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Protein

Bone morphogenetic protein 3

Gene

Bmp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 3
Short name:
BMP-3
Gene namesi
Name:Bmp3
Synonyms:Bmp-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2212. Bmp3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
  • membrane-bounded vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 358336By similarityPRO_0000033840Add
BLAST
Chaini359 – 468110Bone morphogenetic protein 3PRO_0000033841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence analysis
Disulfide bondi366 ↔ 433By similarity
Disulfide bondi395 ↔ 465By similarity
Disulfide bondi399 ↔ 467By similarity
Disulfide bondi432 – 432InterchainBy similarity
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49002.
PRIDEiP49002.

Expressioni

Tissue specificityi

Expressed in embryonic calvaria and femur, and in adult aorta, costa, femur, kidney, lung, ovary, spleen and trachea.1 Publication

Inductioni

Expression increases in mesenchymal cells at fracture sites during healing. Also highly expressed in chondrocytes and osteoblasts at newly formed cartilage and bone.1 Publication

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032031.

Structurei

3D structure databases

ProteinModelPortaliP49002.
SMRiP49002. Positions 361-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP49002.
KOiK05496.
PhylomeDBiP49002.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARGLLCL WLGCFCLNLA QGQRPNLHLP GLRGTESSDR MTGGGPSPDL
60 70 80 90 100
RPHDKVSEHM LWLYDRYSGS NRAQATRTPG SQLPGPQPLR GGNTVRSFRA
110 120 130 140 150
AAAGTLQRKG LHTFNLTSLT KSENILSATL YFYIGELVNT SVNCPESQGC
160 170 180 190 200
SHDSQRQHIQ IDLSAWTLQS NQSQLLGHLS VDTAKPYRDS MSWLSKDITQ
210 220 230 240 250
LLRKAKQDEE FLIGFNITSR AHELPKRMLL FPEPYILVYA NDAAICEPES
260 270 280 290 300
VVSSLQRHRD FTAGTVPRLD SHVREALSVE RRKKRSTGIL LPLQNNELPG
310 320 330 340 350
AEYQYKEAGV WEERKPYKSL QTQPPEKSRS KKKQRKGPHQ KGQTLQFDEQ
360 370 380 390 400
TLKKARRKQW IEPRNCARRY LKVDFADIGW SEWIISPKSF DAYYCSGACQ
410 420 430 440 450
FPMPKSLKPS NHATIQSIVR AVGVVSGIPE PCCVPEKMSS LSILFFDENK
460
NVVLKVYPNM TVDSCACR
Length:468
Mass (Da):52,675
Last modified:February 1, 1996 - v1
Checksum:i05315D4954DC3CA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63860 mRNA. Translation: BAA09922.1.
S77492 mRNA. Translation: AAB33725.1.
PIRiI53032.
RefSeqiNP_058801.1. NM_017105.1.
UniGeneiRn.208979.

Genome annotation databases

GeneIDi25667.
KEGGirno:25667.
UCSCiRGD:2212. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63860 mRNA. Translation: BAA09922.1.
S77492 mRNA. Translation: AAB33725.1.
PIRiI53032.
RefSeqiNP_058801.1. NM_017105.1.
UniGeneiRn.208979.

3D structure databases

ProteinModelPortaliP49002.
SMRiP49002. Positions 361-468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000032031.

Proteomic databases

PaxDbiP49002.
PRIDEiP49002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25667.
KEGGirno:25667.
UCSCiRGD:2212. rat.

Organism-specific databases

CTDi651.
RGDi2212. Bmp3.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000232003.
HOVERGENiHBG004857.
InParanoidiP49002.
KOiK05496.
PhylomeDBiP49002.

Miscellaneous databases

PROiP49002.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR017197. BMP3/BMP3B.
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PIRSFiPIRSF037403. BMP3/GDF10. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of rat bone morphogenetic protein-3b (BMP-3b), a new member of BMP-3."
    Takao M., Hino J., Takeshita N., Konno Y., Nishizawa T., Matsuo H., Kangawa K.
    Biochem. Biophys. Res. Commun. 219:656-662(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Calvaria.
  2. "Sequence and expression of bone morphogenetic protein 3 mRNA in prolonged cultures of fetal rat calvarial osteoblasts and in rat prostate adenocarcinoma PA III cells."
    Chen D., Feng J.Q., Feng M., Harris M.A., Mahy P., Mundy G.R., Harris S.E.
    DNA Cell Biol. 14:235-239(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-468.
    Tissue: Calvaria.
  3. "Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect."
    Wang F.-S., Yang K.D., Kuo Y.-R., Wang C.-J., Sheen-Chen S.-M., Huang H.-C., Chen Y.-J.
    Bone 32:387-396(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiBMP3_RAT
AccessioniPrimary (citable) accession number: P49002
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.