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Protein

Muellerian-inhibiting factor

Gene

Amh

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cell-cell signaling Source: GO_Central
  • gonadal mesoderm development Source: UniProtKB-KW
  • Mullerian duct regression Source: RGD
  • negative regulation of ovarian follicle development Source: RGD
  • positive regulation of gene expression Source: Ensembl
  • positive regulation of NF-kappaB transcription factor activity Source: RGD
  • preantral ovarian follicle growth Source: RGD
  • response to drug Source: RGD
  • response to organic cyclic compound Source: RGD
  • urogenital system development Source: MGI

Keywordsi

Molecular functionGrowth factor
Biological processDifferentiation, Gonadal differentiation

Enzyme and pathway databases

ReactomeiR-RNO-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Muellerian-inhibiting factor
Alternative name(s):
Anti-Muellerian hormone
Short name:
AMH
Muellerian-inhibiting substance
Short name:
MIS
Gene namesi
Name:Amh
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi2108 Amh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000033753? – 553Muellerian-inhibiting factor
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000003375222 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi455 ↔ 519By similarity
Disulfide bondi481 ↔ 550By similarity
Disulfide bondi485 ↔ 552By similarity
Disulfide bondi518InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP49000
PRIDEiP49000

PTM databases

CarbonylDBiP49000

Expressioni

Gene expression databases

BgeeiENSRNOG00000019377
GenevisibleiP49000 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026220

Structurei

3D structure databases

ProteinModelPortaliP49000
SMRiP49000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00390000006337
HOGENOMiHOG000113593
HOVERGENiHBG006358
InParanoidiP49000
KOiK04665
OMAiQRARWGP
OrthoDBiEOG091G09TC
PhylomeDBiP49000
TreeFamiTF335595

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR006799 AMH_N
IPR029034 Cystine-knot_cytokine
IPR021203 Muellerian-inhibiting_factor
IPR001839 TGF-b_C
IPR017948 TGFb_CS
PANTHERiPTHR15009 PTHR15009, 1 hit
PfamiView protein in Pfam
PF04709 AMH_N, 1 hit
PF00019 TGF_beta, 1 hit
PIRSFiPIRSF037270 Muellerian-inhibiting_factor, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P49000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGPHLSLLL LLLATMGAVL QADTVEELTN TRGLIFLEDG VWPPSSPPEP
60 70 80 90 100
LCLVAVRGEG DTSKASLTVV GGLHSYEHAF LEAVQESRWG PQDLATFGVC
110 120 130 140 150
STDSQTTLPA LQRLGAWLGE TGEQQLLVLH LAEVIWEPQL LLKFQEPPPG
160 170 180 190 200
GASRWEQALL VLYPGPGPQV TVTGAGLQGT QSLCPTRDTR YLVLTVHFPA
210 220 230 240 250
GAWSGSGLAL TLQPSKEGAT LTIAQLQAFL FGSDSRCFTR MTPTLVLLPP
260 270 280 290 300
TGPTPQPAHG QLDTVPFPQP GLSLEPEDLP HSADPFLETL TRLVRALRGP
310 320 330 340 350
LTRASNTRLA LDPGALASFP QGLVNLSDPV ALGRLLDGEE PLLLLLSPAA
360 370 380 390 400
ATVGEPMRLH SPTSAPWAAG LARRVAVELQ AAASELRDLP GLPPTAPPLL
410 420 430 440 450
SRLLALCPND SRSAGDPLRA LLLLKALQGL RAEWRGREGR GRAGRSKGTG
460 470 480 490 500
TDGLCALREL SVDLRAERSV LIPETYQANN CQGACAWPQS DRNPRYGNHV
510 520 530 540 550
VLLLKMQARG AALGRLPCCV PTAYTGKLLI SLSEEHISAH HVPNMVATEC

GCR
Length:553
Mass (Da):58,889
Last modified:February 1, 1996 - v1
Checksum:i75DAF3949A038A69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S98336 Genomic DNA Translation: AAB22104.1
PIRiA42499
RefSeqiNP_037034.1, NM_012902.1
UniGeneiRn.19121

Genome annotation databases

EnsembliENSRNOT00000026220; ENSRNOP00000026220; ENSRNOG00000019377
GeneIDi25378
KEGGirno:25378
UCSCiRGD:2108 rat

Similar proteinsi

Entry informationi

Entry nameiMIS_RAT
AccessioniPrimary (citable) accession number: P49000
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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