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Protein

Chitooligosaccharidolytic beta-N-acetylglucosaminidase

Gene
N/A
Organism
Bombyx mori (Silk moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active during metamorphosis to degrade chitin.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB

GO - Biological processi

  1. chitin catabolic process Source: UniProtKB
  2. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Chitin degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitooligosaccharidolytic beta-N-acetylglucosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
Beta-hexosaminidase
OrganismiBombyx mori (Silk moth)
Taxonomic identifieri7091 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaBombycidaeBombycinaeBombyx
ProteomesiUP000005204: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 596573Chitooligosaccharidolytic beta-N-acetylglucosaminidasePRO_0000012013Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP49010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

KOiK12373.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49010-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWLQAICIYT VFIIIGCGIP TAAEEHSLWR WTCENNRCTK IRNEPENKEP
60 70 80 90 100
VLSLEACKMF CDDYGLLWPK PTIETNLGNF LSKINMNTID IQITKQGKSD
110 120 130 140 150
DLLTAAADRF KTLVSSSVPK GFSAKAAGKS VTVYLVNENP YIREFSLDMD
160 170 180 190 200
ESYELYISST SSDKVNATIR GNSFFGVRNG LETLSQLIVY DDIRNNLLIV
210 220 230 240 250
RDVTIKDRPV YPYRGILLDT ARNFYSIDSI KRTIDAMAAV KLNTFHWHIT
260 270 280 290 300
DSQSFPLVLQ KRPNLSKLGA YSPTKVYTKQ DIREVVEYGL ERGVRVLPEF
310 320 330 340 350
DAPAHVGEGW QDTGLTVCFK AEPWTKFCVE PPCGQLNPTK EELYDYLEDI
360 370 380 390 400
YVEMAEAFES TDMFHMGGDE VSERCWNSSE EIQNFMIQNR WNLDKSSFLK
410 420 430 440 450
LWNYFQKNAQ DRAYKAFGKR LPLILWTSTL TDYTHVEKFL DKDEYIIQVW
460 470 480 490 500
TTGADPQIQG LLQKGYRLIM SNYDALYFDC GFGAWVGSGN NWCSPYIGGQ
510 520 530 540 550
KVYGNSPAVM ALSYRDQILG GEVALWSEQS DPATLDGRLW PRAAAFAERM
560 570 580 590
WAEPSTAWQD AEHRMLHVRE RLVRMGIQAE SLEPEWCYQN QGLCYG
Length:596
Mass (Da):68,213
Last modified:February 1, 1996 - v1
Checksum:iF302963E94A3A2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77548 mRNA. Translation: AAC60521.1.
PIRiJC2539.
RefSeqiNP_001037466.1. NM_001044001.1.
UniGeneiBmo.345.

Genome annotation databases

GeneIDi693032.
KEGGibmor:693032.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77548 mRNA. Translation: AAC60521.1.
PIRiJC2539.
RefSeqiNP_001037466.1. NM_001044001.1.
UniGeneiBmo.345.

3D structure databases

ProteinModelPortaliP49010.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi693032.
KEGGibmor:693032.

Phylogenomic databases

KOiK12373.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Purification of a chitooligosaccharidolytic beta-N-acetylglucosaminidase from Bombyx mori larvae during metamorphosis and the nucleotide sequence of its cDNA."
    Nagamatsu Y., Yanagisawa I., Kimoto M., Okamoto E., Koga D.
    Biosci. Biotechnol. Biochem. 59:219-225(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: Kinshu X Showa.

Entry informationi

Entry nameiHEXC_BOMMO
AccessioniPrimary (citable) accession number: P49010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.