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P48992 (G6PD_NOSS1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf
Ordered Locus Names:all4019
OrganismNostoc sp. (strain PCC 7120 / UTEX 2576) [Complete proteome] [HAMAP]
Taxonomic identifier103690 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000068109

Regions

Nucleotide binding104 – 1052NADP By similarity

Sites

Active site2591Proton acceptor By similarity
Binding site621NADP By similarity
Binding site1671NADP By similarity
Binding site1971Substrate By similarity
Binding site2011Substrate By similarity
Binding site2351Substrate By similarity
Binding site2541Substrate By similarity
Binding site3591Substrate By similarity
Binding site3641Substrate By similarity

Experimental info

Sequence conflict4171T → S in AAA98853. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P48992 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: FEC3CFBF7119E977

FASTA50958,304
        10         20         30         40         50         60 
MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV 

        70         80         90        100        110        120 
ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY CPGDIDNPES YQKLKNLLSE 

       130        140        150        160        170        180 
LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG GAGMLDDPYK HRLVIEKPFG RDLASAQSLN 

       190        200        210        220        230        240 
AVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 

       250        260        270        280        290        300 
DRAGYYEKAG ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS 

       310        320        330        340        350        360 
RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG VPFYLRTGKR 

       370        380        390        400        410        420 
MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE GISLRFDVKM PGAEFRTRSV 

       430        440        450        460        470        480 
DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDSPADPA 

       490        500 
TIPQYEAGTW EPAEAEFLIN QDGRRWRRL 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120."
Newman J., Karakaya H., Scanlan D.J., Mann N.H.
FEMS Microbiol. Lett. 133:187-193(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120."
Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takazawa M., Yamada M., Yasuda M., Tabata S.
DNA Res. 8:205-213(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7120 / UTEX 2576.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U33282 Genomic DNA. Translation: AAA98853.1.
BA000019 Genomic DNA. Translation: BAB75718.1.
PIRAD2308.
RefSeqNP_488059.1. NC_003272.1.

3D structure databases

ProteinModelPortalP48992.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING103690.all4019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB75718; BAB75718; BAB75718.
GeneID1107617.
KEGGana:all4019.
PATRIC22778560. VBINosSp37423_4733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000046191.
KOK00036.
OMAAVVFKRA.
OrthoDBEOG61308Z.
ProtClustDBPRK05722.

Enzyme and pathway databases

SABIO-RKP48992.
UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD_NOSS1
AccessionPrimary (citable) accession number: P48992
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2002
Last modified: February 19, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways