SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P49021

- TIM_DROME

UniProt

P49021 - TIM_DROME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Protein timeless
Gene
tim, CG3234
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.5 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein heterodimerization activity Source: FlyBase
  3. transcription factor binding Source: FlyBase

GO - Biological processi

  1. cellular response to light stimulus Source: FlyBase
  2. circadian behavior Source: FlyBase
  3. circadian rhythm Source: FlyBase
  4. circadian temperature homeostasis Source: FlyBase
  5. copulation Source: FlyBase
  6. eclosion rhythm Source: FlyBase
  7. entrainment of circadian clock Source: FlyBase
  8. locomotor rhythm Source: FlyBase
  9. mating behavior Source: FlyBase
  10. negative phototaxis Source: FlyBase
  11. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
  12. negative regulation of transcription regulatory region DNA binding Source: FlyBase
  13. photoperiodism Source: FlyBase
  14. protein import into nucleus Source: FlyBase
  15. regulation of circadian sleep/wake cycle Source: FlyBase
  16. regulation of circadian sleep/wake cycle, sleep Source: FlyBase
  17. regulation of protein import into nucleus Source: FlyBase
  18. rhythmic behavior Source: FlyBase
  19. sleep Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Biological rhythms

Names & Taxonomyi

Protein namesi
Recommended name:
Protein timeless
Gene namesi
Name:tim
ORF Names:CG3234
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0014396. tim.

Subcellular locationi

Nucleus. Cytoplasmperinuclear region
Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with per is required for nuclear localization.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
  3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  4. protein complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mutant flies show loss of both behavioral circadian rhythms and molecular oscillations of per RNA and protein.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13981398Protein timeless
PRO_0000022532Add
BLAST

Post-translational modificationi

Phosphorylated with a circadian rhythmicity.

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in head, photoreceptors, lateral neurons and glial cells in the lamina and medulla of the optic lobes. Expression follows a light-dark cycle, levels show a significant decrease at the end of the night and then remain low throughout the light period (at protein level).2 Publications

Gene expression databases

BgeeiP49021.

Interactioni

Subunit structurei

Forms a heterodimer with period (PER); the complex then translocates into the nucleus.

Protein-protein interaction databases

BioGridi59781. 7 interactions.
DIPiDIP-29425N.
MINTiMINT-344208.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 26832Necessary for normal circadian rhythm
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi550 – 56011Nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi360 – 38930Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi432 – 4376Poly-Pro

Sequence similaritiesi

Belongs to the timeless family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG257888.
GeneTreeiENSGT00390000015124.
InParanoidiP49021.
KOiK12074.
OrthoDBiEOG7SXW2F.

Family and domain databases

InterProiIPR006906. Timeless.
[Graphical view]
PfamiPF04821. TIMELESS. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform B (identifier: P49021-4) [UniParc]FASTAAdd to Basket

