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P49021

- TIM_DROME

UniProt

P49021 - TIM_DROME

Protein

Protein timeless

Gene

tim

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (14 May 2014)
      Previous versions | rss
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    Functioni

    Required for the production of circadian rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the TIM-PER complex. Light induces the degradation of TIM, which promotes elimination of PER. Nuclear activity of the heterodimer coordinatively regulates PER and TIM transcription through a negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition.5 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein heterodimerization activity Source: FlyBase
    3. transcription factor binding Source: FlyBase

    GO - Biological processi

    1. cellular response to light stimulus Source: FlyBase
    2. circadian behavior Source: FlyBase
    3. circadian rhythm Source: FlyBase
    4. circadian temperature homeostasis Source: FlyBase
    5. copulation Source: FlyBase
    6. eclosion rhythm Source: FlyBase
    7. entrainment of circadian clock Source: FlyBase
    8. locomotor rhythm Source: FlyBase
    9. mating behavior Source: FlyBase
    10. negative phototaxis Source: FlyBase
    11. negative regulation of transcription from RNA polymerase II promoter Source: FlyBase
    12. negative regulation of transcription regulatory region DNA binding Source: FlyBase
    13. photoperiodism Source: FlyBase
    14. protein import into nucleus Source: FlyBase
    15. regulation of circadian sleep/wake cycle Source: FlyBase
    16. regulation of circadian sleep/wake cycle, sleep Source: FlyBase
    17. regulation of protein import into nucleus Source: FlyBase
    18. rhythmic behavior Source: FlyBase
    19. sleep Source: FlyBase

    Keywords - Biological processi

    Biological rhythms

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein timeless
    Gene namesi
    Name:tim
    ORF Names:CG3234
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0014396. tim.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasmperinuclear region 1 Publication
    Note: Nuclear at specific periods of the day. First accumulates in the perinuclear region about one hour before translocation into the nucleus. Interaction with per is required for nuclear localization.

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. nucleus Source: FlyBase
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. protein complex Source: FlyBase

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mutant flies show loss of both behavioral circadian rhythms and molecular oscillations of per RNA and protein.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13981398Protein timelessPRO_0000022532Add
    BLAST

    Post-translational modificationi

    Phosphorylated with a circadian rhythmicity.

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Tissue specificityi

    Expressed in head, photoreceptors, lateral neurons and glial cells in the lamina and medulla of the optic lobes. Expression follows a light-dark cycle, levels show a significant decrease at the end of the night and then remain low throughout the light period (at protein level).2 Publications

    Gene expression databases

    BgeeiP49021.

    Interactioni

    Subunit structurei

    Forms a heterodimer with period (PER); the complex then translocates into the nucleus.

    Protein-protein interaction databases

    BioGridi59781. 7 interactions.
    DIPiDIP-29425N.
    MINTiMINT-344208.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni237 – 26832Necessary for normal circadian rhythmAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi550 – 56011Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi360 – 38930Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi432 – 4376Poly-Pro

    Sequence similaritiesi

    Belongs to the timeless family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG257888.
    GeneTreeiENSGT00390000015124.
    InParanoidiP49021.
    KOiK12074.
    OrthoDBiEOG7SXW2F.

    Family and domain databases

    InterProiIPR006906. Timeless.
    [Graphical view]
    PfamiPF04821. TIMELESS. 1 hit.
    [Graphical view]

    Sequences (7)i

    Sequence statusi: Complete.

    This entry describes 7 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform B (identifier: P49021-4) [UniParc]FASTAAdd to Basket

