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Protein

Bone morphogenetic protein 5

Gene

Bmp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

GO - Biological processi

  • allantois development Source: BHF-UCL
  • anterior head development Source: MGI
  • BMP signaling pathway Source: GO_Central
  • cardiac muscle tissue development Source: BHF-UCL
  • cardiac septum morphogenesis Source: BHF-UCL
  • cartilage development Source: UniProtKB-KW
  • cell development Source: GO_Central
  • chorio-allantoic fusion Source: BHF-UCL
  • ear development Source: MGI
  • endocardial cushion formation Source: BHF-UCL
  • heart trabecula morphogenesis Source: BHF-UCL
  • hindbrain development Source: BHF-UCL
  • male genitalia development Source: MGI
  • negative regulation of aldosterone biosynthetic process Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of cortisol biosynthetic process Source: MGI
  • negative regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • negative regulation of steroid biosynthetic process Source: MGI
  • neural fold elevation formation Source: BHF-UCL
  • ossification Source: UniProtKB-KW
  • pattern specification process Source: MGI
  • pericardium morphogenesis Source: BHF-UCL
  • pharyngeal system development Source: BHF-UCL
  • positive regulation of dendrite development Source: MGI
  • positive regulation of DNA-dependent DNA replication Source: MGI
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • skeletal system development Source: MGI
  • SMAD protein signal transduction Source: GO_Central
  • type B pancreatic cell development Source: MGI

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 5
Short name:
BMP-5
Gene namesi
Name:Bmp5
Synonyms:Bmp-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88181 Bmp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000003386826 – 314Sequence analysisAdd BLAST289
ChainiPRO_0000033869315 – 452Bone morphogenetic protein 5Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi343N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi351 ↔ 417By similarity
Disulfide bondi380 ↔ 449By similarity
Disulfide bondi384 ↔ 451By similarity
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi416InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP49003
PaxDbiP49003
PRIDEiP49003

PTM databases

PhosphoSitePlusiP49003

Expressioni

Gene expression databases

BgeeiENSMUSG00000032179
CleanExiMM_BMP5
GenevisibleiP49003 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198365, 1 interactor
STRINGi10090.ENSMUSP00000012281

Structurei

3D structure databases

ProteinModelPortaliP49003
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000249476
HOVERGENiHBG004860
InParanoidiP49003
KOiK04663
OMAiKEYPNRD
OrthoDBiEOG091G0C2J
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P49003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHWTVFLLRG IVGFLWSGWV QVGYAKGGLG DNHVHSSFIY RRLRNHERRE
60 70 80 90 100
IQREILSILG LPHRPRPFSP GKQASSAPLF MLDLYNAMAS EDNPEEYLVR
110 120 130 140 150
VSLAGEAKET RKGYPASPNG YAHRLHLPPR TPLTTQSPPL ASLHDTNFLN
160 170 180 190 200
DADMVMSFVN LVERDKDFSH QRRHYKEFRF DLTQIPHGEA VTAAEFRIYK
210 220 230 240 250
DKGNHRFENE TIKISIYQII KEYTNRDADL FLLDTRKTQA LDVGWLVFDI
260 270 280 290 300
TVTSNHWVIN PQNNLGLQLC AETGDGRSIN VKSAGLVGRH GPQSKQPFMV
310 320 330 340 350
AFFKASEVLL RSVRAASKRK NQNRNKSNSH QDPSRMPSAG DYNTSEQKQA
360 370 380 390 400
CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV
410 420 430 440 450
QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG

CH
Length:452
Mass (Da):51,512
Last modified:February 1, 1996 - v1
Checksum:iAAD9521EC94A78D5
GO
Isoform 2 (identifier: P49003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-95: E → EES

Show »
Length:454
Mass (Da):51,728
Checksum:i722EA34FF25D63A0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04432195E → EES in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41145 mRNA Translation: AAA64612.1
AK033362 mRNA Translation: BAC28247.1
AC079245 Genomic DNA No translation available.
AC144940 Genomic DNA No translation available.
CCDSiCCDS23348.1 [P49003-2]
PIRiI49542
RefSeqiNP_031581.2, NM_007555.4 [P49003-2]
UniGeneiMm.428950

Genome annotation databases

EnsembliENSMUST00000012281; ENSMUSP00000012281; ENSMUSG00000032179 [P49003-2]
GeneIDi12160
KEGGimmu:12160
UCSCiuc009qsu.1 mouse [P49003-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBMP5_MOUSE
AccessioniPrimary (citable) accession number: P49003
Secondary accession number(s): Q8CCE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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