ID   G6PD_ANASP              Reviewed;         509 AA.
AC   P48992;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   16-JUN-2009, entry version 64.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=all4019;
OS   Anabaena sp. (strain PCC 7120).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=96079511; PubMed=8566707; DOI=10.1016/0378-1097(95)00369-G;
RA   Newman J., Karakaya H., Scanlan D.J., Mann N.H.;
RT   "A comparison of gene organization in the zwf region of the genomes of
RT   the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC
RT   7120.";
RL   FEMS Microbiol. Lett. 133:187-193(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=21595285; PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S.,
RA   Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA   Nakazaki N., Shimpo S., Sugimoto M., Takazawa M., Yamada M.,
RA   Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; U33282; AAA98853.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB75718.1; -; Genomic_DNA.
DR   PIR; AD2308; AD2308.
DR   RefSeq; NP_488059.1; -.
DR   HSSP; P11413; 1QKI.
DR   GeneID; 1107617; -.
DR   GenomeReviews; BA000019_GR; all4019.
DR   KEGG; ana:all4019; -.
DR   NMPDR; fig|103690.1.peg.4326; -.
DR   HOGENOM; P48992; -.
DR   OMA; P48992; SRRWAGV.
DR   BioCyc; NSP103690:ALL4019-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DH.
DR   InterPro; IPR019796; Glc-6-P_DH_AS.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    509       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068109.
FT   ACT_SITE    259    259       Proton acceptor (By similarity).
FT   BINDING      30     30       NADP (By similarity).
FT   BINDING      62     62       NADP (By similarity).
FT   BINDING     197    197       Substrate (By similarity).
FT   BINDING     201    201       Substrate (By similarity).
FT   BINDING     364    364       Substrate (By similarity).
FT   CONFLICT    417    417       T -> S (in Ref. 1; AAA98853).
SQ   SEQUENCE   509 AA;  58304 MW;  FEC3CFBF7119E977 CRC64;
     MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV
     ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY CPGDIDNPES YQKLKNLLSE
     LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG GAGMLDDPYK HRLVIEKPFG RDLASAQSLN
     AVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE
     DRAGYYEKAG ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS
     RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG VPFYLRTGKR
     MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE GISLRFDVKM PGAEFRTRSV
     DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDSPADPA
     TIPQYEAGTW EPAEAEFLIN QDGRRWRRL
//