Paxillin - Gallus gallus (Chicken)

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P49024 (PAXI_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 79. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Paxillin

Gene names

Name:

PXN

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of v-CRK.
Subcellular location	Cytoplasm › cytoskeleton. Cell junction › focal adhesion.
Post-translational modification	Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Ref.3
Sequence similarities	Contains 4 LIM zinc-binding domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell junction Cytoplasm Cytoskeleton
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell-matrix adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell focal adhesion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
PTK2	Q00944	2	EBI-2896280,EBI-2896409
VCL	P12003	5	EBI-2896280,EBI-1039563
VCL	P12003-1	2	EBI-2896280,EBI-6138078
VCL	P12003-2	2	EBI-2896280,EBI-6138096

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 559

559

Paxillin

PRO_0000075857

Regions

Domain

326 – 376

LIM zinc-binding 1

Domain

385 – 435

LIM zinc-binding 2

Domain

444 – 494

LIM zinc-binding 3

Domain

503 – 553

LIM zinc-binding 4

Compositional bias

46 – 53

Pro-rich

Amino acid modifications

Modified residue

Phosphotyrosine By similarity

Modified residue

118

Phosphotyrosine; by FAK1

Secondary structure

559

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P49024 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6450270D90B2DE84
Show »

FASTA

559

61,243

        10         20         30         40         50         60 
MDDLDALLAD LESTTSHISK RPVFLTEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 

        70         80         90        100        110        120 
TVIDPLDQWQ PSVSRYGHQQ PQSQSPIYSS SAKSSSASVP RDGLSSPSPR ASEEEHVYSF 

       130        140        150        160        170        180 
PNKQKSAEPS PTMTSTSLGS NLSELDRLLL ELNAVQHNPP SGFSADEVSR SPSLPNVTGP 

       190        200        210        220        230        240 
HYVIPESSSS AGGKAAPPTK EKPKRNGGRG IEDVRPSVES LLDELESSVP SPVPAITVSQ 

       250        260        270        280        290        300 
GEVSSPQRVN ASQQQTRISA SSATRELDEL MASLSDFKFM AQGKAGGSSS PPSTTPKPGS 

       310        320        330        340        350        360 
QLDTMLGSLQ SDLNKLGVAT VAKGVCGACK KPIAGQVVTA MGKTWHPEHF VCTHCQEEIG 

       370        380        390        400        410        420 
SRNFFERDGQ PYCEKDYHNL FSPRCYYCNG PILDKVVTAL DRTWHPEHFF CAQCGVFFGP 

       430        440        450        460        470        480 
EGFHEKDGKA YCRKDYFDMF APKCGGCARA ILENYISALN TLWHPECFVC RECFTPFING 

       490        500        510        520        530        540 
SFFEHDGQPY CEVHYHERRG SLCSGCQKPI TGRCITAMGK KFHPEHFVCA FCLKQLNKGT 

       550 
FKEQNDKPYC QNCFLKLFC

« Hide

References

[1]	"Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL." Salgia R., Li J.-L., Lo S.H., Brunkhorst B., Kansas G.S., Sobhany E.S., Sun Y., Pisick E., Hallek M., Ernst T., Tantravahi R., Chen L.B., Griffin J.D. J. Biol. Chem. 270:5039-5047(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region." Turner C.E., Miller J.T. J. Cell Sci. 107:1583-1591(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase." Bellis S.L., Miller J.T., Turner C.E. J. Biol. Chem. 270:17437-17441(1995) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U14589 mRNA. Translation: AAC59665.1.
L30099 mRNA. Translation: AAC38018.1.

IPI

IPI00585869.

PIR

B55933.

RefSeq

NP_990315.1. NM_204984.1.

UniGene

Gga.4056.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L6F	NMR	-	A	140-275	[»]
2L6G	NMR	-	A	140-161	[»]
2L6H	NMR	-	A	263-275	[»]

ProteinModelPortal

P49024.

SMR

P49024. Positions 434-501.

ModBase

Search...

Protein-protein interaction databases

IntAct

P49024. 4 interactions.

STRING

9031.ENSGALP00000011713.

Proteomic databases

PaxDb

P49024.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

395832.

KEGG

gga:395832.

Organism-specific databases

CTD

5829.

Phylogenomic databases

eggNOG

NOG267887.

HOGENOM

HOG000018764.

HOVERGEN

HBG001512.

InParanoid

P49024.

K05760.

OrthoDB

EOG4TMR25.

Family and domain databases

Gene3D

2.10.110.10. 4 hits.

InterPro

IPR001904. Paxillin.
IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00412. LIM. 4 hits.
[Graphical view]

PRINTS

PR00832. PAXILLIN.

SMART

SM00132. LIM. 4 hits.
[Graphical view]

PROSITE

PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

20815900.

Entry information

Entry name

PAXI_CHICK

Accession

Primary (citable) accession number: P49024

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents