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P48997

- INVO_MOUSE

UniProt

P48997 - INVO_MOUSE

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Protein

Involucrin

Gene

Ivl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:Ivl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96626. Ivl.

Subcellular locationi

Cytoplasm
Note: Constituent of the scaffolding of the cornified envelope.

GO - Cellular componenti

  1. cornified envelope Source: InterPro
  2. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467InvolucrinPRO_0000159739Add
BLAST

Post-translational modificationi

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

Proteomic databases

MaxQBiP48997.
PRIDEiP48997.

PTM databases

PhosphoSiteiP48997.

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Gene expression databases

CleanExiMM_IVL.
GenevestigatoriP48997.

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

Structurei

3D structure databases

ProteinModelPortaliP48997.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the involucrin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG80441.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP48997.
PhylomeDBiP48997.

Family and domain databases

InterProiIPR002360. Involucrin.
IPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PANTHERiPTHR13905. PTHR13905. 1 hit.
PfamiPF06994. Involucrin2. 11 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48997-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHQHTLPVT VPAVVQGPLK TVCSPDHIQQ EQAKQPTPHP TQCQVFTEIQ
60 70 80 90 100
EKGFPKHEEK RPNPVKDLPD QKCEHQQQPG PQKQQLQVKK SQQELQEQEL
110 120 130 140 150
HLEKQQLPQE PQGLLCLEQQ QQQEPQMQEQ HLRQQQQQQQ QQQQQQQQQQ
160 170 180 190 200
QQETQEQGLC LGQKQQQQQQ DMLVPQELHL RQHQEKLQDP ELHLGQQQKT
210 220 230 240 250
PEEQKLIPGE KQQELHLGQR HQEPQEQELH LGQKQKQKLH EPELQLGKQQ
260 270 280 290 300
HQKPSEPELP LGKQQQESPE PELPLGKQQQ QESPEPELQL GKQQQSHEPD
310 320 330 340 350
MAGDQKEKQK LHKPELYLRK QQYQESPDPE LSLGKQQHQE CQEPELQLEE
360 370 380 390 400
KQHQKPPEPE LHLGKQQESH EPDMAEDLEE KQKLGEPELH LGKQQQQQIE
410 420 430 440 450
REGYQGPKSL GQSLKQEKAS REQQLDYSHL EQEKELSDQP LDQALVKKGK
460
QLERKKHELE NRTQQEK
Length:467
Mass (Da):54,919
Last modified:February 1, 1996 - v1
Checksum:i603E1E51B435737D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28819 Genomic DNA. Translation: AAA39330.1.
PIRiA49377.
UniGeneiMm.207365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28819 Genomic DNA. Translation: AAA39330.1 .
PIRi A49377.
UniGenei Mm.207365.

3D structure databases

ProteinModelPortali P48997.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P48997.

Proteomic databases

MaxQBi P48997.
PRIDEi P48997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96626. Ivl.

Phylogenomic databases

eggNOGi NOG80441.
HOGENOMi HOG000172481.
HOVERGENi HBG006166.
InParanoidi P48997.
PhylomeDBi P48997.

Miscellaneous databases

PROi P48997.
SOURCEi Search...

Gene expression databases

CleanExi MM_IVL.
Genevestigatori P48997.

Family and domain databases

InterProi IPR002360. Involucrin.
IPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view ]
PANTHERi PTHR13905. PTHR13905. 1 hit.
Pfami PF06994. Involucrin2. 11 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view ]
PROSITEi PS00795. INVOLUCRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The involucrin genes of the mouse and the rat: study of their shared repeats."
    Djian P., Phillips M., Easley K., Huang E., Simon M., Rice R.H., Green H.
    Mol. Biol. Evol. 10:1136-1149(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NIH Swiss.
  2. "Identification and characterization of a novel component of the cornified envelope, cornifelin."
    Michibata H., Chiba H., Wakimoto K., Seishima M., Kawasaki S., Okubo K., Mitsui H., Torii H., Imai Y.
    Biochem. Biophys. Res. Commun. 318:803-813(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INVOLUCRIN.

Entry informationi

Entry nameiINVO_MOUSE
AccessioniPrimary (citable) accession number: P48997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3