P48995 (TRPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Short transient receptor potential channel 1
Short name=TrpC1

Alternative name(s):
Transient receptor protein 1
Short name=TRP-1

Gene names

Name:	TRPC1
Synonyms:	TRP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	793 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Subunit structure	Interacts with TRPC4AP By similarity. Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4. Ref.6 Ref.8 Ref.9 Ref.10 Ref.11
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Seems to be ubiquitous.
Sequence similarities	Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily. [View classification] Contains 4 ANK repeats.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	ANK repeat Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome cytosolic calcium ion homeostasis Inferred from direct assay PubMed 19052258. Source: BHF-UCL positive regulation of release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 19052258. Source: BHF-UCL response to calcium ion Inferred from direct assay PubMed 14505576PubMed 19052258. Source: BHF-UCL saliva secretion Inferred from electronic annotation. Source: Compara
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: Compara costamere Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.2. Source: ProtInc membrane raft Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara sarcomere Inferred from electronic annotation. Source: Compara
Molecular_function	inositol 1,4,5 trisphosphate binding Inferred from direct assay PubMed 14505576. Source: BHF-UCL store-operated calcium channel activity Traceable author statement Ref.3. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: P48995-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: P48995-2)

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 793	793	Short transient receptor potential channel 1		PRO_0000215303
Regions
	Topological domain	1 – 386	386	Cytoplasmic Potential
	Transmembrane	387 – 407	21	Helical; Potential
	Topological domain	408 – 415	8	Extracellular Potential
	Transmembrane	416 – 436	21	Helical; Potential
	Topological domain	437 – 457	21	Cytoplasmic Potential
	Transmembrane	458 – 475	18	Helical; Potential
	Topological domain	476 – 539	64	Extracellular Potential
	Transmembrane	540 – 560	21	Helical; Potential
	Topological domain	561 – 586	26	Cytoplasmic Potential
	Transmembrane	587 – 607	21	Helical; Potential
	Topological domain	608 – 616	9	Extracellular Potential
	Transmembrane	617 – 637	21	Helical; Potential
	Repeat	46 – 75	30	ANK 1
	Repeat	83 – 111	29	ANK 2
	Repeat	112 – 138	27	ANK 3
	Repeat	158 – 187	30	ANK 4
Natural variations
	Alternative sequence	110 – 143	34	Missing in isoform Short.		VSP_006560

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified February 1, 1996. Version 1. Checksum: F4CC57ADDFA320AE	FASTA	793	91,212
	10 20 30 40 50 60 MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 70 80 90 100 110 120 YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS 130 140 150 160 170 180 EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK 190 200 210 220 230 240 QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL 250 260 270 280 290 300 SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 310 320 330 340 350 360 LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF 370 380 390 400 410 420 WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYNE DKKNTMGPAL 430 440 450 460 470 480 ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKVVAHNKF 490 500 510 520 530 540 HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF 550 560 570 580 590 600 LGMFLLVLFS FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 610 620 630 640 650 660 LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW 670 680 690 700 710 720 KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW 730 740 750 760 770 780 RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG 790 FRTSKYAMFY PRN
	Isoform Short [UniParc]. Checksum: C67F2053F8574122	FASTA	759	87,617
	10 20 30 40 50 60 MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY 70 80 90 100 110 120 YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQK LMERIQNPEY 130 140 150 160 170 180 STTMDVAPVI LAAHRNNYEI LTMLLKQDVS LPKPHAVGCE CTLCSAKNKK DSLRHSRFRL 190 200 210 220 230 240 DIYRCLASPA LIMLTEEDPI LRAFELSADL KELSLVEVEF RNDYEELARQ CKMFAKDLLA 250 260 270 280 290 300 QARNSRELEV ILNHTSSDEP LDKRGLLEER MNLSRLKLAI KYNQKEFVSQ SNCQQFLNTV 310 320 330 340 350 360 WFGQMSGYRR KPTCKKIMTV LTVGIFWPVL SLCYLIAPKS QFGRIIHTPF MKFIIHGASY 370 380 390 400 410 420 FTFLLLLNLY SLVYNEDKKN TMGPALERID YLLILWIIGM IWSDIKRLWY EGLEDFLEES 430 440 450 460 470 480 RNQLSFVMNS LYLATFALKV VAHNKFHDFA DRKDWDAFHP TLVAEGLFAF ANVLSYLRLF 490 500 510 520 530 540 FMYTTSSILG PLQISMGQML QDFGKFLGMF LLVLFSFTIG LTQLYDKGYT SKEQKDCVGI 550 560 570 580 590 600 FCEQQSNDTF HSFIGTCFAL FWYIFSLAHV AIFVTRFSYG EELQSFVGAV IVGTYNVVVV 610 620 630 640 650 660 IVLTKLLVAM LHKSFQLIAN HEDKEWKFAR AKLWLSYFDD KCTLPPPFNI IPSPKTICYM 670 680 690 700 710 720 ISSLSKWICS HTSKGKVKRQ NSLKEWRNLK QKRDENYQKV MCCLVHRYLT SMRQKMQSTD 730 740 750 QATVENLNEL RQDLSKFRNE IRDLLGFRTS KYAMFYPRN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a widely expressed human homologue for the Drosophila trp gene." Zhu X., Chu P.B., Peyton M., Birnbaumer L. FEBS Lett. 373:193-198(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"TRPC1, a human homolog of a Drosophila store-operated channel." Wes P.D., Chevesich J., Jeromin A., Rosenberg C., Stetten G., Montell C. Proc. Natl. Acad. Sci. U.S.A. 92:9652-9656(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Brain.
[3]	"Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion." Zitt C., Zobel A., Obukhov A.G., Harteneck C., Kalkbrenner F., Lueckhoff A., Schultz G. Neuron 16:1189-1196(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). Tissue: Brain.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
[6]	"Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains." Lockwich T.P., Liu X., Singh B.B., Jadlowiec J., Weiland S., Ambudkar I.S. J. Biol. Chem. 275:11934-11942(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ITPR3.
[7]	"TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells." Xu S.-Z., Beech D.J. Circ. Res. 88:84-87(2001) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[8]	"Subunit composition of mammalian transient receptor potential channels in living cells." Hofmann T., Schaefer M., Schultz G., Gudermann T. Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[9]	"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC." Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G. J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MX1.
[10]	"RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC." Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G. Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RNF24.
[11]	"Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening." Shim S., Yuan J.P., Kim J.Y., Zeng W., Huang G., Milshteyn A., Kern D., Muallem S., Ming G.L., Worley P.F. Neuron 64:471-483(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FKBP4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U31110 mRNA. Translation: AAA93251.1. U31110 mRNA. Translation: AAA93252.1. X89066 mRNA. Translation: CAA61447.1. Z73903 mRNA. Translation: CAA98108.1. CH471052 Genomic DNA. Translation: EAW78963.1. BC112338 mRNA. Translation: AAI12339.1. BC113953 mRNA. Translation: AAI13954.1.
IPI	IPI00012081. IPI00220579.
PIR	S68238.
RefSeq	NP_001238774.1. NM_001251845.1. NP_003295.1. NM_003304.4.
UniGene	Hs.250687.
3D structure databases
ProteinModelPortal	P48995.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-35698N.
IntAct	P48995. 38 interactions.
STRING	9606.ENSP00000273481.
Protein family/group databases
TCDB	1.A.4.1.3. transient receptor potential Ca2+ channel (TRP-CC) family.
PTM databases
PhosphoSite	P48995.
Polymorphism databases
DMDM	1351302.
Proteomic databases
PaxDb	P48995.
PRIDE	P48995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273482; ENSP00000273482; ENSG00000144935. ENST00000476941; ENSP00000419313; ENSG00000144935.
GeneID	7220.
KEGG	hsa:7220.
UCSC	uc003evb.3. human. uc003evc.3. human.
Organism-specific databases
CTD	7220.
GeneCards	GC03P142440.
HGNC	HGNC:12333. TRPC1.
HPA	CAB009387. HPA021130.
MIM	602343. gene.
neXtProt	NX_P48995.
PharmGKB	PA357.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG245138.
HOGENOM	HOG000020589.
HOVERGEN	HBG068337.
InParanoid	P48995.
KO	K04964.
OMA	MLLKQDI.
OrthoDB	EOG47D9FG.
PhylomeDB	P48995.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_6900. Immune System.
Gene expression databases
Bgee	P48995.
CleanEx	HS_TRPC1.
Genevestigator	P48995.
GermOnline	ENSG00000144935. Homo sapiens.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans_dom. IPR004729. TRP_channel. IPR013555. TRP_dom. IPR005457. TRPC1_channel. IPR002153. TRPC_channel. [Graphical view]
PANTHER	PTHR10117. PTHR10117. 1 hit. PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfam	PF12796. Ank_2. 1 hit. PF00520. Ion_trans. 1 hit. PF08344. TRP_2. 1 hit. [Graphical view]
PRINTS	PR01097. TRNSRECEPTRP. PR01642. TRPCHANNEL1.
SMART	SM00248. ANK. 3 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
TIGRFAMs	TIGR00870. trp. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. False negative. PS50088. ANK_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TRPC1. human.
GenomeRNAi	7220.
NextBio	28276.
SOURCE	Search...

Entry information

Entry name

TRPC1_HUMAN

Accession

Primary (citable) accession number: P48995
Secondary accession number(s): Q14CE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	February 1, 1996
Last modified:	May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.