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P48992

- G6PD_NOSS1

UniProt

P48992 - G6PD_NOSS1

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

zwf

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei62 – 621NADPUniRule annotation
    Binding sitei167 – 1671NADPUniRule annotation
    Binding sitei197 – 1971SubstrateUniRule annotation
    Binding sitei201 – 2011SubstrateUniRule annotation
    Binding sitei235 – 2351SubstrateUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei259 – 2591Proton acceptorUniRule annotation
    Binding sitei359 – 3591SubstrateUniRule annotation
    Binding sitei364 – 3641SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi104 – 1052NADPUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    SABIO-RKP48992.
    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PDUniRule annotation
    Gene namesi
    Name:zwfUniRule annotation
    Ordered Locus Names:all4019
    OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
    Taxonomic identifieri103690 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
    ProteomesiUP000002483: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenasePRO_0000068109Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi103690.all4019.

    Structurei

    3D structure databases

    ProteinModelPortaliP48992.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiMQIGAVR.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P48992-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR    50
    IPPETTIVGV ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY 100
    CPGDIDNPES YQKLKNLLSE LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG 150
    GAGMLDDPYK HRLVIEKPFG RDLASAQSLN AVVQKYCKEH QVYRIDHYLG 200
    KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE DRAGYYEKAG 250
    ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS 300
    RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG 350
    VPFYLRTGKR MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE 400
    GISLRFDVKM PGAEFRTRSV DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ 450
    TLFTRADEVE AAWQVVTPAL SVWDSPADPA TIPQYEAGTW EPAEAEFLIN 500
    QDGRRWRRL 509
    Length:509
    Mass (Da):58,304
    Last modified:January 23, 2002 - v2
    Checksum:iFEC3CFBF7119E977
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti417 – 4171T → S in AAA98853. (PubMed:8566707)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33282 Genomic DNA. Translation: AAA98853.1.
    BA000019 Genomic DNA. Translation: BAB75718.1.
    PIRiAD2308.
    RefSeqiNP_488059.1. NC_003272.1.
    WP_010998159.1. NC_003272.1.

    Genome annotation databases

    EnsemblBacteriaiBAB75718; BAB75718; BAB75718.
    GeneIDi1107617.
    KEGGiana:all4019.
    PATRICi22778560. VBINosSp37423_4733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U33282 Genomic DNA. Translation: AAA98853.1 .
    BA000019 Genomic DNA. Translation: BAB75718.1 .
    PIRi AD2308.
    RefSeqi NP_488059.1. NC_003272.1.
    WP_010998159.1. NC_003272.1.

    3D structure databases

    ProteinModelPortali P48992.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 103690.all4019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB75718 ; BAB75718 ; BAB75718 .
    GeneIDi 1107617.
    KEGGi ana:all4019.
    PATRICi 22778560. VBINosSp37423_4733.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi MQIGAVR.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .
    SABIO-RK P48992.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120."
      Newman J., Karakaya H., Scanlan D.J., Mann N.H.
      FEMS Microbiol. Lett. 133:187-193(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7120 / UTEX 2576.

    Entry informationi

    Entry nameiG6PD_NOSS1
    AccessioniPrimary (citable) accession number: P48992
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1996
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3