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P49009

- HEXA_ENTHI

UniProt

P49009 - HEXA_ENTHI

Protein

Beta-hexosaminidase subunit alpha

Gene

HEXA

Organism
Entamoeba histolytica
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Hexoaminidase complex may contribute to amoebic pathogenicity and may be involved in the destruction of extracellular matrix components.1 Publication

    Catalytic activityi

    Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

    GO - Molecular functioni

    1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH20. Glycoside Hydrolase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-hexosaminidase subunit alpha (EC:3.2.1.52)
    Alternative name(s):
    Beta-GlcNAcase subunit alpha
    Beta-N-acetylhexosaminidase subunit alpha
    N-acetyl-beta-glucosaminidase subunit alpha
    Gene namesi
    Name:HEXA
    Synonyms:BEX-1, HEX-A1
    OrganismiEntamoeba histolytica
    Taxonomic identifieri5759 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba

    Subcellular locationi

    Cytoplasmic granule 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1414By similarityAdd
    BLAST
    Chaini15 – 564550Beta-hexosaminidase subunit alphaPRO_0000012011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.

    Structurei

    3D structure databases

    ProteinModelPortaliP49009.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 20 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3525.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProiIPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view]
    PfamiPF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSiPR00738. GLHYDRLASE20.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49009-1 [UniParc]FASTAAdd to Basket

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    MLFIFIVFIS SVFAGNGLNV QNQLLLMPYP SSVSFQWKSP LAIALTSSIQ    50
    LNVKSTCNTD CMNFLKSNFN HTISFPLQQQ TGLQDFKVSL FKEIDLPRIT 100
    PSVSSVITDV VVELSSSNPM PKLQIGFDES YILEVTTNSI SIKAVTVYGA 150
    RHAFETLLQL IRISSNKFVI SQLPIKISDA PRFKWRGLMV DPSRNPLSPL 200
    MFKRIIDTLA SVKANVLHIH LSDAQTFVFE SKKYPLLHQK GMYDESFVLT 250
    QSFLRELAQY GANRGVIVYG EIDTPAHTAS WNLGYPGVVA NCWDYIVSTS 300
    MRYGENVLSL NPANPNTFPI IDALMKELSD TFGTDYVHVG GDEVWTSGWS 350
    KSKEYSDIQK FMKSKGLNSL TELEGYFNKY AQEQVIHNGK HPVVWEEVFK 400
    KGNADKNTII QVWDDIRLLQ QVVNSGYKAI FSAGFYLDKQ MPLCNSYDSS 450
    TCVNTHSMWV WTNRDMYDND PVKSLSSSEK ENVLGGEGCS WGESTDEQNF 500
    FDRVFQRYSA IAERLWSKES VVDKESHEVR ANYLRCLDVR RDIMKGTGPL 550
    YHSFCQLPKK EKSN 564
    Length:564
    Mass (Da):63,935
    Last modified:March 15, 2005 - v2
    Checksum:i8EFE1D34609C86A4
    GO

    Sequence cautioni

    The sequence AAA80165.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ582954 Genomic DNA. Translation: CAE46968.1.
    AJ634053 Genomic DNA. Translation: CAG23943.1.
    U09735 mRNA. Translation: AAA80165.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ582954 Genomic DNA. Translation: CAE46968.1 .
    AJ634053 Genomic DNA. Translation: CAG23943.1 .
    U09735 mRNA. Translation: AAA80165.1 . Different initiation.

    3D structure databases

    ProteinModelPortali P49009.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH20. Glycoside Hydrolase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG3525.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    3.30.379.10. 1 hit.
    InterProi IPR025705. Beta_hexosaminidase_sua/sub.
    IPR029018. Chitobiase/Hex_dom_2-like.
    IPR015883. Glyco_hydro_20_cat-core.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR029019. HEX_eukaryotic_N.
    [Graphical view ]
    Pfami PF00728. Glyco_hydro_20. 1 hit.
    PF14845. Glycohydro_20b2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
    PRINTSi PR00738. GLHYDRLASE20.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    SSF55545. SSF55545. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The beta-N-acetylhexosaminidase of Entamoeba histolytica is composed of two homologous chains and has been localized to cytoplasmic granules."
      Riekenberg S., Flockenhaus B., Vahrmann A., Mueller M.C.M., Leippe M., Kiess M., Scholze H.H.
      Mol. Biochem. Parasitol. 138:217-225(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION, INTERACTION WITH HEXB.
      Strain: ATCC 30459 / HM-1:IMSS.
    2. Scholze H.H.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 30459 / HM-1:IMSS.
    3. "The primary structure of an Entamoeba histolytica beta-hexosaminidase A subunit."
      Beanan M.J., Bailey G.B.
      J. Eukaryot. Microbiol. 42:632-636(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-564.
      Strain: ATCC 30459 / HM-1:IMSS.

    Entry informationi

    Entry nameiHEXA_ENTHI
    AccessioniPrimary (citable) accession number: P49009
    Secondary accession number(s): Q70FJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3