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P48995 (TRPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Short transient receptor potential channel 1

Short name=TrpC1
Alternative name(s):
Transient receptor protein 1
Short name=TRP-1
Gene names
Name:TRPC1
Synonyms:TRP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length793 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Ref.9

Subunit structure

Interacts with TRPC4AP By similarity. Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4. Ref.6 Ref.8 Ref.10 Ref.11 Ref.12

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Seems to be ubiquitous.

Post-translational modification

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. [View classification]

Contains 4 ANK repeats.

Ontologies

Keywords
   Biological processCalcium transport
Ion transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Transmembrane
Transmembrane helix
   LigandCalcium
   Molecular functionCalcium channel
Ion channel
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Traceable author statement. Source: Reactome

calcium ion transmembrane transport

Traceable author statement. Source: Reactome

calcium ion transport

Traceable author statement PubMed 8646775. Source: ProtInc

cytosolic calcium ion homeostasis

Inferred from direct assay PubMed 19052258. Source: BHF-UCL

ion transmembrane transport

Traceable author statement. Source: Reactome

positive regulation of release of sequestered calcium ion into cytosol

Inferred from direct assay PubMed 19052258. Source: BHF-UCL

response to calcium ion

Inferred from direct assay PubMed 14505576PubMed 19052258. Source: BHF-UCL

saliva secretion

Inferred from electronic annotation. Source: Ensembl

transmembrane transport

Traceable author statement. Source: Reactome

   Cellular_componentbasolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

costamere

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Traceable author statement Ref.2. Source: ProtInc

membrane raft

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 14505576. Source: BHF-UCL

receptor complex

Inferred from direct assay PubMed 23382219. Source: MGI

sarcomere

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium channel activity

Traceable author statement PubMed 8646775. Source: ProtInc

cation channel activity

Inferred from experiment. Source: Reactome

inositol 1,4,5 trisphosphate binding

Inferred from direct assay PubMed 14505576. Source: BHF-UCL

ion channel binding

Inferred from physical interaction PubMed 10097141. Source: BHF-UCL

store-operated calcium channel activity

Traceable author statement Ref.3. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Long (identifier: P48995-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P48995-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 793793Short transient receptor potential channel 1
PRO_0000215303

Regions

Topological domain1 – 386386Cytoplasmic Potential
Transmembrane387 – 40721Helical; Potential
Topological domain408 – 4158Extracellular Potential
Transmembrane416 – 43621Helical; Potential
Topological domain437 – 45721Cytoplasmic Potential
Transmembrane458 – 47518Helical; Potential
Topological domain476 – 53964Extracellular Potential
Transmembrane540 – 56021Helical; Potential
Topological domain561 – 58626Cytoplasmic Potential
Transmembrane587 – 60721Helical; Potential
Topological domain608 – 6169Extracellular Potential
Transmembrane617 – 63721Helical; Potential
Repeat46 – 7530ANK 1
Repeat83 – 11129ANK 2
Repeat112 – 13827ANK 3
Repeat158 – 18730ANK 4

Natural variations

Alternative sequence110 – 14334Missing in isoform Short.
VSP_006560

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified February 1, 1996. Version 1.
Checksum: F4CC57ADDFA320AE

FASTA79391,212
        10         20         30         40         50         60 
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 

        70         80         90        100        110        120 
YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS 

       130        140        150        160        170        180 
EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK 

       190        200        210        220        230        240 
QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL 

       250        260        270        280        290        300 
SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 

       310        320        330        340        350        360 
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF 

       370        380        390        400        410        420 
WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYNE DKKNTMGPAL 

       430        440        450        460        470        480 
ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKVVAHNKF 

       490        500        510        520        530        540 
HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF 

       550        560        570        580        590        600 
LGMFLLVLFS FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 

       610        620        630        640        650        660 
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW 

       670        680        690        700        710        720 
KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW 

       730        740        750        760        770        780 
RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG 

       790 
FRTSKYAMFY PRN 

« Hide

Isoform Short [UniParc].

Checksum: C67F2053F8574122
Show »

FASTA75987,617

References

« Hide 'large scale' references
[1]"Molecular cloning of a widely expressed human homologue for the Drosophila trp gene."
Zhu X., Chu P.B., Peyton M., Birnbaumer L.
FEBS Lett. 373:193-198(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"TRPC1, a human homolog of a Drosophila store-operated channel."
Wes P.D., Chevesich J., Jeromin A., Rosenberg C., Stetten G., Montell C.
Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Brain.
[3]"Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion."
Zitt C., Zobel A., Obukhov A.G., Harteneck C., Kalkbrenner F., Lueckhoff A., Schultz G.
Neuron 16:1189-1196(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
Tissue: Brain.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
[6]"Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains."
Lockwich T.P., Liu X., Singh B.B., Jadlowiec J., Weiland S., Ambudkar I.S.
J. Biol. Chem. 275:11934-11942(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ITPR3.
[7]"TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells."
Xu S.-Z., Beech D.J.
Circ. Res. 88:84-87(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[8]"Subunit composition of mammalian transient receptor potential channels in living cells."
Hofmann T., Schaefer M., Schultz G., Gudermann T.
Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[9]"Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells."
Ahmmed G.U., Mehta D., Vogel S., Holinstat M., Paria B.C., Tiruppathi C., Malik A.B.
J. Biol. Chem. 279:20941-20949(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION.
[10]"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MX1.
[11]"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RNF24.
[12]"Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening."
Shim S., Yuan J.P., Kim J.Y., Zeng W., Huang G., Milshteyn A., Kern D., Muallem S., Ming G.L., Worley P.F.
Neuron 64:471-483(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FKBP4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U31110 mRNA. Translation: AAA93251.1.
U31110 mRNA. Translation: AAA93252.1.
X89066 mRNA. Translation: CAA61447.1.
Z73903 mRNA. Translation: CAA98108.1.
CH471052 Genomic DNA. Translation: EAW78963.1.
BC112338 mRNA. Translation: AAI12339.1.
BC113953 mRNA. Translation: AAI13954.1.
PIRS68238.
RefSeqNP_001238774.1. NM_001251845.1.
NP_003295.1. NM_003304.4.
UniGeneHs.250687.
Hs.684389.

3D structure databases

ProteinModelPortalP48995.
SMRP48995. Positions 48-200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113071. 17 interactions.
DIPDIP-35698N.
IntActP48995. 38 interactions.
STRING9606.ENSP00000273481.

Chemistry

GuidetoPHARMACOLOGY486.

Protein family/group databases

TCDB1.A.4.1.3. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSiteP48995.

Polymorphism databases

DMDM1351302.

Proteomic databases

PaxDbP48995.
PRIDEP48995.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273482; ENSP00000273482; ENSG00000144935. [P48995-2]
ENST00000476941; ENSP00000419313; ENSG00000144935. [P48995-1]
GeneID7220.
KEGGhsa:7220.
UCSCuc003evb.3. human. [P48995-2]
uc003evc.3. human. [P48995-1]

Organism-specific databases

CTD7220.
GeneCardsGC03P142440.
HGNCHGNC:12333. TRPC1.
HPACAB009387.
HPA021130.
MIM602343. gene.
neXtProtNX_P48995.
PharmGKBPA357.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245138.
HOGENOMHOG000020589.
HOVERGENHBG068337.
InParanoidP48995.
KOK04964.
OMAMLLKQDI.
OrthoDBEOG72G17P.
PhylomeDBP48995.
TreeFamTF313147.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_15518. Transmembrane transport of small molecules.
REACT_6900. Immune System.

Gene expression databases

BgeeP48995.
CleanExHS_TRPC1.
GenevestigatorP48995.

Family and domain databases

Gene3D1.25.40.20. 1 hit.
InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMSSF48403. SSF48403. 1 hit.
TIGRFAMsTIGR00870. trp. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTRPC1. human.
GeneWikiTRPC1.
GenomeRNAi7220.
NextBio28276.
PROP48995.
SOURCESearch...

Entry information

Entry nameTRPC1_HUMAN
AccessionPrimary (citable) accession number: P48995
Secondary accession number(s): Q14CE4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM