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Protein

Hydroxycarboxylic acid receptor 3

Gene

HCAR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.2 Publications

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-32536-MONOMER.
ReactomeiR-HSA-3296197. Hydroxycarboxylic acid-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxycarboxylic acid receptor 3
Alternative name(s):
G-protein coupled receptor 109B
G-protein coupled receptor HM74
G-protein coupled receptor HM74B
Niacin receptor 2
Nicotinic acid receptor 2
Gene namesi
Name:HCAR3
Synonyms:GPR109B, HCA3, HM74B, NIACR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16824. HCAR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 50Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini51 – 63CytoplasmicSequence analysisAdd BLAST13
Transmembranei64 – 85Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini86 – 102ExtracellularSequence analysisAdd BLAST17
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 194ExtracellularSequence analysisAdd BLAST31
Transmembranei195 – 209Helical; Name=5Sequence analysisAdd BLAST15
Topological domaini210 – 236CytoplasmicSequence analysisAdd BLAST27
Transmembranei237 – 256Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini257 – 273ExtracellularSequence analysisAdd BLAST17
Transmembranei274 – 298Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini299 – 387CytoplasmicSequence analysisAdd BLAST89

GO - Cellular componenti

  • cell junction Source: HPA
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi111R → A: Abrogates completely the activation by OH-octanoid acid. 1 Publication1

Organism-specific databases

DisGeNETi8843.
OpenTargetsiENSG00000255398.
PharmGKBiPA165512827.

Chemistry databases

ChEMBLiCHEMBL4421.
DrugBankiDB00627. Niacin.
GuidetoPHARMACOLOGYi313.

Polymorphism and mutation databases

BioMutaiHCAR3.
DMDMi519668680.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696041 – 387Hydroxycarboxylic acid receptor 3Add BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP49019.
PaxDbiP49019.
PeptideAtlasiP49019.
PRIDEiP49019.

PTM databases

PhosphoSitePlusiP49019.

Expressioni

Tissue specificityi

Expression largely restricted to adipose tissue and spleen.1 Publication

Gene expression databases

BgeeiENSG00000255398.
CleanExiHS_GPR109B.
GenevisibleiP49019. HS.

Organism-specific databases

HPAiHPA028660.

Interactioni

Protein-protein interaction databases

IntActiP49019. 1 interactor.
STRINGi9606.ENSP00000436714.

Chemistry databases

BindingDBiP49019.

Structurei

3D structure databases

ProteinModelPortaliP49019.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKI5. Eukaryota.
ENOG4110VUM. LUCA.
GeneTreeiENSGT00510000046798.
HOVERGENiHBG051680.
InParanoidiP49019.
KOiK08402.
OMAiANVCISF.
OrthoDBiEOG091G0AN6.
PhylomeDBiP49019.
TreeFamiTF330775.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028017. HCAR2/3_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF0. PTHR24231:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P49019-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRHHLQDHF LEIDKKNCCV FRDDFIAKVL PPVLGLEFIF GLLGNGLALW
60 70 80 90 100
IFCFHLKSWK SSRIFLFNLA VADFLLIICL PFVMDYYVRR SDWKFGDIPC
110 120 130 140 150
RLVLFMFAMN RQGSIIFLTV VAVDRYFRVV HPHHALNKIS NWTAAIISCL
160 170 180 190 200
LWGITVGLTV HLLKKKLLIQ NGTANVCISF SICHTFRWHE AMFLLEFFLP
210 220 230 240 250
LGIILFCSAR IIWSLRQRQM DRHAKIKRAI TFIMVVAIVF VICFLPSVVV
260 270 280 290 300
RIHIFWLLHT SGTQNCEVYR SVDLAFFITL SFTYMNSMLD PVVYYFSSPS
310 320 330 340 350
FPNFFSTLIN RCLQRKITGE PDNNRSTSVE LTGDPNKTRG APEALIANSG
360 370 380
EPWSPSYLGP TSNNHSKKGH CHQEPASLEK QLGCCIE
Length:387
Mass (Da):44,478
Last modified:June 26, 2013 - v3
Checksum:i887BA427B6134A3F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94K → N in BAA01721 (PubMed:7505609).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038715173T → P.4 PublicationsCorresponds to variant rs1798192dbSNPEnsembl.1
Natural variantiVAR_038716198F → L.4 PublicationsCorresponds to variant rs17884481dbSNPEnsembl.1
Natural variantiVAR_038717253H → R.4 PublicationsCorresponds to variant rs118091133dbSNPEnsembl.1
Natural variantiVAR_038718317I → M.4 PublicationsCorresponds to variant rs116821988dbSNPEnsembl.1
Natural variantiVAR_038719346I → M.4 PublicationsCorresponds to variant rs56308926dbSNPEnsembl.1
Natural variantiVAR_038720350G → S.Corresponds to variant rs201835480dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10923 mRNA. Translation: BAA01721.1.
AB065865 Genomic DNA. Translation: BAC06083.1.
AK290930 mRNA. Translation: BAF83619.1.
AK313212 mRNA. Translation: BAG36027.1.
EU293604 Genomic DNA. Translation: ABX64359.1.
AC026333 Genomic DNA. No translation available.
BC047891 mRNA. Translation: AAH47891.1.
CCDSiCCDS53842.1.
PIRiI69202.
RefSeqiNP_006009.2. NM_006018.2.
UniGeneiHs.458425.

Genome annotation databases

EnsembliENST00000528880; ENSP00000436714; ENSG00000255398.
GeneIDi8843.
KEGGihsa:8843.
UCSCiuc001ucy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10923 mRNA. Translation: BAA01721.1.
AB065865 Genomic DNA. Translation: BAC06083.1.
AK290930 mRNA. Translation: BAF83619.1.
AK313212 mRNA. Translation: BAG36027.1.
EU293604 Genomic DNA. Translation: ABX64359.1.
AC026333 Genomic DNA. No translation available.
BC047891 mRNA. Translation: AAH47891.1.
CCDSiCCDS53842.1.
PIRiI69202.
RefSeqiNP_006009.2. NM_006018.2.
UniGeneiHs.458425.

3D structure databases

ProteinModelPortaliP49019.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP49019. 1 interactor.
STRINGi9606.ENSP00000436714.

Chemistry databases

BindingDBiP49019.
ChEMBLiCHEMBL4421.
DrugBankiDB00627. Niacin.
GuidetoPHARMACOLOGYi313.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP49019.

Polymorphism and mutation databases

BioMutaiHCAR3.
DMDMi519668680.

Proteomic databases

MaxQBiP49019.
PaxDbiP49019.
PeptideAtlasiP49019.
PRIDEiP49019.

Protocols and materials databases

DNASUi8843.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528880; ENSP00000436714; ENSG00000255398.
GeneIDi8843.
KEGGihsa:8843.
UCSCiuc001ucy.4. human.

Organism-specific databases

CTDi8843.
DisGeNETi8843.
GeneCardsiHCAR3.
H-InvDBHIX0036803.
HGNCiHGNC:16824. HCAR3.
HPAiHPA028660.
MIMi606039. gene.
neXtProtiNX_P49019.
OpenTargetsiENSG00000255398.
PharmGKBiPA165512827.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKI5. Eukaryota.
ENOG4110VUM. LUCA.
GeneTreeiENSGT00510000046798.
HOVERGENiHBG051680.
InParanoidiP49019.
KOiK08402.
OMAiANVCISF.
OrthoDBiEOG091G0AN6.
PhylomeDBiP49019.
TreeFamiTF330775.

Enzyme and pathway databases

BioCyciZFISH:G66-32536-MONOMER.
ReactomeiR-HSA-3296197. Hydroxycarboxylic acid-binding receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii8843.
PROiP49019.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255398.
CleanExiHS_GPR109B.
GenevisibleiP49019. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028017. HCAR2/3_rcpt.
[Graphical view]
PANTHERiPTHR24231:SF0. PTHR24231:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHCAR3_HUMAN
AccessioniPrimary (citable) accession number: P49019
Secondary accession number(s): A8K4G5
, B2R830, E9PI97, Q8NGE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: June 26, 2013
Last modified: November 2, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.