Also known as: P, Q

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDWLLATPQL YSAFSSLGCL EGDTYVVNPN ALAILEEINY KLTYEDQTLR     50
TFRRAIGFGQ NVRSDLIPLL ENAKDDAVLE SVIRILVNLT VPVECLFSVD 100
VMYRTDVGRH TIFELNKLLY TSKEAFTEAR STKSVVEYMK HILESDPKLS 150
PHKCDQINNC LLLLRNILHI PETHAHCVMP MMQSMPHGIS MQNTILWNLF 200
IQSIDKLLLY LMTCPQRAFW GVTMVQLIAL IYKDQHVSTL QKLLSLWFEA 250
SLSESSEDNE SNTSPPKQGS GDSSPMLTSD PTSDSSDNGS NGRGMGGGMR 300
EGTAATLQEV SRKGQEYQNA MARVPADKPD GSEEASDMTG NDSEQPGSPE 350
QSQPAGESMD DGDYEDQRHR QLNEHGEEDE DEDEVEEEEY LQLGPASEPL 400
NLTQQPADKV NNTTNPTSSA PQGCLGNEPF KPPPPLPVRA STSAHAQMQK 450
FNESSYASHV SAVKLGQKSP HAGQLQLTKG KCCPQKRECP SSQSELSDCG 500
YGTQVENQES ISTSSNDDDG PQGKPQHQKP PCNTKPRNKP RTIMSPMDKK 550
ELRRKKLVKR SKSSLINMKG LVQHTPTDDD ISNLLKEFTV DFLLKGYSYL 600
VEELHMQLLS NAKVPIDTSH FFWLVTYFLK FAAQLELDME HIDTILTYDV 650
LSYLTYEGVS LCEQLELNAR QEGSDLKPYL RRMHLVVTAI REFLQAIDTY 700
NKVTHLNEDD KAHLRQLQLQ ISEMSDLRCL FVLLLRRFNP SIHSKQYLQD 750
LVVTNHILLL ILDSSAKLGG CQTIRLSEHI TQFATLEVMH YYGILLEDFN 800
NNGEFVNDCI FTMMHHIGGD LGQIGVLFQP IILKTYSRIW EADYELCDDW 850
SDLIEYVIHK FMNTPPKSPL TIPTTSLTEM TKEHNQEHTV CSWSQEEMDT 900
LYWYYVQSKK NNDIVGKIVK LFSNNGNKLK TRISIIQQLL QQDIITLLEY 950
DDLMKFEDAE YQRTLLTTPT SATTESGIEI KECAYGKPSD DVQILLDLII 1000
KENKAQHLLW LQRILIECCF VKLTLRSGLK VPEGDHIMEP VAYHCICKQK 1050
SIPVVQWNNE QSTTMLYQPF VLLLHKLGIQ LPADAGSIFA RIPDYWTPET 1100
MYGLAKKLGP LDKLNLKFDA SELEDATASS PSRYHHTGPR NSLSSVSSLD 1150
VDLGDTEELA LIPEVDAAVE KAHAMASTPS PSEIFAVPKT KHCNSIIRYT 1200
PDPTPPVPNW LQLVMRSKCN HRTGPSGDPS DCIGSSSTTV DDEGFGKSIS 1250
AATSQAASTS MSTVNPTTTL SLNMLNTFMG SHNENSSSSG CGGTVSSLSM 1300
VALMSTGAAG GGGNTSGLEM DVDASMKSSF ERLEVNGSHF SRANNLDQEY 1350
SAMVASVYEK EKELNSDNVS LASDLTRMYV SDEDDRLERT EIRVPHYH 1398
Length:1,398
Mass (Da):156,382
Last modified:May 14, 2014 - v3
Checksum:iE7974EDCF6F94A88
GO
Isoform R (identifier: P49021-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-268: Missing.

Note: No experimental confirmation available.

Show »
Length:1,366
Mass (Da):152,847
Checksum:i06F0104288A8703F
GO
Isoform O (identifier: P49021-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     891-891: C → W
     892-1398: Missing.

Note: No experimental confirmation available.

Show »
Length:891
Mass (Da):100,623
Checksum:iAB62EC51D0F761AD
GO
Isoform N (identifier: P49021-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-613: Missing.
     891-891: C → W
     892-1398: Missing.

Note: No experimental confirmation available.

Show »
Length:890
Mass (Da):100,495
Checksum:iBC8202CC37F333B3
GO
Isoform S (identifier: P49021-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-268: Missing.
     1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
     1132-1398: Missing.

Note: No experimental confirmation available.

Show »
Length:1,099
Mass (Da):124,696
Checksum:i80AA3EF3AB03EF6C
GO
Isoform M (identifier: P49021-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
     1132-1398: Missing.

Note: No experimental confirmation available.

Show »
Length:1,131
Mass (Da):128,231
Checksum:i608FBAE2361C8271
GO
Isoform L (identifier: P49021-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     613-613: Missing.

Note: No experimental confirmation available.

