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Protein

Bone morphogenetic protein 3

Gene

Bmp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Gene namesi
Name:Bmp3
Synonyms:Bmp-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2212 Bmp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003384023 – 358By similarityAdd BLAST336
ChainiPRO_0000033841359 – 468Bone morphogenetic protein 3Add BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi139N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi366 ↔ 433By similarity
Disulfide bondi395 ↔ 465By similarity
Disulfide bondi399 ↔ 467By similarity
Disulfide bondi432InterchainBy similarity
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49002
PRIDEiP49002

Expressioni

Tissue specificityi

Expressed in embryonic calvaria and femur, and in adult aorta, costa, femur, kidney, lung, ovary, spleen and trachea.1 Publication

Inductioni

Expression increases in mesenchymal cells at fracture sites during healing. Also highly expressed in chondrocytes and osteoblasts at newly formed cartilage and bone.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032031

Structurei

3D structure databases

ProteinModelPortaliP49002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
HOGENOMiHOG000232003
HOVERGENiHBG004857
InParanoidiP49002
KOiK05496
PhylomeDBiP49002

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR017197 BMP3/BMP3B
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PIRSFiPIRSF037403 BMP3/GDF10, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARGLLCL WLGCFCLNLA QGQRPNLHLP GLRGTESSDR MTGGGPSPDL
60 70 80 90 100
RPHDKVSEHM LWLYDRYSGS NRAQATRTPG SQLPGPQPLR GGNTVRSFRA
110 120 130 140 150
AAAGTLQRKG LHTFNLTSLT KSENILSATL YFYIGELVNT SVNCPESQGC
160 170 180 190 200
SHDSQRQHIQ IDLSAWTLQS NQSQLLGHLS VDTAKPYRDS MSWLSKDITQ
210 220 230 240 250
LLRKAKQDEE FLIGFNITSR AHELPKRMLL FPEPYILVYA NDAAICEPES
260 270 280 290 300
VVSSLQRHRD FTAGTVPRLD SHVREALSVE RRKKRSTGIL LPLQNNELPG
310 320 330 340 350
AEYQYKEAGV WEERKPYKSL QTQPPEKSRS KKKQRKGPHQ KGQTLQFDEQ
360 370 380 390 400
TLKKARRKQW IEPRNCARRY LKVDFADIGW SEWIISPKSF DAYYCSGACQ
410 420 430 440 450
FPMPKSLKPS NHATIQSIVR AVGVVSGIPE PCCVPEKMSS LSILFFDENK
460
NVVLKVYPNM TVDSCACR
Length:468
Mass (Da):52,675
Last modified:February 1, 1996 - v1
Checksum:i05315D4954DC3CA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63860 mRNA Translation: BAA09922.1
S77492 mRNA Translation: AAB33725.1
PIRiI53032
RefSeqiNP_058801.1, NM_017105.1
UniGeneiRn.208979

Genome annotation databases

GeneIDi25667
KEGGirno:25667
UCSCiRGD:2212 rat

Similar proteinsi

Entry informationi

Entry nameiBMP3_RAT
AccessioniPrimary (citable) accession number: P49002
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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