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P48997

- INVO_MOUSE

UniProt

P48997 - INVO_MOUSE

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Protein

Involucrin

Gene
Ivl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.

GO - Biological processi

  1. keratinization Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Keratinization

Names & Taxonomyi

Protein namesi
Recommended name:
Involucrin
Gene namesi
Name:Ivl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96626. Ivl.

Subcellular locationi

Cytoplasm
Note: Constituent of the scaffolding of the cornified envelope.

GO - Cellular componenti

  1. cornified envelope Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467InvolucrinPRO_0000159739Add
BLAST

Post-translational modificationi

Substrate of transglutaminase. Specific glutamines or lysines are cross-linked to keratins, desmoplakin and to inter involucrin molecules.

Proteomic databases

PRIDEiP48997.

PTM databases

PhosphoSiteiP48997.

Expressioni

Tissue specificityi

Keratinocytes of epidermis and other stratified squamous epithelia.

Gene expression databases

CleanExiMM_IVL.
GenevestigatoriP48997.

Interactioni

Subunit structurei

Directly or indirectly cross-linked to cornifelin (CNFN).

Structurei

3D structure databases

ProteinModelPortaliP48997.

Family & Domainsi

Sequence similaritiesi

Belongs to the involucrin family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG80441.
HOGENOMiHOG000172481.
HOVERGENiHBG006166.
InParanoidiP48997.
PhylomeDBiP48997.

Family and domain databases

InterProiIPR002360. Involucrin.
IPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view]
PANTHERiPTHR13905. PTHR13905. 1 hit.
PfamiPF06994. Involucrin2. 11 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view]
PROSITEiPS00795. INVOLUCRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48997-1 [UniParc]FASTAAdd to Basket

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MSHQHTLPVT VPAVVQGPLK TVCSPDHIQQ EQAKQPTPHP TQCQVFTEIQ    50
EKGFPKHEEK RPNPVKDLPD QKCEHQQQPG PQKQQLQVKK SQQELQEQEL 100
HLEKQQLPQE PQGLLCLEQQ QQQEPQMQEQ HLRQQQQQQQ QQQQQQQQQQ 150
QQETQEQGLC LGQKQQQQQQ DMLVPQELHL RQHQEKLQDP ELHLGQQQKT 200
PEEQKLIPGE KQQELHLGQR HQEPQEQELH LGQKQKQKLH EPELQLGKQQ 250
HQKPSEPELP LGKQQQESPE PELPLGKQQQ QESPEPELQL GKQQQSHEPD 300
MAGDQKEKQK LHKPELYLRK QQYQESPDPE LSLGKQQHQE CQEPELQLEE 350
KQHQKPPEPE LHLGKQQESH EPDMAEDLEE KQKLGEPELH LGKQQQQQIE 400
REGYQGPKSL GQSLKQEKAS REQQLDYSHL EQEKELSDQP LDQALVKKGK 450
QLERKKHELE NRTQQEK 467
Length:467
Mass (Da):54,919
Last modified:February 1, 1996 - v1
Checksum:i603E1E51B435737D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28819 Genomic DNA. Translation: AAA39330.1.
PIRiA49377.
UniGeneiMm.207365.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L28819 Genomic DNA. Translation: AAA39330.1 .
PIRi A49377.
UniGenei Mm.207365.

3D structure databases

ProteinModelPortali P48997.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P48997.

Proteomic databases

PRIDEi P48997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96626. Ivl.

Phylogenomic databases

eggNOGi NOG80441.
HOGENOMi HOG000172481.
HOVERGENi HBG006166.
InParanoidi P48997.
PhylomeDBi P48997.

Miscellaneous databases

PROi P48997.
SOURCEi Search...

Gene expression databases

CleanExi MM_IVL.
Genevestigatori P48997.

Family and domain databases

InterProi IPR002360. Involucrin.
IPR009733. Involucrin2.
IPR019743. Involucrin_CS.
IPR019571. Involucrin_N.
[Graphical view ]
PANTHERi PTHR13905. PTHR13905. 1 hit.
Pfami PF06994. Involucrin2. 11 hits.
PF10583. Involucrin_N. 1 hit.
[Graphical view ]
PROSITEi PS00795. INVOLUCRIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The involucrin genes of the mouse and the rat: study of their shared repeats."
    Djian P., Phillips M., Easley K., Huang E., Simon M., Rice R.H., Green H.
    Mol. Biol. Evol. 10:1136-1149(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NIH Swiss.
  2. "Identification and characterization of a novel component of the cornified envelope, cornifelin."
    Michibata H., Chiba H., Wakimoto K., Seishima M., Kawasaki S., Okubo K., Mitsui H., Torii H., Imai Y.
    Biochem. Biophys. Res. Commun. 318:803-813(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INVOLUCRIN.

Entry informationi

Entry nameiINVO_MOUSE
AccessioniPrimary (citable) accession number: P48997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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