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Protein

Short transient receptor potential channel 1

Gene

TRPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.1 Publication

GO - Molecular functioni

  • calcium channel activity Source: Reactome
  • cation channel activity Source: Reactome
  • inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  • ion channel binding Source: BHF-UCL
  • store-operated calcium channel activity Source: ProtInc

GO - Biological processi

  • calcium ion transmembrane transport Source: Reactome
  • calcium ion transport Source: ProtInc
  • manganese ion transport Source: GO_Central
  • melanin biosynthetic process Source: CACAO
  • positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
  • regulation of cardiac conduction Source: Reactome
  • regulation of cytosolic calcium ion concentration Source: BHF-UCL
  • response to calcium ion Source: BHF-UCL

Keywordsi

Molecular functionCalcium channel, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-5578775 Ion homeostasis
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

TCDBi1.A.4.1.3 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:TRPC1
Synonyms:TRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi

Organism-specific databases

EuPathDBiHostDB:ENSG00000144935.14
HGNCiHGNC:12333 TRPC1
MIMi602343 gene
neXtProtiNX_P48995

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 386CytoplasmicSequence analysisAdd BLAST386
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 415ExtracellularSequence analysis8
Transmembranei416 – 436HelicalSequence analysisAdd BLAST21
Topological domaini437 – 457CytoplasmicSequence analysisAdd BLAST21
Transmembranei458 – 475HelicalSequence analysisAdd BLAST18
Topological domaini476 – 539ExtracellularSequence analysisAdd BLAST64
Transmembranei540 – 560HelicalSequence analysisAdd BLAST21
Topological domaini561 – 586CytoplasmicSequence analysisAdd BLAST26
Transmembranei587 – 607HelicalSequence analysisAdd BLAST21
Topological domaini608 – 616ExtracellularSequence analysis9
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7220
OpenTargetsiENSG00000144935
PharmGKBiPA357

Chemistry databases

GuidetoPHARMACOLOGYi486

Polymorphism and mutation databases

BioMutaiTRPC1
DMDMi1351302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153031 – 793Short transient receptor potential channel 1Add BLAST793

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP48995
PaxDbiP48995
PeptideAtlasiP48995
PRIDEiP48995

PTM databases

iPTMnetiP48995
PhosphoSitePlusiP48995
SwissPalmiP48995

Expressioni

Tissue specificityi

Seems to be ubiquitous.

Gene expression databases

BgeeiENSG00000144935
CleanExiHS_TRPC1
ExpressionAtlasiP48995 baseline and differential
GenevisibleiP48995 HS

Organism-specific databases

HPAiCAB009387
HPA021130

Interactioni

Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.By similarity5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi113071, 16 interactors
CORUMiP48995
DIPiDIP-35698N
IntActiP48995, 40 interactors
STRINGi9606.ENSP00000273482

Structurei

3D structure databases

ProteinModelPortaliP48995
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati46 – 75ANK 1Add BLAST30
Repeati83 – 111ANK 2Add BLAST29
Repeati112 – 138ANK 3Add BLAST27
Repeati158 – 187ANK 4Add BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3609 Eukaryota
ENOG410XQ0Y LUCA
GeneTreeiENSGT00760000119180
HOGENOMiHOG000020589
HOVERGENiHBG068337
InParanoidiP48995
KOiK04964
OMAiPKTICYL
OrthoDBiEOG091G029I
PhylomeDBiP48995
TreeFamiTF313147

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR013555 TRP_dom
IPR005457 TRPC1_channel
IPR002153 TRPC_channel
PANTHERiPTHR10117 PTHR10117, 1 hit
PTHR10117:SF56 PTHR10117:SF56, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF08344 TRP_2, 1 hit
PRINTSiPR01097 TRNSRECEPTRP
PR01642 TRPCHANNEL1
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P48995-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,212
Last modified:February 1, 1996 - v1
Checksum:iF4CC57ADDFA320AE
GO
Isoform Short (identifier: P48995-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,617
Checksum:iC67F2053F8574122
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006560110 – 143Missing in isoform Short. 3 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31110 mRNA Translation: AAA93251.1
U31110 mRNA Translation: AAA93252.1
X89066 mRNA Translation: CAA61447.1
Z73903 mRNA Translation: CAA98108.1
CH471052 Genomic DNA Translation: EAW78963.1
BC112338 mRNA Translation: AAI12339.1
BC113953 mRNA Translation: AAI13954.1
CCDSiCCDS3126.1 [P48995-2]
CCDS58856.1 [P48995-1]
PIRiS68238
RefSeqiNP_001238774.1, NM_001251845.1 [P48995-1]
NP_003295.1, NM_003304.4 [P48995-2]
UniGeneiHs.250687
Hs.684389

Genome annotation databases

EnsembliENST00000273482; ENSP00000273482; ENSG00000144935 [P48995-2]
ENST00000476941; ENSP00000419313; ENSG00000144935 [P48995-1]
ENST00000612385; ENSP00000481537; ENSG00000144935 [P48995-2]
GeneIDi7220
KEGGihsa:7220
UCSCiuc003evb.4 human [P48995-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRPC1_HUMAN
AccessioniPrimary (citable) accession number: P48995
Secondary accession number(s): Q14CE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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