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Protein

Noggin

Gene

nog

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Patterns the embryo by interrupting bone morphogenetic proteins (BMP) signaling. Binds BMP-4 and BMP-2 with high affinity. Can abolish BMP-4 activity by blocking binding to cognate cell-surface receptors. Capable of inducing dorsal development in embryos. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with xWNT-8 and nuclear, sequence-specific DNA-binding protein xBRA. None of these molecules causes dorsal mesoderm formation when expressed alone.1 Publication

GO - Biological processi

  • cartilage development Source: UniProtKB-KW
  • cell differentiation Source: UniProtKB-KW
  • muscle organ development Source: UniProtKB
  • negative regulation of BMP signaling pathway Source: CACAO
  • negative regulation of cell differentiation Source: InterPro

Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Noggin
Gene namesi
Name:nog
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-864891. nog.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001982120 – 222NogginAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 182By similarity
Disulfide bondi168 ↔ 218By similarity
Disulfide bondi174 ↔ 220By similarity
Disulfide bondi197 ↔ 205By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expression starts at late blastula stages in the dorsal marginal zone and persists throughout gastrulation in the prechordal plat and the presumptive notochord, both derivatives of the Spemann organizer. At later stages expression is initiated at several new sites, including the roof plate of the neural tube and skeletogenic cells in the branchial arches.

Inductioni

By activin.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP49011.
SMRiP49011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the noggin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006514.
KOiK04658.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR008717. Noggin.
PANTHERiPTHR10494. PTHR10494. 1 hit.
PIRSFiPIRSF008129. Noggin. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSQCLVTI YALMVFLGLR IDQGGCQHYL HIRPAPSENL PLVDLIEHPD
60 70 80 90 100
PIYDPKEKDL NETLLRTLMV GHFDPNFMAT ILPEERLGVE DLGELDLLLR
110 120 130 140 150
QKPSGAMPAE IKGLEFYEGL QSKKHRLSKK LRRKLQMWLW SQTFCPVLYT
160 170 180 190 200
WNDLGTRFWP RYVKVGSCYS KRSCSVPEGM VCKAAKSMHL TILRWRCQRR
210 220
VQQKCAWITI QYPVISECKC SC
Length:222
Mass (Da):25,799
Last modified:February 1, 1996 - v1
Checksum:i99A11096CD21A8C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98807 mRNA. Translation: AAA49916.1.
PIRiA43343.
RefSeqiNP_001079113.1. NM_001085644.1.
UniGeneiXl.834.

Genome annotation databases

GeneIDi373646.
KEGGixla:373646.

Similar proteinsi

Entry informationi

Entry nameiNOGG_XENLA
AccessioniPrimary (citable) accession number: P49011
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 10, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families