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Reviewed, UniProtKB/Swiss-Prot P49007 (HEXB_PSEO7)

Last modified June 16, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Beta-hexosaminidase B
    EC=3.2.1.52
Alternative name(s):
    N-acetyl-beta-glucosaminidase
    Beta-GlcNAcase
    Beta-N-acetylhexosaminidase
      Short name=Beta-NAHase
Gene names
Name: nag096
OrganismPseudoalteromonas piscicida
Taxonomic identifier43662 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas

Protein attributes

Sequence length773 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 773754Beta-hexosaminidase B
PRO_0000012015

Sites

Active site5311Proton donor By similarity

Amino acid modifications

Disulfide bond46 ↔ 53 By similarity
Disulfide bond389 ↔ 397 By similarity
Disulfide bond496 ↔ 542 By similarity

Sequences

Sequence LengthMass (Da)Tools
P49007-1 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: DBB379885E004642

FASTA77386,760
        10         20         30         40         50         60 
MKFNRLMALL FGVSSPLYAL DQTAVNWLGQ NLDVKYTLLD TKPTTCPKAQ QKCYYSELSF 

        70         80         90        100        110        120 
SVRKENTKAN NDFAIFFSQL MPIYHVEGDN FAITHINGDI HKITPAAGFS GFSSAPTTVR 

       130        140        150        160        170        180 
FYTKDSQVTR SEVYAKLCCE RTRSLKLTPQ VIKSTQTQRD NDTGLDCNLN LTPFVTLNQL 

       190        200        210        220        230        240 
QTSSKDDTPW MGSEYLYQHQ VKPTLDAAIG LIPKPKQLTV LSDKRLNLAA GINLQLSGIS 

       250        260        270        280        290        300 
ADAIAMAQQR LNTLGVKSTK EGLVVNVAVK PNKQSSPHYQ LTVAENNISI QGNNSAAAFY 

       310        320        330        340        350        360 
ALQSLAGLLD INDLRIPMVD IIDTPRYDFR GLHVDVARNF RSKAFILQTI EQMAAYKLNK 

       370        380        390        400        410        420 
LHLHLADDEG WRLAIDGLDE LTSVGAYRCF DLTETRCLLP QLGAGNDKNA QVNGFYSAED 

       430        440        450        460        470        480 
YIEILRYAKA HHIEVLPSLD MPGHSRAAII AMEARYKKLM AQGKPEDAQK YRLVETADKT 

       490        500        510        520        530        540 
RYSSIQHYND NTLNVCIANT YTFIDKVLSE VKVLHDRAGV PLNTYHIGAD ETAVLWLESP 

       550        560        570        580        590        600 
ACKKLQASVK DFTNFNGYFI ERVAKLLDKK GIQVAGWSDG LGDVRAANMP ANIQSNGLGD 

       610        620        630        640        650        660 
IKRKRAPVAH RFANQGWQVV LSSPDVTYFD FPYQSHPEER GNHWASRAIE SKKMFEFMPD 

       670        680        690        700        710        720 
NLPAHAEIWK NTNNHAYIAN DSDSSLNKGV QFAGLQGHLW SEMLRSDAQA EYMLYPRLLA 

       730        740        750        760        770 
LAERAWHHAE WELPYQAGRI YSQSSGYFTA KLQAQREADW QRFVAILGNS RTT 

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References

[1]"Molecular cloning of the gene which encodes beta-N-acetylglucosaminidase from a marine bacterium, Alteromonas sp. strain O-7."
Tsujibo H., Fujimoto K., Tanno H., Miyamoto K., Kimura Y., Imada C., Okami Y., Inamori Y.
Appl. Environ. Microbiol. 61:804-806(1995) [PubMed: 7574618] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: O-7.

Cross-references

Sequence databases

D29665 Genomic DNA. Translation: BAA06136.1.

3D structure databases

HSSPHSSP built from PDB template 1QBA based on UniProtKB Q54468.
ModBaseSearch...

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.

Family and domain databases

InterProIPR004866. CB_bd_Hex_N.
IPR012291. CBD_carb_bd.
IPR001540. Glyco_hydro_20.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_sg_catalytic.
IPR015882. HexNAc-like_b.
[Graphical view]
Gene3DG3DSA:2.60.40.290. CBD_carb_bd. 1 hit.
G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
PANTHERPTHR22600. Glyco_hydro_20. 1 hit.
PfamPF03173. CHB_HEX. 1 hit.
PF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PRINTSPR00738. GLHYDRLASE20.
ProtoNetSearch...

Entry information

Entry nameHEXB_PSEO7
AccessionPrimary (citable) accession number: P49007
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents