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Protein

Involucrin

Gene

Ivl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:Ivl
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620141. Ivl.

Subcellular locationi

  • Cytoplasm

  • Note: Constituent of the scaffolding of the cornified envelope.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001597431 – 568InvolucrinAdd BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei472PhosphoserineCombined sources1

Post-translational modificationi

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48998.
PRIDEiP48998.

PTM databases

iPTMnetiP48998.
PhosphoSitePlusiP48998.

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012343.

Structurei

3D structure databases

ProteinModelPortaliP48998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP48998.
PhylomeDBiP48998.

Family and domain databases

InterProiIPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PfamiPF06994. Involucrin2. 10 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQHTVPVT VPAVVQESLK TVCSPAQTQQ EQTKQPTPYP AQCQVFTDTQ
60 70 80 90 100
EKGFPKHEEK EANPVKDLPE QESEHHQQPG PQKQQLQVKK PEQELQEQEL
110 120 130 140 150
HSEKQPQEPQ GLLCLGQQQQ REPQEQEQHL RQHQQPQQES QGQGLCLGQQ
160 170 180 190 200
QDVLAPQELH MGQHQKEKLQ EPELPLGQQQ KTPEEQELIL GEKQQKLHLV
210 220 230 240 250
ERHQEPQEQE LHHGQKQKQQ QPQEQELQLV QHQKQKQHEP ELCLRKQQQQ
260 270 280 290 300
ESHERELHLG KQQQQESHEP ELHLGKQQHQ ESHEPELHLG KQQHQESCEP
310 320 330 340 350
ELHLGEQQHQ EQQQHQESCE PELHLGKQQH QETQESELQL GKQQKPHEPD
360 370 380 390 400
MVLDPKEKQK LHDPELHLGK QQHQESQESE LQVEKKQHEK SPEPELHLGK
410 420 430 440 450
QQELHEPDMT EDQKEKQSLH EPELHLGKQQ ESHEPDMTED QKEKQSLYEP
460 470 480 490 500
ELHLGKQQEQ QIEYEGYQRS KSLNQLLKQE KASRGQELDD SHLEQEKELL
510 520 530 540 550
DQRLDQELVN KDEQLERKKH KLENLTQKEK QIKQLVPSTD RVQETQPIQP
560
VKEDSLTTKK QQHSHEVQ
Length:568
Mass (Da):67,021
Last modified:February 1, 1996 - v1
Checksum:iE2B07740FE779345
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28818 Genomic DNA. Translation: AAA41445.1.
PIRiI61106.
RefSeqiNP_071531.1. NM_022195.1.
UniGeneiRn.142591.

Genome annotation databases

GeneIDi60583.
KEGGirno:60583.
UCSCiRGD:620141. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28818 Genomic DNA. Translation: AAA41445.1.
PIRiI61106.
RefSeqiNP_071531.1. NM_022195.1.
UniGeneiRn.142591.

3D structure databases

ProteinModelPortaliP48998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012343.

PTM databases

iPTMnetiP48998.
PhosphoSitePlusiP48998.

Proteomic databases

PaxDbiP48998.
PRIDEiP48998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60583.
KEGGirno:60583.
UCSCiRGD:620141. rat.

Organism-specific databases

CTDi3713.
RGDi620141. Ivl.

Phylogenomic databases

eggNOGiENOG410JDU1. Eukaryota.
ENOG410Z08K. LUCA.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP48998.
PhylomeDBiP48998.

Miscellaneous databases

PROiP48998.

Family and domain databases

InterProiIPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PfamiPF06994. Involucrin2. 10 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINVO_RAT
AccessioniPrimary (citable) accession number: P48998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.