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Protein

Muellerian-inhibiting factor

Gene

Amh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

GO - Molecular functioni

  • transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  • aging Source: RGD
  • gonadal mesoderm development Source: UniProtKB-KW
  • Mullerian duct regression Source: RGD
  • negative regulation of ovarian follicle development Source: RGD
  • positive regulation of NF-kappaB transcription factor activity Source: RGD
  • preantral ovarian follicle growth Source: RGD
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • urogenital system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Keywords - Biological processi

Differentiation, Gonadal differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Muellerian-inhibiting factor
Alternative name(s):
Anti-Muellerian hormone
Short name:
AMH
Muellerian-inhibiting substance
Short name:
MIS
Gene namesi
Name:Amh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2108. Amh.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 553Muellerian-inhibiting factorPRO_0000033753
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – ?Sequence analysisPRO_0000033752

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi455 ↔ 519By similarity
Disulfide bondi481 ↔ 550By similarity
Disulfide bondi485 ↔ 552By similarity
Disulfide bondi518 – 518InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49000.

Expressioni

Gene expression databases

GenevisibleiP49000. RN.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

  • transforming growth factor beta receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026220.

Structurei

3D structure databases

ProteinModelPortaliP49000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000006337.
HOGENOMiHOG000113593.
HOVERGENiHBG006358.
InParanoidiP49000.
KOiK04665.
OMAiQRARWGP.
OrthoDBiEOG7C8GHS.
PhylomeDBiP49000.
TreeFamiTF335595.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006799. AMH_N.
IPR029034. Cystine-knot_cytokine.
IPR021203. Muellerian-inhibiting_factor.
IPR001839. TGF-b_C.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR15009. PTHR15009. 1 hit.
PfamiPF04709. AMH_N. 1 hit.
PF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037270. Muellerian-inhibiting_factor. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPHLSLLL LLLATMGAVL QADTVEELTN TRGLIFLEDG VWPPSSPPEP
60 70 80 90 100
LCLVAVRGEG DTSKASLTVV GGLHSYEHAF LEAVQESRWG PQDLATFGVC
110 120 130 140 150
STDSQTTLPA LQRLGAWLGE TGEQQLLVLH LAEVIWEPQL LLKFQEPPPG
160 170 180 190 200
GASRWEQALL VLYPGPGPQV TVTGAGLQGT QSLCPTRDTR YLVLTVHFPA
210 220 230 240 250
GAWSGSGLAL TLQPSKEGAT LTIAQLQAFL FGSDSRCFTR MTPTLVLLPP
260 270 280 290 300
TGPTPQPAHG QLDTVPFPQP GLSLEPEDLP HSADPFLETL TRLVRALRGP
310 320 330 340 350
LTRASNTRLA LDPGALASFP QGLVNLSDPV ALGRLLDGEE PLLLLLSPAA
360 370 380 390 400
ATVGEPMRLH SPTSAPWAAG LARRVAVELQ AAASELRDLP GLPPTAPPLL
410 420 430 440 450
SRLLALCPND SRSAGDPLRA LLLLKALQGL RAEWRGREGR GRAGRSKGTG
460 470 480 490 500
TDGLCALREL SVDLRAERSV LIPETYQANN CQGACAWPQS DRNPRYGNHV
510 520 530 540 550
VLLLKMQARG AALGRLPCCV PTAYTGKLLI SLSEEHISAH HVPNMVATEC

GCR
Length:553
Mass (Da):58,889
Last modified:February 1, 1996 - v1
Checksum:i75DAF3949A038A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S98336 Genomic DNA. Translation: AAB22104.1.
PIRiA42499.
RefSeqiNP_037034.1. NM_012902.1.
UniGeneiRn.19121.

Genome annotation databases

EnsembliENSRNOT00000026220; ENSRNOP00000026220; ENSRNOG00000019377.
GeneIDi25378.
KEGGirno:25378.
UCSCiRGD:2108. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S98336 Genomic DNA. Translation: AAB22104.1.
PIRiA42499.
RefSeqiNP_037034.1. NM_012902.1.
UniGeneiRn.19121.

3D structure databases

ProteinModelPortaliP49000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026220.

Proteomic databases

PaxDbiP49000.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000026220; ENSRNOP00000026220; ENSRNOG00000019377.
GeneIDi25378.
KEGGirno:25378.
UCSCiRGD:2108. rat.

Organism-specific databases

CTDi268.
RGDi2108. Amh.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00390000006337.
HOGENOMiHOG000113593.
HOVERGENiHBG006358.
InParanoidiP49000.
KOiK04665.
OMAiQRARWGP.
OrthoDBiEOG7C8GHS.
PhylomeDBiP49000.
TreeFamiTF335595.

Miscellaneous databases

NextBioi606415.
PROiP49000.

Gene expression databases

GenevisibleiP49000. RN.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006799. AMH_N.
IPR029034. Cystine-knot_cytokine.
IPR021203. Muellerian-inhibiting_factor.
IPR001839. TGF-b_C.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR15009. PTHR15009. 1 hit.
PfamiPF04709. AMH_N. 1 hit.
PF00019. TGF_beta. 1 hit.
[Graphical view]
PIRSFiPIRSF037270. Muellerian-inhibiting_factor. 1 hit.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of the rat gene for Mullerian inhibiting substance."
    Haqq C., Lee M.M., Tizard R., Wysk M., Demarinis J., Donahoe P.K., Cate R.L.
    Genomics 12:665-669(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMIS_RAT
AccessioniPrimary (citable) accession number: P49000
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.