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P49001 (BMP2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bone morphogenetic protein 2

Short name=BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name=BMP-2A
Gene names
Name:Bmp2
Synonyms:Bmp-2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces cartilage and bone formation.

Subunit structure

Homodimer; disulfide-linked. Interacts with SOSTDC1 and GREM2. Interacts with ASPN By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed in femur, calvaria, trachea, lung and ovary.

Sequence similarities

Belongs to the TGF-beta family.

Ontologies

Keywords
   Biological processChondrogenesis
Differentiation
Osteogenesis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
Developmental protein
Growth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from direct assay PubMed 12398941. Source: RGD

SMAD protein signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

cartilage development

Inferred from electronic annotation. Source: UniProtKB-KW

growth

Inferred from electronic annotation. Source: InterPro

mesenchymal cell differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

ossification

Inferred from electronic annotation. Source: UniProtKB-KW

ovulation cycle

Inferred from expression pattern PubMed 15283681. Source: RGD

positive regulation of neurogenesis

Inferred from direct assay PubMed 8616889. Source: MGI

positive regulation of pathway-restricted SMAD protein phosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 8616889. Source: MGI

response to mechanical stimulus

Inferred from expression pattern PubMed 10404008. Source: RGD

response to retinoic acid

Inferred from expression pattern PubMed 8385738. Source: RGD

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15589212. Source: RGD

extracellular space

Inferred from direct assay PubMed 18758911. Source: RGD

membrane-bounded vesicle

Inferred from direct assay PubMed 18758911. Source: RGD

protein complex

Inferred from direct assay PubMed 12871556. Source: RGD

   Molecular_functiongrowth factor activity

Inferred from direct assay PubMed 12398941. Source: RGD

protein homodimerization activity

Inferred from direct assay PubMed 12871556. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Propeptide20 – 279260Cleaved by PCSK5 Probable
PRO_0000033830
Chain280 – 393114Bone morphogenetic protein 2
PRO_0000033831

Amino acid modifications

Glycosylation1331N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential
Glycosylation3351N-linked (GlcNAc...) Potential
Disulfide bond293 ↔ 358 By similarity
Disulfide bond322 ↔ 390 By similarity
Disulfide bond326 ↔ 392 By similarity
Disulfide bond357Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P49001 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 7D20865852E0F213

FASTA39344,383
        10         20         30         40         50         60 
MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASRPL SRPSEDVLSE FELRLLSMFG 

        70         80         90        100        110        120 
LKQRPTPSKD VVVPPYMLDL YRRHSGQPGA LAPDHRLERA ASRANTVLSF HHEEAIEELS 

       130        140        150        160        170        180 
EMSGKTSRRF FFNLSSVPTD EFLTSAELQI FREQMQEALG NSSFQHRINI YEIIKPATAS 

       190        200        210        220        230        240 
SKFPVTRLLD TRLVTQNTSQ WESFDVTPAV MRWTAQGHTN HGFVVEVAHL EEKPGVSKRH 

       250        260        270        280        290        300 
VRISRSLHQD EHSWSQVRPL LVTFGHDGKG HPLHKREKRQ AKHKQRKRLK SSCKRHPLYV 

       310        320        330        340        350        360 
DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN SKIPKACCVP 

       370        380        390 
TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR 

« Hide

References

[1]Feng J.Q., Chen D., Feng M., Harris M.A., Mundy G.R., Harris S.E.
Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Bone.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z25868 mRNA. Translation: CAA81088.1.
PIRS37073.
RefSeqNP_058874.1. NM_017178.1.
UniGeneRn.90931.

3D structure databases

ProteinModelPortalP49001.
SMRP49001. Positions 288-393.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028904.

PTM databases

PhosphoSiteP49001.

Proteomic databases

PaxDbP49001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29373.
KEGGrno:29373.
UCSCRGD:2211. rat.

Organism-specific databases

CTD650.
RGD2211. Bmp2.

Phylogenomic databases

eggNOGNOG243555.
HOGENOMHOG000249478.
HOVERGENHBG004860.
InParanoidP49001.
KOK04662.

Gene expression databases

GenevestigatorP49001.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608935.
PROP49001.

Entry information

Entry nameBMP2_RAT
AccessionPrimary (citable) accession number: P49001
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: January 22, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families