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P48997

- INVO_MOUSE

UniProt

P48997 - INVO_MOUSE

Protein

Involucrin

Gene

Ivl

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

    GO - Biological processi

    1. keratinization Source: UniProtKB-KW

    Keywords - Biological processi

    Keratinization

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Involucrin
    Gene namesi
    Name:Ivl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96626. Ivl.

    Subcellular locationi

    Cytoplasm
    Note: Constituent of the scaffolding of the cornified envelope.

    GO - Cellular componenti

    1. cornified envelope Source: InterPro
    2. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 467467InvolucrinPRO_0000159739Add
    BLAST

    Post-translational modificationi

    Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

    Proteomic databases

    PRIDEiP48997.

    PTM databases

    PhosphoSiteiP48997.

    Expressioni

    Tissue specificityi

    Keratinocytes of epidermis and other stratified squamous epithelia.

    Gene expression databases

    CleanExiMM_IVL.
    GenevestigatoriP48997.

    Interactioni

    Subunit structurei

    Directly or indirectly cross-linked to cornifelin (CNFN).

    Structurei

    3D structure databases

    ProteinModelPortaliP48997.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the involucrin family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG80441.
    HOGENOMiHOG000172481.
    HOVERGENiHBG006166.
    InParanoidiP48997.
    PhylomeDBiP48997.

    Family and domain databases

    InterProiIPR002360. Involucrin.
    IPR009733. Involucrin2.
    IPR019743. Involucrin_CS.
    IPR019571. Involucrin_N.
    [Graphical view]
    PANTHERiPTHR13905. PTHR13905. 1 hit.
    PfamiPF06994. Involucrin2. 11 hits.
    PF10583. Involucrin_N. 1 hit.
    [Graphical view]
    PROSITEiPS00795. INVOLUCRIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48997-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHQHTLPVT VPAVVQGPLK TVCSPDHIQQ EQAKQPTPHP TQCQVFTEIQ    50
    EKGFPKHEEK RPNPVKDLPD QKCEHQQQPG PQKQQLQVKK SQQELQEQEL 100
    HLEKQQLPQE PQGLLCLEQQ QQQEPQMQEQ HLRQQQQQQQ QQQQQQQQQQ 150
    QQETQEQGLC LGQKQQQQQQ DMLVPQELHL RQHQEKLQDP ELHLGQQQKT 200
    PEEQKLIPGE KQQELHLGQR HQEPQEQELH LGQKQKQKLH EPELQLGKQQ 250
    HQKPSEPELP LGKQQQESPE PELPLGKQQQ QESPEPELQL GKQQQSHEPD 300
    MAGDQKEKQK LHKPELYLRK QQYQESPDPE LSLGKQQHQE CQEPELQLEE 350
    KQHQKPPEPE LHLGKQQESH EPDMAEDLEE KQKLGEPELH LGKQQQQQIE 400
    REGYQGPKSL GQSLKQEKAS REQQLDYSHL EQEKELSDQP LDQALVKKGK 450
    QLERKKHELE NRTQQEK 467
    Length:467
    Mass (Da):54,919
    Last modified:February 1, 1996 - v1
    Checksum:i603E1E51B435737D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28819 Genomic DNA. Translation: AAA39330.1.
    PIRiA49377.
    UniGeneiMm.207365.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L28819 Genomic DNA. Translation: AAA39330.1 .
    PIRi A49377.
    UniGenei Mm.207365.

    3D structure databases

    ProteinModelPortali P48997.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P48997.

    Proteomic databases

    PRIDEi P48997.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96626. Ivl.

    Phylogenomic databases

    eggNOGi NOG80441.
    HOGENOMi HOG000172481.
    HOVERGENi HBG006166.
    InParanoidi P48997.
    PhylomeDBi P48997.

    Miscellaneous databases

    PROi P48997.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_IVL.
    Genevestigatori P48997.

    Family and domain databases

    InterProi IPR002360. Involucrin.
    IPR009733. Involucrin2.
    IPR019743. Involucrin_CS.
    IPR019571. Involucrin_N.
    [Graphical view ]
    PANTHERi PTHR13905. PTHR13905. 1 hit.
    Pfami PF06994. Involucrin2. 11 hits.
    PF10583. Involucrin_N. 1 hit.
    [Graphical view ]
    PROSITEi PS00795. INVOLUCRIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The involucrin genes of the mouse and the rat: study of their shared repeats."
      Djian P., Phillips M., Easley K., Huang E., Simon M., Rice R.H., Green H.
      Mol. Biol. Evol. 10:1136-1149(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NIH Swiss.
    2. "Identification and characterization of a novel component of the cornified envelope, cornifelin."
      Michibata H., Chiba H., Wakimoto K., Seishima M., Kawasaki S., Okubo K., Mitsui H., Torii H., Imai Y.
      Biochem. Biophys. Res. Commun. 318:803-813(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH INVOLUCRIN.

    Entry informationi

    Entry nameiINVO_MOUSE
    AccessioniPrimary (citable) accession number: P48997
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3