    Also known as: P, Q

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDWLLATPQL YSAFSSLGCL EGDTYVVNPN ALAILEEINY KLTYEDQTLR     50
    TFRRAIGFGQ NVRSDLIPLL ENAKDDAVLE SVIRILVNLT VPVECLFSVD 100
    VMYRTDVGRH TIFELNKLLY TSKEAFTEAR STKSVVEYMK HILESDPKLS 150
    PHKCDQINNC LLLLRNILHI PETHAHCVMP MMQSMPHGIS MQNTILWNLF 200
    IQSIDKLLLY LMTCPQRAFW GVTMVQLIAL IYKDQHVSTL QKLLSLWFEA 250
    SLSESSEDNE SNTSPPKQGS GDSSPMLTSD PTSDSSDNGS NGRGMGGGMR 300
    EGTAATLQEV SRKGQEYQNA MARVPADKPD GSEEASDMTG NDSEQPGSPE 350
    QSQPAGESMD DGDYEDQRHR QLNEHGEEDE DEDEVEEEEY LQLGPASEPL 400
    NLTQQPADKV NNTTNPTSSA PQGCLGNEPF KPPPPLPVRA STSAHAQMQK 450
    FNESSYASHV SAVKLGQKSP HAGQLQLTKG KCCPQKRECP SSQSELSDCG 500
    YGTQVENQES ISTSSNDDDG PQGKPQHQKP PCNTKPRNKP RTIMSPMDKK 550
    ELRRKKLVKR SKSSLINMKG LVQHTPTDDD ISNLLKEFTV DFLLKGYSYL 600
    VEELHMQLLS NAKVPIDTSH FFWLVTYFLK FAAQLELDME HIDTILTYDV 650
    LSYLTYEGVS LCEQLELNAR QEGSDLKPYL RRMHLVVTAI REFLQAIDTY 700
    NKVTHLNEDD KAHLRQLQLQ ISEMSDLRCL FVLLLRRFNP SIHSKQYLQD 750
    LVVTNHILLL ILDSSAKLGG CQTIRLSEHI TQFATLEVMH YYGILLEDFN 800
    NNGEFVNDCI FTMMHHIGGD LGQIGVLFQP IILKTYSRIW EADYELCDDW 850
    SDLIEYVIHK FMNTPPKSPL TIPTTSLTEM TKEHNQEHTV CSWSQEEMDT 900
    LYWYYVQSKK NNDIVGKIVK LFSNNGNKLK TRISIIQQLL QQDIITLLEY 950
    DDLMKFEDAE YQRTLLTTPT SATTESGIEI KECAYGKPSD DVQILLDLII 1000
    KENKAQHLLW LQRILIECCF VKLTLRSGLK VPEGDHIMEP VAYHCICKQK 1050
    SIPVVQWNNE QSTTMLYQPF VLLLHKLGIQ LPADAGSIFA RIPDYWTPET 1100
    MYGLAKKLGP LDKLNLKFDA SELEDATASS PSRYHHTGPR NSLSSVSSLD 1150
    VDLGDTEELA LIPEVDAAVE KAHAMASTPS PSEIFAVPKT KHCNSIIRYT 1200
    PDPTPPVPNW LQLVMRSKCN HRTGPSGDPS DCIGSSSTTV DDEGFGKSIS 1250
    AATSQAASTS MSTVNPTTTL SLNMLNTFMG SHNENSSSSG CGGTVSSLSM 1300
    VALMSTGAAG GGGNTSGLEM DVDASMKSSF ERLEVNGSHF SRANNLDQEY 1350
    SAMVASVYEK EKELNSDNVS LASDLTRMYV SDEDDRLERT EIRVPHYH 1398
    Length:1,398
    Mass (Da):156,382
    Last modified:May 14, 2014 - v3
    Checksum:iE7974EDCF6F94A88
    GO
    Isoform R (identifier: P49021-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-268: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,366
    Mass (Da):152,847
    Checksum:i06F0104288A8703F
    GO
    Isoform O (identifier: P49021-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         891-891: C → W
         892-1398: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:891
    Mass (Da):100,623
    Checksum:iAB62EC51D0F761AD
    GO
    Isoform N (identifier: P49021-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         613-613: Missing.
         891-891: C → W
         892-1398: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:890
    Mass (Da):100,495
    Checksum:iBC8202CC37F333B3
    GO
    Isoform S (identifier: P49021-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-268: Missing.
         1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
         1132-1398: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,099
    Mass (Da):124,696
    Checksum:i80AA3EF3AB03EF6C
    GO
    Isoform M (identifier: P49021-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1114-1131: LNLKFDASELEDATASSP → RELKSTTEKNNPFVIPQR
         1132-1398: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,131
    Mass (Da):128,231
    Checksum:i608FBAE2361C8271
    GO
    Isoform L (identifier: P49021-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         613-613: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,397
    Mass (Da):156,253
    Checksum:iCFA4573C81C95F41
    GO

    Sequence cautioni

    The sequence AAN71179.1 differs from that shown. Reason: Intron retention.
    The sequence AAC46920.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence AAL13507.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAN71179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence ACX54883.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1233 – 12331I → V in AAB94890. (PubMed:9365248)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei237 – 26832Missing in isoform R and isoform S. 1 PublicationVSP_004457Add
    BLAST
    Alternative sequencei613 – 6131Missing in isoform L and isoform N. 1 PublicationVSP_054859
    Alternative sequencei891 – 8911C → W in isoform N and isoform O. 2 PublicationsVSP_007693
    Alternative sequencei892 – 1398507Missing in isoform N and isoform O. 2 PublicationsVSP_007694Add
    BLAST
    Alternative sequencei1114 – 113118LNLKF…TASSP → RELKSTTEKNNPFVIPQR in isoform S and isoform M. CuratedVSP_054860Add
    BLAST
    Alternative sequencei1132 – 1398267Missing in isoform S and isoform M. CuratedVSP_054861Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37018 mRNA. Translation: AAC46920.1. Different initiation.
    AF032401, AF032400 Genomic DNA. Translation: AAB94890.1.
    AE014134 Genomic DNA. Translation: AAF51097.1.
    AE014134 Genomic DNA. Translation: AAF51098.4.
    AE014134 Genomic DNA. Translation: AAN10371.3.
    AE014134 Genomic DNA. Translation: AAN10372.3.
    AE014134 Genomic DNA. Translation: AAX52649.2.
    AE014134 Genomic DNA. Translation: ABC65862.2.
    AE014134 Genomic DNA. Translation: ACL82987.2.
    AE014134 Genomic DNA. Translation: ACL82988.2.
    AE014134 Genomic DNA. Translation: ADV36936.2.
    Y09930 Genomic DNA. No translation available.
    Y09931 Genomic DNA. No translation available.
    Y09932 Genomic DNA. No translation available.
    Y09933 Genomic DNA. No translation available.
    Y09934 Genomic DNA. No translation available.
    Y09935 Genomic DNA. No translation available.
    AY058278 mRNA. Translation: AAL13507.1. Different initiation.
    BT001424 mRNA. Translation: AAN71179.1. Sequence problems.
    BT024951 mRNA. Translation: ABE01181.1.
    BT099999 mRNA. Translation: ACX54883.1. Different initiation.
    AF038501 Genomic DNA. Translation: AAB94929.1.
    PIRiA57655.
    RefSeqiNP_001014463.2. NM_001014463.3. [P49021-6]
    NP_001033872.2. NM_001038783.3. [P49021-7]
    NP_001137780.2. NM_001144308.3. [P49021-2]
    NP_001137781.2. NM_001144309.3. [P49021-3]
    NP_001188686.2. NM_001201757.1. [P49021-5]
    NP_001188687.2. NM_001201758.2. [P49021-4]
    NP_722912.3. NM_164540.4. [P49021-4]
    NP_722913.3. NM_164541.5. [P49021-8]
    NP_722914.3. NM_164542.4. [P49021-4]
    UniGeneiDm.2663.

    Genome annotation databases

    EnsemblMetazoaiFBtr0333253; FBpp0305451; FBgn0014396. [P49021-7]
    FBtr0333254; FBpp0305452; FBgn0014396. [P49021-5]
    FBtr0333255; FBpp0305453; FBgn0014396. [P49021-3]
    FBtr0333258; FBpp0305456; FBgn0014396. [P49021-2]
    FBtr0333259; FBpp0305457; FBgn0014396. [P49021-6]
    GeneIDi33571.
    KEGGidme:Dmel_CG3234.
    UCSCiCG3234-RA. d. melanogaster. [P49021-4]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U37018 mRNA. Translation: AAC46920.1 . Different initiation.
    AF032401 , AF032400 Genomic DNA. Translation: AAB94890.1 .
    AE014134 Genomic DNA. Translation: AAF51097.1 .
    AE014134 Genomic DNA. Translation: AAF51098.4 .
    AE014134 Genomic DNA. Translation: AAN10371.3 .
    AE014134 Genomic DNA. Translation: AAN10372.3 .
    AE014134 Genomic DNA. Translation: AAX52649.2 .
    AE014134 Genomic DNA. Translation: ABC65862.2 .
    AE014134 Genomic DNA. Translation: ACL82987.2 .
    AE014134 Genomic DNA. Translation: ACL82988.2 .
    AE014134 Genomic DNA. Translation: ADV36936.2 .
    Y09930 Genomic DNA. No translation available.
    Y09931 Genomic DNA. No translation available.
    Y09932 Genomic DNA. No translation available.
    Y09933 Genomic DNA. No translation available.
    Y09934 Genomic DNA. No translation available.
    Y09935 Genomic DNA. No translation available.
    AY058278 mRNA. Translation: AAL13507.1 . Different initiation.
    BT001424 mRNA. Translation: AAN71179.1 . Sequence problems.
    BT024951 mRNA. Translation: ABE01181.1 .
    BT099999 mRNA. Translation: ACX54883.1 . Different initiation.
    AF038501 Genomic DNA. Translation: AAB94929.1 .
    PIRi A57655.
    RefSeqi NP_001014463.2. NM_001014463.3. [P49021-6 ]
    NP_001033872.2. NM_001038783.3. [P49021-7 ]
    NP_001137780.2. NM_001144308.3. [P49021-2 ]
    NP_001137781.2. NM_001144309.3. [P49021-3 ]
    NP_001188686.2. NM_001201757.1. [P49021-5 ]
    NP_001188687.2. NM_001201758.2. [P49021-4 ]
    NP_722912.3. NM_164540.4. [P49021-4 ]
    NP_722913.3. NM_164541.5. [P49021-8 ]
    NP_722914.3. NM_164542.4. [P49021-4 ]
    UniGenei Dm.2663.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 59781. 7 interactions.
    DIPi DIP-29425N.
    MINTi MINT-344208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0333253 ; FBpp0305451 ; FBgn0014396 . [P49021-7 ]
    FBtr0333254 ; FBpp0305452 ; FBgn0014396 . [P49021-5 ]
    FBtr0333255 ; FBpp0305453 ; FBgn0014396 . [P49021-3 ]
    FBtr0333258 ; FBpp0305456 ; FBgn0014396 . [P49021-2 ]
    FBtr0333259 ; FBpp0305457 ; FBgn0014396 . [P49021-6 ]
    GeneIDi 33571.
    KEGGi dme:Dmel_CG3234.
    UCSCi CG3234-RA. d. melanogaster. [P49021-4 ]

