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P48995

- TRPC1_HUMAN

UniProt

P48995 - TRPC1_HUMAN

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Protein

Short transient receptor potential channel 1

Gene

TRPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.1 Publication

GO - Molecular functioni

  1. calcium channel activity Source: ProtInc
  2. cation channel activity Source: Reactome
  3. inositol 1,4,5 trisphosphate binding Source: BHF-UCL
  4. ion channel binding Source: BHF-UCL
  5. store-operated calcium channel activity Source: ProtInc

GO - Biological processi

  1. axon guidance Source: Reactome
  2. calcium ion transmembrane transport Source: Reactome
  3. calcium ion transport Source: ProtInc
  4. cytosolic calcium ion homeostasis Source: BHF-UCL
  5. ion transmembrane transport Source: Reactome
  6. positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
  7. response to calcium ion Source: BHF-UCL
  8. saliva secretion Source: Ensembl
  9. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_169333. TRP channels.
REACT_22228. Role of second messengers in netrin-1 signaling.

Protein family/group databases

TCDBi1.A.4.1.3. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Short transient receptor potential channel 1
Short name:
TrpC1
Alternative name(s):
Transient receptor protein 1
Short name:
TRP-1
Gene namesi
Name:TRPC1
Synonyms:TRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12333. TRPC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 386386CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei387 – 40721HelicalSequence AnalysisAdd
BLAST
Topological domaini408 – 4158ExtracellularSequence Analysis
Transmembranei416 – 43621HelicalSequence AnalysisAdd
BLAST
Topological domaini437 – 45721CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei458 – 47518HelicalSequence AnalysisAdd
BLAST
Topological domaini476 – 53964ExtracellularSequence AnalysisAdd
BLAST
Transmembranei540 – 56021HelicalSequence AnalysisAdd
BLAST
Topological domaini561 – 58626CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei587 – 60721HelicalSequence AnalysisAdd
BLAST
Topological domaini608 – 6169ExtracellularSequence Analysis
Transmembranei617 – 63721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. costamere Source: Ensembl
  3. integral component of plasma membrane Source: ProtInc
  4. membrane raft Source: Ensembl
  5. plasma membrane Source: BHF-UCL
  6. receptor complex Source: MGI
  7. sarcomere Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA357.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 793793Short transient receptor potential channel 1PRO_0000215303Add
BLAST

Post-translational modificationi

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48995.
PRIDEiP48995.

PTM databases

PhosphoSiteiP48995.

Expressioni

Tissue specificityi

Seems to be ubiquitous.

Gene expression databases

BgeeiP48995.
CleanExiHS_TRPC1.
GenevestigatoriP48995.

Organism-specific databases

HPAiCAB009387.
HPA021130.

Interactioni

Subunit structurei

Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5. Interacts with TRPC3, TRPC4 and TRPC5. Interacts with ITPR3. Interacts with MX1 and RNF24. Interacts with FKBP4.By similarity5 Publications

Protein-protein interaction databases

BioGridi113071. 17 interactions.
DIPiDIP-35698N.
IntActiP48995. 38 interactions.
STRINGi9606.ENSP00000273481.

Structurei

3D structure databases

ProteinModelPortaliP48995.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati46 – 7530ANK 1Add
BLAST
Repeati83 – 11129ANK 2Add
BLAST
Repeati112 – 13827ANK 3Add
BLAST
Repeati158 – 18730ANK 4Add
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG245138.
GeneTreeiENSGT00760000119180.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
InParanoidiP48995.
KOiK04964.
OMAiMLLKQDI.
OrthoDBiEOG72G17P.
PhylomeDBiP48995.
TreeFamiTF313147.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: P48995-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL
60 70 80 90 100
FLLACDKGDY YMVKKILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL
110 120 130 140 150
QLLLDYGCQS ADALLVAIDS EVVGAVDILL NHRPKRSSRP TIVKLMERIQ
160 170 180 190 200
NPEYSTTMDV APVILAAHRN NYEILTMLLK QDVSLPKPHA VGCECTLCSA
210 220 230 240 250
KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILRAFEL SADLKELSLV
260 270 280 290 300
EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS SDEPLDKRGL
310 320 330 340 350
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK
360 370 380 390 400
IMTVLTVGIF WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL
410 420 430 440 450
LNLYSLVYNE DKKNTMGPAL ERIDYLLILW IIGMIWSDIK RLWYEGLEDF
460 470 480 490 500
LEESRNQLSF VMNSLYLATF ALKVVAHNKF HDFADRKDWD AFHPTLVAEG
510 520 530 540 550
LFAFANVLSY LRLFFMYTTS SILGPLQISM GQMLQDFGKF LGMFLLVLFS
560 570 580 590 600
FTIGLTQLYD KGYTSKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
610 620 630 640 650
LAHVAIFVTR FSYGEELQSF VGAVIVGTYN VVVVIVLTKL LVAMLHKSFQ
660 670 680 690 700
LIANHEDKEW KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK
710 720 730 740 750
WICSHTSKGK VKRQNSLKEW RNLKQKRDEN YQKVMCCLVH RYLTSMRQKM
760 770 780 790
QSTDQATVEN LNELRQDLSK FRNEIRDLLG FRTSKYAMFY PRN
Length:793
Mass (Da):91,212
Last modified:February 1, 1996 - v1
Checksum:iF4CC57ADDFA320AE
GO
Isoform Short (identifier: P48995-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     110-143: Missing.

Show »
Length:759
Mass (Da):87,617
Checksum:iC67F2053F8574122
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei110 – 14334Missing in isoform Short. 3 PublicationsVSP_006560Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31110 mRNA. Translation: AAA93251.1.
U31110 mRNA. Translation: AAA93252.1.
X89066 mRNA. Translation: CAA61447.1.
Z73903 mRNA. Translation: CAA98108.1.
CH471052 Genomic DNA. Translation: EAW78963.1.
BC112338 mRNA. Translation: AAI12339.1.
BC113953 mRNA. Translation: AAI13954.1.
CCDSiCCDS3126.1. [P48995-2]
CCDS58856.1. [P48995-1]
PIRiS68238.
RefSeqiNP_001238774.1. NM_001251845.1. [P48995-1]
NP_003295.1. NM_003304.4. [P48995-2]
UniGeneiHs.250687.
Hs.684389.

Genome annotation databases

EnsembliENST00000273482; ENSP00000273482; ENSG00000144935. [P48995-2]
ENST00000476941; ENSP00000419313; ENSG00000144935. [P48995-1]
ENST00000612385; ENSP00000481537; ENSG00000144935. [P48995-2]
GeneIDi7220.
KEGGihsa:7220.
UCSCiuc003evb.3. human. [P48995-2]
uc003evc.3. human. [P48995-1]

Polymorphism databases

DMDMi1351302.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31110 mRNA. Translation: AAA93251.1 .
U31110 mRNA. Translation: AAA93252.1 .
X89066 mRNA. Translation: CAA61447.1 .
Z73903 mRNA. Translation: CAA98108.1 .
CH471052 Genomic DNA. Translation: EAW78963.1 .
BC112338 mRNA. Translation: AAI12339.1 .
BC113953 mRNA. Translation: AAI13954.1 .
CCDSi CCDS3126.1. [P48995-2 ]
CCDS58856.1. [P48995-1 ]
PIRi S68238.
RefSeqi NP_001238774.1. NM_001251845.1. [P48995-1 ]
NP_003295.1. NM_003304.4. [P48995-2 ]
UniGenei Hs.250687.
Hs.684389.

3D structure databases

ProteinModelPortali P48995.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113071. 17 interactions.
DIPi DIP-35698N.
IntActi P48995. 38 interactions.
STRINGi 9606.ENSP00000273481.

Chemistry

GuidetoPHARMACOLOGYi 486.

Protein family/group databases

TCDBi 1.A.4.1.3. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

PhosphoSitei P48995.

Polymorphism databases

DMDMi 1351302.

Proteomic databases

PaxDbi P48995.
PRIDEi P48995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273482 ; ENSP00000273482 ; ENSG00000144935 . [P48995-2 ]
ENST00000476941 ; ENSP00000419313 ; ENSG00000144935 . [P48995-1 ]
ENST00000612385 ; ENSP00000481537 ; ENSG00000144935 . [P48995-2 ]
GeneIDi 7220.
KEGGi hsa:7220.
UCSCi uc003evb.3. human. [P48995-2 ]
uc003evc.3. human. [P48995-1 ]

Organism-specific databases

CTDi 7220.
GeneCardsi GC03P142440.
HGNCi HGNC:12333. TRPC1.
HPAi CAB009387.
HPA021130.
MIMi 602343. gene.
neXtProti NX_P48995.
PharmGKBi PA357.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG245138.
GeneTreei ENSGT00760000119180.
HOGENOMi HOG000020589.
HOVERGENi HBG068337.
InParanoidi P48995.
KOi K04964.
OMAi MLLKQDI.
OrthoDBi EOG72G17P.
PhylomeDBi P48995.
TreeFami TF313147.

Enzyme and pathway databases

Reactomei REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_169333. TRP channels.
REACT_22228. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSi TRPC1. human.
GeneWikii TRPC1.
GenomeRNAii 7220.
NextBioi 28276.
PROi P48995.
SOURCEi Search...

Gene expression databases

Bgeei P48995.
CleanExi HS_TRPC1.
Genevestigatori P48995.

Family and domain databases

Gene3Di 1.25.40.20. 1 hit.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005457. TRPC1_channel.
IPR002153. TRPC_channel.
[Graphical view ]
PANTHERi PTHR10117. PTHR10117. 1 hit.
PTHR10117:SF3. PTHR10117:SF3. 1 hit.
Pfami PF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view ]
PRINTSi PR01097. TRNSRECEPTRP.
PR01642. TRPCHANNEL1.
SMARTi SM00248. ANK. 3 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene."
    Zhu X., Chu P.B., Peyton M., Birnbaumer L.
    FEBS Lett. 373:193-198(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Brain.
  3. "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion."
    Zitt C., Zobel A., Obukhov A.G., Harteneck C., Kalkbrenner F., Lueckhoff A., Schultz G.
    Neuron 16:1189-1196(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
  6. "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains."
    Lockwich T.P., Liu X., Singh B.B., Jadlowiec J., Weiland S., Ambudkar I.S.
    J. Biol. Chem. 275:11934-11942(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITPR3.
  7. "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells."
    Xu S.-Z., Beech D.J.
    Circ. Res. 88:84-87(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  8. "Subunit composition of mammalian transient receptor potential channels in living cells."
    Hofmann T., Schaefer M., Schultz G., Gudermann T.
    Proc. Natl. Acad. Sci. U.S.A. 99:7461-7466(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  9. "Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells."
    Ahmmed G.U., Mehta D., Vogel S., Holinstat M., Paria B.C., Tiruppathi C., Malik A.B.
    J. Biol. Chem. 279:20941-20949(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  10. "MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
    Lussier M.P., Cayouette S., Lepage P.K., Bernier C.L., Francoeur N., St-Hilaire M., Pinard M., Boulay G.
    J. Biol. Chem. 280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MX1.
  11. "RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC."
    Lussier M.P., Lepage P.K., Bousquet S.M., Boulay G.
    Cell Calcium 43:432-443(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF24.
  12. "Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening."
    Shim S., Yuan J.P., Kim J.Y., Zeng W., Huang G., Milshteyn A., Kern D., Muallem S., Ming G.L., Worley P.F.
    Neuron 64:471-483(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FKBP4.

Entry informationi

Entry nameiTRPC1_HUMAN
AccessioniPrimary (citable) accession number: P48995
Secondary accession number(s): Q14CE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 26, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3