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P49008 (HEXA_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-hexosaminidase
EC=3.2.1.52
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
Short name=Beta-NAHase
N-acetyl-beta-glucosaminidase
Gene names
Name:nahA
Ordered Locus Names:PG_0043
OrganismPorphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]
Taxonomic identifier242619 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas ›

Protein attributes

Sequence length777 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Subcellular location

Cell outer membrane; Lipid-anchor Probable.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   Cellular componentCell membrane
Cell outer membrane
Membrane
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 777759Beta-hexosaminidase
PRO_0000012016

Amino acid modifications

Lipidation191N-palmitoyl cysteine Probable
Lipidation191S-diacylglycerol cysteine Probable

Experimental info

Sequence conflict2581R → H in CAA55582. Ref.1
Sequence conflict2651E → M in CAA55582. Ref.1
Sequence conflict282 – 2832LA → FR in CAA55582. Ref.1
Sequence conflict5751T → S in CAA55582. Ref.1
Sequence conflict7471G → A in CAA55582. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P49008 [UniParc].

Last modified October 3, 2003. Version 2.
Checksum: D0A55D2C2FFAD864

FASTA77787,661
        10         20         30         40         50         60 
MKRLTFGACI CCLLSLMACS QKAKQVQIPE YDKGINIIPL PMQLTESDDS FEVDDKTTIC 

        70         80         90        100        110        120 
VSAEELKPIA KLLADKLRAS ADLSLQIEIG EEPSGNAIYI GVDTALPLKE EGYMLRSDKR 

       130        140        150        160        170        180 
GVSIIGKSAH GAFYGMQTLL QLLPAEVESS NEVLLPMTVP GVEIKDEPAF GYRGFMLDVC 

       190        200        210        220        230        240 
RHFLSVEDIK KHIDIMAMFK INRFHWHLTE DQAWRIEIKK YPRLTEVGST RTEGDGTQYS 

       250        260        270        280        290        300 
GFYTQEQVRD IVQYASDRFI TVIPEIEMPG HAMAALAAYP QLACFPREFK PRIIWGVEQD 

       310        320        330        340        350        360 
VYCAGKDSVF RFISDVIDEV APLFPGTYFH IGGDECPKDR WKACSLCQKR MRDNGLKDEH 

       370        380        390        400        410        420 
ELQSYFIKQA EKVLQKHGKR LIGWDEILEG GLAPSATVMS WRGEDGGIAA ANMNHDVIMT 

       430        440        450        460        470        480 
PGSGGLYLDH YQGDPTVEPV AIGGYAPLEQ VYAYNPLPKE LPADKHRYVL GAQANLWAEY 

       490        500        510        520        530        540 
LYTSERYDYQ AYPRLLAVAE LTWTPLAKKD FADFCRRLDN ACVRLDMHGI NYHIPLPEQP 

       550        560        570        580        590        600 
GGSSDFIAFT DKAKLTFTTS RPMKMVYTLD ETEPTLTSTP YTVPLEFAQT GLLKIRTVTA 

       610        620        630        640        650        660 
GGKMSPVRRI RVEKQPFNMS MEVPAPKPGL TIRTAYGDLY DVPDLQQVAS WEVGTVSSLE 

       670        680        690        700        710        720 
EIMHGKEKIT SPEVLERRVV EATGYVLIPE DGVYEFSTEN NEFWIDNVKL IDNVGEVKKF 

       730        740        750        760        770 
SRRNSSRALQ KGYHPIKTIW VGAIQGGWPT YWNYSRVMIR LKGEEKFKPI SSDMLFQ

« Hide

References

« Hide 'large scale' references
[1]"Cloning and expression in Escherichia coli of the nahA gene from Porphyromonas gingivalis indicates that beta-N-acetylhexosaminidase is an outer-membrane-associated lipoprotein."
Lovatt A., Roberts I.S.
Microbiology 140:3399-3406(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC BAA-308 / W83.
[2]"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83."
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. expand/collapse author list , Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.
J. Bacteriol. 185:5591-5601(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-308 / W83.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X78979 Genomic DNA. Translation: CAA55582.1.
AE015924 Genomic DNA. Translation: AAQ65295.1.
RefSeqNP_904396.1. NC_002950.2.

3D structure databases

ProteinModelPortalP49008.
ModBaseSearch...

Protein-protein interaction databases

STRING242619.PG0043.

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAQ65295; AAQ65295; PG_0043.
GeneID2552216.
KEGGpgi:PG0043.
PATRIC22977240. VBIPorGin134034_0039.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3525.
KOK12373.
OMADVNINTH.
ProtClustDBCLSK826754.

Enzyme and pathway databases

BioCycPGIN242619:GHX8-41-MONOMER.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
3.90.182.10. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR004867. CHB_HEX_C_dom.
IPR015883. Glyco_hydro_20_cat-core.
IPR015882. Glyco_hydro_20b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR011658. PA14.
[Graphical view]
PfamPF03174. CHB_HEX_C. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSPR00738. GLHYDRLASE20.
SMARTSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEXA_PORGI
AccessionPrimary (citable) accession number: P49008
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2003
Last modified: May 29, 2013
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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