Show »
Length:1,397
Mass (Da):156,253
Checksum:iCFA4573C81C95F41
GO

Sequence cautioni

The sequence AAN71179.1 differs from that shown. Reason: Intron retention.
The sequence AAC46920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AAL13507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAN71179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence ACX54883.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 26832Missing in isoform R and isoform S.
VSP_004457Add
BLAST
Alternative sequencei613 – 6131Missing in isoform L and isoform N.
VSP_054859
Alternative sequencei891 – 8911C → W in isoform N and isoform O.
VSP_007693
Alternative sequencei892 – 1398507Missing in isoform N and isoform O.
VSP_007694Add
BLAST
Alternative sequencei1114 – 113118LNLKF…TASSP → RELKSTTEKNNPFVIPQR in isoform S and isoform M.
VSP_054860Add
BLAST
Alternative sequencei1132 – 1398267Missing in isoform S and isoform M.
VSP_054861Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1233 – 12331I → V in AAB94890. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37018 mRNA. Translation: AAC46920.1. Different initiation.
AF032401, AF032400 Genomic DNA. Translation: AAB94890.1.
AE014134 Genomic DNA. Translation: AAF51097.1.
AE014134 Genomic DNA. Translation: AAF51098.4.
AE014134 Genomic DNA. Translation: AAN10371.3.
AE014134 Genomic DNA. Translation: AAN10372.3.
AE014134 Genomic DNA. Translation: AAX52649.2.
AE014134 Genomic DNA. Translation: ABC65862.2.
AE014134 Genomic DNA. Translation: ACL82987.2.
AE014134 Genomic DNA. Translation: ACL82988.2.
AE014134 Genomic DNA. Translation: ADV36936.2.
Y09930 Genomic DNA. No translation available.
Y09931 Genomic DNA. No translation available.
Y09932 Genomic DNA. No translation available.
Y09933 Genomic DNA. No translation available.
Y09934 Genomic DNA. No translation available.
Y09935 Genomic DNA. No translation available.
AY058278 mRNA. Translation: AAL13507.1. Different initiation.
BT001424 mRNA. Translation: AAN71179.1. Sequence problems.
BT024951 mRNA. Translation: ABE01181.1.
BT099999 mRNA. Translation: ACX54883.1. Different initiation.
AF038501 Genomic DNA. Translation: AAB94929.1.
PIRiA57655.
RefSeqiNP_001014463.2. NM_001014463.3. [P49021-6]
NP_001033872.2. NM_001038783.3. [P49021-7]
NP_001137780.2. NM_001144308.3. [P49021-2]
NP_001137781.2. NM_001144309.3. [P49021-3]
NP_001188686.2. NM_001201757.1. [P49021-5]
NP_001188687.2. NM_001201758.2. [P49021-4]
NP_722912.3. NM_164540.4. [P49021-4]
NP_722913.3. NM_164541.5. [P49021-8]
NP_722914.3. NM_164542.4. [P49021-4]
UniGeneiDm.2663.

Genome annotation databases

EnsemblMetazoaiFBtr0333253; FBpp0305451; FBgn0014396. [P49021-7]
FBtr0333254; FBpp0305452; FBgn0014396. [P49021-5]
FBtr0333255; FBpp0305453; FBgn0014396. [P49021-3]
FBtr0333258; FBpp0305456; FBgn0014396. [P49021-2]
FBtr0333259; FBpp0305457; FBgn0014396. [P49021-6]
GeneIDi33571.
KEGGidme:Dmel_CG3234.
UCSCiCG3234-RA. d. melanogaster. [P49021-4]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U37018 mRNA. Translation: AAC46920.1 . Different initiation.
AF032401 , AF032400 Genomic DNA. Translation: AAB94890.1 .
AE014134 Genomic DNA. Translation: AAF51097.1 .
AE014134 Genomic DNA. Translation: AAF51098.4 .
AE014134 Genomic DNA. Translation: AAN10371.3 .
AE014134 Genomic DNA. Translation: AAN10372.3 .
AE014134 Genomic DNA. Translation: AAX52649.2 .
AE014134 Genomic DNA. Translation: ABC65862.2 .
AE014134 Genomic DNA. Translation: ACL82987.2 .
AE014134 Genomic DNA. Translation: ACL82988.2 .
AE014134 Genomic DNA. Translation: ADV36936.2 .
Y09930 Genomic DNA. No translation available.
Y09931 Genomic DNA. No translation available.
Y09932 Genomic DNA. No translation available.
Y09933 Genomic DNA. No translation available.
Y09934 Genomic DNA. No translation available.
Y09935 Genomic DNA. No translation available.
AY058278 mRNA. Translation: AAL13507.1 . Different initiation.
BT001424 mRNA. Translation: AAN71179.1 . Sequence problems.
BT024951 mRNA. Translation: ABE01181.1 .
BT099999 mRNA. Translation: ACX54883.1 . Different initiation.
AF038501 Genomic DNA. Translation: AAB94929.1 .
PIRi A57655.
RefSeqi NP_001014463.2. NM_001014463.3. [P49021-6 ]
NP_001033872.2. NM_001038783.3. [P49021-7 ]
NP_001137780.2. NM_001144308.3. [P49021-2 ]
NP_001137781.2. NM_001144309.3. [P49021-3 ]
NP_001188686.2. NM_001201757.1. [P49021-5 ]
NP_001188687.2. NM_001201758.2. [P49021-4 ]
NP_722912.3. NM_164540.4. [P49021-4 ]
NP_722913.3. NM_164541.5. [P49021-8 ]
NP_722914.3. NM_164542.4. [P49021-4 ]
UniGenei Dm.2663.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 59781. 7 interactions.
DIPi DIP-29425N.
MINTi MINT-344208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0333253 ; FBpp0305451 ; FBgn0014396 . [P49021-7 ]
FBtr0333254 ; FBpp0305452 ; FBgn0014396 . [P49021-5 ]
FBtr0333255 ; FBpp0305453 ; FBgn0014396 . [P49021-3 ]
FBtr0333258 ; FBpp0305456 ; FBgn0014396 . [P49021-2 ]
FBtr0333259 ; FBpp0305457 ; FBgn0014396 . [P49021-6 ]
GeneIDi 33571.
KEGGi dme:Dmel_CG3234.
UCSCi CG3234-RA. d. melanogaster. [P49021-4 ]

Organism-specific databases

CTDi 107698.
FlyBasei FBgn0014396. tim.

Phylogenomic databases

eggNOGi NOG257888.
GeneTreei ENSGT00390000015124.
InParanoidi P49021.
KOi K12074.
OrthoDBi EOG7SXW2F.

Miscellaneous databases

ChiTaRSi ARHGEF5. drosophila.
GenomeRNAii 33571.
NextBioi 784249.

Gene expression databases

Bgeei P49021.

Family and domain databases

InterProi IPR006906. Timeless.
[Graphical view ]
Pfami PF04821. TIMELESS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Positional cloning and sequence analysis of the Drosophila clock gene, timeless."
    Myers M.P., Wager-Smith K., Wesley C.S., Young M.W., Sehgal A.
    Science 270:805-808(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM R).
  2. "Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein."
    Myers M.P., Rothenfluh A., Chang M., Young M.W.
    Nucleic Acids Res. 25:4710-4714(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. "Conceptual translation of timeless reveals alternative initiating methionines in Drosophila."
    Rosato E., Trevisan A., Sandrelli F., Zordan M., Kyriacou C.P., Costa R.
    Nucleic Acids Res. 25:455-458(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30, ALTERNATIVE INITIATION.
    Strain: Canton-S, CO-TG14, CO-TG20, PER+, PER01 and PERS.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-1398 (ISOFORM O), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1398 (ISOFORMS B/L/R).
    Strain: Berkeley.
    Tissue: Head.
  7. Stapleton M., Booth B., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 907-1398 (ISOFORMS B/L/R).
    Strain: Berkeley.
  8. "Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies."
    Ousley A., Zafarullah K., Chen Y., Emerson M., Hickman L., Sehgal A.
    Genetics 148:815-825(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-284, FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "Block in nuclear localization of period protein by a second clock mutation, timeless."
    Vosshall L.B., Price J.L., Sehgal A., Saez L., Young M.W.
    Science 263:1606-1609(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation."
    Sehgal A., Rothenfluh-Hilfiker A., Hunter-Ensor M., Chen Y., Myers M.P., Young M.W.
    Science 270:808-810(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL."
    Gekakis N., Saez L., Delahaye-Brown A.M., Myers M.P., Sehgal A., Young M.W., Weitz C.J.
    Science 270:811-815(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PER.
  12. "Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light."
    Hunter-Ensor M., Ousley A., Sehgal A.
    Cell 84:677-685(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTIM_DROME
AccessioniPrimary (citable) accession number: P49021
Secondary accession number(s): A4V040
, B7Z007, B7Z008, C9QPB7, M9MRE9, O44380, Q1WWF5, Q59E16, Q8I037, Q95U67, Q9VQR6, Q9VQR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 14, 2014
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi