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P48992

- G6PD_NOSS1

UniProt

P48992 - G6PD_NOSS1

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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene
zwf, all4019
Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei62 – 621NADP By similarity
Binding sitei167 – 1671NADP By similarity
Binding sitei197 – 1971Substrate By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei235 – 2351Substrate By similarity
Binding sitei254 – 2541Substrate By similarity
Active sitei259 – 2591Proton acceptor By similarity
Binding sitei359 – 3591Substrate By similarity
Binding sitei364 – 3641Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1052NADP By similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKP48992.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:zwf
Ordered Locus Names:all4019
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Glucose-6-phosphate 1-dehydrogenaseUniRule annotationPRO_0000068109Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi103690.all4019.

Structurei

3D structure databases

ProteinModelPortaliP48992.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiMQIGAVR.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P48992-1 [UniParc]FASTAAdd to Basket

« Hide

MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR    50
IPPETTIVGV ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY 100
CPGDIDNPES YQKLKNLLSE LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG 150
GAGMLDDPYK HRLVIEKPFG RDLASAQSLN AVVQKYCKEH QVYRIDHYLG 200
KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE DRAGYYEKAG 250
ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS 300
RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG 350
VPFYLRTGKR MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE 400
GISLRFDVKM PGAEFRTRSV DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ 450
TLFTRADEVE AAWQVVTPAL SVWDSPADPA TIPQYEAGTW EPAEAEFLIN 500
QDGRRWRRL 509
Length:509
Mass (Da):58,304
Last modified:January 23, 2002 - v2
Checksum:iFEC3CFBF7119E977
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti417 – 4171T → S in AAA98853. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33282 Genomic DNA. Translation: AAA98853.1.
BA000019 Genomic DNA. Translation: BAB75718.1.
PIRiAD2308.
RefSeqiNP_488059.1. NC_003272.1.
WP_010998159.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75718; BAB75718; BAB75718.
GeneIDi1107617.
KEGGiana:all4019.
PATRICi22778560. VBINosSp37423_4733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U33282 Genomic DNA. Translation: AAA98853.1 .
BA000019 Genomic DNA. Translation: BAB75718.1 .
PIRi AD2308.
RefSeqi NP_488059.1. NC_003272.1.
WP_010998159.1. NC_003272.1.

3D structure databases

ProteinModelPortali P48992.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 103690.all4019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB75718 ; BAB75718 ; BAB75718 .
GeneIDi 1107617.
KEGGi ana:all4019.
PATRICi 22778560. VBINosSp37423_4733.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi MQIGAVR.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
SABIO-RK P48992.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120."
    Newman J., Karakaya H., Scanlan D.J., Mann N.H.
    FEMS Microbiol. Lett. 133:187-193(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiG6PD_NOSS1
AccessioniPrimary (citable) accession number: P48992
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2002
Last modified: September 3, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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