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Protein

Bone morphogenetic protein 2

Gene

Bmp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  1. BMP receptor binding Source: GO_Central
  2. cytokine activity Source: GO_Central
  3. growth factor activity Source: RGD
  4. protein domain specific binding Source: RGD
  5. protein homodimerization activity Source: RGD
  6. receptor binding Source: RGD
  7. transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

  1. BMP signaling pathway Source: RGD
  2. cartilage development Source: UniProtKB-KW
  3. cellular response to BMP stimulus Source: RGD
  4. cellular response to mechanical stimulus Source: RGD
  5. growth Source: InterPro
  6. mesenchymal cell differentiation Source: UniProtKB
  7. negative regulation of transcription from RNA polymerase II promoter Source: GO_Central
  8. ossification Source: UniProtKB-KW
  9. ovulation cycle Source: RGD
  10. positive regulation of neurogenesis Source: MGI
  11. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  12. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  13. regulation of apoptotic process Source: GO_Central
  14. regulation of MAPK cascade Source: GO_Central
  15. response to mechanical stimulus Source: RGD
  16. response to retinoic acid Source: RGD
  17. SMAD protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:Bmp2
Synonyms:Bmp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2211. Bmp2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
  4. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 279260Cleaved by PCSK5CuratedPRO_0000033830Add
BLAST
Chaini280 – 393114Bone morphogenetic protein 2PRO_0000033831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi293 ↔ 358By similarity
Disulfide bondi322 ↔ 390By similarity
Disulfide bondi326 ↔ 392By similarity
Glycosylationi335 – 3351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi357 – 357InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49001.

PTM databases

PhosphoSiteiP49001.

Expressioni

Tissue specificityi

Expressed in femur, calvaria, trachea, lung and ovary.

Gene expression databases

GenevestigatoriP49001.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1 and GREM2. Interacts with ASPN (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028904.

Structurei

3D structure databases

ProteinModelPortaliP49001.
SMRiP49001. Positions 288-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP49001.
KOiK04662.
PhylomeDBiP49001.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASRPL SRPSEDVLSE
60 70 80 90 100
FELRLLSMFG LKQRPTPSKD VVVPPYMLDL YRRHSGQPGA LAPDHRLERA
110 120 130 140 150
ASRANTVLSF HHEEAIEELS EMSGKTSRRF FFNLSSVPTD EFLTSAELQI
160 170 180 190 200
FREQMQEALG NSSFQHRINI YEIIKPATAS SKFPVTRLLD TRLVTQNTSQ
210 220 230 240 250
WESFDVTPAV MRWTAQGHTN HGFVVEVAHL EEKPGVSKRH VRISRSLHQD
260 270 280 290 300
EHSWSQVRPL LVTFGHDGKG HPLHKREKRQ AKHKQRKRLK SSCKRHPLYV
310 320 330 340 350
DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN
360 370 380 390
SKIPKACCVP TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR
Length:393
Mass (Da):44,383
Last modified:February 1, 1996 - v1
Checksum:i7D20865852E0F213
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25868 mRNA. Translation: CAA81088.1.
PIRiS37073.
RefSeqiNP_058874.1. NM_017178.1.
UniGeneiRn.90931.

Genome annotation databases

GeneIDi29373.
KEGGirno:29373.
UCSCiRGD:2211. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25868 mRNA. Translation: CAA81088.1.
PIRiS37073.
RefSeqiNP_058874.1. NM_017178.1.
UniGeneiRn.90931.

3D structure databases

ProteinModelPortaliP49001.
SMRiP49001. Positions 288-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028904.

PTM databases

PhosphoSiteiP49001.

Proteomic databases

PaxDbiP49001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29373.
KEGGirno:29373.
UCSCiRGD:2211. rat.

Organism-specific databases

CTDi650.
RGDi2211. Bmp2.

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP49001.
KOiK04662.
PhylomeDBiP49001.

Miscellaneous databases

NextBioi608935.
PROiP49001.

Gene expression databases

GenevestigatoriP49001.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Feng J.Q., Chen D., Feng M., Harris M.A., Mundy G.R., Harris S.E.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone.

Entry informationi

Entry nameiBMP2_RAT
AccessioniPrimary (citable) accession number: P49001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.