Reviewed, UniProtKB/Swiss-Prot P48992 (G6PD_ANASP)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	all4019

Organism

Anabaena sp. (strain PCC 7120) [Complete proteome] [HAMAP]

Taxonomic identifier

103690 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068109
Sites
	Active site	259	1	Proton acceptor By similarity
	Binding site	30	1	NADP By similarity
	Binding site	62	1	NADP By similarity
	Binding site	197	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	364	1	Substrate By similarity
Experimental info
	Sequence conflict	417	1	T → S in AAA98853. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P48992-1 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: FEC3CFBF7119E977	FASTA	509	58,304
	10 20 30 40 50 60 MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV 70 80 90 100 110 120 ARREWSHEYF REQMQKGMEE AHSSVELGEL WQDFSQGLFY CPGDIDNPES YQKLKNLLSE 130 140 150 160 170 180 LDEKRGTRGN RMFYLSVAPN FFPEAIKQLG GAGMLDDPYK HRLVIEKPFG RDLASAQSLN 190 200 210 220 230 240 AVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE 250 260 270 280 290 300 DRAGYYEKAG ALRDMLQNHL MQLYCLTAME APNSMDADSI RTEKVKVLQA TRLADVHNLS 310 320 330 340 350 360 RSAIRGQYSA GWMKGQQVPG YRTEPGVDPN SSTPTYVGMK FLVDNWRWQG VPFYLRTGKR 370 380 390 400 410 420 MPKKVSEISI HFRDVPSRMF QSAAQQRNAN ILAMRIQPNE GISLRFDVKM PGAEFRTRSV 430 440 450 460 470 480 DMDFSYGSFG IEATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDSPADPA 490 500 TIPQYEAGTW EPAEAEFLIN QDGRRWRRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of gene organization in the zwf region of the genomes of the cyanobacteria Synechococcus sp. PCC 7942 and Anabaena sp. PCC 7120." Newman J., Karakaya H., Scanlan D.J., Mann N.H. FEMS Microbiol. Lett. 133:187-193(1995) [PubMed: 8566707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence of the filamentous nitrogen-fixing cyanobacterium Anabaena sp. strain PCC 7120." Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A., Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M. , Takazawa M., Yamada M., Yasuda M., Tabata S. DNA Res. 8:205-213(2001) [PubMed: 11759840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U33282 Genomic DNA. Translation: AAA98853.1. BA000019 Genomic DNA. Translation: BAB75718.1.
PIR	AD2308.
RefSeq	NP_488059.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	1107617.
GenomeReviews	Gene locus all4019 in contig BA000019_GR.
KEGG	ana:all4019.
NMPDR	fig|103690.1.peg.4326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P48992.
Enzyme and pathway databases
BioCyc	NSP103690:ALL4019-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_ANASP

Accession

Primary (citable) accession number: P48992

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
Last sequence update:	January 23, 2002
Last modified:	November 25, 2008
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)