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P49008

- HEXA_PORGI

UniProt

P49008 - HEXA_PORGI

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Protein

Beta-hexosaminidase

Gene

nahA

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-41-MONOMER.

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
Short name:
Beta-NAHase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:nahA
Ordered Locus Names:PG_0043
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818PROSITE-ProRule annotationAdd
BLAST
Chaini19 – 777759Beta-hexosaminidasePRO_0000012016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi19 – 191N-palmitoyl cysteineCurated
Lipidationi19 – 191S-diacylglycerol cysteineCurated

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi242619.PG0043.

Structurei

3D structure databases

ProteinModelPortaliP49008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
KOiK12373.
OMAiVNINTHV.
OrthoDBiEOG6DC6HQ.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
3.90.182.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR004867. CHB_HEX_C_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR011658. PA14.
[Graphical view]
PfamiPF03174. CHB_HEX_C. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view]
PRINTSiPR00738. GLHYDRLASE20.
SMARTiSM00758. PA14. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49008-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRLTFGACI CCLLSLMACS QKAKQVQIPE YDKGINIIPL PMQLTESDDS
60 70 80 90 100
FEVDDKTTIC VSAEELKPIA KLLADKLRAS ADLSLQIEIG EEPSGNAIYI
110 120 130 140 150
GVDTALPLKE EGYMLRSDKR GVSIIGKSAH GAFYGMQTLL QLLPAEVESS
160 170 180 190 200
NEVLLPMTVP GVEIKDEPAF GYRGFMLDVC RHFLSVEDIK KHIDIMAMFK
210 220 230 240 250
INRFHWHLTE DQAWRIEIKK YPRLTEVGST RTEGDGTQYS GFYTQEQVRD
260 270 280 290 300
IVQYASDRFI TVIPEIEMPG HAMAALAAYP QLACFPREFK PRIIWGVEQD
310 320 330 340 350
VYCAGKDSVF RFISDVIDEV APLFPGTYFH IGGDECPKDR WKACSLCQKR
360 370 380 390 400
MRDNGLKDEH ELQSYFIKQA EKVLQKHGKR LIGWDEILEG GLAPSATVMS
410 420 430 440 450
WRGEDGGIAA ANMNHDVIMT PGSGGLYLDH YQGDPTVEPV AIGGYAPLEQ
460 470 480 490 500
VYAYNPLPKE LPADKHRYVL GAQANLWAEY LYTSERYDYQ AYPRLLAVAE
510 520 530 540 550
LTWTPLAKKD FADFCRRLDN ACVRLDMHGI NYHIPLPEQP GGSSDFIAFT
560 570 580 590 600
DKAKLTFTTS RPMKMVYTLD ETEPTLTSTP YTVPLEFAQT GLLKIRTVTA
610 620 630 640 650
GGKMSPVRRI RVEKQPFNMS MEVPAPKPGL TIRTAYGDLY DVPDLQQVAS
660 670 680 690 700
WEVGTVSSLE EIMHGKEKIT SPEVLERRVV EATGYVLIPE DGVYEFSTEN
710 720 730 740 750
NEFWIDNVKL IDNVGEVKKF SRRNSSRALQ KGYHPIKTIW VGAIQGGWPT
760 770
YWNYSRVMIR LKGEEKFKPI SSDMLFQ
Length:777
Mass (Da):87,661
Last modified:October 3, 2003 - v2
Checksum:iD0A55D2C2FFAD864
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti258 – 2581R → H in CAA55582. (PubMed:7881557)Curated
Sequence conflicti265 – 2651E → M in CAA55582. (PubMed:7881557)Curated
Sequence conflicti282 – 2832LA → FR in CAA55582. (PubMed:7881557)Curated
Sequence conflicti575 – 5751T → S in CAA55582. (PubMed:7881557)Curated
Sequence conflicti747 – 7471G → A in CAA55582. (PubMed:7881557)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78979 Genomic DNA. Translation: CAA55582.1.
AE015924 Genomic DNA. Translation: AAQ65295.1.
RefSeqiNP_904396.1. NC_002950.2.
WP_005873538.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ65295; AAQ65295; PG_0043.
GeneIDi2552216.
KEGGipgi:PG0043.
PATRICi22977240. VBIPorGin134034_0039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78979 Genomic DNA. Translation: CAA55582.1 .
AE015924 Genomic DNA. Translation: AAQ65295.1 .
RefSeqi NP_904396.1. NC_002950.2.
WP_005873538.1. NC_002950.2.

3D structure databases

ProteinModelPortali P49008.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG0043.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ65295 ; AAQ65295 ; PG_0043 .
GeneIDi 2552216.
KEGGi pgi:PG0043.
PATRICi 22977240. VBIPorGin134034_0039.

Phylogenomic databases

eggNOGi COG3525.
KOi K12373.
OMAi VNINTHV.
OrthoDBi EOG6DC6HQ.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-41-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
3.90.182.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR004867. CHB_HEX_C_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
IPR011658. PA14.
[Graphical view ]
Pfami PF03174. CHB_HEX_C. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
PF07691. PA14. 1 hit.
[Graphical view ]
PRINTSi PR00738. GLHYDRLASE20.
SMARTi SM00758. PA14. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression in Escherichia coli of the nahA gene from Porphyromonas gingivalis indicates that beta-N-acetylhexosaminidase is an outer-membrane-associated lipoprotein."
    Lovatt A., Roberts I.S.
    Microbiology 140:3399-3406(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.

Entry informationi

Entry nameiHEXA_PORGI
AccessioniPrimary (citable) accession number: P49008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2003
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3