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P49007 (HEXB_PSEO7) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase B

EC=3.2.1.52
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
Short name=Beta-NAHase
N-acetyl-beta-glucosaminidase
Gene names
Name:nag096
OrganismPseudoalteromonas piscicida
Taxonomic identifier43662 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

polysaccharide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 773754Beta-hexosaminidase B
PRO_0000012015

Sites

Active site5311Proton donor By similarity

Amino acid modifications

Disulfide bond46 ↔ 53 By similarity
Disulfide bond389 ↔ 397 By similarity
Disulfide bond496 ↔ 542 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49007 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: DBB379885E004642

FASTA77386,760
        10         20         30         40         50         60 
MKFNRLMALL FGVSSPLYAL DQTAVNWLGQ NLDVKYTLLD TKPTTCPKAQ QKCYYSELSF 

        70         80         90        100        110        120 
SVRKENTKAN NDFAIFFSQL MPIYHVEGDN FAITHINGDI HKITPAAGFS GFSSAPTTVR 

       130        140        150        160        170        180 
FYTKDSQVTR SEVYAKLCCE RTRSLKLTPQ VIKSTQTQRD NDTGLDCNLN LTPFVTLNQL 

       190        200        210        220        230        240 
QTSSKDDTPW MGSEYLYQHQ VKPTLDAAIG LIPKPKQLTV LSDKRLNLAA GINLQLSGIS 

       250        260        270        280        290        300 
ADAIAMAQQR LNTLGVKSTK EGLVVNVAVK PNKQSSPHYQ LTVAENNISI QGNNSAAAFY 

       310        320        330        340        350        360 
ALQSLAGLLD INDLRIPMVD IIDTPRYDFR GLHVDVARNF RSKAFILQTI EQMAAYKLNK 

       370        380        390        400        410        420 
LHLHLADDEG WRLAIDGLDE LTSVGAYRCF DLTETRCLLP QLGAGNDKNA QVNGFYSAED 

       430        440        450        460        470        480 
YIEILRYAKA HHIEVLPSLD MPGHSRAAII AMEARYKKLM AQGKPEDAQK YRLVETADKT 

       490        500        510        520        530        540 
RYSSIQHYND NTLNVCIANT YTFIDKVLSE VKVLHDRAGV PLNTYHIGAD ETAVLWLESP 

       550        560        570        580        590        600 
ACKKLQASVK DFTNFNGYFI ERVAKLLDKK GIQVAGWSDG LGDVRAANMP ANIQSNGLGD 

       610        620        630        640        650        660 
IKRKRAPVAH RFANQGWQVV LSSPDVTYFD FPYQSHPEER GNHWASRAIE SKKMFEFMPD 

       670        680        690        700        710        720 
NLPAHAEIWK NTNNHAYIAN DSDSSLNKGV QFAGLQGHLW SEMLRSDAQA EYMLYPRLLA 

       730        740        750        760        770 
LAERAWHHAE WELPYQAGRI YSQSSGYFTA KLQAQREADW QRFVAILGNS RTT 

« Hide

References

[1]"Molecular cloning of the gene which encodes beta-N-acetylglucosaminidase from a marine bacterium, Alteromonas sp. strain O-7."
Tsujibo H., Fujimoto K., Tanno H., Miyamoto K., Kimura Y., Imada C., Okami Y., Inamori Y.
Appl. Environ. Microbiol. 61:804-806(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: O-7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D29665 Genomic DNA. Translation: BAA06136.1.

3D structure databases

ProteinModelPortalP49007.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.290. 1 hit.
3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR008965. Carb-bd_dom.
IPR012291. CBD_carb-bd_dom.
IPR004866. CHB/HEX_N_dom.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR015882. HEX_bac_N.
[Graphical view]
PfamPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PRINTSPR00738. GLHYDRLASE20.
SMARTSM01081. CHB_HEX. 1 hit.
[Graphical view]
SUPFAMSSF49384. SSF49384. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEXB_PSEO7
AccessionPrimary (citable) accession number: P49007
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries