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P49001

- BMP2_RAT

UniProt

P49001 - BMP2_RAT

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Protein

Bone morphogenetic protein 2

Gene
Bmp2, Bmp-2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces cartilage and bone formation.

GO - Molecular functioni

  1. growth factor activity Source: RGD
  2. protein domain specific binding Source: RGD
  3. protein homodimerization activity Source: RGD
  4. receptor binding Source: RGD

GO - Biological processi

  1. BMP signaling pathway Source: RGD
  2. cartilage development Source: UniProtKB-KW
  3. growth Source: InterPro
  4. mesenchymal cell differentiation Source: UniProtKB
  5. ossification Source: UniProtKB-KW
  6. ovulation cycle Source: RGD
  7. positive regulation of neurogenesis Source: MGI
  8. positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
  9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  10. response to mechanical stimulus Source: RGD
  11. response to retinoic acid Source: RGD
  12. SMAD protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein 2
Short name:
BMP-2
Alternative name(s):
Bone morphogenetic protein 2A
Short name:
BMP-2A
Gene namesi
Name:Bmp2
Synonyms:Bmp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2211. Bmp2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
  3. membrane-bounded vesicle Source: RGD
  4. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Propeptidei20 – 279260Cleaved by PCSK5 InferredPRO_0000033830Add
BLAST
Chaini280 – 393114Bone morphogenetic protein 2PRO_0000033831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi133 – 1331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi161 – 1611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi197 – 1971N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi293 ↔ 358 By similarity
Disulfide bondi322 ↔ 390 By similarity
Disulfide bondi326 ↔ 392 By similarity
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi357 – 357Interchain By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49001.

PTM databases

PhosphoSiteiP49001.

Expressioni

Tissue specificityi

Expressed in femur, calvaria, trachea, lung and ovary.

Gene expression databases

GenevestigatoriP49001.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with SOSTDC1 and GREM2. Interacts with ASPN By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028904.

Structurei

3D structure databases

ProteinModelPortaliP49001.
SMRiP49001. Positions 288-393.

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG243555.
HOGENOMiHOG000249478.
HOVERGENiHBG004860.
InParanoidiP49001.
KOiK04662.
PhylomeDBiP49001.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49001-1 [UniParc]FASTAAdd to Basket

« Hide

MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASRPL SRPSEDVLSE    50
FELRLLSMFG LKQRPTPSKD VVVPPYMLDL YRRHSGQPGA LAPDHRLERA 100
ASRANTVLSF HHEEAIEELS EMSGKTSRRF FFNLSSVPTD EFLTSAELQI 150
FREQMQEALG NSSFQHRINI YEIIKPATAS SKFPVTRLLD TRLVTQNTSQ 200
WESFDVTPAV MRWTAQGHTN HGFVVEVAHL EEKPGVSKRH VRISRSLHQD 250
EHSWSQVRPL LVTFGHDGKG HPLHKREKRQ AKHKQRKRLK SSCKRHPLYV 300
DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN 350
SKIPKACCVP TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR 393
Length:393
Mass (Da):44,383
Last modified:February 1, 1996 - v1
Checksum:i7D20865852E0F213
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25868 mRNA. Translation: CAA81088.1.
PIRiS37073.
RefSeqiNP_058874.1. NM_017178.1.
UniGeneiRn.90931.

Genome annotation databases

GeneIDi29373.
KEGGirno:29373.
UCSCiRGD:2211. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z25868 mRNA. Translation: CAA81088.1 .
PIRi S37073.
RefSeqi NP_058874.1. NM_017178.1.
UniGenei Rn.90931.

3D structure databases

ProteinModelPortali P49001.
SMRi P49001. Positions 288-393.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028904.

PTM databases

PhosphoSitei P49001.

Proteomic databases

PaxDbi P49001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 29373.
KEGGi rno:29373.
UCSCi RGD:2211. rat.

Organism-specific databases

CTDi 650.
RGDi 2211. Bmp2.

Phylogenomic databases

eggNOGi NOG243555.
HOGENOMi HOG000249478.
HOVERGENi HBG004860.
InParanoidi P49001.
KOi K04662.
PhylomeDBi P49001.

Miscellaneous databases

NextBioi 608935.
PROi P49001.

Gene expression databases

Genevestigatori P49001.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
PRINTSi PR00669. INHIBINA.
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Feng J.Q., Chen D., Feng M., Harris M.A., Mundy G.R., Harris S.E.
    Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone.

Entry informationi

Entry nameiBMP2_RAT
AccessioniPrimary (citable) accession number: P49001
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 11, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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