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Protein

2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Gene

COQ5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).UniRule annotation1 Publication

Miscellaneous

Present with 8100 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.UniRule annotation2 Publications

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation2 Publications
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei122S-adenosyl-L-methionineUniRule annotation1 Publication1
Binding sitei148S-adenosyl-L-methionineUniRule annotation1 Publication1
Binding sitei197S-adenosyl-L-methionineUniRule annotation1 Publication1

GO - Molecular functioni

  • 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity Source: SGD
  • 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity Source: UniProtKB

GO - Biological processi

  • aerobic respiration Source: SGD
  • methylation Source: UniProtKB
  • ubiquinone biosynthetic process Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processUbiquinone biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciMetaCyc:YML110C-MONOMER
YEAST:YML110C-MONOMER
BRENDAi2.1.1.201 984
UniPathwayiUPA00232

Names & Taxonomyi

Protein namesi
Recommended name:
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial1 PublicationUniRule annotation (EC:2.1.1.201UniRule annotation2 Publications)
Alternative name(s):
2-hexaprenyl-6-methoxy-1,4-benzoquinol methyltransferase1 Publication
Ubiquinone biosynthesis methyltransferase COQ51 PublicationUniRule annotation
Gene namesi
Name:COQ52 PublicationsUniRule annotation
Synonyms:DBI56
Ordered Locus Names:YML110CImported
ORF Names:YM8339.09C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YML110C
SGDiS000004578 COQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionUniRule annotationAdd BLAST19
ChainiPRO_000019336120 – 3072-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrialAdd BLAST288

Proteomic databases

MaxQBiP49017
PaxDbiP49017
PRIDEiP49017

Interactioni

Subunit structurei

Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.UniRule annotation1 Publication

Protein-protein interaction databases

BioGridi35094, 184 interactors
DIPiDIP-1639N
IntActiP49017, 8 interactors
MINTiP49017
STRINGi4932.YML110C

Structurei

Secondary structure

1307
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi74 – 86Combined sources13
Turni87 – 89Combined sources3
Helixi90 – 101Combined sources12
Beta strandi114 – 119Combined sources6
Helixi124 – 137Combined sources14
Beta strandi143 – 149Combined sources7
Helixi151 – 164Combined sources14
Beta strandi166 – 169Combined sources4
Beta strandi173 – 177Combined sources5
Turni180 – 182Combined sources3
Beta strandi191 – 198Combined sources8
Helixi200 – 202Combined sources3
Helixi206 – 216Combined sources11
Beta strandi217 – 228Combined sources12
Helixi234 – 255Combined sources22
Helixi258 – 270Combined sources13
Helixi274 – 283Combined sources10
Beta strandi286 – 294Combined sources9
Helixi295 – 297Combined sources3
Beta strandi299 – 306Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OBWX-ray2.40A/B/C/D61-307[»]
4OBXX-ray2.20A/B/C/D61-307[»]
ProteinModelPortaliP49017
SMRiP49017
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni179 – 180S-adenosyl-L-methionine bindingUniRule annotation1 Publication2

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotationCurated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000001654
HOGENOMiHOG000249463
InParanoidiP49017
KOiK06127
OMAiVRNFENL
OrthoDBiEOG092C4DR2

Family and domain databases

HAMAPiMF_01813 MenG_UbiE_methyltr, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR004033 UbiE/COQ5_MeTrFase
IPR023576 UbiE/COQ5_MeTrFase_CS
PfamiView protein in Pfam
PF01209 Ubie_methyltran, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR01934 MenG_MenH_UbiE, 1 hit
PROSITEiView protein in PROSITE
PS51608 SAM_MT_UBIE, 1 hit
PS01183 UBIE_1, 1 hit
PS01184 UBIE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLISSRIVRS SLVNVPLRLS RCFTQAHRAC KEEEVNSPLS SAAEQPEQKY
60 70 80 90 100
THFGSKTVLK STKQKLVGDV FSSVANRYDL MNDVMSLGIH RLWKDHFINK
110 120 130 140 150
LDAGKRPNST TPLNFIDVAG GSGDIAFGLL DHAESKFGDT ESTMDIVDIN
160 170 180 190 200
PDMLKEGEKR AMEQGKYFKD PRVRFLVSNG EKLEEIDSDS KDIYTVSFGI
210 220 230 240 250
RNFTDIQKGL NTAYRVLKPG GIFYCLEFSK IENPLMDFAY QQWAKVLPVM
260 270 280 290 300
GSMIANDYDS YQYLVESIER FPDQETFKSM IEKAGFKSAG YESLTFGICA

IHWGIKV
Length:307
Mass (Da):34,685
Last modified:February 1, 1996 - v1
Checksum:iC8951F9C8FFF8F41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49210 Genomic DNA Translation: CAA89108.1
AY693194 Genomic DNA Translation: AAT93213.1
BK006946 Genomic DNA Translation: DAA09788.1
PIRiS53962
RefSeqiNP_013597.1, NM_001182472.1

Genome annotation databases

EnsemblFungiiYML110C; YML110C; YML110C
GeneIDi854930
KEGGisce:YML110C

Similar proteinsi

Entry informationi

Entry nameiCOQ5_YEAST
AccessioniPrimary (citable) accession number: P49017
Secondary accession number(s): D6W0H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

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