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P48995

- TRPC1_HUMAN

UniProt

P48995 - TRPC1_HUMAN

Protein

Short transient receptor potential channel 1

Gene

TRPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.1 Publication

    GO - Molecular functioni

    1. calcium channel activity Source: ProtInc
    2. cation channel activity Source: Reactome
    3. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
    4. ion channel binding Source: BHF-UCL
    5. protein binding Source: BHF-UCL
    6. store-operated calcium channel activity Source: ProtInc

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. calcium ion transmembrane transport Source: Reactome
    3. calcium ion transport Source: ProtInc
    4. cytosolic calcium ion homeostasis Source: BHF-UCL
    5. ion transmembrane transport Source: Reactome
    6. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
    7. response to calcium ion Source: BHF-UCL
    8. saliva secretion Source: Ensembl
    9. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_169333. TRP channels.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Protein family/group databases

    TCDBi1.A.4.1.3. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short transient receptor potential channel 1
    Short name:
    TrpC1
    Alternative name(s):
    Transient receptor protein 1
    Short name:
    TRP-1
    Gene namesi
    Name:TRPC1
    Synonyms:TRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12333. TRPC1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. costamere Source: Ensembl
    3. integral component of plasma membrane Source: ProtInc
    4. membrane raft Source: Ensembl
    5. plasma membrane Source: BHF-UCL
    6. receptor complex Source: MGI
    7. sarcomere Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA357.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 793793Short transient receptor potential channel 1PRO_0000215303Add
    BLAST

    Post-translational modificationi

    Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP48995.
    PRIDEiP48995.

    PTM databases

    PhosphoSiteiP48995.

    Expressioni

    Tissue specificityi

    Seems to be ubiquitous.

    Gene expression databases

    BgeeiP48995.
    CleanExiHS_TRPC1.
    GenevestigatoriP48995.

    Organism-specific databases

    HPAiCAB009387.
    HPA021130.

    Interactioni

    Subunit structurei

    Interacts with TRPC4AP By similarity. Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.By similarity5 Publications

    Protein-protein interaction databases

    BioGridi113071. 17 interactions.
    DIPiDIP-35698N.
    IntActiP48995. 38 interactions.
    STRINGi9606.ENSP00000273481.

    Structurei

    3D structure databases

    ProteinModelPortaliP48995.
    SMRiP48995. Positions 48-200.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 386386CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini408 – 4158ExtracellularSequence Analysis
    Topological domaini437 – 45721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini476 – 53964ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini561 – 58626CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini608 – 6169ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei387 – 40721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei416 – 43621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei458 – 47518HelicalSequence AnalysisAdd
    BLAST
    Transmembranei540 – 56021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei587 – 60721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati46 – 7530ANK 1Add
    BLAST
    Repeati83 – 11129ANK 2Add
    BLAST
    Repeati112 – 13827ANK 3Add
    BLAST
    Repeati158 – 18730ANK 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.Curated

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG245138.
    HOGENOMiHOG000020589.
    HOVERGENiHBG068337.
    InParanoidiP48995.
    KOiK04964.
    OMAiMLLKQDI.
    OrthoDBiEOG72G17P.
    PhylomeDBiP48995.
    TreeFamiTF313147.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view]
    PANTHERiPTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view]
    PRINTSiPR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTiSM00248. ANK. 3 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: P48995-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL    50
    FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL 100
    QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ 150
    NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA 200
    KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV 250
    EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL 300
    LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK 350
    IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL 400
    LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF 450
    LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG 500
    LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS 550
    FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS 600
    LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ 650
    LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK 700
    WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM 750
    QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN 793
    Length:793
    Mass (Da):91,212
    Last modified:February 1, 1996 - v1
    Checksum:iF4CC57ADDFA320AE
    GO
    Isoform Short (identifier: P48995-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         110-143: Missing.

    Show »
    Length:759
    Mass (Da):87,617
    Checksum:iC67F2053F8574122
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei110 – 14334Missing in isoform Short. 3 PublicationsVSP_006560Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31110 mRNA. Translation: AAA93251.1.
    U31110 mRNA. Translation: AAA93252.1.
    X89066 mRNA. Translation: CAA61447.1.
    Z73903 mRNA. Translation: CAA98108.1.
    CH471052 Genomic DNA. Translation: EAW78963.1.
    BC112338 mRNA. Translation: AAI12339.1.
    BC113953 mRNA. Translation: AAI13954.1.
    CCDSiCCDS3126.1. [P48995-2]
    CCDS58856.1. [P48995-1]
    PIRiS68238.
    RefSeqiNP_001238774.1. NM_001251845.1. [P48995-1]
    NP_003295.1. NM_003304.4. [P48995-2]
    UniGeneiHs.250687.
    Hs.684389.

    Genome annotation databases

    EnsembliENST00000273482; ENSP00000273482; ENSG00000144935. [P48995-2]
    ENST00000476941; ENSP00000419313; ENSG00000144935. [P48995-1]
    GeneIDi7220.
    KEGGihsa:7220.
    UCSCiuc003evb.3. human. [P48995-2]
    uc003evc.3. human. [P48995-1]

    Polymorphism databases

    DMDMi1351302.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U31110 mRNA. Translation: AAA93251.1 .
    U31110 mRNA. Translation: AAA93252.1 .
    X89066 mRNA. Translation: CAA61447.1 .
    Z73903 mRNA. Translation: CAA98108.1 .
    CH471052 Genomic DNA. Translation: EAW78963.1 .
    BC112338 mRNA. Translation: AAI12339.1 .
    BC113953 mRNA. Translation: AAI13954.1 .
    CCDSi CCDS3126.1. [P48995-2 ]
    CCDS58856.1. [P48995-1 ]
    PIRi S68238.
    RefSeqi NP_001238774.1. NM_001251845.1. [P48995-1 ]
    NP_003295.1. NM_003304.4. [P48995-2 ]
    UniGenei Hs.250687.
    Hs.684389.

    3D structure databases

    ProteinModelPortali P48995.
    SMRi P48995. Positions 48-200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113071. 17 interactions.
    DIPi DIP-35698N.
    IntActi P48995. 38 interactions.
    STRINGi 9606.ENSP00000273481.

    Chemistry

    GuidetoPHARMACOLOGYi 486.

    Protein family/group databases

    TCDBi 1.A.4.1.3. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei P48995.

    Polymorphism databases

    DMDMi 1351302.

    Proteomic databases

    PaxDbi P48995.
    PRIDEi P48995.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273482 ; ENSP00000273482 ; ENSG00000144935 . [P48995-2 ]
    ENST00000476941 ; ENSP00000419313 ; ENSG00000144935 . [P48995-1 ]
    GeneIDi 7220.
    KEGGi hsa:7220.
    UCSCi uc003evb.3. human. [P48995-2 ]
    uc003evc.3. human. [P48995-1 ]

    Organism-specific databases

    CTDi 7220.
    GeneCardsi GC03P142440.
    HGNCi HGNC:12333. TRPC1.
    HPAi CAB009387.
    HPA021130.
    MIMi 602343. gene.
    neXtProti NX_P48995.
    PharmGKBi PA357.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245138.
    HOGENOMi HOG000020589.
    HOVERGENi HBG068337.
    InParanoidi P48995.
    KOi K04964.
    OMAi MLLKQDI.
    OrthoDBi EOG72G17P.
    PhylomeDBi P48995.
    TreeFami TF313147.

    Enzyme and pathway databases

    Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_169333. TRP channels.
    REACT_22228. Role of second messengers in netrin-1 signaling.

    Miscellaneous databases

    ChiTaRSi TRPC1. human.
    GeneWikii TRPC1.
    GenomeRNAii 7220.
    NextBioi 28276.
    PROi P48995.
    SOURCEi Search...

    Gene expression databases

    Bgeei P48995.
    CleanExi HS_TRPC1.
    Genevestigatori P48995.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR013555. TRP_dom.
    IPR005457. TRPC1_channel.
    IPR002153. TRPC_channel.
    [Graphical view ]
    PANTHERi PTHR10117. PTHR10117. 1 hit.
    PTHR10117:SF3. PTHR10117:SF3. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    PF08344. TRP_2. 1 hit.
    [Graphical view ]
    PRINTSi PR01097. TRNSRECEPTRP.
    PR01642. TRPCHANNEL1.
    SMARTi SM00248. ANK. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene."
      Zhu X., Chu P.B., Peyton M., Birnbaumer L.
      FEBS Lett. 373:193-198(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Brain.
    3. "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion."
      Zitt C., Zobel A., Obukhov A.G., Harteneck C., Kalkbrenner F., Lueckhoff A., Schultz G.
      Neuron 16:1189-1196(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
    6. "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains."
      Lockwich T.P., Liu X., Singh B.B., Jadlowiec J., Weiland S., Ambudkar I.S.
      J. Biol. Chem. 275:11934-11942(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ITPR3.
    7. "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells."
      Xu S.-Z., Beech D.J.
      Circ. Res. 88:84-87(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    8. "Subunit composition of mammalian transient receptor potential channels in living cells."
      Hofmann T., Schaefer M., Schultz G., Gudermann T.
      Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    9. "Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells."
      Ahmmed G.U., Mehta D., Vogel S., Holinstat M., Paria B.C., Tiruppathi C., Malik A.B.
      J. Biol. Chem. 279:20941-20949(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    10. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
      Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
      J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MX1.
    11. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
      Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
      Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF24.
    12. "Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening."
      Shim S., Yuan J.P., Kim J.Y., Zeng W., Huang G., Milshteyn A., Kern D., Muallem S., Ming G.L., Worley P.F.
      Neuron 64:471-483(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FKBP4.

    Entry informationi

    Entry nameiTRPC1_HUMAN
    AccessioniPrimary (citable) accession number: P48995
    Secondary accession number(s): Q14CE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3