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P49001

- BMP2_RAT

UniProt

P49001 - BMP2_RAT

Protein

Bone morphogenetic protein 2

Gene

Bmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Induces cartilage and bone formation.

    GO - Molecular functioni

    1. growth factor activity Source: RGD
    2. protein domain specific binding Source: RGD
    3. protein homodimerization activity Source: RGD
    4. receptor binding Source: RGD

    GO - Biological processi

    1. BMP signaling pathway Source: RGD
    2. cartilage development Source: UniProtKB-KW
    3. growth Source: InterPro
    4. mesenchymal cell differentiation Source: UniProtKB
    5. ossification Source: UniProtKB-KW
    6. ovulation cycle Source: RGD
    7. positive regulation of neurogenesis Source: MGI
    8. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. response to mechanical stimulus Source: RGD
    11. response to retinoic acid Source: RGD
    12. SMAD protein signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Growth factor

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bone morphogenetic protein 2
    Short name:
    BMP-2
    Alternative name(s):
    Bone morphogenetic protein 2A
    Short name:
    BMP-2A
    Gene namesi
    Name:Bmp2
    Synonyms:Bmp-2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2211. Bmp2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. extracellular space Source: RGD
    3. membrane-bounded vesicle Source: RGD
    4. protein complex Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Propeptidei20 – 279260Cleaved by PCSK5CuratedPRO_0000033830Add
    BLAST
    Chaini280 – 393114Bone morphogenetic protein 2PRO_0000033831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi293 ↔ 358By similarity
    Disulfide bondi322 ↔ 390By similarity
    Disulfide bondi326 ↔ 392By similarity
    Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi357 – 357InterchainBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP49001.

    PTM databases

    PhosphoSiteiP49001.

    Expressioni

    Tissue specificityi

    Expressed in femur, calvaria, trachea, lung and ovary.

    Gene expression databases

    GenevestigatoriP49001.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Interacts with SOSTDC1 and GREM2. Interacts with ASPN By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028904.

    Structurei

    3D structure databases

    ProteinModelPortaliP49001.
    SMRiP49001. Positions 288-393.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG243555.
    HOGENOMiHOG000249478.
    HOVERGENiHBG004860.
    InParanoidiP49001.
    KOiK04662.
    PhylomeDBiP49001.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR00669. INHIBINA.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P49001-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASRPL SRPSEDVLSE    50
    FELRLLSMFG LKQRPTPSKD VVVPPYMLDL YRRHSGQPGA LAPDHRLERA 100
    ASRANTVLSF HHEEAIEELS EMSGKTSRRF FFNLSSVPTD EFLTSAELQI 150
    FREQMQEALG NSSFQHRINI YEIIKPATAS SKFPVTRLLD TRLVTQNTSQ 200
    WESFDVTPAV MRWTAQGHTN HGFVVEVAHL EEKPGVSKRH VRISRSLHQD 250
    EHSWSQVRPL LVTFGHDGKG HPLHKREKRQ AKHKQRKRLK SSCKRHPLYV 300
    DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN 350
    SKIPKACCVP TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR 393
    Length:393
    Mass (Da):44,383
    Last modified:February 1, 1996 - v1
    Checksum:i7D20865852E0F213
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25868 mRNA. Translation: CAA81088.1.
    PIRiS37073.
    RefSeqiNP_058874.1. NM_017178.1.
    UniGeneiRn.90931.

    Genome annotation databases

    GeneIDi29373.
    KEGGirno:29373.
    UCSCiRGD:2211. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z25868 mRNA. Translation: CAA81088.1 .
    PIRi S37073.
    RefSeqi NP_058874.1. NM_017178.1.
    UniGenei Rn.90931.

    3D structure databases

    ProteinModelPortali P49001.
    SMRi P49001. Positions 288-393.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028904.

    PTM databases

    PhosphoSitei P49001.

    Proteomic databases

    PaxDbi P49001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29373.
    KEGGi rno:29373.
    UCSCi RGD:2211. rat.

    Organism-specific databases

    CTDi 650.
    RGDi 2211. Bmp2.

    Phylogenomic databases

    eggNOGi NOG243555.
    HOGENOMi HOG000249478.
    HOVERGENi HBG004860.
    InParanoidi P49001.
    KOi K04662.
    PhylomeDBi P49001.

    Miscellaneous databases

    NextBioi 608935.
    PROi P49001.

    Gene expression databases

    Genevestigatori P49001.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR002405. Inhibin_asu.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR015615. TGF-beta-rel.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR00669. INHIBINA.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Feng J.Q., Chen D., Feng M., Harris M.A., Mundy G.R., Harris S.E.
      Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone.

    Entry informationi

    Entry nameiBMP2_RAT
    AccessioniPrimary (citable) accession number: P49001
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3