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Protein

Bone morphogenetic protein 2

Gene

Bmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: GO_Central
  • cytokine activity Source: GO_Central
  • growth factor activity Source: RGD
  • protein domain specific binding Source: RGD
  • protein homodimerization activity Source: RGD
  • receptor binding Source: RGD
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  • BMP signaling pathway Source: RGD
  • cartilage development Source: UniProtKB-KW
  • cellular response to BMP stimulus Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • mesenchymal cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • ossification Source: UniProtKB-KW
  • ovulation cycle Source: RGD
  • positive regulation of neurogenesis Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • response to mechanical stimulus Source: RGD
  • response to retinoic acid Source: RGD
  • SMAD protein signal transduction Source: UniProtKB

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:Bmp2
Synonyms:Bmp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2211. Bmp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003383020 – 279Cleaved by PCSK5CuratedAdd BLAST260
ChainiPRO_0000033831280 – 393Bone morphogenetic protein 2Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi293 ↔ 358By similarity
Disulfide bondi322 ↔ 390By similarity
Disulfide bondi326 ↔ 392By similarity
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi357InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49001.

PTM databases

PhosphoSitePlusiP49001.

Expressioni

Tissue specificityi

Expressed in femur, calvaria, trachea, lung and ovary.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1 and GREM2. Interacts with ASPN. Interacts with MFAP5. Interacts with FBN1 (via N-terminal domain) and FBN2.By similarity

GO - Molecular functioni

  • BMP receptor binding Source: GO_Central
  • cytokine activity Source: GO_Central
  • growth factor activity Source: RGD
  • protein domain specific binding Source: RGD
  • protein homodimerization activity Source: RGD
  • receptor binding Source: RGD
  • transforming growth factor beta receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028904.

Structurei

3D structure databases

ProteinModelPortaliP49001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP49001.
KOiK21283.
PhylomeDBiP49001.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiView protein in InterPro
IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_propeptide.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiView protein in Pfam
PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
SMARTiView protein in SMART
SM00204. TGFB. 1 hit.
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiView protein in PROSITE
PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASRPL SRPSEDVLSE
60 70 80 90 100
FELRLLSMFG LKQRPTPSKD VVVPPYMLDL YRRHSGQPGA LAPDHRLERA
110 120 130 140 150
ASRANTVLSF HHEEAIEELS EMSGKTSRRF FFNLSSVPTD EFLTSAELQI
160 170 180 190 200
FREQMQEALG NSSFQHRINI YEIIKPATAS SKFPVTRLLD TRLVTQNTSQ
210 220 230 240 250
WESFDVTPAV MRWTAQGHTN HGFVVEVAHL EEKPGVSKRH VRISRSLHQD
260 270 280 290 300
EHSWSQVRPL LVTFGHDGKG HPLHKREKRQ AKHKQRKRLK SSCKRHPLYV
310 320 330 340 350
DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN
360 370 380 390
SKIPKACCVP TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR
Length:393
Mass (Da):44,383
Last modified:February 1, 1996 - v1
Checksum:i7D20865852E0F213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25868 mRNA. Translation: CAA81088.1.
PIRiS37073.
RefSeqiNP_058874.1. NM_017178.1.
UniGeneiRn.90931.

Genome annotation databases

GeneIDi29373.
KEGGirno:29373.
UCSCiRGD:2211. rat.

Similar proteinsi

Entry informationi

Entry nameiBMP2_RAT
AccessioniPrimary (citable) accession number: P49001
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families