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P49008

- HEXA_PORGI

UniProt

P49008 - HEXA_PORGI

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Protein
Beta-hexosaminidase
Gene
nahA, PG_0043
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-41-MONOMER.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
Short name:
Beta-NAHase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nahA
Ordered Locus Names:PG_0043
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 777759Beta-hexosaminidase
PRO_0000012016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteine Inferred
Lipidationi19 – 191S-diacylglycerol cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0043.

Structurei

3D structure databases

ProteinModelPortaliP49008.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
KOiK12373.
OMAiVNINTHV.
OrthoDBiEOG6DC6HQ.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
3.90.182.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR004867. CHB_HEX_C_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR011658. PA14.
[Graphical view]
PfamiPF03174. CHB_HEX_C. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49008-1 [UniParc]FASTAAdd to Basket

« Hide

MKRLTFGACI CCLLSLMACS QKAKQVQIPE YDKGINIIPL PMQLTESDDS    50
FEVDDKTTIC VSAEELKPIA KLLADKLRAS ADLSLQIEIG EEPSGNAIYI 100
GVDTALPLKE EGYMLRSDKR GVSIIGKSAH GAFYGMQTLL QLLPAEVESS 150
NEVLLPMTVP GVEIKDEPAF GYRGFMLDVC RHFLSVEDIK KHIDIMAMFK 200
INRFHWHLTE DQAWRIEIKK YPRLTEVGST RTEGDGTQYS GFYTQEQVRD 250
IVQYASDRFI TVIPEIEMPG HAMAALAAYP QLACFPREFK PRIIWGVEQD 300
VYCAGKDSVF RFISDVIDEV APLFPGTYFH IGGDECPKDR WKACSLCQKR 350
MRDNGLKDEH ELQSYFIKQA EKVLQKHGKR LIGWDEILEG GLAPSATVMS 400
WRGEDGGIAA ANMNHDVIMT PGSGGLYLDH YQGDPTVEPV AIGGYAPLEQ 450
VYAYNPLPKE LPADKHRYVL GAQANLWAEY LYTSERYDYQ AYPRLLAVAE 500
LTWTPLAKKD FADFCRRLDN ACVRLDMHGI NYHIPLPEQP GGSSDFIAFT 550
DKAKLTFTTS RPMKMVYTLD ETEPTLTSTP YTVPLEFAQT GLLKIRTVTA 600
GGKMSPVRRI RVEKQPFNMS MEVPAPKPGL TIRTAYGDLY DVPDLQQVAS 650
WEVGTVSSLE EIMHGKEKIT SPEVLERRVV EATGYVLIPE DGVYEFSTEN 700
NEFWIDNVKL IDNVGEVKKF SRRNSSRALQ KGYHPIKTIW VGAIQGGWPT 750
YWNYSRVMIR LKGEEKFKPI SSDMLFQ 777
Length:777
Mass (Da):87,661
Last modified:October 3, 2003 - v2
Checksum:iD0A55D2C2FFAD864
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581R → H in CAA55582. 1 Publication
Sequence conflicti265 – 2651E → M in CAA55582. 1 Publication
Sequence conflicti282 – 2832LA → FR in CAA55582. 1 Publication
Sequence conflicti575 – 5751T → S in CAA55582. 1 Publication
Sequence conflicti747 – 7471G → A in CAA55582. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78979 Genomic DNA. Translation: CAA55582.1.
AE015924 Genomic DNA. Translation: AAQ65295.1.
RefSeqiNP_904396.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65295; AAQ65295; PG_0043.
GeneIDi2552216.
KEGGipgi:PG0043.
PATRICi22977240. VBIPorGin134034_0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78979 Genomic DNA. Translation: CAA55582.1 .
AE015924 Genomic DNA. Translation: AAQ65295.1 .
RefSeqi NP_904396.1. NC_002950.2.

3D structure databases

ProteinModelPortali P49008.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0043.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65295 ; AAQ65295 ; PG_0043 .
GeneIDi 2552216.
KEGGi pgi:PG0043.
PATRICi 22977240. VBIPorGin134034_0039.

Phylogenomic databases

eggNOGi COG3525.
KOi K12373.
OMAi VNINTHV.
OrthoDBi EOG6DC6HQ.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-41-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
3.90.182.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR004867. CHB_HEX_C_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR011658. PA14.
[Graphical view ]
Pfami PF03174. CHB_HEX_C. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SMARTi SM00758. PA14. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression in Escherichia coli of the nahA gene from Porphyromonas gingivalis indicates that beta-N-acetylhexosaminidase is an outer-membrane-associated lipoprotein."
    Lovatt A., Roberts I.S.
    Microbiology 140:3399-3406(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiHEXA_PORGI
AccessioniPrimary (citable) accession number: P49008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2003
Last modified: June 11, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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