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P48992

- G6PD_NOSS1

UniProt

P48992 - G6PD_NOSS1

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NADPUniRule annotation
Binding sitei167 – 1671NADPUniRule annotation
Binding sitei197 – 1971SubstrateUniRule annotation
Binding sitei201 – 2011SubstrateUniRule annotation
Binding sitei235 – 2351SubstrateUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Active sitei259 – 2591Proton acceptorUniRule annotation
Binding sitei359 – 3591SubstrateUniRule annotation
Binding sitei364 – 3641SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1052NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP48992.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PDUniRule annotation
Gene namesi
Name:zwfUniRule annotation
Ordered Locus Names:all4019
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenasePRO_0000068109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all4019.

Structurei

3D structure databases

ProteinModelPortaliP48992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiMQIGAVR.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48992-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR
60 70 80 90 100
IPPETTIVGV ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY
110 120 130 140 150
CPGDIDNPES YQKLKNLLSE LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG
160 170 180 190 200
GAGMLDDPYK HRLVIEKPFG RDLASAQSLN AVVQKYCKEH QVYRIDHYLG
210 220 230 240 250
KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE DRAGYYEKAG
260 270 280 290 300
ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS
310 320 330 340 350
RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG
360 370 380 390 400
VPFYLRTGKR MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE
410 420 430 440 450
GISLRFDVKM PGAEFRTRSV DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ
460 470 480 490 500
TLFTRADEVE AAWQVVTPAL SVWDSPADPA TIPQYEAGTW EPAEAEFLIN

QDGRRWRRL
Length:509
Mass (Da):58,304
Last modified:January 23, 2002 - v2
Checksum:iFEC3CFBF7119E977
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti417 – 4171T → S in AAA98853. (PubMed:8566707)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33282 Genomic DNA. Translation: AAA98853.1.
BA000019 Genomic DNA. Translation: BAB75718.1.
PIRiAD2308.
RefSeqiNP_488059.1. NC_003272.1.
WP_010998159.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75718; BAB75718; BAB75718.
GeneIDi1107617.
KEGGiana:all4019.
PATRICi22778560. VBINosSp37423_4733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33282 Genomic DNA. Translation: AAA98853.1 .
BA000019 Genomic DNA. Translation: BAB75718.1 .
PIRi AD2308.
RefSeqi NP_488059.1. NC_003272.1.
WP_010998159.1. NC_003272.1.

3D structure databases

ProteinModelPortali P48992.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB75718 ; BAB75718 ; BAB75718 .
GeneIDi 1107617.
KEGGi ana:all4019.
PATRICi 22778560. VBINosSp37423_4733.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi MQIGAVR.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
SABIO-RK P48992.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120."
    Newman J., Karakaya H., Scanlan D.J., Mann N.H.
    FEMS Microbiol. Lett. 133:187-193(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiG6PD_NOSS1
AccessioniPrimary (citable) accession number: P48992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2002
Last modified: October 1, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3