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Protein

Bone morphogenetic protein 5

Gene

Bmp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

GO - Biological processi

  • allantois development Source: BHF-UCL
  • BMP signaling pathway Source: GO_Central
  • cardiac muscle tissue development Source: BHF-UCL
  • cardiac septum morphogenesis Source: BHF-UCL
  • cartilage development Source: UniProtKB-KW
  • cell development Source: GO_Central
  • chorio-allantoic fusion Source: BHF-UCL
  • endocardial cushion formation Source: BHF-UCL
  • growth Source: InterPro
  • heart trabecula morphogenesis Source: BHF-UCL
  • hindbrain development Source: BHF-UCL
  • male genitalia development Source: MGI
  • negative regulation of aldosterone biosynthetic process Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cortisol biosynthetic process Source: MGI
  • negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • negative regulation of steroid biosynthetic process Source: MGI
  • neural fold elevation formation Source: BHF-UCL
  • ossification Source: UniProtKB-KW
  • pattern specification process Source: MGI
  • pericardium morphogenesis Source: BHF-UCL
  • pharyngeal system development Source: BHF-UCL
  • positive regulation of dendrite development Source: MGI
  • positive regulation of DNA-dependent DNA replication Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • skeletal system development Source: MGI
  • SMAD protein signal transduction Source: GO_Central
  • type B pancreatic cell development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 5
Short name:
BMP-5
Gene namesi
Name:Bmp5
Synonyms:Bmp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88181. Bmp5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000003386826 – 314Sequence analysisAdd BLAST289
ChainiPRO_0000033869315 – 452Bone morphogenetic protein 5Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi351 ↔ 417By similarity
Disulfide bondi380 ↔ 449By similarity
Disulfide bondi384 ↔ 451By similarity
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi416InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP49003.
PaxDbiP49003.
PRIDEiP49003.

PTM databases

PhosphoSitePlusiP49003.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032179.
CleanExiMM_BMP5.
GenevisibleiP49003. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198365. 1 interactor.
STRINGi10090.ENSMUSP00000012281.

Structurei

3D structure databases

ProteinModelPortaliP49003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP49003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG091G0C2J.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHWTVFLLRG IVGFLWSGWV QVGYAKGGLG DNHVHSSFIY RRLRNHERRE
60 70 80 90 100
IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMAS EDNPEEYLVR
110 120 130 140 150
VSLAGEAKET RKGYPASPNG YAHRLHLPPR TPLTTQSPPL ASLHDTNFLN
160 170 180 190 200
DADMVMSFVN LVERDKDFSH QRRHYKEFRF DLTQIPHGEA VTAAEFRIYK
210 220 230 240 250
DKGNHRFENE TIKISIYQII KEYTNRDADL FLLDTRKTQA LDVGWLVFDI
260 270 280 290 300
TVTSNHWVIN PQNNLGLQLC AETGDGRSIN VKSAGLVGRH GPQSKQPFMV
310 320 330 340 350
AFFKASEVLL RSVRAASKRK NQNRNKSNSH QDPSRMPSAG DYNTSEQKQA
360 370 380 390 400
CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV
410 420 430 440 450
QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG

CH
Length:452
Mass (Da):51,512
Last modified:February 1, 1996 - v1
Checksum:iAAD9521EC94A78D5
GO
Isoform 2 (identifier: P49003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: E → EES

Show »
Length:454
Mass (Da):51,728
Checksum:i722EA34FF25D63A0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04432195E → EES in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41145 mRNA. Translation: AAA64612.1.
AK033362 mRNA. Translation: BAC28247.1.
AC079245 Genomic DNA. No translation available.
AC144940 Genomic DNA. No translation available.
CCDSiCCDS23348.1. [P49003-2]
PIRiI49542.
RefSeqiNP_031581.2. NM_007555.4. [P49003-2]
UniGeneiMm.428950.

Genome annotation databases

EnsembliENSMUST00000012281; ENSMUSP00000012281; ENSMUSG00000032179. [P49003-2]
GeneIDi12160.
KEGGimmu:12160.
UCSCiuc009qsu.1. mouse. [P49003-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41145 mRNA. Translation: AAA64612.1.
AK033362 mRNA. Translation: BAC28247.1.
AC079245 Genomic DNA. No translation available.
AC144940 Genomic DNA. No translation available.
CCDSiCCDS23348.1. [P49003-2]
PIRiI49542.
RefSeqiNP_031581.2. NM_007555.4. [P49003-2]
UniGeneiMm.428950.

3D structure databases

ProteinModelPortaliP49003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198365. 1 interactor.
STRINGi10090.ENSMUSP00000012281.

PTM databases

PhosphoSitePlusiP49003.

Proteomic databases

MaxQBiP49003.
PaxDbiP49003.
PRIDEiP49003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012281; ENSMUSP00000012281; ENSMUSG00000032179. [P49003-2]
GeneIDi12160.
KEGGimmu:12160.
UCSCiuc009qsu.1. mouse. [P49003-2]

Organism-specific databases

CTDi653.
MGIiMGI:88181. Bmp5.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000249476.
HOVERGENiHBG004860.
InParanoidiP49003.
KOiK04663.
OMAiFRIYKDQ.
OrthoDBiEOG091G0C2J.
TreeFamiTF316134.

Miscellaneous databases

ChiTaRSiBmp5. mouse.
PROiP49003.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032179.
CleanExiMM_BMP5.
GenevisibleiP49003. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 2 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBMP5_MOUSE
AccessioniPrimary (citable) accession number: P49003
Secondary accession number(s): Q8CCE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.