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Protein

Bone morphogenetic protein 5

Gene

Bmp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 5
Short name:
BMP-5
Gene namesi
Name:Bmp5
Synonyms:Bmp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88181. Bmp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Propeptidei26 – 314289Sequence analysisPRO_0000033868Add
BLAST
Chaini315 – 452138Bone morphogenetic protein 5PRO_0000033869Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence analysis
Disulfide bondi351 ↔ 417By similarity
Disulfide bondi380 ↔ 449By similarity
Disulfide bondi384 ↔ 451By similarity
Glycosylationi393 – 3931N-linked (GlcNAc...)Sequence analysis
Disulfide bondi416 – 416InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP49003.
PaxDbiP49003.
PRIDEiP49003.

PTM databases

PhosphoSiteiP49003.

Expressioni

Gene expression databases

BgeeiP49003.
CleanExiMM_BMP5.
GenevisibleiP49003. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198365. 1 interaction.
STRINGi10090.ENSMUSP00000012281.

Structurei

3D structure databases

ProteinModelPortaliP49003.
SMRiP49003. Positions 245-452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP49003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG7J9VPQ.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHWTVFLLRG IVGFLWSGWV QVGYAKGGLG DNHVHSSFIY RRLRNHERRE
60 70 80 90 100
IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMAS EDNPEEYLVR
110 120 130 140 150
VSLAGEAKET RKGYPASPNG YAHRLHLPPR TPLTTQSPPL ASLHDTNFLN
160 170 180 190 200
DADMVMSFVN LVERDKDFSH QRRHYKEFRF DLTQIPHGEA VTAAEFRIYK
210 220 230 240 250
DKGNHRFENE TIKISIYQII KEYTNRDADL FLLDTRKTQA LDVGWLVFDI
260 270 280 290 300
TVTSNHWVIN PQNNLGLQLC AETGDGRSIN VKSAGLVGRH GPQSKQPFMV
310 320 330 340 350
AFFKASEVLL RSVRAASKRK NQNRNKSNSH QDPSRMPSAG DYNTSEQKQA
360 370 380 390 400
CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV
410 420 430 440 450
QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG

CH
Length:452
Mass (Da):51,512
Last modified:February 1, 1996 - v1
Checksum:iAAD9521EC94A78D5
GO
Isoform 2 (identifier: P49003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: E → EES

Show »
Length:454
Mass (Da):51,728
Checksum:i722EA34FF25D63A0
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 951E → EES in isoform 2. 1 PublicationVSP_044321

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41145 mRNA. Translation: AAA64612.1.
AK033362 mRNA. Translation: BAC28247.1.
AC079245 Genomic DNA. No translation available.
AC144940 Genomic DNA. No translation available.
CCDSiCCDS23348.1. [P49003-2]
PIRiI49542.
RefSeqiNP_031581.2. NM_007555.4. [P49003-2]
UniGeneiMm.428950.

Genome annotation databases

EnsembliENSMUST00000012281; ENSMUSP00000012281; ENSMUSG00000032179. [P49003-2]
GeneIDi12160.
KEGGimmu:12160.
UCSCiuc009qsu.1. mouse. [P49003-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41145 mRNA. Translation: AAA64612.1.
AK033362 mRNA. Translation: BAC28247.1.
AC079245 Genomic DNA. No translation available.
AC144940 Genomic DNA. No translation available.
CCDSiCCDS23348.1. [P49003-2]
PIRiI49542.
RefSeqiNP_031581.2. NM_007555.4. [P49003-2]
UniGeneiMm.428950.

3D structure databases

ProteinModelPortaliP49003.
SMRiP49003. Positions 245-452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198365. 1 interaction.
STRINGi10090.ENSMUSP00000012281.

PTM databases

PhosphoSiteiP49003.

Proteomic databases

MaxQBiP49003.
PaxDbiP49003.
PRIDEiP49003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012281; ENSMUSP00000012281; ENSMUSG00000032179. [P49003-2]
GeneIDi12160.
KEGGimmu:12160.
UCSCiuc009qsu.1. mouse. [P49003-2]

Organism-specific databases

CTDi653.
MGIiMGI:88181. Bmp5.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP49003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG7J9VPQ.
TreeFamiTF316134.

Miscellaneous databases

ChiTaRSiBmp5. mouse.
NextBioi280507.
PROiP49003.
SOURCEiSearch...

Gene expression databases

BgeeiP49003.
CleanExiMM_BMP5.
GenevisibleiP49003. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice."
    King J.A., Marker P.C., Seung K.J., Kingsley D.M.
    Dev. Biol. 166:112-122(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/KW.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiBMP5_MOUSE
AccessioniPrimary (citable) accession number: P49003
Secondary accession number(s): Q8CCE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.