    Organism-specific databases

    CTDi 107698.
    FlyBasei FBgn0014396. tim.

    Phylogenomic databases

    eggNOGi NOG257888.
    GeneTreei ENSGT00390000015124.
    InParanoidi P49021.
    KOi K12074.
    OrthoDBi EOG7SXW2F.

    Miscellaneous databases

    ChiTaRSi ARHGEF5. drosophila.
    GenomeRNAii 33571.
    NextBioi 784249.

    Gene expression databases

    Bgeei P49021.

    Family and domain databases

    InterProi IPR006906. Timeless.
    [Graphical view ]
    Pfami PF04821. TIMELESS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positional cloning and sequence analysis of the Drosophila clock gene, timeless."
      Myers M.P., Wager-Smith K., Wesley C.S., Young M.W., Sehgal A.
      Science 270:805-808(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM R).
    2. "Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D. virilis suggests a new conserved structure for the TIMELESS protein."
      Myers M.P., Rothenfluh A., Chang M., Young M.W.
      Nucleic Acids Res. 25:4710-4714(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. "Conceptual translation of timeless reveals alternative initiating methionines in Drosophila."
      Rosato E., Trevisan A., Sandrelli F., Zordan M., Kyriacou C.P., Costa R.
      Nucleic Acids Res. 25:455-458(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30, ALTERNATIVE INITIATION.
      Strain: Canton-S, CO-TG14, CO-TG20, PER+, PER01 and PERS.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-1398 (ISOFORM O), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1398 (ISOFORMS B/L/R).
      Strain: Berkeley.
      Tissue: Head.
    7. Stapleton M., Booth B., Carlson J., Chavez C., Frise E., George R., Pacleb J., Park S., Wan K., Yu C., Celniker S.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM N), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 907-1398 (ISOFORMS B/L/R).
      Strain: Berkeley.
    8. "Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies."
      Ousley A., Zafarullah K., Chen Y., Emerson M., Hickman L., Sehgal A.
      Genetics 148:815-825(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 220-284, FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    9. "Block in nuclear localization of period protein by a second clock mutation, timeless."
      Vosshall L.B., Price J.L., Sehgal A., Saez L., Young M.W.
      Science 263:1606-1609(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    10. "Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation."
      Sehgal A., Rothenfluh-Hilfiker A., Hunter-Ensor M., Chen Y., Myers M.P., Young M.W.
      Science 270:808-810(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL."
      Gekakis N., Saez L., Delahaye-Brown A.M., Myers M.P., Sehgal A., Young M.W., Weitz C.J.
      Science 270:811-815(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PER.
    12. "Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light."
      Hunter-Ensor M., Ousley A., Sehgal A.
      Cell 84:677-685(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiTIM_DROME
    AccessioniPrimary (citable) accession number: P49021
    Secondary accession number(s): A4V040
    , B7Z007, B7Z008, C9QPB7, M9MRE9, O44380, Q1WWF5, Q59E16, Q8I037, Q95U67, Q9VQR6, Q9VQR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3