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P48997 (INVO_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Involucrin
Gene names
Name:Ivl
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length467 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

Subunit structure

Directly or indirectly cross-linked to cornifelin (CNFN).

Subcellular location

Cytoplasm. Note: Constituent of the scaffolding of the cornified envelope.

Tissue specificity

Keratinocytes of epidermis and other stratified squamous epithelia.

Post-translational modification

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

Sequence similarities

Belongs to the involucrin family.

Ontologies

Keywords
   Biological processKeratinization
   Cellular componentCytoplasm
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processkeratinization

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcornified envelope

Inferred from electronic annotation. Source: InterPro

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 467467Involucrin
PRO_0000159739

Sequences

Sequence LengthMass (Da)Tools
P48997 [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: 603E1E51B435737D

FASTA46754,919
        10         20         30         40         50         60 
MSHQHTLPVT VPAVVQGPLK TVCSPDHIQQ EQAKQPTPHP TQCQVFTEIQ EKGFPKHEEK 

        70         80         90        100        110        120 
RPNPVKDLPD QKCEHQQQPG PQKQQLQVKK SQQELQEQEL HLEKQQLPQE PQGLLCLEQQ 

       130        140        150        160        170        180 
QQQEPQMQEQ HLRQQQQQQQ QQQQQQQQQQ QQETQEQGLC LGQKQQQQQQ DMLVPQELHL 

       190        200        210        220        230        240 
RQHQEKLQDP ELHLGQQQKT PEEQKLIPGE KQQELHLGQR HQEPQEQELH LGQKQKQKLH 

       250        260        270        280        290        300 
EPELQLGKQQ HQKPSEPELP LGKQQQESPE PELPLGKQQQ QESPEPELQL GKQQQSHEPD 

       310        320        330        340        350        360 
MAGDQKEKQK LHKPELYLRK QQYQESPDPE LSLGKQQHQE CQEPELQLEE KQHQKPPEPE 

       370        380        390        400        410        420 
LHLGKQQESH EPDMAEDLEE KQKLGEPELH LGKQQQQQIE REGYQGPKSL GQSLKQEKAS 

       430        440        450        460 
REQQLDYSHL EQEKELSDQP LDQALVKKGK QLERKKHELE NRTQQEK 

« Hide

References

[1]"The involucrin genes of the mouse and the rat: study of their shared repeats."
Djian P., Phillips M., Easley K., Huang E., Simon M., Rice R.H., Green H.
Mol. Biol. Evol. 10:1136-1149(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NIH Swiss.
[2]"Identification and characterization of a novel component of the cornified envelope, cornifelin."
Michibata H., Chiba H., Wakimoto K., Seishima M., Kawasaki S., Okubo K., Mitsui H., Torii H., Imai Y.
Biochem. Biophys. Res. Commun. 318:803-813(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH INVOLUCRIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L28819 Genomic DNA. Translation: AAA39330.1.
PIRA49377.
UniGeneMm.207365.

3D structure databases

ProteinModelPortalP48997.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP48997.

Proteomic databases

PRIDEP48997.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96626. Ivl.

Phylogenomic databases

eggNOGNOG80441.
HOGENOMHOG000172481.
HOVERGENHBG006166.
InParanoidP48997.
PhylomeDBP48997.

Gene expression databases

CleanExMM_IVL.
GenevestigatorP48997.

Family and domain databases

InterProIPR002360. Involucrin.
IPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PANTHERPTHR13905. PTHR13905. 1 hit.
PfamPF06994. Involucrin2. 11 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEPS00795. INVOLUCRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP48997.
SOURCESearch...

Entry information

Entry nameINVO_MOUSE
AccessionPrimary (citable) accession number: P48997
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot