organism-specific databases

CTDi11113.
MGIiMGI:105313. Cit.

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
HOGENOMiHOG000015347.
HOVERGENiHBG071093.
InParanoidiP49025.
PhylomeDBiP49025.

Enzyme and pathway databases

ReactomeiR-MMU-5625900. RHO GTPases activate CIT.

Miscellaneous databases

PROiP49025.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CIT.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 6 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF038145. Citron_Rho-interacting_kinase. 1 hit.
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTRO_MOUSE
AccessioniPrimary (citable) accession number: P49025
Secondary accession number(s): O88528
, O88937, O88938, Q3UM99, Q8CIJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.