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Protein

Beta-hexosaminidase subunit alpha

Gene

HEXA

Organism
Entamoeba histolytica
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hexoaminidase complex may contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components.1 Publication

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase subunit alpha (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase subunit alpha
Beta-N-acetylhexosaminidase subunit alpha
N-acetyl-beta-glucosaminidase subunit alpha
Gene namesi
Name:HEXA
Synonyms:BEX-1, HEX-A1
OrganismiEntamoeba histolytica
Taxonomic identifieri5759 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 14By similarityAdd BLAST14
ChainiPRO_000001201115 – 564Beta-hexosaminidase subunit alphaAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

PTM databases

iPTMnetiP49009.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.

Structurei

3D structure databases

ProteinModelPortaliP49009.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499. Eukaryota.
COG3525. LUCA.

Family and domain databases

Gene3Di3.30.379.10. 1 hit.
InterProiView protein in InterPro
IPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat.
IPR017853. Glycoside_hydrolase_SF.
IPR029018. Hex-like_dom2.
IPR029019. HEX_eukaryotic_N.
PfamiView protein in Pfam
PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFIFIVFIS SVFAGNGLNV QNQLLLMPYP SSVSFQWKSP LAIALTSSIQ
60 70 80 90 100
LNVKSTCNTD CMNFLKSNFN HTISFPLQQQ TGLQDFKVSL FKEIDLPRIT
110 120 130 140 150
PSVSSVITDV VVELSSSNPM PKLQIGFDES YILEVTTNSI SIKAVTVYGA
160 170 180 190 200
RHAFETLLQL IRISSNKFVI SQLPIKISDA PRFKWRGLMV DPSRNPLSPL
210 220 230 240 250
MFKRIIDTLA SVKANVLHIH LSDAQTFVFE SKKYPLLHQK GMYDESFVLT
260 270 280 290 300
QSFLRELAQY GANRGVIVYG EIDTPAHTAS WNLGYPGVVA NCWDYIVSTS
310 320 330 340 350
MRYGENVLSL NPANPNTFPI IDALMKELSD TFGTDYVHVG GDEVWTSGWS
360 370 380 390 400
KSKEYSDIQK FMKSKGLNSL TELEGYFNKY AQEQVIHNGK HPVVWEEVFK
410 420 430 440 450
KGNADKNTII QVWDDIRLLQ QVVNSGYKAI FSAGFYLDKQ MPLCNSYDSS
460 470 480 490 500
TCVNTHSMWV WTNRDMYDND PVKSLSSSEK ENVLGGEGCS WGESTDEQNF
510 520 530 540 550
FDRVFQRYSA IAERLWSKES VVDKESHEVR ANYLRCLDVR RDIMKGTGPL
560
YHSFCQLPKK EKSN
Length:564
Mass (Da):63,935
Last modified:March 15, 2005 - v2
Checksum:i8EFE1D34609C86A4
GO

Sequence cautioni

The sequence AAA80165 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ582954 Genomic DNA. Translation: CAE46968.1.
AJ634053 Genomic DNA. Translation: CAG23943.1.
U09735 mRNA. Translation: AAA80165.1. Different initiation.

Similar proteinsi

Entry informationi

Entry nameiHEXA_ENTHI
AccessioniPrimary (citable) accession number: P49009
Secondary accession number(s): Q70FJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: March 15, 2005
Last modified: February 28, 2018
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)