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Reviewed, UniProtKB/Swiss-Prot P49015 (ATP7A_CRIGR)

Last modified November 25, 2008. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Copper-transporting ATPase 1
    EC=3.6.3.4
Alternative name(s):
    Copper pump 1
Gene names
Name: ATP7A
OrganismCricetulus griseus (Chinese hamster)
Taxonomic identifier10029 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus

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Protein attributes

Sequence length1476 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

May function in the export of copper from the cytoplasm to an intracellular organelle. It may serve as well for the export of other metals.

Catalytic activity

ATP + H(2)O + Cu(2+)(In) = ADP + phosphate + Cu(2+)(Out).

Subunit structure

Monomer.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in most tissues except liver.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family.

Contains 6 HMA domains.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›1476›1476Copper-transporting ATPase 1
PRO_0000046310

Regions

Topological domain1 – 642642Cytoplasmic Potential
Transmembrane643 – 66523 Potential
Transmembrane695 – 71723 Potential
Transmembrane736 – 76025 Potential
Transmembrane770 – 78819 Potential
Transmembrane930 – 95223 Potential
Transmembrane978 – 99821 Potential
Transmembrane1347 – 137327 Potential
Transmembrane1379 – 139719 Potential
Domain9 – 7567HMA 1
Domain172 – 23867HMA 2
Domain277 – 34367HMA 3
Domain377 – 44367HMA 4
Domain479 – 54567HMA 5
Domain555 – 62167HMA 6

Sites

Active site103414-aspartylphosphate intermediate Probable

Amino acid modifications

Modified residue3521Phosphoserine By similarity
Modified residue3551Phosphoserine By similarity
Modified residue3561Phosphoserine By similarity
Glycosylation6741N-linked (GlcNAc...) Potential
Glycosylation6851N-linked (GlcNAc...) Potential
Glycosylation8871N-linked (GlcNAc...) Potential
Glycosylation9531N-linked (GlcNAc...) Potential
Glycosylation11301N-linked (GlcNAc...) Potential
Glycosylation11341N-linked (GlcNAc...) Potential
Glycosylation14481N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue14761

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Sequences

Sequence LengthMass (Da)Tools
P49015-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 6B36F5A2AC358C0B

FASTA1,476160,336
        10         20         30         40         50         60 
MEPSMDVNSV TISVEGMTCI SCVRTIEQKI GKENGIHHIK VSLEEKSATI IYDPKLQTPK 

        70         80         90        100        110        120 
TLQEAIDDMG FDALLHNANP LPVLTDTLFL TVTASLTLPW DHIQSTLLKT KGVTDIKIFP 

       130        140        150        160        170        180 
QKRTLAVTII PSIVNANQIK ELVPELSLET GTLEKRSGAC EDHSMAQAGE VVLKIKVEGM 

       190        200        210        220        230        240 
TCHSCTSTTE GKIGKLQGVQ RIKVSLDNQE ATIVYQPHLI SVEEIKKQIE AMGFPAFVKK 

       250        260        270        280        290        300 
QPKYLKLGAI DVERLKNTPV KSLEGSQQRP SYPSDSTATF IIEGMHCKSC VSNIESALPT 

       310        320        330        340        350        360 
LQYVSSIAVS LENRSAIVKY NASSVTPEML IKAIEAVSPG QYRVSIANEV ESTSSSPSSS 

       370        380        390        400        410        420 
SLQKMPLNVV SQPLTQETVI NISGMTCNSC VQSIEGVVSK KPGVKSIHVS LANSFGTVEY 

       430        440        450        460        470        480 
DPLLTAPETL REVIVDMGFD AVLPDMSEPL VVIAQPSLET PLLPSTNDQD NMMTAVHSKC 

       490        500        510        520        530        540 
YIQVSGMTCA SCVANIERNL RREEGIYSVL VALMAGKAEV RYNPAVIQPP VIAEFIRELG 

       550        560        570        580        590        600 
FGATVMENAD EGDGILKLVV RGMTCASCVH KIESTLTKHK GIFYCSVALA TNKAHIKYDP 

       610        620        630        640        650        660 
EIIGPRDIIH TIGSLGFEAS LVKKDRSASH LDHKREIKQW RSSFLVSLFF CTPVMGLMMY 

       670        680        690        700        710        720 
MMAMEHHFAT IHHNQSMSNE EMIKNHSSMF LERQILPGLS IMNLLSLLLC LPVQFFGGWY 

       730        740        750        760        770        780 
FYIQAYKALK HKTANMDVLI VLATTIAFAY SLIILLVAMY ERAKVNPITS FDTPPMLFVF 

       790        800        810        820        830        840 
IALGRWLEHI AKGKTSEALA KLISLQATEA TIVTLDSDNI LLSEEQVDVE LVQRGDIIKV 

       850        860        870        880        890        900 
VPGGKFPVDG RVIEGHSMVD ESLITGEAMP VAKKPGSTVI AGSINQNGSL LICATHVGAD 

       910        920        930        940        950        960 
TTLSQIVKLV EEAQTSKAPI QQFADKLGGY FVPFIVLVSI ATLLVWIIIG FQNFTIVETY 

       970        980        990       1000       1010       1020 
FPGYSRSISR TETIIRFAFQ ASITVLCIAC PCSLGLATPT AVMVGTGVGA QNGILIKGGE 

      1030       1040       1050       1060       1070       1080 
PLEMAHKVKV VVFDKTGTIT HGTPVVNQVK VLVESNKIPR SKILAIVGTA ESNSEHPLGA 

      1090       1100       1110       1120       1130       1140 
AVTKYCKQEL DTETLGTCTD FQVVPGCGIS CKVTNIEGLL HKSNLKIEEN NTKNASLVQI 

      1150       1160       1170       1180       1190       1200 
DAINEQSSTS SSMIIDAPLS NAVDTQQYKV LIGNREWMIR NGLVISNDVD DSMIDHGRKG 

      1210       1220       1230       1240       1250       1260 
RPAVLVTIDD ELCGLIAIAD TVKPEAELAV HILKSMGLEV VLMTGDNSKT ARSIASQVGI 

      1270       1280       1290       1300       1310       1320 
TKVFAEVLPS HKVAKVKQLQ EEGKRVAMVG DGINDSPALA MANVGIAIGT GTDVTIEAAD 

      1330       1340       1350       1360       1370       1380 
VVFIRNDLLD VVASIDLSRK TVKRIRINFL FPLIYNLVGI PIAAGVFLPI GLVFQPWMGS 

      1390       1400       1410       1420       1430       1440 
AAMAASSVSV VLSSLFLKLY RKPTYDNYEL RTRSHTGQRS PSEISVHVGI DDASRNSPRL 

      1450       1460       1470 
GLLDRIVNYS RASINSLLSD KRSLNSVVNS EPDKHS

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References

[1]"Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux."
Camakaris J., Petris M.J., Bailey L., Shen P., Lockhart P., Glover T.W., Barcroft C., Patton J., Mercer J.F.B.
Hum. Mol. Genet. 4:2117-2123(1995) [PubMed: 8589689] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Ovary.

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Web resources

Protein Spotlight

Heavy metal - Issue 79 of February 2007

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Cross-references

Sequence databases

U29946 mRNA. Translation: AAB39918.1.

3D structure databases

HSSPHSSP built from PDB template 1AW0 based on UniProtKB Q04656.
SMRP49015. Positions 1-79, 164-246, 274-350, 374-445.
ModBaseSearch...

Phylogenomic databases

HOVERGENP49015.

Family and domain databases

InterProIPR006416. ATPase-IB_hvy.
IPR001757. ATPase_P.
IPR006403. ATPase_P_cat/Cu.
IPR001877. Cu_ATPase1.
IPR006122. Cu_ion_bd.
IPR005834. Dehalogen-like_hydro.
IPR008250. E1-E2_ATPase_reg.
IPR006121. HeavyMe_transpt.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 6 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00942. CUATPASEI.
TIGRFAMsTIGR01511. ATPase-IB1_Cu. 1 hit.
TIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
TIGR00003. Cu_ion_bd. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 5 hits.
PS50846. HMA_2. 6 hits.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATP7A_CRIGR
AccessionPrimary (citable) accession number: P49015
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 25, 2008
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents